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Massive chinese study aims to unlock Dementia's secrets

NCT ID NCT03653156

Knowledge-focused Sponsor: Capital Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is following 100,000 people in China over many years to learn more about dementia and memory loss. Researchers will track who develops these conditions, look for risk factors like genes and lifestyle, and find better ways to diagnose and prevent dementia. The goal is to improve care and create strategies to fight these diseases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2000

Expected to finish

Jan 2038

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Mild cognitive impairment (MCI) and its subtypes、Sporadic Alzheimer's disease (SAD)、 Familial Alzheimer's disease (FAD)、Vascular dementia (VaD)、Normal control in Community population and Hospital population.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Community population: age ≥ 55 years, male or female, with consent to participant the study. Hospital population: subjects are all over 18 years old. Through clinical evaluation, neuropsychological test, imaging examination, blood and cerebrospinal fluid examination, etc, we will comprehensively evaluate the cognitive function and various test measures. (1) MCI and its subtypes Inclusion criteria: 1. Diagnosis according to 2004 Peterson's MCI criteria. 2. CDR = 0.5. 3. Memory loss is prominent, and may also be with other cognitive domain dysfunction. 4. Insidious onset, slow progress. 5. Not reaching the level of dementia. Exclusion criteria: 1. With history of stroke and a neurological focal sign, the imaging findings are consistent with cerebral small vessal disease (Fazekas score ≥ 2 points). 2. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 3. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 4. Mental and neurodevelopmental retardation. 5. Contraindications to MRI. 6. Suffering from a disease that cannot be combined with cognitive examination. 7. Refuse to draw blood. 8. Refuse to sign the informed consent at baseline (2) Sporadic Alzheimer's disease (SAD) Inclusion criteria: 1. Dementia is diagnosed according to the criteria described by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-R). The diagnosis of AD is made using the National Institute of Neurologic and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) or National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria. 2. Subjects and their informed persons can complete relevant and follow- up examinations. 3. Subjects or their authorized legal guardians sign the informed consent. Exclusion criteria: 1. With a family history of dementia. 2. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 3. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 4. Mental and neurodevelopmental retardation. 5. Contraindications to MRI. 6. Suffering from a disease that cannot be combined with cognitive examination. 7. Refuse to draw blood. 8. Refuse to sign the informed consent at baseline (3) Familial Alzheimer's disease (FAD) Inclusion criteria: 1. Written informed consent obtained from participant or legal guardian prior to any study-related procedures. 2. Members in FAD pedigree (FAD is defined as at least two first- degree relatives suffer from AD). 3. Aged 18 (inclusive) or older. 4. At least two persons who can provide reliable information for the study. Note: Dementia is diagnosed according to the criteria described by DSM-IV-R. The diagnosis of AD is made using NINCDS-ADRDA or NIA-AA criteria. A diagnosis of MCI is assigned according to Petersen criteria. Exclusion criteria: 1. Dementia caused by other factors such as depression, other psychiatric illnesses, thyroid dysfunction, encephalitis, multiple sclerosis, brain trauma, brain tumor, syphilis, acquired immunodeficiency syndrome (AIDS), Creutzfeldt-Jakob disease and other types of dementias such as vascular dementia (VaD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD). 2. MRI and laboratory tests do not support or rule out a diagnosis of AD. 3. Severe circulatory, respiratory, urinary, digestive, hematopoietic diseases (such as unstable angina, uncontrollable asthma, active gastric bleeding) and cancer. 4. Participant has severe psychiatric illness or severe dementia that would interfere in completing initial and follow-up clinical assessments. 5. With history of alcohol or drug abuse. 6. Pregnant or lactating women. 7. No reliable insiders. 8. Refuse to sign the informed consent at baseline. (4) Vascular dementia (VaD) Inclusion criteria: Diagnosis for probable VaD according to NINDS-AIREN diagnostic criteria. MRI inclusion criteria: All patients who meet clinical inclusion criteria should accept MRI scans which include an assessment of hippocampal volume. 1. multiple (≥3) supratentorial subcortical small infarcts (3-20 mm in diameter) with or without any degree of white matter lesion (WML); or moderate to severe WML (Fazekas score ≥ 2), with or without small infarction; or ≥ 1 subcortical small infarct in key regions, such as caudate nucleus, globus pallidus, or thalamus. 2. no cortical and watershed infarction, hemorrhage, hydrocephalus, or WML with specific causes (such as multiple sclerosis). 3. no hippocampus or entorhinal cortex atrophy (MTA score = 0 point). Exclusion criteria: 1. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 2. Other systemic diseases that can cause cognitive impairment (such as liver insufficiency, renal insufficiency, thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 3. With a history of mental illness or those with congenital mental retardation. 4. Suffering from a disease that cannot be combined with a cognitive examination. 5. Contraindications to MRI. 6. Refuse to draw blood. 7. Refuse to sign informed consent. (5) Normal control Inclusion criteria: 1. Aged 18 (inclusive) or above. 2. Normal MMSE and MoCA evaluations. MMSE\>19 points for illiteracy, \>24 points for those educated less than 7 years, \>27 points for those educated equal to or more than 7 years. MoCA\>13 points for illiteracy, \>19 points for those educated less than 7 years, \>24 points for those educated equal to or more than 7 years. Exclusion criteria: 1. Subjects with abnormal MMSE or MoCA scores. 2. Subjects with a history of cerebral infarction, traumatic brain injury or related manifestations in MRI. 3. Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.). 4. Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.). 5. Mental and neurodevelopmental retardation. 6. Suffering from a disease that cannot be combined with a cognitive examination. 7. Contraindications to MRI. 8. Refuse to draw blood. 9. Refuse to sign the informed consent at baseline.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Alzheimer disease 2 Cognitive Dysfunction dementia/parkinsonism with non-Alzheimer amyloid plaques familial Alzheimer disease vascular dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease, late onset Familial Alzheimer disease (FAD) Mild cognitive impairment (MCI) Non-Alzheimer degenerative dementia Normal control Vascular dementia (VAD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    65 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Zhongshan hospital of Dalian university

    RECRUITING

    Dalian, Liaoning, China

  • Affiliated Hospital of North Sichuan Medical College

    RECRUITING

    Nanchong, Sichuan, China

  • Baotou Central Hospital

    RECRUITING

    Baotou, Nei Monggol, China

  • Beijing Chao Yang Hospital

    RECRUITING

    Chaoyang, Beijing Municipality, China

  • Beijing Geriatric Hospital

    RECRUITING

    Changping, Beijing Municipality, China

  • Changda Hospital, Anshan

    RECRUITING

    Anshan, Liaoning, China

  • China-Japan Friendship Hospital

    RECRUITING

    Chaoyang, Beijing Municipality, China

  • China-Japan friendship Hospital of Jilin university

    RECRUITING

    Changchun, Jilin, China

  • Chinese PLA General Hospital

    RECRUITING

    Haidian, Beijing Municipality, China

  • Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

    RECRUITING

    Yuzhong, Chongqing Municipality, China

  • Dongfang Hospital Affiliated to Beijing University of Chinese Medicine

    RECRUITING

    Fengtai, Beijing Municipality, China

  • First Affiliated Hospital Xi'an Jiaotong University

    RECRUITING

    Xi’an, Shanxi, China

  • First Affiliated Hospital of Guangxi Medical University

    RECRUITING

    Nanning, Guangxi, China

  • First Affiliated Hospital of Harbin Medical University

    RECRUITING

    Haerbin, Heilongjiang, China

  • First Affiliated Hospital of Wenzhou Medical Univeristy

    RECRUITING

    Wenzhou, Zhejiang, China

  • First Affiliated Hospital of Zhejiang University

    RECRUITING

    Hangzhou, Zhejiang, China

  • First Hospital of China Medical University

    RECRUITING

    Shenyang, Liaoning, China

  • First Hospital of Shijiazhuang City

    RECRUITING

    Shijiazhuang, Hebei, China

  • Fu Xing Hospital, Capital Medical University

    RECRUITING

    Haidian, Beijing Municipality, China

  • Fujian Medical University Union Hospital

    RECRUITING

    Fujian, Guangdong, China

  • General Hospital of Ningxia Medical University

    RECRUITING

    Yinchuan, Ningxia, China

  • Guangzhou Psychiatric Hospital

    RECRUITING

    Guangzhou, Guangdong, China

  • Handan Central Hospital

    RECRUITING

    Handan, Hebei, China

  • Hebei General Hospital

    RECRUITING

    Zhijiazhuang, Hebei, China

  • Henan Provincial People's Hospital

    RECRUITING

    Zhengzhou, Henan, China

  • Jiangxi Provincial People's Hospital

    RECRUITING

    Nanchang, Jiangxi, China

  • Kaifeng Central Hospital

    RECRUITING

    Kaifeng, Henan, China

  • Mineral General Hospital, Xuzhou

    RECRUITING

    Xuzhou, Jiangsu, China

  • Nantong University Affiliated Hospital

    RECRUITING

    Nantong, Jiangsu, China

  • Ningbo City Medical Treatment Center Lihuili Hospital

    RECRUITING

    Ningbo, Zhejiang, China

  • Peking Union Medical College Hospital

    RECRUITING

    Xicheng, Beijing Municipality, China

  • Peking University First Hospital

    RECRUITING

    Xicheng, Beijing Municipality, China

  • Peking University Third Hospital

    RECRUITING

    Haidian, Beijing Municipality, China

  • People's Hospital Affiliated Hubei Medical University

    RECRUITING

    Wuhan, Hubei, China

  • People's Hospital of Zhengzhou

    RECRUITING

    Zhengzhou, Henan, China

  • Qilu Hospital of Shandong University

    RECRUITING

    Jinan, Shandong, China

  • Qilu Hospital of Shandong University (Qingdao)

    RECRUITING

    Qingdao, Shandong, China

  • QingDao Municipal Hospital

    RECRUITING

    Qingdao, Shandong, China

  • RenJi Hospital

    RECRUITING

    Putong, Shanghai Municipality, China

  • Ruijin Hospital

    RECRUITING

    Luwan, Shanghai Municipality, China

  • Shandong Provincial Hospital

    RECRUITING

    Jining, Shandong, China

  • Shanghai Changzheng Hospital

    RECRUITING

    Huangpu, Shanghai Municipality, China

  • Shao Yifu Hospital of Zhejiang Medical University

    RECRUITING

    Hangzhou, Zhejiang, China

  • Subei People's Hospital of Jiangsu

    RECRUITING

    Subei, Jiangsu, China

  • Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

    RECRUITING

    Zhongshan, Guangdong, China

  • Tang-Du Hospital

    RECRUITING

    Xi’an, Shanxi, China

  • Tangshan Worker's Hospital

    RECRUITING

    Tangshan, Hebei, China

  • The 88th Hospital of PLA

    RECRUITING

    Tai’an, Shandong, China

  • The Affiliated Hospital Of Guizhou Medical University

    RECRUITING

    Guiyang, Guizhou, China

  • The Affiliated Hospital of Qingdao University

    RECRUITING

    Qingdao, Shandong, China

  • The First Affiliated Hospital of Anhui Medical University

    RECRUITING

    Hefei, Anhui, China

  • The First Affiliated Hospital of Dalian Medical University

    RECRUITING

    Dalian, Liaoning, China

  • The First Affiliated Hospital of Shanxi Medical University

    RECRUITING

    Taiyuan, Shanxi, China

  • The First Hospital of Jilin University

    RECRUITING

    Changchun, Jilin, China

  • The People's Hospital of Ningxia

    RECRUITING

    Yinchuan, Ningxia, China

  • The Second Affiliated Hospital of Chongqing Medical University

    RECRUITING

    Yuzhong, Chongqing Municipality, China

  • The Third Xiangya Hospital of Central South University

    RECRUITING

    Wuhan, Hunan, China

  • Tianjin Huanhu Hospital

    RECRUITING

    Xianshuigu, Tianjin Municipality, China

  • Tianjin Medical University General Hospital

    RECRUITING

    Xiaobailou, Tianjin Municipality, China

  • Tongji Hospital

    RECRUITING

    Wuhan, Hubei, China

  • Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region

    RECRUITING

    Ürümqi, Xinjiang, China

  • Wuhan University Zhongnan Hospital

    RECRUITING

    Wuhan, Hunan, China

  • Xiangya Hospital of Central South University

    RECRUITING

    Wuhan, Hunan, China

  • Zhejiang Provincial People's Hospital

    RECRUITING

    Hangzhou, Zhejiang, China

  • Zigong First People's Hospital

    RECRUITING

    Zigong, Sichuan, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.