MILD COGNITIVE IMPAIRMENT(MCI)

This study follows 120 people with early Alzheimer's disease or mild cognitive impairment who are taking lecanemab, a new FDA-approved drug that targets harmful protein clumps in the brain. Researchers will track changes in memory, daily function, and brain scans over 18 months. …

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's. Researchers think these drugs might slow memory decline by blocking a process linked to Alzheimer's. About …

This study tests a drug called NPC-1 (made of two compounds) in 40 adults aged 55+ who have Alzheimer's disease, mild cognitive impairment, or subjective memory concerns. The goal is to see if NPC-1 is safe and can improve blood markers related to Alzheimer's brain changes. Parti…

This study is testing whether a blood test can help screen for Alzheimer's disease in older adults living in the community. Researchers will enroll 3,000 people aged 60-80 and measure specific blood markers. Those with abnormal results will receive further cognitive testing to se…

This study tests a program that combines mindfulness exercises with dual-task training (doing two things at once) to help people who have mild memory or thinking problems after a stroke. The goal is to see if this combined approach improves both cognitive function and physical pe…

This study tests whether a rapid form of brain stimulation, called accelerated deep Transcranial Magnetic Stimulation (dTMS), combined with memory exercises can safely improve thinking and memory in older adults who have mild memory issues. About 30 participants aged 55-85 will r…

This study tests a digital cognitive rehabilitation system called RICORDO for people with mild memory complaints, mild cognitive impairment, or early Alzheimer's dementia. The goal is to see if it improves overall thinking skills and helps participants better manage their own hea…

This study tests a new approach to help people with mild cognitive impairment (MCI) who also have mood or behavior issues like anxiety or depression. Instead of in-person therapy, participants receive personalized coaching through automated text or voice messages on their smartph…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with cognitive training can improve thinking skills and mood in people with mild cognitive impairment or early dementia. Fifty participants will receive both real and placebo stimulation in two sepa…

This study tests a 12-week group program for people with mild cognitive impairment (MCI) that combines brain exercises and lifestyle advice. The goal is to see if it improves memory, thinking, and daily function compared to just giving an information booklet. Forty participants w…

This study tests whether playing soft sounds during deep sleep can improve memory and slow cognitive decline in older adults. Sixty people aged 60-85 with mild memory problems will use a home device for 4 weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests a new way to improve sleep in people with mild cognitive impairment (MCI). It combines gentle brain stimulation (transcranial magnetic stimulation) with talk therapy (cognitive behavioral therapy for insomnia). The goal is to see if this approach can reduce insom…

This study tests a treatment that combines gentle, non-invasive brain stimulation with computer-based thinking exercises for people with mild cognitive impairment (MCI), a condition that can lead to memory and thinking problems. About 50 older adults (ages 60-85) will receive the…

This study tests an online education and skill-building program for people aged 60+ with early-stage dementia or mild cognitive impairment who live alone. Participants join Zoom sessions to learn ways to reduce stress, improve well-being, and plan for the future. The goal is to s…

This study tests whether doing crossword puzzles can improve thinking skills and daily function in people with mild cognitive impairment (MCI), a condition that raises the risk of dementia. Researchers will compare doing 4 puzzles per week, 1 puzzle per week, and a health educati…

This study tests a mobile app called SuperBrain BOOM that gives personalized physical activities to older adults (ages 50-85) with mild cognitive impairment (MCI). The goal is to see if using the app for 12 weeks can improve memory, thinking, physical function, and mood compared …

This study tests a safe, painless brain stimulation method called tACS to see if it can improve working memory in people with mild cognitive impairment (MCI). Twenty adults aged 60 and older with MCI will receive 1-hour sessions, 5 days a week for 2 weeks. Researchers will measur…

This study tests whether a 24-week online positive psychology program can improve memory, thinking, and well-being in older adults with very early signs of dementia. About 128 people with subjective cognitive decline or mild cognitive impairment will join. Half take the program (…

This study tests whether a digital program called RICORDO can help people aged 50+ with mild memory problems better manage their own health and daily life. Participants will use RICORDO or a standard education program at home for five weeks. Researchers will compare changes in he…

This study looks at whether a computer-based brain training program can improve thinking skills, memory, and emotional well-being in healthy older adults and those with mild cognitive impairment (MCI). About 156 Spanish-speaking adults aged 65 and older will take part. The goal i…

This observational study will follow 50,000 people with Alzheimer's or related dementias for many years, collecting medical information from routine doctor visits. Researchers hope to better understand how the disease progresses and how well treatments work in everyday practice. …

This study tests a smartphone app that changes the difficulty of brain games based on how well you do. Researchers want to see if the app works differently for people with mild memory problems compared to healthy adults. About 55 people will use the app for 6 weeks. The goal is t…

This study aims to track 100,000 adults aged 55 and older across China to learn more about dementia, including Alzheimer's disease. Researchers will collect health data, genetic samples, and brain scans to find risk factors and early signs of memory loss. The goal is to improve d…

This study tests a memory support program for Chinese American adults aged 55 and older with mild cognitive impairment (MCI). The program, originally designed for English speakers, will be adapted for Mandarin and Cantonese speakers. The goal is to see if the program is practical…

This study tests whether a safe, non-invasive electrical stimulation can improve working memory and attention in healthy older adults (ages 60-85) and those with mild cognitive impairment. Participants will receive both real and sham stimulation in random order, while their brain…

This study aims to find genetic factors that increase the risk of developing dementia before age 70. Researchers will analyze DNA from 1,000 participants, including people with memory concerns or early-onset dementia and their family members. The goal is to better understand how …

This study tests a program that sends educational videos and messages through a patient portal to older adults with mild cognitive impairment or dementia and their care partners. The goal is to help them discuss and reduce medications that may be harmful or unnecessary. About 100…

This study tests if a mild electrical pulse on the ear can improve decision-making and problem-solving. Researchers will include healthy adults, people with mild cognitive impairment, and those with Parkinson's disease. The goal is to understand how this stimulation affects brain…

This observational study in Seoul, Korea, follows 180 adults aged 60 and older to see how everyday emotional stress impacts memory and thinking. Participants use a smartphone app and a smartwatch for two weeks, then return for check-ups at 6 months and 1 year. The goal is to find…

This study checks if an online cognitive assessment platform (Creyos) works as well as traditional paper-and-pencil tests for tracking memory and thinking changes in older adults. About 150 participants with mild cognitive impairment, remitted depression, or healthy aging will ta…

This study follows 1,000 adults with primary aldosteronism (a hormone disorder that causes high blood pressure) to see how often they develop memory or thinking problems. Participants take regular cognitive tests and health check-ups for up to 5 years. The goal is to understand t…

This study tests whether a digital intervention can improve working memory and self-control in older adults, including those with mild cognitive impairment. Participants will complete cognitive tests and surveys before and after up to 8 weeks of at-home brain training, with a fol…

This study looks at how dementia and mild cognitive impairment (MCI) affect thinking, daily activities, and mood. Researchers will assess 151 adults aged 50-86 to better understand these conditions and improve personalized care. The goal is to gather information, not to test a ne…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study tests a computer program designed to help older adults improve their memory for everyday tasks. It includes healthy seniors, those with memory complaints, and people with mild cognitive impairment. The program uses memory strategies based on daily activities. The goal …

This study looks at whether a combination of genetic tests, blood markers, and data from wearable devices can predict early memory problems in people aged 55 and older who carry the ApoE4 gene, which raises Alzheimer's risk. Researchers will follow 100 participants for two years …