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Can online speech therapy help slow language loss in dementia?

NCT ID NCT06739967

Symptom relief Sponsor: Istituti Clinici Scientifici Maugeri SpA Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests personalized speech therapy delivered online for people with primary progressive aphasia (PPA), a condition that slowly destroys language skills. Researchers will enroll 30 adults with mild PPA and tailor exercises to their specific variant. The goal is to see if therapy can improve naming, grammar, and daily communication, and whether benefits last up to six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
speech and language therapy
What this could lead to
If successful, this could provide a practical, online treatment option to help people with PPA maintain language skills longer.
What could go wrong
This is a small pilot study with only 30 participants, so results may not apply to everyone. The disease is progressive, so any improvements may be temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with primary progressive aphasia.

Ages

40 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of PPA according to the current clinical criteria (Gorno-Tempini et al., 2011) * Mild PPA defined using the Progressive Aphasia Severity Scale (PASS) * Age between 40 and 85 years * Patients with Italian mother tongue * Patients with the ability to sign the informed consent * Patients with the ability to comply with the study procedures * Patients with stable pharmacological treatment for at least 4 weeks. Exclusion Criteria: * Mini-Mental State Exam (MMSE) Score \<15 * Presence of other neurological or psychiatric diseases, including cerebrovascular disease * Severe and uncorrected hearing loss or visual disturbances * Inability to repeat multi-syllable words (4 syllables) * Concurrent participation in other pharmacological and non-pharmacological experimental studies

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Conditions

The condition(s) this trial relates to.

communication disorder dementia frontotemporal dementia neurodegenerative disease primary progressive aphasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary progressive aphasia(PPA)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • IRCCS Ospedale San Raffaele

    RECRUITING

    Milan, 20132, Italy

  • Istituti Clinici Scientifici Maugeri IRCCS

    RECRUITING

    Bari, 70124, Italy

More trials for these conditions

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