Fluorescent dye reveals hidden brain drains in cadavers
NCT ID NCT07682155
First seen Jul 02, 2026 · Last updated Aug 20, 2026 · Updated 2 times
Summary
This study investigates how fluid drains from the brain to lymph nodes in the neck, a connection that may be important for clearing waste linked to Alzheimer's disease. Researchers will inject a fluorescent dye into the meningeal space of recently deceased organ donors and track its movement with a special camera. The goal is to map the drainage pathways and identify which neck lymph nodes are involved, providing insights that could guide future treatments for neurological disorders.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- indocyanine green
- What this could lead to
- If this study maps the brain's drainage pathways clearly, it could help researchers develop better treatments for Alzheimer's and other brain disorders.
- What could go wrong
- This is a very small, early-stage study in cadavers, so findings may not fully apply to living humans. The dye may not migrate as expected, limiting what can be learned.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Feb 2026
- Expected to finish
-
Dec 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Potential organ donor patients, both in Brain Death and in Controlled Asystole, candidates to perform organ harvesting authorized by the Transplant and Tissue Coordination of the Universitary Germans Trias i Pujols Hospital, according to the usual channels and whose family members have previously signed the authorization of the donation and the specific informed consent of the study. Will be included in the study always after death is certified by neurological or cardiocirculatory criteria Exclusion Criteria: * Absence of informed consent signed by family members. * Individuals with a history of having intracranial lymphatic drainage affected.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Anatomical description are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Germans Trias i Pujol Universitary Hospital
RECRUITINGBadalona, Barcelona, 08916, Spain