MILD COGNITIVE IMPAIRMENT (MCI)

This study follows 120 people with early Alzheimer's disease who are receiving the medication Lecanemab. Researchers will track patients for 18 months to see how their memory and thinking skills change and to monitor for any side effects. The goal is to better understand how well…

This study is testing whether doing crossword puzzles can help slow cognitive decline in older adults with mild memory problems. Researchers will compare doing four puzzles per week to one puzzle per week, and to a health education group, over 78 weeks. They will measure changes …

This early-stage study is testing whether two HIV medications (emtricitabine and Descovy) are safe for people with mild cognitive impairment, which often leads to Alzheimer's disease. Researchers want to see if these drugs, which block a specific enzyme, might help slow memory de…

This study is testing whether a gentle, non-invasive electrical stimulation applied to the scalp can improve working memory in people with mild cognitive impairment (MCI), a condition that often precedes Alzheimer's disease. Researchers will enroll 20 participants aged 60+ with M…

This study is testing whether a personalized digital brain training program, used at home on a tablet, can help older adults with mild memory problems become more confident and active in managing their own health and daily life. Researchers will compare this program to a standard…

This study is testing whether a personalized exercise program delivered through a smartphone or tablet app, called SuperBrain BOOM, can help improve thinking skills, mood, and physical ability in older adults (ages 50-85) with mild cognitive impairment (MCI). For 12 weeks, one gr…

This study is testing whether gentle electrical stimulation applied to the ear can improve thinking skills like decision-making and problem-solving. Researchers want to see if this non-invasive stimulation helps both healthy adults and people with Parkinson's disease. Participant…

This study is testing whether a free, online group program focused on building positive emotions and strengths can help improve thinking skills and brain function in older adults with early memory concerns. About 128 participants with either subjective memory complaints or mild c…

This study is testing an online support program for people with early-stage memory loss or dementia who live alone. About 70 participants across the US will attend group Zoom sessions to learn skills for managing stress, improving communication, and planning for the future. Resea…

This study is testing a new computer-based training program designed to help older adults manage memory changes. It aims to see if practicing memory strategies on a computer can help people with normal aging, memory complaints, or mild cognitive impairment perform daily tasks mor…

This study is testing a digital brain training program called RICORDO to see if it can help improve memory and thinking skills in older adults. It will compare the digital program to standard paper-and-pencil exercises. Participants will do the training at home for 5 weeks to see…

This study is testing whether combining two treatments can improve sleep for people aged 60+ who have both insomnia and mild memory problems. One treatment is a safe, gentle form of brain stimulation (TMS), and the other is a type of talk therapy for insomnia (CBT-I). Researchers…

This study is testing whether a non-invasive brain stimulation technique, combined with online memory training, can improve thinking skills in older adults with mild memory concerns. Researchers will compare a real stimulation treatment to a fake one to see if it's safe and if it…

This study is testing whether automated, personalized text messages can help people with mild cognitive impairment manage their mood and behavior symptoms. The messages deliver Acceptance and Commitment Therapy, a type of psychological support, and are sent based on each particip…

This study is testing whether a proven memory support system can be helpful for older Chinese Americans who have mild thinking and memory problems. Researchers are adapting the program for Mandarin and Cantonese speakers to see if it improves daily life and memory skills. The stu…

This study is testing whether using a brain-training app on a tablet for 8 weeks can help improve memory and focus in older adults, including those experiencing mild memory problems. Researchers will compare two different training apps to see if they help. Participants will do al…

This study aims to understand if people with a hormone condition called primary aldosteronism are more likely to develop memory problems or dementia. Researchers will follow 1,000 patients for up to 5 years, giving them regular memory tests and health check-ups. The goal is to le…

This study aims to understand how different types of dementia develop and progress over time. It is observing over 1,500 adults in Canada, some with memory problems and some without. Researchers are tracking changes in thinking skills, brain scans, and body samples to find patter…

This is a large, long-term observational study aiming to understand dementia and cognitive decline in China. It will follow up to 100,000 people, including those with normal cognition, mild impairment, and different types of dementia, over many years. The main goal is to collect …

This study aims to test whether an online brain assessment platform called Creyos works well for older adults with mild memory concerns or past depression. Researchers want to see if this online tool can track changes in thinking skills as accurately as traditional paper-and-penc…

This study aims to better understand how dementia and mild cognitive impairment (MCI) affect a person's ability to think, perform daily tasks, and manage their mood. Researchers will look back at the medical records of 151 patients to see how these conditions progress over time. …

This study is testing a smartphone app designed to measure thinking skills in older adults. It aims to see if the app's adaptive difficulty system works similarly for people with mild memory problems and healthy individuals. Researchers want to learn if the app can reliably detec…