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Could a gentle brain zap improve speech in progressive language disorders?

NCT ID NCT05368350

Symptom relief Sponsor: The University of Texas at Dallas Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a gentle, low-level electric current applied to specific brain areas can improve speech and language difficulties in people with primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). The treatment is called high-definition transcranial direct current stimulation (HD-tDCS). The study involves 12 participants aged 18 to 85 who have a formal diagnosis of PPA or PAOS. Researchers will measure changes in speech, language, and other cognitive abilities using standard tests and brain wave recordings (EEG).

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Jun 2022

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 85 years of age * A formal diagnosis of primary progressive aphasia (nonfluent/agrammatic, semantic, logopenic variants or mixed) and/or progressive apraxia of speech * Capable of understanding and signing an informed consent. Medical information/history, as well as mental status exam and diagnosis provided by referring physician will determine whether or not a caregiver is required to be involved during this process. Exclusion Criteria: * Has an implanted device, such as a pacemaker, metallic cranial implant, or a neurostimulator * Skull defects * Pregnant * A significant history of arrhythmia or epileptic seizures. * Not a native English speaker * Currently receiving speech-language intervention * Unable to communicated verbally

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Conditions

The condition(s) this trial relates to.

apraxia childhood apraxia of speech primary progressive aphasia primary progressive apraxia of speech

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Apraxia of speech Primary progressive aphasia

Contacts and locations

Locations

  • The University of Texas at Dallas

    Dallas, Texas, 75235, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.