Cognitive disorder

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

This study tests a new drug called ARO-MAPT-SC in healthy people and those with early Alzheimer's. The goal is to check if it is safe and how the body processes it. Participants receive either the drug or a placebo by injection under the skin. The trial is still in early stages, …

This early-phase trial will test whether a special form of resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for three months. The study will also measure how the drug …

This study tests whether the insomnia medication lemborexant (Dayvigo) can lower blood markers of brain damage in adults aged 40–65 with insomnia. Twenty participants will take the drug or a placebo for two weeks each, then have their blood tested for proteins linked to Alzheimer…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

Researchers are testing whether a home-use pulsed electromagnetic therapy device can slow cognitive decline in people with mild to moderate Alzheimer's disease, Lewy body dementia, or vascular dementia. About 48 participants will use the device three times a day for 15 minutes ov…

This study tests whether taking a daily probiotic (Lab4P) for 12 weeks can improve memory, thinking speed, and blood sugar control in overweight adults aged 18-40 with prediabetes (mildly high blood sugar). Seventy participants will be randomly assigned to receive either the prob…

This study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…

This early-stage trial is testing a long-acting injectable form of the drug cariprazine, called AX251, in 48 adults with stable schizophrenia. The study aims to see how the drug moves through the body and whether it is safe when given as a single shot at different doses. If resul…

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, a…

This Phase 2 study tests an investigational drug called emraclidine in about 268 adults with schizophrenia. The trial has two parts: Part A looks at how the drug moves through the body and its safety at different doses, while Part B measures whether it improves symptoms like hall…

This early-stage trial tests a drug called ALN-APP (mivelsiran) in 60 adults with mild cognitive impairment or mild dementia due to early-onset Alzheimer's disease. The drug is given via a spinal injection to see if it safely lowers certain proteins linked to Alzheimer's in the b…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This study tests whether a drug called dexmedetomidine, which promotes sleep, can prevent delirium (sudden confusion) in patients aged 60 and older after heart surgery. Delirium is common in the ICU and can lead to longer hospital stays and worse recovery. The trial will compare …

This phase 3 trial tests whether KarXT (a combination of xanomeline and trospium chloride) can prevent relapse in people with schizophrenia. Participants who have had a recent hospitalization for schizophrenia and still have symptoms will receive KarXT or a placebo. The study mea…

This study looks at whether giving free reading or distance glasses to older adults in rural areas can slow down memory and thinking problems. About 964 people aged 60-79 with poor eyesight but normal hearing and memory will take part. Half will get glasses, and the other half wi…

This study is testing the long-term safety of a new medication called LB-102 for adults with stable schizophrenia. About 900 participants will take the drug for 52 weeks to see what side effects occur. The goal is to make sure the drug is safe enough for ongoing use to control sc…

This trial tests whether citicoline, a neuroprotective agent, can prevent or slow cognitive decline in older adults who develop delirium while hospitalized for a hip fracture. Delirium is a common complication that can lead to lasting memory and thinking problems. Participants wi…

This phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…

This study tests whether drugs that target tau protein, alone or with donanemab, can reduce tau buildup and slow memory decline in people aged 50-80 with early Alzheimer's. Participants will receive treatment for 30 months and undergo brain scans and cognitive tests. The goal is …

This study tests a drug called mivelsiran in 58 adults with Down syndrome who have early-stage Alzheimer's. Participants receive either the drug or a placebo via injection into the spine every few months for two years. The goal is to see if the drug can reduce brain changes linke…

This early-stage trial tests an experimental gene therapy called VY1706 in people with early Alzheimer's disease. The goal is to see if it is safe and tolerable, and whether it can reduce tau protein buildup in the brain, a hallmark of the disease. Participants receive one of thr…

This phase 3 trial is testing whether the drug KarXT can safely and effectively treat schizophrenia in adolescents aged 13 to 17. About 166 teens will receive either KarXT or a placebo, and researchers will track changes in symptoms like delusions and social withdrawal. The goal …

This study tests whether adding brenipatide to standard schizophrenia medication is safe and effective. About 450 adults with schizophrenia will receive either brenipatide or a placebo for up to 12 months. The study looks at weight changes, cognitive function, and time to relapse…

This early-stage trial tests whether adding special cells (DUOC-01) into the spinal fluid is safe for children with inherited metabolic diseases that damage the brain. Participants are ages 1 week to 21 years and are already receiving a standard umbilical cord blood transplant. T…

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This trial tests two experimental drugs, donanemab and RG6289, in people who carry a specific genetic mutation that causes an inherited, early-onset form of Alzheimer's disease. The study first gives donanemab to clear amyloid plaques from the brain, then randomly assigns partici…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether eating peanuts and peanut products daily for six months can improve blood sugar, blood pressure, thinking skills, and gut health in people with prediabetes. Researchers will enroll 72 adults from diverse racial backgrounds. Participants will eat different…

This early-stage study is testing a long-acting injectable form of the drug KarXT in 116 people with schizophrenia. The main goal is to check the drug's safety and how the body processes it. Researchers hope this injectable version could offer a more convenient treatment option t…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …

This early-stage trial tests whether the experimental drug aticaprant is safe and tolerable when added to standard antipsychotic treatment for schizophrenia. About 64 clinically stable outpatients will receive either aticaprant or a placebo. The main goals are to see if the study…

This study tests a program called PICU Up! that helps critically ill children start moving earlier while in the pediatric intensive care unit. The program includes daily activity plans, better sedation management, and family involvement. Researchers want to see if this approach r…

This trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …

This trial tests whether nicotinamide riboside (NR), a form of vitamin B3, can slow the progression of early Alzheimer's disease. About 270 adults with early-stage Alzheimer's will take NR or a placebo daily for two years. Researchers will measure changes in memory, thinking, and…

This study tests whether tracking smartphone activity and offering extra support from peer specialists can help veterans with serious mental illness avoid emergency room visits and hospital stays. About 400 veterans who are at high risk will take part. The goal is to catch early …

This phase 2 trial tests whether an oral drug called SAR448851 can slow the progression of early Alzheimer's disease. It includes people with mild cognitive impairment or mild dementia due to Alzheimer's, who have brain amyloid plaques. Participants receive either the drug or a p…

This trial tests whether a single dose of levetiracetam, a drug used for epilepsy, can reduce overactivity in the hippocampus — a brain area linked to thinking and memory problems in psychosis. People aged 18–40 who are at risk of psychosis will take either the drug or a placebo …

This study is for people aged 18-35 experiencing their first episode of psychosis. Researchers will use genetic tests and MRI brain scans to see if certain markers can predict which antipsychotic drug (aripiprazole, risperidone, or clozapine) will work best. The goal is to improv…

This study tests the drug acoramidis in people with transthyretin amyloid cardiomyopathy (ATTR-CM), a condition where abnormal proteins build up in the heart, weakening it. Over 36 months, researchers measure whether acoramidis improves heart function and structure using cardiac …

This Phase 3 trial is testing whether two existing drugs—atomoxetine, typically used for ADHD, and metformin, a diabetes medication—can slow cognitive and functional decline in people with Alzheimer's disease. Around 1,200 participants aged 55 and older with mild to moderate Alzh…

This study tests a Transition Care Team (TCT) designed to help people with first episode psychosis successfully move from hospital to outpatient mental health services. The TCT provides short-term support including therapy, case management, and coordination with community program…

This study tests whether a drug called CORT108297, which blocks a stress hormone, can improve memory and thinking in people with mild cognitive impairment or those at risk for Alzheimer's disease. Participants take the drug or a placebo for two weeks, then complete memory and att…

This study tests whether very low doses of radiation delivered to the whole brain are safe and can help preserve thinking and memory in people with Alzheimer's disease or certain dementias with inflammation. Participants receive an initial course of 10 radiation sessions, followe…

This phase 4 trial tests lecanemab, an antibody treatment for Alzheimer's disease, in 100 people with mild cognitive impairment or mild Alzheimer's dementia. Participants receive lecanemab infusions every two weeks for 18 months. The study also evaluates a new blood test that use…

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will enroll 120 people who had a stroke in the past 6 months. Participants will do a mix of exercises, and the study will measure chan…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This pilot study explores whether computer-assisted music remediation can improve memory, attention, and thinking in young people aged 18 to 30 who have had a first psychotic episode. Participants attend weekly group sessions using music software to practice memory and executive …

This study tests whether a daily polyphenol supplement (like berry capsules) can slow cognitive decline in 300 older adults at risk for Alzheimer's. Participants take the supplement or a placebo for 12 months, providing blood, stool, and brain scans. The goal is to see if the sup…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This early-stage trial is testing whether a nasal spray containing exosomes from umbilical cord stem cells is safe and might help people with mild to moderate Alzheimer's. The study involves 33 participants and will first test different doses, then compare the best dose to a plac…

This study tests whether a drug called leronlimab is safe for people with mild Alzheimer's or mild cognitive impairment. Twenty volunteers over age 50 will receive weekly injections for 12 weeks. Researchers will use brain scans and blood tests to see if the drug lowers brain inf…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can slow cognitive decline in people with early Alzheimer's disease. The treatment targets a key brain region affected by Alzheimer's. Fifty-five partici…

This early-stage study tests whether it is safe to combine a drug called etanercept with repeated ultrasound sessions to temporarily open the blood-brain barrier in people with mild Alzheimer's disease. The goal is to let more of the drug reach the brain to reduce inflammation. O…

This Phase 2 trial tests whether ambroxol, a common cough medicine ingredient, can slow cognitive decline and improve symptoms in people with early dementia with Lewy bodies. 180 participants will receive either ambroxol or a placebo for 18 months. The study measures changes in t…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce cannabis use in people with schizophrenia. 110 motivated participants will receive either real or sham stimulation over 5 days. Researchers will track changes in cannabis consumption, cravi…

This Phase 2 trial tests whether fasudil, a drug already used in Japan and China for brain blood vessel spasms, can improve memory and brain function in people with early Alzheimer's disease. Two hundred participants will receive either fasudil or a placebo for 12 months, with re…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults aged 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, undergo memory tests, and have MRI scans over a year…

This Phase 3 trial tests a personalized care plan for 500 young people aged 15-30 with early psychosis. The plan combines cognitive training (using apps and virtual reality) with supplements (vitamin B12, folinic acid, Omega 3, NAC) tailored to each person's needs. The goal is to…

This study tests whether a clinical pharmacist calling a patient's general practitioner 90 days after hospital discharge can reduce readmissions and emergency visits. It includes 800 patients aged 65 and older who take at least seven medications. The goal is to improve communicat…

This study is testing a new version of a gut antibiotic called rifaximin in 20 people with mild-to-moderate Alzheimer's or vascular dementia. The goal is to see if changing the bacteria in the gut can improve brain function and reduce inflammation. Participants will take the drug…

This study tests whether ocrelizumab, a drug that suppresses certain immune cells, can reduce psychosis symptoms in people whose schizophrenia or bipolar disorder may be caused by auto-antibodies attacking brain receptors. Forty participants aged 18–35 will receive either ocreliz…

This study compares a new ambulatory (same-day) stroke care model to standard hospital care for patients aged 60 and older who have had a mild stroke or transient ischemic attack (TIA). Participants receive a full neurological assessment and treatment plan on the same day and the…

This Phase II trial tests whether siponimod, a drug already approved for multiple sclerosis, can safely slow brain atrophy in people with mild Alzheimer's disease. Over 18 months, 105 participants will receive either the drug or a placebo. Researchers will measure brain volume ch…

This study looks at whether drinking non-alcoholic red wine, which is rich in natural compounds called polyphenols, can help older adults keep their thinking sharp and muscles strong. Researchers will give 72 people aged 60-74 either non-alcoholic red wine or water, both as part …

This global study tests whether applying a sunlight-reflecting coating to roofs can lower indoor temperatures and improve health. Researchers will enroll 3,200 households in five hot cities across Africa, Asia, Latin America, and the Pacific. They will measure heart rate, blood s…

Researchers are studying whether a combination of blood tests, retinal imaging, and brain scans can improve the detection and staging of Alzheimer's disease in Chinese adults. The study enrolls 300 people, including those with probable Alzheimer's dementia and those without. Part…

This study is testing a smartphone app that records and analyzes speech to help diagnose and monitor neurodegenerative conditions like dementia, Parkinson's disease, multiple sclerosis, and motor neuron disease. Researchers will compare speech patterns from 150 people with these …

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

Researchers are building AI models that score standard physical and cognitive screening tests from video and audio, and that predict results a person did not obtain. The study enrolls adults 18 and older and follows them for life, linking records to a long-term aging study to che…

This study tests whether a radioactive tracer called 18F-S16/T807 can help diagnose tau-related brain diseases. Tau is a protein that builds up abnormally in conditions like Alzheimer's and other neurodegenerative disorders. Researchers will give 500 adults a single injection of …

This trial tests whether PET/CT scans using special radioactive tracers can detect amyloid protein buildup in various diseases, including cardiac amyloidosis. Researchers will give each participant a single injection of one of several tracers, then perform imaging to measure how …

This study tests a new radioactive tracer called [18F]NIDF that binds to tau tangles in the brain, which are linked to Alzheimer's and other neurodegenerative diseases. Researchers will give the tracer to 20 healthy volunteers and patients, then use PET scans to see how well it h…

This study tests whether a special imaging agent called 18F-FPyCO/SMBT-1 can help diagnose Parkinson's disease and related conditions by detecting a brain enzyme called MAO-B. About 200 adults with suspected or confirmed Parkinson's will receive a single injection of the agent an…

This study tests whether PET/CT scans using two radioactive tracers, 18F-92/AV45 and 11C-PIB, can detect beta amyloid buildup in the brain. Researchers will enroll 500 adults with suspected or known neurodegenerative diseases linked to amyloid. Each participant receives one injec…

This study is testing a new imaging agent called [18F]FT8 to see if it can help doctors better see and diagnose amyloidosis, a disease where abnormal proteins build up in organs like the heart. The study will involve 20 patients with amyloidosis and 5 healthy volunteers. Research…

This study tests a single injection of AMDX-2011P, a dye that may stick to Alzheimer's-related plaques in the retina. Researchers want to see if it is safe and can detect these plaques using eye imaging. 25 adults with confirmed Alzheimer's will participate. If successful, this c…

This trial asks whether a home sleep apnea test can be a better first step than an overnight lab study for diagnosing obstructive sleep apnea in people with dementia or mild cognitive impairment. Sleep apnea is common in these conditions and can worsen thinking problems, but many…

This study looks at whether measuring certain proteins in the blood (p-tau217 and neurofilament light) can help doctors diagnose Alzheimer's disease more quickly and confidently in people with memory problems. About 550 participants visiting a memory clinic will have their blood …

This study is testing whether a blood test that measures specific proteins (pTau217) can help primary care doctors diagnose Alzheimer's disease in people with memory concerns. Researchers will compare the test's accuracy against standard evaluations and track how it changes docto…

This study is testing whether blood tests can help screen for Alzheimer's disease in older adults during routine check-ups. Researchers will enroll 3,000 people aged 60-80 from communities and clinics. Participants will give blood samples, and those with abnormal results will tak…

This study is testing a new, non-invasive way to detect Alzheimer's disease by looking for specific proteins (amyloid and tau) in stool samples. The goal is to see if these proteins can serve as early warning signs, potentially allowing for earlier diagnosis and treatment. Resear…

This study is testing a new memory assessment tool called NEM (New evaluation of Episodic Memory) to see if it can better diagnose Alzheimer's disease in people with mild memory problems. Researchers will compare the NEM test with standard memory tests in 150 adults aged 50 and o…

This study is testing whether new blood tests can accurately diagnose the cause of memory loss or dementia, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If success…

This study aims to make it easier for family doctors to detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using blood tests and brain scans. The goal is to see if these tools can accurately identify who has …

This study is testing a new device called TES HT100 that uses low-power electromagnetic waves to screen for brain injuries in adults coming to the emergency room with mild head trauma or certain neurological symptoms. The device is non-invasive, takes about 5 minutes, and gives a…

This study is testing whether a simple voice recording can help detect Alzheimer's disease early. Researchers will analyze speech patterns from 100 volunteers aged 50 and older and compare them to standard Alzheimer's biomarkers. If successful, this could replace painful lumbar p…

This study is testing a new serious game called REALSoCog to see if it can detect social behavior problems in people with Alzheimer's, Lewy body dementia, or frontotemporal degeneration. Researchers will ask 120 patients to play the game on a laptop, which presents 16 social situ…

This study aims to improve early detection of Alzheimer's disease in people aged 60 and older. Researchers will equip general practitioners and specialists with digital cognitive tests and blood-based biomarkers to identify those with early cognitive decline. The goal is to creat…

This study tests a brain health service designed to assess and reduce dementia risk in people aged 55 to 85 who have subjective cognitive decline (memory concerns without objective impairment). Participants are randomly assigned to either a personalized 6-month program—combining …

This pilot study will test whether teaching people aged 50 to 75 how to cook healthy meals can reduce their risk of type 2 diabetes and dementia. Forty participants at higher risk will either attend weekly cooking classes with at-home practice or receive nutrition handouts. The s…

This study tests whether the experimental drug trontinemab can prevent or delay memory loss and dementia in people who have early biological signs of Alzheimer's but no cognitive symptoms. Participants receive either trontinemab or a placebo intravenously for several years. The g…

This trial tests whether a nighttime care routine called the Triple Sleep-Promotion Protocol can lower the chance of delirium in adults staying in intensive care units (ICUs). Delirium, a state of sudden confusion, is common in ICUs and may be linked to broken sleep and frequent …

This trial tests whether immersive virtual reality (VR) nature scenes can prevent delirium in intensive care unit (ICU) patients on ventilators. Half of the 300 participants will watch nature videos through a VR headset for 20 minutes daily, while the other half watches the same …

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This large study is testing whether taking atorvastatin (a statin) can help healthy adults aged 75 and older avoid dementia, disability, and death. Participants are randomly assigned to take either the drug or a placebo for several years. The goal is to see if this simple pill ca…

This trial tests whether taking golden oyster mushroom powder every day for two years can help preserve memory and thinking in middle-aged and older adults who are at higher risk for dementia. Around 600 community-living adults aged 45 to 80, who have a family history of dementia…

This study tests a structured care program to prevent postoperative delirium (sudden confusion) in patients aged 70 and older undergoing surgery. Over 18,000 participants will receive evidence-based prevention measures, with electronic tracking to ensure consistency. Additional s…

This trial tests whether giving melatonin intravenously during surgery can prevent the agitation and delirium some children experience when waking up from anesthesia. About 1 in 4 children show these distressing behaviors, which include crying, thrashing, and confusion. The study…

This study tests whether using hearing aids and related support can help slow memory decline in adults aged 55-75 who have mild to moderate hearing loss and early signs of memory problems. Participants are randomly assigned to receive either a hearing intervention or a health edu…

This study tests whether giving ICU patients 0.5 liters of wheat beer each evening for 6 days can lower their risk of developing delirium, compared to patients who receive water. Delirium is a sudden confused state common in intensive care. The trial will include 380 adults who h…

This study tests whether lifestyle changes like diet and exercise can help prevent dementia in adults aged 55 and older. Researchers will track 2,000 participants over three years, measuring memory, thinking skills, and how well people stick to healthy habits. The goal is to find…

This study tests if a daily probiotic powder can prevent or reduce weight gain, high blood sugar, and high cholesterol caused by certain antipsychotic drugs. About 112 adults starting or recently starting olanzapine, quetiapine, risperidone, or clozapine will take either the prob…

This study explores whether mindfulness training can help prevent cognitive decline in Latino adults aged 65 and older, a group at higher risk for Alzheimer's disease. Researchers will measure brain activity and thinking skills in 60 participants before and after mindfulness prac…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study tests a brief problem-solving therapy to prevent suicide in adults aged 50 and older who have suicidal thoughts. The therapy is delivered in three formats: face-to-face, by phone, or via a smartphone app. 212 participants will be randomly assigned to one of these forma…

This study tests a tailored program called REMINDER4Care for adults aged 65 and older living in residential or daycare facilities. The program focuses on social and cognitive activities to reduce dementia risk. Researchers will compare the program's effects on thinking skills, mo…

This study tests whether regular aerobic exercise can prevent or slow memory decline in older adults (ages 50-80) who have memory complaints but no dementia. Participants will be randomly assigned to either an aerobic exercise program or a stretching and toning group for six mont…

This study tests a simple program for people aged 60+ having heart surgery. Before surgery, participants will get help improving sleep and do brain exercises. After surgery, they receive extra pain relief. The goal is to see if this bundle reduces delirium (sudden confusion and a…

This study tests Exercogs®, a digital game that uses augmented reality to combine mental challenges, physical exercise, and social interaction. Researchers will enroll 150 adults aged 55 and older who have at least one risk factor for dementia. Participants will play the game thr…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

Researchers at Hannover Medical School are testing whether intermittent theta-burst stimulation (iTBS), a non-invasive brain stimulation technique, can reduce negative symptoms and improve thinking in people with schizophrenia. The trial enrolls 60 adults aged 18 to 65 with a sch…

This study tests whether a dietary supplement called AP-Brain can improve cognitive function in healthy adults aged 18-39 who feel they have attention problems. Participants will take different doses of AP-Brain or a placebo for 56 days and complete memory and attention tests. Th…

This study is testing whether a dietary supplement called AP-Brain can improve memory and thinking in healthy adults aged 40 to 79 who feel their memory is slipping. Participants will take different doses (1g, 3g, or 5g) or a placebo for 56 days and complete computer-based memory…

Researchers are testing whether transcranial random noise stimulation (tRNS), a non-invasive brain stimulation technique, can improve behavioral and psychological symptoms in people with early Alzheimer's disease. The trial enrolls 40 participants who receive either active tRNS o…

Many people who care for a family member with dementia struggle with sleep. This trial tests an 8-week program that combines a sleep self-help manual, cartoon videos, and weekly telephone coaching. Researchers randomly assign 120 caregivers to either the sleep program or an educa…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

Researchers test whether a non-invasive brain stimulation called tACS can help people with schizophrenia better tell themselves apart from others. The trial delivers 10 Hz current to the medial prefrontal cortex for 20 minutes daily over five days. Participants include patients w…

Researchers are testing a home-use pulsed electromagnetic therapy device in 40 people with mild to moderate Alzheimer's disease. Participants use the device three times a day for 15 minutes over 120 days. The study measures changes in thinking and memory using standard tests, wit…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the drug combo or a placebo for 14 weeks. The main goal is to se…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults will receive either the drug combo or a placebo for 14 weeks. The main goal is to see if agitation symptoms improve, as…

This study tests a medicated skin patch (dexmedetomidine) to see if it can reduce agitation in people with Alzheimer's dementia. About 150 adults living in care facilities will receive either the patch or a placebo for 96 hours. The goal is to measure changes in agitated behavior…

This study is testing the long-term safety of a combination of two drugs, KarXT and KarX-EC, for treating agitation in people with Alzheimer's disease. It is an open-label extension, meaning everyone knows they are getting the treatment. The study enrolls 600 participants who hav…

Researchers are testing whether a home-based program combining adapted exercise and mindfulness training can improve walking ability and sleep quality in people with rare neurodegenerative diseases such as leukodystrophy, ataxia, and adrenomyeloneuropathy. The study enrolls about…

Researchers are testing a once-weekly tablet of brexpiprazole against placebo in adults hospitalized for an acute episode of schizophrenia. The trial enrolls about 450 people aged 18 to 74 who need hospital care for a relapse. Over seven weeks, participants receive either the act…

Care homes face shortages of trained staff, and more than half of residents have some form of dementia. Researchers are testing whether retired volunteers can lead a group music and discussion program called Making Connections Thru Music. The study enrolls 196 people: volunteers …

Researchers are testing a digital app called BRAIN that uses artificial intelligence to personalize cognitive stimulation for people with dementia. The app tailors activities to each person's interests and background, aiming to improve engagement, quality of life, and relationshi…

Researchers are testing nursing care built on the Salutogenesis Model, which aims to strengthen a person's sense of coherence: how understandable, manageable, and meaningful life feels. The study enrolls 73 adults with mild to moderate dementia and assigns them to face-to-face se…

People with treatment-resistant schizophrenia often take clozapine, a drug that can cause serious weight gain and metabolic problems. This pilot study tests whether a daily infusion made from the leaves of the Nitraria retusa plant can reduce those side effects. Thirty patients w…

VoiceLove is a phone app that lets family members and ICU patients share messages and information securely. Researchers at Vanderbilt University Medical Center are comparing the app with usual care to see whether it improves communication, family engagement, and delirium in criti…

This study tests an experimental drug called evenamide for people with schizophrenia that hasn't improved with standard antipsychotics. About 400 adults will receive either evenamide or a placebo added to their current medication for 12 weeks. The goal is to see if evenamide redu…

This study explores whether a virtual reality mindfulness meditation program is practical and well-liked by older adults with mild to moderate cognitive impairment living in long-term care homes. About 36 participants will try up to 8 VR sessions over 4 weeks, and researchers wil…

This study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…

This study looks at whether eating pecans every day for three months can improve memory, mood, and brain function in people aged 50 and older with mild cognitive impairment. Sixty participants will be randomly assigned to eat either pecans or pretzels as a snack. Researchers will…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

This pilot study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can safely improve memory in people with mild-to-moderate Alzheimer's disease. The treatment targets the precuneus, a brain region important f…

This study tests whether combining home-based brain stimulation (tDCS) with virtual speech therapy can improve communication in adults with primary progressive aphasia, a language disorder often caused by Alzheimer's disease. Eighty participants will receive either active or plac…

This Phase 3 trial tests whether the drug KarXT can safely reduce psychosis (hallucinations and delusions) in people with Alzheimer's disease. About 500 participants aged 55 to 90 with mild to severe Alzheimer's and moderate to severe psychosis will receive either KarXT or a plac…

This study tests whether an immersive virtual reality program using nature scenes can improve cognitive and emotional well-being in older adults with mild to moderate cognitive impairment. Participants will attend 10 group sessions that combine virtual nature environments with mi…

This study tests whether a smartphone app can help people with schizophrenia in Ghana feel better. Researchers will compare usual care to two app-based programs. The goal is to see if the apps reduce symptoms like depression, anxiety, and paranoia.

This study tests whether a brain-computer interface (BCI) that reads your brain waves while you play a video game can deliver targeted magnetic stimulation to improve focus and thinking. Researchers will enroll 180 adults, including those with mild cognitive impairment, to compar…

This study will test whether using a virtual reality (VR) headset for cognitive and physical exercises is practical and well-liked by people with mild cognitive impairment. Ten participants will do three supervised VR sessions per week for six weeks. The goal is to see if they ca…

This study tests whether adding cannabidiol (CBD) to standard antipsychotic medication can improve symptoms in people experiencing their first episode of psychosis who haven't responded well to initial treatment. About 250 participants aged 16-40 will receive either CBD or a plac…

This study tests an experimental oral medication (BMS-986368) to reduce agitation in people with Alzheimer's disease. About 120 participants will receive either a low dose, high dose, or placebo. The main goal is to see if the drug safely decreases agitated behaviors, such as pac…

This study tests an experimental drug, ITI-1284, to see if it can safely reduce psychosis symptoms like hallucinations and delusions in people with Alzheimer's disease. About 370 participants will receive either the drug or a placebo, and doctors will track changes in symptom sev…

Researchers at the University of Alabama at Birmingham are testing whether short online activities can change mood and attitudes. The study includes 200 adults aged 18 to 65, some with a psychotic disorder such as schizophrenia and some healthy controls. Participants complete the…

This study tests whether a non-invasive magnetic brain stimulation technique (rTMS) can improve thinking and memory in people with mild-to-moderate Alzheimer's disease. Researchers will also use brain scans to see if the treatment helps clear waste from the brain. The trial invol…

This trial tests whether an accelerated form of brain stimulation, called intermittent theta burst stimulation (iTBS), is safe and feasible for young people at clinical high risk for psychosis. Participants receive either active or sham stimulation over five days, targeting a bra…

This study tests the safety and tolerability of the drug Zunveyl in 150 adults aged 50 and older with mild to moderate Alzheimer's disease. Over 12 weeks, researchers will monitor side effects and whether the drug helps reduce neuropsychiatric symptoms like agitation or mood chan…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This trial tests whether personalized repetitive transcranial magnetic stimulation (rTMS) can reduce cognitive fluctuations—sudden changes in alertness and attention—in people with dementia with Lewy bodies (DLB). Forty participants will receive both an experimental rTMS conditio…

This study tests a quick, 5-day brain stimulation treatment for the 'negative symptoms' of schizophrenia, like low motivation and social withdrawal. 75 adults with stable schizophrenia will get either real or fake (placebo) stimulation. The goal is to see if this approach is safe…

This study tests whether a talking therapy called Compassion Focused Therapy (CFT) can help people with conditions like depression, bipolar disorder, or schizophrenia feel less shame and self-stigma. Participants will be randomly assigned to receive CFT, a standard psychoeducatio…

This study is developing and testing an online platform called LEND that shares personal stories from people with dementia and their carers. The goal is to see if these relatable narratives can boost wellbeing, confidence, and quality of life for both groups. The trial involves i…

This study tests whether a noninvasive brain stimulation technique called iTBS can improve working memory in people with early-stage schizophrenia. Researchers will use magnetic pulses and EEG to measure brain activity before and after stimulation. The goal is to see if iTBS can …

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exerc…

This pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …

This study tests whether a very low dose of levetiracetam, a drug used for epilepsy, can reduce abnormal overactivity in a key memory area of the brain. It includes 40 people who have a parent or sibling with Alzheimer's and have memory concerns but still score normally on thinki…

This study tests an experimental oral drug called GXV813 in 142 hospitalized adults with schizophrenia. The goal is to see if it safely reduces symptoms like hallucinations and withdrawal during an acute episode. Participants are randomly assigned to receive GXV813 or a placebo, …

This randomized trial tests whether a structured, personalized music program (MUSIC CARE©) can reduce care refusal during daily hygiene care in nursing home residents with dementia. Care refusal—resisting bathing, dressing, or medication—is common and stressful for both residents…

This early-stage trial is testing whether the drug MDMA (commonly known as ecstasy) is safe and tolerable for people with schizophrenia. The goal is to see if it can help with social withdrawal, a common and hard-to-treat symptom. Twenty stable participants will receive three dif…

This study tests whether letting a child aged 2 to 6 video chat with a parent on a tablet while being taken to the operating room can reduce agitation when they wake up from anesthesia. It compares live video interaction, watching a cartoon, and standard care in 150 children havi…

This study investigates whether complex rhythmic movement training, like dancing with new partners, can improve mobility and learning in people with Parkinson's disease or mild cognitive impairment. Researchers will compare how participants with Parkinson's, those with memory pro…

This study tests whether acetazolamide, a drug currently used for altitude sickness and glaucoma, can reduce positive symptoms (like hallucinations or delusions) in people with treatment-resistant schizophrenia. Sixty adults aged 18-55 who still have significant symptoms despite …

This study tests whether a safe, non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve working memory in people with dementia. The stimulation is timed to each person's brain waves, measured by EEG, to help brain regions communicate b…

This study tests whether a week of morning bright light therapy improves sleep, alertness, mood, and thinking in healthy university students. Participants use a 10,000-lux light box for 30 minutes each morning for one week, and their results are compared to a week with usual ligh…

This study tests a four-week financial counseling and advocacy program for family caregivers of people with Alzheimer's or related dementias who are in early or middle adulthood. Participants receive financial coaching, self-advocacy support, and referrals, and researchers measur…

This study tests whether daridorexant, a sleep medication, can improve sleep in people with mild cognitive impairment or mild-to-moderate Alzheimer's disease who also have insomnia. Sixty-two participants will receive either the drug or a placebo for one month, and their sleep wi…

This study tests whether a virtual reality game can help older adults with mild cognitive disorders improve their inhibitory control—the ability to stop and think before acting. 48 participants will play the game either on a VR headset or a tablet for 20 minutes, twice a week for…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve memory and thinking in people with mild cognitive impairment. Forty participants will receive either real or fake light sessions for 12 weeks. Researchers will measure brain acti…

This study tests a web-based version of cognitive behavioral therapy for insomnia (CBT-I) in 60 family caregivers of people with dementia. Caregivers will complete four online sessions focused on sleep habits, relaxation, and changing unhelpful thoughts. The goal is to improve sl…

This study tests a non-invasive brain stimulation technique called temporal interference stimulation (TIS) to see if it can improve cognitive function in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive either real TIS or a sham …

This study tests whether training mental health professionals to deliver a short psychoeducational program (BREF) can reduce the burden on caregivers of people with schizophrenia or first psychotic episode. The trial will include 206 caregivers, comparing those who receive the pr…

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This study tests whether giving melatonin at bedtime can help older ICU patients (55+) recover faster from hypoactive delirium, a state of confusion and low activity. Researchers will compare melatonin to a placebo in 190 patients, measuring how long delirium lasts and overall re…

This study tests whether combining mental exercises (cognitive stimulation therapy) with physical activities (motor stimulation) can improve thinking and mobility in people with mild-to-moderate dementia. About 421 participants aged 65 and older will attend 14 sessions over 7 wee…

This study tests a new live video program called Resilient Together for Dementia (RT-D) for couples where one partner has early-stage dementia. The program is designed to help both partners manage emotional distress after a recent diagnosis. The study will include 24 couples and …

This study tests two types of speech therapy for adults with mild-to-moderate primary progressive aphasia, a condition that slowly impairs language. Researchers will compare the therapies in 200 participants to see which better improves communication and reduces caregiver burden.…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help people wake up faster after surgery. Researchers will also see if it reduces confusion and depression after the operation. The study involves 40 adults having lumbar spine surgery.

This study tests whether restricting eating to a 10-hour daytime window (fasting 14 hours overnight) can reduce sleep problems and cognitive decline in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try the diet for 3 or 6 …

This study tests whether an app called Genus, which provides videos, exercises, and quizzes, can help people with knee osteoarthritis learn more about their condition and feel more confident in treatment decisions. About 204 adults over 50 who are waiting for a specialist appoint…

This study tests whether combining a non-invasive brain stimulation technique called accelerated iTBS with computerized cognitive training can help people with mild cognitive impairment (MCI). Fifty adults aged 60-85 will receive the brain stimulation and be randomly assigned to …

This study tests whether people with schizophrenia who hear voices that medication doesn't help can learn to quiet them using a special brain-training technique. Participants get real-time feedback from an fMRI scanner to help them shift their brain activity away from the halluci…

This study tests whether learning music—rhythm, singing, and body movements—can improve attention and thinking in people with schizophrenia. About 120 adults with stable schizophrenia will take part. The goal is to see if music-based training is a more engaging and effective way …

This study explores whether intensive singing lessons can improve thinking, memory, and mood in people with early-stage Alzheimer's. Over 5 months, participants will take twice-weekly singing lessons with a personal teacher, then switch to once-a-month sessions. Researchers will …

This study tests whether using robots at home can reduce apathy—loss of motivation and interest—in people with mild cognitive impairment or dementia. About 75 adults over 40 with apathy will be randomly assigned to interact with a telepresence robot, a social robot, or receive st…

This study tests a 6-week group therapy program for adults with schizophrenia or related disorders. The therapy focuses on changing negative core beliefs (like feeling worthless or that others are dangerous) using compassion-focused techniques. The goal is to see if this approach…

This study tests a new kind of talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early dementia. The therapy uses artificial intelligence to guide conversations about past memories, aiming to reduce troubling symptoms like agi…

This study tests whether adding tablet-based cognitive exercises to standard non-drug care (like better sleep and mobility) can reduce delirium in older adults. Sixty people aged 60+ in a subacute care unit will receive either standard care alone or standard care plus twice-daily…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study tests a web-based program called NiteCAPP designed to improve sleep in people caring for a loved one with dementia, especially those living in rural areas. One hundred caregiver-patient pairs will use the program for 4 weekly sessions plus follow-up boosters. Researche…

This study tests whether exercising to beat-accented music helps older adults (65+) with memory concerns stay active and improve thinking skills. Eighty participants will be randomly assigned to a 6-month exercise program with or without special music. The goal is to see if music…

This study tests whether giving 3-5 year olds a daily prebiotic fiber powder for several weeks can improve their mood, sleep, emotional control, and thinking. Parents of 106 children with low fiber intake will report on their child's behavior and emotions. The study is double-bli…

This study tests whether estradiol patches can improve anhedonia (loss of pleasure) and psychosis symptoms that start during perimenopause. About 100 women aged 44-55 will receive either estradiol or a placebo patch for three weeks, plus a short course of progesterone. Researcher…

This study tests whether adding a trauma-focused therapy called EMDR to usual care can help reduce trauma symptoms in people with schizophrenia spectrum disorders. Many people with these conditions have experienced trauma, which can make their illness worse, but trauma treatment …

This study looks at whether taking ETAS® daily for 12 weeks can improve memory, mood, and brain activity in healthy adults aged 60 to 80 who have mild memory complaints. Participants will be randomly assigned to receive either ETAS® or a placebo, and will undergo memory tests, br…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with cognitive training, can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can improve thinking, memory, and other symptoms in people with long COVID. About 91 adults who have had cognitive problems for at least 3 months after a COVID infection will be ra…

This study tests whether taking caffeine for 30 weeks can slow down memory and thinking problems in people with early-to-moderate Alzheimer's disease. About 248 adults aged 50 and older will receive either caffeine pills or a placebo (dummy pill) to see if caffeine helps keep the…

This study tests whether exercising before a mild brain stimulation session can improve memory in people with mild cognitive impairment linked to heart or blood vessel problems. 64 adults aged 50 and older will be randomly assigned to receive either real or sham brain stimulation…

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce apathy in people with dementia or mild cognitive impairment. Ten participants will receive rTMS, some also taking the medication methyl…

This study tests whether using a gentle nerve-stimulating device on the ear, combined with computer-based brain training, can improve thinking skills and mood in adults aged 45 to 80 who have noticed changes in their memory or attention. Participants will do 10 sessions at home a…

This study tests a 16-week partner exercise program called BUDPA for people with mild dementia and their family caregivers. The program involves group workouts and at-home practice, aiming to improve thinking, mood, and the relationship between the pair. Researchers will track 23…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study tests whether early occupational therapy—focused on motivating activities and sleep routines—can reduce delirium (sudden confusion) in patients after heart bypass surgery. Researchers will compare the therapy to standard care in 300 adults. The goal is to see if this a…

This study tests whether a non-invasive brain stimulation technique called tACS can safely improve thinking and memory in people with frontotemporal dementia (FTD). Thirty adults with FTD will receive both real and sham (fake) stimulation in a crossover design, so each person act…

This study tests a program called Connect-Home ADRD that helps nursing home staff and caregivers support dementia patients when they move to home, assisted living, or long-term care. About 360 patients and their caregivers will take part. The goal is to see if the program reduces…

This study tests a workshop series designed for people aged 60 and older with early-stage memory loss who live alone. The program provides education and skills training via Zoom to reduce stress, improve well-being, and help with future planning. Researchers will gather feedback …

This study tests whether melatonin, a natural sleep hormone, can help treat delirium in intensive care unit (ICU) patients. Delirium is a state of confusion and disorientation common in critically ill people. The trial will give 30 patients either melatonin or a placebo every eve…

This study explores whether a yoga-based group program is practical and helpful for outpatients with schizophrenia. Sixty participants will be randomly assigned to yoga, strength training, or standard care. Researchers will measure stress, symptoms, and well-being over 12 weeks a…

This study tests whether a computer-based program can reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and also help their care partners feel less burdened. About 388 pairs (patient and care partner) will take part. The program involves …

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. Sixty participants will either use the app plus their usual treatment, or just usual treatment alone, for 12 weeks. Researchers will mea…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This study tests personalized speech therapy delivered online for people with primary progressive aphasia (PPA), a condition that slowly destroys language skills. Researchers will enroll 30 adults with mild PPA and tailor exercises to their specific variant. The goal is to see if…

This study compares two approaches for treating newly diagnosed Alzheimer's disease: the drug donepezil versus a non-drug approach using cognitive stimulation or remediation. Researchers will measure changes in thinking and memory over 6 months in 240 participants aged 50 and old…

This study tests whether a 12-week exercise program, done twice a week, can improve physical function, thinking skills, and reduce fall risk in older adults living in nursing homes. The program includes strength, balance, and aerobic exercises. Researchers will compare it to a st…

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study tests whether playful breathing exercises—like blowing bubbles or cotton balls—can lower anxiety before surgery and reduce confusion after waking up in children aged 3 to 7. About 80 kids will practice these games at home starting 2-3 days before their planned operatio…

This study tests a digital cognitive rehabilitation system called RICORDO for people with mild memory complaints, mild cognitive impairment, or early Alzheimer's dementia. About 102 participants will use the digital program or standard paper-and-pencil exercises at home for 5 wee…

This study is developing a short, personalized program called PERI-MIND to help menopausal women who are worried about dementia. The program includes education about menopause and dementia risk, plus practical skills to cope with fear. Researchers will first hold focus groups to …

Researchers are building a large database of cognitive, behavioral, lifestyle, and genetic information from people with neurodegenerative diseases such as Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. The goal is to find biomarkers that help do…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

DREAM-10 is a 10-year observational study that follows 1,000 adults aged 30 to 60 who have imaging signs of cerebral small vessel disease but no known dementia. Researchers collect clinical data, memory and thinking tests, brain MRI scans, and detailed eye imaging to track how th…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

Researchers are following thousands of people with Alzheimer's disease who receive lecanemab-irmb in routine care to see how often serious brain side effects occur. The study uses a national registry to track brain swelling, small bleeds, seizures, allergic reactions, strokes, an…

This study aims to find the genetic causes of movement disorders and dementias by analyzing DNA from up to 12,000 participants, including patients and their family members. Researchers will collect blood or saliva samples and look for gene mutations linked to these conditions. Th…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

Researchers want to know why older adults get distracted more easily. They are focusing on a small brain region called the locus coeruleus and its connections to other brain networks. The study will test whether two weeks of at-home tablet attention games can improve focus and st…

This study looks at whether sleep patterns in the two weeks before major orthopedic surgery can help predict delirium (sudden confusion) after the operation. Researchers will ask 150 older adults (70+) to wear a watch that tracks sleep and to give blood samples. The goal is to fi…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

This study tests an online training program called DERA for community health workers. The goal is to see if it improves their knowledge about dementia, reduces stigma, and boosts their confidence in helping people with dementia. About 100 community health workers will take the tr…

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

This study looks at heart electrical patterns (ECGs) in 240 people hospitalized for methamphetamine use, comparing those with and without psychosis. Researchers will check ECGs at admission and before discharge to see if psychosis is linked to more heart strain. The goal is to be…

This study investigates repetitive behaviors—like repeating words or actions—in people with Alzheimer's disease. Researchers want to understand how common these behaviors are, what types occur, and whether they are linked to memory problems or lack of awareness of the condition. …

This study follows 150 people diagnosed with methamphetamine-induced psychotic disorder for one year. Researchers will track factors like medication adherence, social support, and insight into illness to see how they relate to changes in psychiatric symptoms. The goal is to bette…

This study will follow 90 people hospitalized with methamphetamine-induced psychotic disorder, comparing those who have also used cannabis in their lifetime to those who have not. Researchers will assess psychiatric symptoms, insight, addiction severity, and sleep quality weekly …

This study collects blood or brain tissue from families with two or more members diagnosed with Alzheimer's or dementia. The goal is to build a large DNA bank that researchers can use to find genes linked to the disease. No individual results are returned, but the data may lead t…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study uses PET and MRI brain scans to see if antipsychotic medication causes lasting changes in dopamine receptors in people with schizophrenia. Researchers will compare three groups: healthy volunteers, patients who have never taken antipsychotics, and patients who have bee…

This observational study follows 500 people with atypical parkinsonian syndromes, including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy, and corticobasal degeneration. Researchers track motor and non-motor symptoms and imaging changes every …

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This study uses a special PET scan with a radioactive tracer called AV-1451 to look at tau protein buildup in the brains of 100 older adults with mild cognitive impairment or Alzheimer's disease. The goal is to see how tau patterns relate to other brain changes and thinking abili…

This early-stage study is testing an experimental drug called LY3439539 in 30 people with mild-to-moderate Alzheimer's disease. The main goal is to see if the drug changes certain proteins in the spinal fluid that are linked to Alzheimer's. Participants will receive the drug thro…

Researchers are studying tiny particles released by brain cells into the blood, called glial extracellular vesicles, to see if they carry signs of inflammation that change as Alzheimer's disease advances. They will follow 48 people across three stages of the disease, from mild fo…

Researchers at Duke and UNC are building a long-term research group of 500 adults to study how memory and thinking change with age. Participants range from healthy younger adults to those with mild cognitive impairment or dementia. Over time, they will provide blood, urine, and s…

This study aims to enroll 50,000 adults aged 45 and older in France to test for a gene called APOE, which is linked to Alzheimer's risk. Participants provide a saliva sample at home and complete online questionnaires. The goal is to build a large registry of genetic and health da…

This study looks at 48 teenagers with autism who were checked for psychotic symptoms 10 years ago. Researchers want to see how their mental health and daily functioning are now. They will compare those who had early signs of psychosis with those who did not, using interviews and …

This study follows 600 people with neurodegenerative diseases such as Parkinson's, Alzheimer's, and related conditions over 1 to 10 years. Researchers collect data from routine clinical exams, brain imaging, movement analysis, and blood tests. They use statistical tools and artif…

This study looks at whether people with mild cognitive impairment or dementia also have problems with their autonomic nervous system, which controls automatic body functions like sweating and pupil response. Researchers will use two non-invasive devices, Sudoscan and automated pu…

This study investigates how a person's genetic makeup influences their response to cannabis, including risk for addiction and psychosis. Healthy adults aged 21-60 receive either a very low or medium dose of THC (the active ingredient in cannabis) or a placebo intravenously. Resea…

Researchers at the University of South Florida are studying whether the microorganisms in the gut and mouth differ between people with healthy brains and those with memory problems. The study will compare young adults, healthy older adults, people with mild cognitive impairment, …

Researchers at the University of Pennsylvania are building a large repository of blood, DNA, and family history data from people with age-related brain diseases like Alzheimer's, Parkinson's, and ALS, as well as their family members. The goal is to support studies into the geneti…

This study is looking at 800 veterans to see if mild traumatic brain injury (concussion) increases the risk of dementia later in life. Researchers will test memory, brain waves, brain scans, and proteins in blood and spinal fluid. The goal is to find early warning signs of diseas…

This study tests whether a non-invasive electrical brain stimulation technique called TES-TI can temporarily alter sleep spindles—brain rhythms often reduced in schizophrenia. Researchers will apply the stimulation during sleep in 20 people (half with schizophrenia spectrum disor…

This pilot study explores whether adding a digital health platform called Lōvu to standard prenatal care is practical and well-received by pregnant people. Participants use a Bluetooth scale, blood pressure cuff, and fetal Doppler that send data to their care team, alongside ment…

This pilot study investigates whether changes in the body clock, influenced by light exposure, are linked to delirium in critical care patients. Researchers will measure light levels at the bedside, collect blood samples to check for body clock markers and proteins related to del…

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This study looks at women who carry the gene for X-linked adrenoleukodystrophy (X-ALD), a rare inherited condition that mainly affects the nervous system. Although the disease is linked to the X chromosome, up to 80% of female carriers may develop symptoms like leg weakness and b…

This study explores whether methane gas produced by gut microbes is linked to the progression of Parkinson's disease and related conditions like dementia. Researchers will measure breath methane levels in 200 adults—including those with Parkinson's, those at high risk (REM sleep …

This trial explores whether physical activity, specifically walking in different visual environments, can improve the sense of self in people with schizophrenia, borderline personality disorder, or vestibular syndromes. Participants will complete walking sessions in three environ…

This study investigates why some people with early-onset Alzheimer's disease or a variant called posterior cortical atrophy show different patterns of brain damage. Using advanced PET and MRI scans, researchers will map tau protein deposits and brain network activity to identify …

This study follows a large group of people with Parkinson's disease and related conditions in France to map how the disease unfolds over time. Researchers collect detailed information on symptoms, treatments, and genetic samples at regular visits. The goal is to identify distinct…

This study uses MRI to compare brain structure and cognitive function in retired female professional soccer players who experienced repeated mild head impacts against high-level athletes in non-contact sports. The goal is to see whether years of heading and minor injuries are lin…

This study tests a digital tool called CGM ASSIST that combines a continuous glucose monitor with easy-to-read displays. The goal is to help people with Alzheimer's or dementia and diabetes, along with their caregivers, better understand blood sugar levels and make informed decis…

This study investigates whether anti-AChR antibodies, found in the spinal fluid of people with myasthenia gravis, are associated with cognitive disorders. Researchers will compare antibody levels in stored spinal fluid and a fresh blood sample from adults with myasthenia and cogn…

This study investigates why people with schizophrenia or depression often experience apathy—a loss of motivation and goal-directed behavior. Researchers will use cognitive tasks and EEG brain recordings to examine three distinct forms of apathy: executive, emotional, and initiati…

This study investigates how fluid drains from the brain to lymph nodes in the neck, a connection that may be important for clearing waste linked to Alzheimer's disease. Researchers will inject a fluorescent dye into the meningeal space of recently deceased organ donors and track …

This study aims to create simple screening tools to identify financial hardship in people with Alzheimer's and their caregivers. Researchers will interview patients and caregivers, then survey large groups to develop and test the measures. The goal is to help healthcare providers…

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This study is a long-running registry that collects detailed health information from all stroke and dementia patients in Erlangen, Germany. It aims to understand how these diseases develop and affect people over time, regardless of age or severity. Participants are followed for l…

This study looks at whether a drug called fampridine, which blocks potassium channels in the brain, can improve working memory in people with cocaine use disorder. Forty chronic cocaine users will receive either the drug or a placebo and then take memory tests. The goal is to und…

This study looks at how chemotherapy for colon or rectal cancer affects thinking and memory. Researchers will track changes in brain function and blood proteins in 60 patients during and after treatment. The goal is to find tests that could identify who is at risk for 'chemo brai…

This study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…

This study aims to understand why people with Alzheimer's disease differ from each other and from healthy older adults. Researchers will use advanced brain imaging (7T MRI), brain wave recordings (EEG), and blood and stool samples to look for patterns that might reflect different…

This study looks at older adults hospitalized for heart, lung, or orthopedic issues to see how many also have undiagnosed mild cognitive impairment or dementia. Participants take a memory test at admission, and those with possible problems get a full brain evaluation and a follow…

This study is testing whether a program delivered remotely (by video or phone) that combines exercise and dementia caregiving support is practical and helpful for older adults with Down syndrome and their caregivers. About 40 participants will take part. The goal is to see if the…

This study explores whether using physical actions, imagined movements, or videos can improve memory in people with early-stage Alzheimer's disease. Researchers will compare recall in 80 older adults (some with Alzheimer's, some healthy) after they watch videos of daily activitie…

This study investigates whether markers of inflammation in the blood could serve as diagnostic or severity biomarkers across several psychiatric conditions, including bipolar disorder, schizophrenia, and depressive episodes with psychotic features. Researchers will collect blood …

This study is testing whether a smartphone app can help predict the risk of developing Alzheimer's disease. Researchers will collect health data like weight, blood pressure, and blood sugar from people with mild cognitive concerns. An artificial intelligence model will analyze th…

This study investigates whether reduced sensitivity to social rewards contributes to social anhedonia—a lack of pleasure from social interactions—in people who have recently experienced their first episode of psychosis. Participants, aged 18 to 35, will undergo brain scans while …

This study follows 5,000 people with mild cognitive impairment or mild-to-moderate dementia living at home in Bavaria, along with their family caregivers. Researchers collect detailed information on health, daily function, care needs, and quality of life over several years. The g…

This observational study asks whether older patients placed under isolation precautions in the hospital are more likely to develop delirium or experience cognitive decline. Researchers will compare isolated patients aged 70 and older with similar non-isolated patients, tracking d…

This study is testing whether a risk score can predict which older adults will experience confusion or memory problems after a common urological procedure. Researchers will follow 150 patients aged 65 and older undergoing transurethral resection, using cognitive tests before and …

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study tests a new monitor (Ceribell) to see if it can help doctors spot delirium in ICU patients sooner than standard checks. About 100 adults in the ICU will take part. The goal is to see if earlier detection leads to better treatment decisions.

This study is testing whether proteins in the blood can accurately diagnose Alzheimer's disease and predict how quickly it will progress. Researchers will follow 2,000 adults with memory complaints for five years, collecting annual blood samples. The goal is to find a less invasi…

This study investigates whether early-detection programs for psychosis can reduce the time people live with untreated symptoms and whether that leads to better long-term functioning. Researchers will follow adults newly diagnosed with schizophrenia-spectrum disorders in two Danis…

This study investigates whether immune inflammation in the blood and brain is linked to brain structure, function, and symptoms in people with schizophrenia. Researchers will follow 200 participants for three months, collecting clinical data, brain scans, and biological samples. …

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in 180 adults with depression, OCD, anxiety, or schizophrenia. Participants receive accelerated TMS over two days while completing behavioral tests and questionnaires. The goal is to understand which br…

This study uses advanced PET scans and blood tests to examine brain inflammation and white matter damage in people with corticobasal syndrome, a rare movement and thinking disorder. Researchers will compare these brain changes across different subtypes of the condition and agains…

This study investigates whether microRNAs found in brain-derived particles in the blood can serve as biomarkers for schizophrenia. Researchers will compare blood samples from 80 people recently diagnosed with first-episode schizophrenia and 80 healthy volunteers, tracking changes…

This study investigates whether digital biometrics and blood-based markers can help detect, predict, and track delirium in older adults admitted to the intensive care unit (ICU). Participants wear a digital device to collect data like activity and heart rate, and provide blood sa…

This study follows older adults (ages 70-95) who have memory concerns but no dementia, tracking them for up to 5 years to see who develops Alzheimer's. Researchers use brain scans, EEG, eye movement tests, and memory assessments to spot early warning signs. The goal is to better …

This study uses special PET scans to measure brain inflammation and tau protein buildup in people with different forms of Alzheimer's disease, including those with memory, vision, or language problems. Researchers aim to understand how inflammation relates to other brain changes …

This study looks at whether adding a website and virtual coaching to basic activity tracking can help older adults who live alone, have mild memory concerns, and are not very active. 86 participants will wear a Garmin device, set step goals, and get weekly texts. Half will also g…

This study aims to create a 'patient library' by collecting blood, stool, and hair samples from 250 people aged 15 to 30 who have had a first psychotic episode or are at high risk. Researchers will track their mental health over 10 years using the CAARMS test. The goal is to bett…

This study looks at how differences in the NOTCH2NLC gene affect the symptoms and course of neuronal intranuclear inclusion disease (NIID), a rare inherited brain disorder. Researchers will follow 12 members of one family, including those with NIID, gene carriers without symptoms…

This study tests a new, non-invasive MRI technique to detect early brain changes linked to Alzheimer's disease. Researchers will compare brain scans from 50 people with mild memory concerns to healthy volunteers. The goal is to find a simple, affordable way to identify those at r…

This study looks at early changes in mitochondria (the energy centers of cells) and metabolic markers in blood cells of people with Alzheimer's or related dementias. Researchers will compare these measures between those with and without Alzheimer's to find clues about how the dis…

This study tests a program that uses a patient portal to help older adults with mild cognitive impairment or dementia, along with their care partners, reduce medications that may be harmful. Participants receive educational materials and can meet with a pharmacist to review their…

This study aims to create a French-language memory task that can be used during brain scans to measure source-monitoring—the ability to remember where information came from. Researchers will test the task on 120 people, including those with schizophrenia and healthy volunteers. T…

This study tests whether a 3-day training program called REFOCUS helps mental health teams provide care that supports personal recovery. About 760 people with severe mental disorders (like schizophrenia or bipolar disorder) will take part across 18 centers. Researchers will measu…

This study looks at how depression and very early (preclinical) Alzheimer's disease affect driving habits in adults aged 65 and older who still drive regularly. Participants will have their driving tracked with a GPS device and undergo brain scans to measure Alzheimer-related pro…

This study uses a special PET scan to look at tau protein buildup in the brain and see if it relates to memory and thinking problems. Researchers will study 900 adults, some with normal memory and some with mild dementia. The goal is to better understand Alzheimer's disease, not …

This study uses brain scans (PET and MRI) to find early signs of Alzheimer's disease in 650 adults with normal cognition or early-stage symptoms. Participants receive special tracers that highlight amyloid and tau proteins in the brain. The goal is to understand how these biomark…

This study looks at how older adults who worry about their memory may use extra brain power to stay mentally sharp. Researchers will give a medication that temporarily affects a brain chemical to see how attention networks respond. The goal is to understand these compensatory bra…

The CROWN-I study is an observational research project involving 160 people with Alzheimer's disease or mild cognitive impairment. Participants will provide samples and undergo assessments over time to help researchers understand the molecular and genetic features that distinguis…

This observational study is recruiting 600 participants to improve detection and understanding of dementia with Lewy bodies (DLB). Researchers will collect clinical data, brain scans, and spinal fluid samples from people with early symptoms like hallucinations or movement problem…

This study looks at brain activity during sleep in people with early-course schizophrenia compared to healthy individuals. Researchers will play soft tones during deep sleep using a wearable headband to see if it can strengthen sleep-related brain waves and improve memory. The go…

This study is testing whether subtle changes in how people speak can predict who will develop schizophrenia. Researchers will record and analyze free speech from 215 young people aged 15-30 who are at ultra-high risk for psychosis. By using computer programs to detect semantic an…

This study looks at why people with Alzheimer's disease may move more slowly. Researchers will use brain MRI scans and simple reaction time tests in 155 participants with mild cognitive impairment or early dementia. The goal is to link brain lesions to attention-related motor slo…

This study looks at 120 people having their first episode of psychosis. They get brain scans and then take either risperidone or aripiprazole for 12 weeks. The goal is to see if brain scan patterns can predict who will respond well to which drug, potentially personalizing treatme…

This study is collecting blood samples and questionnaires from 1,100 people with bipolar disorder or schizophrenia. Researchers are looking for links between genetics, inflammation, and a dormant virus called HERV-W. The goal is to find new biomarkers and pave the way for future …

This study follows 20 people from families with a genetic risk for frontotemporal dementia (FTD), including those already diagnosed and those at risk. Over five years, researchers will track changes in health and brain function to better understand how the disease develops. The g…

This study is creating a new computer-based cognitive assessment to help detect Alzheimer's disease in its earliest stages. Researchers are working with memory nurses and older adults to design the test and a training course for nurses. 120 older adults with memory concerns will …

This study enrolls adults with Down syndrome ages 25-55 into a ready-to-test group. Researchers will track memory, thinking, and brain changes over time to better understand how Alzheimer's disease develops in this population. The goal is to make future clinical trials faster and…

This study looks at whether special brain cells called tanycytes play a role in Alzheimer's disease and frontotemporal dementia. Researchers will measure hormone levels in blood and spinal fluid from 102 participants to see if these cells help control metabolism and hormone signa…

This study aims to find genes that increase the risk of developing Alzheimer's disease. Researchers are recruiting 10,000 people, including those with Alzheimer's and their family members, from all ethnic backgrounds. By analyzing DNA, they hope to discover new genetic clues that…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study is for adults with depression who have recently attempted suicide. It tests a group program that teaches emotion regulation and values to improve daily functioning and prevent future suicide attempts. Researchers will also measure thinking skills, quality of life, and …

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…

This study uses brain imaging (PET scans) and memory tests to understand why some people with Parkinson's disease develop dementia. Researchers will follow 320 participants over several years, using scans to look for abnormal proteins and track thinking changes. The goal is to id…

This study tests new methods to improve how dementia clinical trials are run. Researchers want to see if a combined score of thinking and daily function can better measure treatment effects. They will also check if blood proteins can predict who responds to the Alzheimer's drug d…

This study is testing a new, non-invasive ultrasound technique called Tissue Pulsatility Imaging (TPI) to measure tiny brain movements. Researchers will compare these measurements in 300 people with mild versus major cognitive disorders. The goal is to see if brain pulse patterns…

This study looks at how people with schizophrenia-spectrum disorders update their beliefs after treatment for persecutory delusions. Researchers will use therapy, brain scans, and learning tasks to see if treatment changes how the brain responds to uncertainty. The goal is to bet…

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in patients over 70. Researchers will monitor 70 participants in the hospital to see if nighttime hypoxia increases the risk of complications like infec…

This study is testing whether a non-invasive electrical stimulation technique can improve working memory, attention, and thinking skills in healthy older adults and those with mild cognitive impairment. The stimulation targets deep brain structures without surgery, using special …

This study at Mayo Clinic looks at two different types of Progressive Apraxia of Speech, a condition that makes it hard to speak clearly. Researchers will use brain scans, speech assessments, and thinking tests in 47 adults to better tell these types apart. The goal is to improve…

This study looks at how social and emotional thinking skills relate to everyday behavior in people with Alzheimer's disease and similar conditions. Researchers will give 120 participants tests of social cognition and ask their study partners to complete behavior checklists. They …

This study tests a 4-week training program for assisted living staff (nurses, administrators, and coordinators) to improve palliative care for residents with dementia. The goal is to increase advance care planning discussions and reduce caregiver burnout. About 792 participants f…

This study tests whether eating walnuts daily for a week can improve thinking and memory in adults who feel their memory is slipping. Participants will eat either walnuts or a white chocolate bar each day, then switch after a break. Researchers will measure brain function and gut…

This study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…

This study tests whether improving sleep with a special headband and doing mild exercise twice a week can lower biological markers linked to dementia. Thirty adults with mild memory or thinking problems will use the DREEM 2 headband for sleep therapy and follow a guided exercise …

This study tests whether a special training toolkit helps doctors and nurses have better conversations about future medical care with people living with Alzheimer's or related dementias. The researchers will compare clinics that use the toolkit to those that continue usual care, …

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. The goal …

This study looks at slow brain waves during sleep and wakefulness in 90 people: young adults, healthy seniors, and early-stage Alzheimer's patients. Researchers will measure these waves and test memory and attention. They will also play sounds during sleep to see if it boosts mem…

CAPTURE ALS is a long-term study that collects health data and biological samples from 150 people with ALS and related conditions. The goal is to create a shared resource for researchers worldwide to better understand the disease and develop new treatments. No experimental drugs …

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study tests whether a video camera and artificial intelligence can accurately measure delirium severity in ICU patients over 50. Researchers will compare the camera data with standard bedside assessments. The goal is to create a passive digital marker that works automaticall…

This study explores how aging affects the ability to learn who to trust. Researchers will use real-time fMRI to give older adults feedback on their brain activity while they practice trust-related tasks. The goal is to see if this brain training can improve their decision-making …

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study is testing whether neighborhood pharmacies can help identify older adults with early memory problems and guide them to the right support. Over 1,000 participants aged 60 and older will take a digital memory test at their pharmacy. If the test shows concerns, the pharma…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study looks at how different exercise intensities affect the brain in people with type 2 diabetes. 75 inactive adults aged 30-75 will do supervised cycling at high or moderate intensity for 6 months, three times a week. Researchers will use brain scans, cognitive tests, and …

This study tests a non-invasive device that uses light and sound at a specific frequency (gamma) to see if it can change brain activity. Researchers will measure effects using brain scans and tests in 150 healthy adults and people with Alzheimer's. The goal is to see if this appr…

This study is tracking 850 adults with normal cognition or early memory problems, some of whom have prediabetes. Researchers will monitor memory, brain scans, and spinal fluid over time to see how blood sugar issues might affect Alzheimer's risk. The goal is to better understand …

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is…

This study looks at language difficulties in people with psychosis, including those at risk, experiencing a first episode, or diagnosed with schizophrenia. Researchers will give a full language test to 90 patients and compare results with a healthy control group. The goal is to b…

This study is for 244 people with early-stage Alzheimer's disease. Researchers want to find new blood markers that show why some people's brains are more resilient to the disease. Participants will give blood samples and take memory tests over time. No new treatment is being test…

This study tests a communication program called COACH-Cog for older adults with both dementia and cancer. It includes a training video for doctors and a coaching session for patients and their care partners. The goal is to see if this helps everyone work together better when maki…

This study investigates how people with schizophrenia experience time and sensory information differently. Researchers will use a visual illusion task to see if small timing disruptions affect perception. The goal is to better understand the link between time processing and psych…

This study looks at how people with schizophrenia sense time through touch. Researchers measure finger movements and brain signals to see if problems with timing can help predict who might develop psychosis. The goal is to find early markers for better care.

This study investigates how the immune system influences psychotic symptoms and response to antipsychotic medication. Researchers will collect blood and spinal fluid from 500 participants, including those starting or changing antipsychotics and healthy controls. The goal is to fi…

This study is following 100,000 people in China over many years to learn more about dementia and memory loss. Researchers will track who develops these conditions, look for risk factors like genes and lifestyle, and find better ways to diagnose and prevent dementia. The goal is t…

This study is following 40,000 people from families with a strong history of Alzheimer's disease in China. Researchers are collecting genetic, brain imaging, and thinking and memory test data to learn how the disease develops over time. The goal is to find early signs of the dise…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study follows healthy people who have a family history and genetic risk for ALS. Researchers want to find early warning signs and understand what triggers the disease. Participants do not receive any treatment, but their health is tracked over time. The goal is to learn how …

This study follows 225 children whose mothers had type 1 diabetes during pregnancy and took part in the CONCEPTT trial. Researchers will assess the children's thinking, behavior, and emotional skills using parent questionnaires. The goal is to understand if maternal diabetes affe…

This study aims to better understand how blood flow and sugar use in the brain are altered in Alzheimer's disease, especially in people who also have type 2 diabetes. Researchers will use advanced PET scans to measure these changes in 60 participants across three groups: people w…

This study follows 1,000 adults in Lombardy, Italy, who have early memory complaints but no dementia. Researchers will use blood tests and annual check-ups over 5 years to see if certain biomarkers can predict who later develops Alzheimer's. The goal is to improve early detection…

This study uses a special two-way mirror device to see how teenagers and young adults at risk for psychosis recognize themselves versus others. Participants sit opposite a healthy volunteer and report who they see as lighting changes. The goal is to find differences in self-other…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study looks at how speech changes over time in people at higher risk for Alzheimer's disease. Researchers will have 165 participants complete speech tasks and surveys on an iPad at home for 3 years. The goal is to see if remote speech tracking is a useful and easy way to mon…

This study uses virtual reality games and EEG brain scans to understand how people with schizophrenia or bipolar disorder experience the passage of time. Researchers will compare 120 participants (patients and healthy volunteers) as they perform tasks in virtual environments. The…

This study looks at whether taking L-serine (an amino acid) with or without strength training can improve memory, thinking, and physical fitness in healthy adults aged 65 to 85. Over 48 weeks, participants will take either a placebo, L-serine, or L-serine plus strength training. …

This study tests a program called DECLARE that helps caregivers of people with dementia who receive home health care. Caregivers will answer a short assessment and get faster access to a social worker trained in dementia care. Researchers want to see if this improves caregiver co…

This study is looking for new, less invasive ways to diagnose and track Parkinson's disease, Alzheimer's disease, and type 2 diabetes. Researchers will study 500 participants using blood tests, brain scans, and genetic analysis to find early signs of these conditions. The goal is…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can improve how people with schizophrenia recognize emotions in faces. Researchers will use brain scans to see if the stimulation changes activity in motion-processing areas. The goal is to understan…

This study looks at how brain structure and gene activity in the blood are linked in people with early schizophrenia. About 1,899 participants, including healthy volunteers, will have brain scans and blood tests at the start and after one year of regular medication. The goal is t…

This study looks at how people with schizophrenia experience nicotine withdrawal when they stop vaping or smoking for 24 hours. Researchers will compare withdrawal symptoms, mood, and thinking skills between daily vapers and daily smokers. The goal is to understand nicotine depen…

This study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…

This study is testing whether a new blood test can help tell the difference between depression and schizophrenia, and whether it can show if a treatment is working. Researchers will take blood samples and do mental health check-ins with 500 adults over several visits. The goal is…

This study aims to see if blood markers for Alzheimer's and brain injury can help predict death and hospital readmission in older patients. Researchers will follow 400 hospitalized seniors, including those with neurological issues or dementia. The goal is to develop a tool that u…

This study is a large national registry that will collect health data, questionnaires, and test results from 5,000 people with early dementia or memory problems. No new treatments are given; instead, researchers will track how dementia progresses and how it is currently diagnosed…

This long-term study is tracking 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk due to family history or early signs. Researchers will collect medical records and questionnaires every 6 months to find what factors lead to b…

This study tests whether daily nurse screening for delirium using a tool called UB-CAM can improve detection and reduce complications in hospitalized adults aged 70 and older. About 1,050 patients across three hospitals will take part. Researchers will measure how accurate the sc…

This study looks at whether social isolation contributes to the early health problems seen in people with schizophrenia, who often die 10–20 years earlier than others. Researchers will follow 650 participants (500 with schizophrenia and 150 siblings) aged 40–70, tracking medical …

This study is looking at whether certain substances in the blood can help predict postoperative delirium—a state of confusion that can occur after surgery in older adults. Researchers will measure specific biomarkers before and after surgery in 1,170 patients aged 65 and older un…

This study is creating and testing a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness or trouble focusing, which are often missed. About 230 participants will fill out the questionnaire and t…

The TRIAD study is testing whether combining biological markers, psychological tests, and social factors can help diagnose Alzheimer's disease earlier and more accurately. Researchers will follow 80 patients with cognitive decline and their caregivers, collecting data through mem…

This study looks at how the help provided by family caregivers changes as Alzheimer's disease gets worse. Researchers will track 312 people with Alzheimer's and their caregivers to measure the time and cost of informal care. The goal is to understand what factors—like memory loss…

This study tests whether diroximel fumarate, a drug already used for multiple sclerosis, can increase levels of the antioxidant glutathione in the brains of people with schizophrenia. Thirty participants will take the drug for two weeks, then be randomly assigned to continue the …

This study is looking for better, cheaper ways to detect Alzheimer's disease early. Researchers will collect blood samples, brain wave recordings, and speech recordings from 250 people who have noticed memory problems but still function normally. They will use machine learning to…

This observational study looks at 300 adults with new-onset cognitive impairment to see how often certain immune system markers (neuronal synaptic antibodies) are present. Researchers aim to develop a scoring system to help diagnose autoimmune dementia more accurately. The study …

This study tests whether a type of brain stimulation called repetitive TMS can increase natural brain inhibition in 34 people with schizophrenia. The goal is to see if this change relates to better thinking and memory. Participants will receive five days of treatment and undergo …

This study tests whether analyzing speech recordings with artificial intelligence can help predict when someone with psychosis might relapse. About 360 participants, including people with psychosis and healthy volunteers, will provide weekly voice samples and answer questions via…