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Can retraining word meanings restore lost speech?

NCT ID NCT04957537

Symptom relief Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests whether a specialized speech therapy that focuses on word meanings can help people with mild-to-moderate semantic aphasia—a condition where brain damage impairs understanding and use of words. Participants first undergo a control period of standard language exercises, then receive the semantic training in multiple sessions. Researchers measure improvements in naming accuracy and speed, and check if gains last a month later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A structured speech therapy program focused on semantic training (analyzing word meanings) compared with a control phase of lexico-phonological exercises.
What this could lead to
If effective, this therapy could help people with semantic aphasia regain word-finding ability and slow language decline, improving daily communication.
What could go wrong
This is a very small early-stage study (15 people) without a control group, so results may not generalize. Benefits may be modest or not persist after therapy ends.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of primary progressive semantic aphasia according to the criteria of Gorno-Tempini et al (2011) (Appendix A) * Being in the mild to moderate stage of dementia (MMSE score between 10 and 28) (Crum et al., 1993; Derouesné et al., 1999) * Common French * Being affiliated to a social security scheme * Being over the age of 18 years old Exclusion Criteria: * Have significant uncorrected visual and/or hearing impairment * Have a history of brain injuries, major head trauma * Have untreated psychiatric disorders * Have significant motor and/or comprehension problems that make it impossible to take part in the study * Chronical use of drugs and/or alcohol * Under guardians or curators * Severe depression (Beck's depression scale score \> 9) (Beck \& al., 1961)

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Conditions

The condition(s) this trial relates to.

communication disorder nominal aphasia Pick disease primary progressive aphasia semantic dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary progressive aphasia

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • CHU Toulouse

    RECRUITING

    Toulouse, France

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