Online brain games put to the test in landmark 5-Year study

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

General Inclusion Criteria: * Ability to read and communicate in English * Availability of a study partner who has regular contact with the participant General Exclusion Criteria: * Lifetime DSM 5 diagnosis of schizophrenia, bipolar disorder, or OCD * DSM 5 diagnosis of alcohol or other substance use disorder within the past 12 months * High risk for suicide * Significant neurological conditions (e.g. stroke, seizure disorder, MS) * Unstable medical illnesses (e.g. uncontrolled diabetes mellitus or hypertension) * Taking anticonvulsants or other psychotropic medication that may interfere with cognitive testing that cannot be safely tapered and discontinued * Current depressive symptoms defined as a MADRS score of 10 or above Specific Eligibility Criteria for the MCI Group: Inclusion: * Aged 60 or older * Meets DSM 5 criteria for Minor Neurocognitive Disorder ("MCI") Exclusion: * Having taken a cognitive enhancer within the past 6 weeks Specific Eligibility Criteria for the rMDD Group: Inclusion: * Aged 65 or older * Meets DSM 5 criteria for one or more major depressive episode(s) (MDE) during their adult life (i.e. 18 years of age or older) with: (a) an offset of 2 months to 5 years from the screening visit date, or (b) an offset of 5 years or more, with at least one MDE receiving medical attention (e.g. previously been on an antidepressant, saw a psychiatrist, primary care physician, or had a previous hospitalization Exclusion: * Having taken a cognitive enhancer within the past 6 weeks * Having received electroconvulsive therapy (ECT) within 6 months of baseline neuropsychological testing Specific Eligibility Criteria for the Control Group: Inclusion: * Aged 60 or older Exclusion: * Meets DSM 5 criteria for MDD at anytime during their lifetime * Meets DSM 5 criteria for Minor Neurocognitive Disorder ("MCI")