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5,000 patients join national effort to unlock Dementia's secrets

NCT ID NCT07433010

Knowledge-focused Sponsor: RWTH Aachen University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is a large national registry that will collect health data, questionnaires, and test results from 5,000 people with early dementia or memory problems. No new treatments are given; instead, researchers will track how dementia progresses and how it is currently diagnosed and treated in Germany. The goal is to improve future diagnosis and care by learning from real-world patterns.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this registry could help doctors better diagnose and manage dementia by identifying key biomarkers and risk factors.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve anyone's health, and results may take years to influence care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 5,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Dec 2099

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This registry will be conducted in adult patients with a diagnosis of SCD, MCI or early dementia of different etiology and existing biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria for Patient: * Ability of the participant and/or his/her legally authorized representative (e.g., spouse or legal guardian), as appropriate and applicable, to understand the purpose and risks of the register and provide signed and dated informed consent and authorization to use protected health information (PHI) in accordance with national and local privacy regulations. * Participating patients must have a diagnosis of SCD, MCI or early dementia of different etiology (i.e. Alzheimer's Disease, Frontotemporal Dementia, Parkinson's Disease, Lewy-Body Dementia, Progressive Supranuclear Palsy, Corticobasal Degeneration, Normal Pressure Hydrocephalus, Major Depression; Vascular Dementia; TDP-43 associated limbic encephalopathy (LATE), Mixed Dementia AD + VaD, Prion-Associated Dementia) together with biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging. * At least 18 years of age. Inclusion Criteria for family member: * At least 18 years of age. * Patient was included in the registry * Family member is strongly involved to the patient's life according to the patient's statement * Ability of the participant, as appropriate and applicable, to understand the purpose and risks of the register Exclusion Criteria: Exclusion Criteria for Patient: * Unwilling to provide informed consent. * No available biomarkers such as cerebrospinal fluids (CSF) amyloid beta 1-42, amyloid beta 1-40, amyloid beta 1-42/amyloid beta 1-40 ratio, total tau and phosphorylated tau, amyloid or tau imaging. Exclusion Criteria for family member: * Unable or unwilling to provide informed consent.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia Nerve Degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dementia disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    24 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Asklepios Klinik Nord

    RECRUITING

    Hamburg, Free and Hanseatic City of Hamburg, 22419, Germany

  • Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, State of Berlin, 10117, Germany

  • Charité Campus Benjamin Franklin

    RECRUITING

    Berlin, State of Berlin, 12203, Germany

  • Greifswald University Medicine

    RECRUITING

    Greifswald, Mecklenburg-Vorpommern, 17489, Germany

  • Heidelberg University Hospital

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Immanuel Klinik Rüdersdorf

    RECRUITING

    Rüdersdorf, Brandenburg, 15562, Germany

  • Klinikum Bremen-Ost

    RECRUITING

    Bremen, Free Hanseatic City of Bremen, 28325, Germany

  • Klinikum Frankfurt (Oder)

    RECRUITING

    Frankfurt (Oder), Brandenburg, 15236, Germany

  • Madical Faculty University Hospital Magdeburg

    RECRUITING

    Magdeburg, Saxony-Anhalt, 39120, Germany

  • Medical Center Hamburg-Eppendorf

    RECRUITING

    Hamburg, Free and Hanseatic City of Hamburg, 20251, Germany

  • Pfalzklinikum Klingenmünster

    RECRUITING

    Klingenmünster, Rhineland-Palatinate, 76889, Germany

  • RWTH Aachen University Hospital

    RECRUITING

    Aachen, North Rhine-Westphalia, 52074, Germany

  • Saarland University Medical Center

    RECRUITING

    Homburg, Saarland, 66421, Germany

  • Ulm University Hospital

    RECRUITING

    Ulm, Baden-Wurttemberg, 89070, Germany

  • University Hospital Cologne

    NOT_YET_RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • University Hospital Essen

    RECRUITING

    Essen, North Rhine-Westphalia, 45147, Germany

  • University Hospital Jena

    NOT_YET_RECRUITING

    Jena, Thuringia, 07747, Germany

  • University Hospital Schleswig-Holstein

    RECRUITING

    Kiel, Schleswig-Holstein, 24105, Germany

  • University Hospital Tübingen

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University Medical Center Göttingen

    RECRUITING

    Göttingen, Lower Saxony, 37075, Germany

  • University Medical Center Mainz

    NOT_YET_RECRUITING

    Mainz, Rhineland-Palatinate, 55131, Germany

  • University of Leipzig Medical Center

    RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Erlangen

    RECRUITING

    Erlangen, Bavaria, 91054, Germany

  • ZI Mannheim

    RECRUITING

    Mannheim, Baden-Wurttemberg, 68159, Germany

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