MILD COGNITIVE IMPAIRMENT(MCI)

This study tests whether a natural soy compound called genistein can slow down memory and thinking problems in people with mild cognitive impairment, often an early sign of Alzheimer's disease. Over 18 months, 150 adults aged 50+ will take either genistein or a placebo pill, with…

This study tests whether monoclonal antibody drugs can slow the progression of Alzheimer's disease in 120 people with mild cognitive impairment or mild Alzheimer's. Researchers will use PET scans to measure brain changes and see who benefits most from continued treatment, even if…

This study tests an experimental tablet called RP902 in people with mild cognitive impairment caused by Alzheimer's disease. The goal is to see if it can slow down memory and thinking problems. The trial will involve 360 participants across about 50 sites in China, and treatment …

This study tests a home-based training program for people with Parkinson's disease who also have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while doing brain games on a tablet, three times a week for 30 minutes. The g…

This study tests whether community-based screening and new treatments—including stem cell therapy and wearable brain-computer interface devices—can slow or stop memory loss in adults 55 and older with mild cognitive impairment (MCI). Researchers will enroll 600 participants acros…

This study will see if an artificial intelligence (AI) tool can analyze speech recordings to help identify people with memory problems who need specialist dementia care. Researchers will record 440 Danish-speaking adults over 50 as they perform cognitive tests and speaking tasks.…

This study aims to see if a blood test can help primary care doctors diagnose Alzheimer's disease at an early stage. Researchers will test 1,000 adults aged 55 and older who have memory concerns. The goal is to find Alzheimer-related proteins (amyloid and tau) in the blood, which…

This study tests a personalized lifestyle program delivered via smartphone and smartwatch to prevent memory loss in adults aged 55-75 who are at higher risk for dementia. 300 participants will either get a tailored plan with coaching or standard health advice. The goal is to see …

This study tests whether older adults with mild cognitive impairment can complete a virtual reality maze training program. Participants will wear VR goggles and walk through up to 50 different mazes over 4 months. The goal is to see if this training improves their ability to navi…

This early-stage study tests a single injection of a new drug called QLH2405 in 68 healthy volunteers and people with mild memory problems or mild Alzheimer's disease. The main goal is to check if the drug is safe and how the body processes it. This is a first step to see if the …

This study compares two types of training for older adults (65+) with mild cognitive impairment (MCI), a condition that affects memory and thinking. One group will do computer-based brain exercises, while the other will practice moving and thinking at the same time (dual-task tra…

This study tests a special mindfulness program for older adults (65+) with mild cognitive impairment and high stress. Participants will either take the mindfulness course or a health education class. The goal is to see if mindfulness can lower stress and improve memory, mood, and…

This study looks at whether adding a stress-reduction program to cognitive stimulation therapy can improve thinking and memory in Pakistani adults with mild cognitive impairment. About 12 people aged 45 and older with mild memory problems and moderate to high stress will take par…

This study tests whether playing interactive games with a social robot can improve thinking skills, mood, and quality of life in older adults with mild cognitive impairment or dementia. About 200 people aged 50 and older will be randomly assigned to either 12 weeks of robot game …

This study tests a computer-based stepping game (Smart±step) designed to combine thinking and movement training in 70 older adults with mild cognitive impairment (MCI). The goal is to see if the program can lower fall risk, improve balance, and boost thinking skills. Participants…

This study looks at whether a carefully planned ketogenic diet can help people who have both osteoarthritis (joint pain) and mild cognitive impairment (memory issues). Ten adults will follow the diet under supervision for a period, and researchers will measure changes in pain, ph…

This study tests whether a 5-week virtual cognitive training program works as well as an 8-week version for people aged 65+ with mild cognitive impairment (MCI). Participants will attend weekly group sessions online and complete memory tests and questionnaires. The goal is to imp…

This study tests whether sensory integration training—activities that engage multiple senses—can improve thinking skills, daily life quality, and social participation in older adults with mild cognitive impairment (MCI). Researchers will enroll 40 people aged 65-85 with MCI and m…

This study tests whether a home-based exercise program (walking and strength training) can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4 and 5) who already have mild cognitive impairment. About 124 participants wi…

This study tests whether a short program combining healthy lifestyle lessons and brain exercises can improve memory and thinking in older adults with mild cognitive impairment (MCI). Researchers will enroll 200 people aged 60+ with MCI from local senior centers. Participants will…

This study tests a device called iNAP that uses gentle suction through the nose to keep the airway open during sleep. It is for people aged 50-75 with mild cognitive impairment (MCI) and moderate-to-severe obstructive sleep apnea (OSA). The goal is to see if using iNAP every nigh…

This early-stage study will test whether a dietary supplement called gamma glutamylcysteine (GGC) is safe for people with mild cognitive impairment (MCI), a condition that can lead to memory loss. Nine volunteers aged 55 to 80 will take different doses of GGC daily for three mont…

This study tests whether simple changes to the bedroom environment and basic sleep tips can improve sleep in older adults (65+) who live alone, have memory concerns, and struggle with insomnia. Over 8 weeks, researchers will visit participants' homes to make agreed-upon adjustmen…

This study looks at how mental health problems, like depression or anxiety, affect people with mild cognitive impairment (MCI). Researchers will study 118 adults aged 50-72 to see how these issues impact their awareness of memory problems and their daily social and work life. The…

This study aims to find early signs of dementia by looking at how older adults walk, their body composition, and a blood marker linked to brain health. Researchers will compare 60 people with mild cognitive impairment to healthy older adults. Participants complete one session of …

This study tests whether combining mindfulness meditation with non-invasive brain stimulation can improve attention and memory in healthy adults and people with mild cognitive impairment. Participants will play a memory game while wearing an EEG cap that reads their brain waves a…

This study looks at how different types of exercise—cycling or strength training—affect brain blood flow and physical frailty in older adults with mild cognitive impairment (MCI), an early stage of memory loss. Thirty-six participants aged 60-85 will exercise for 12 weeks and be …

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…

This study checks if a Greek version of the Montreal Cognitive Assessment (MoCA) is a reliable tool for spotting early signs of memory loss and dementia. Researchers will test 250 Greek-speaking adults aged 55-85 to see how accurate and consistent the quiz is. The goal is to give…

This study aims to develop a safer, cheaper way to monitor Alzheimer's treatment using advanced MRI scans and blood tests instead of repeated PET scans. Researchers will track 50 people with early Alzheimer's who are receiving antibody therapy (lecanemab or donanemab) to build pe…

This study tests a wearable system (insoles and ankle sensors) to see if changes in walking patterns can help detect early signs of Alzheimer's or related dementias. Researchers will collect walking data from 150 adults aged 55 and older, both in a lab and during daily life for o…

This study aims to validate an Italian version of the dynamic Neurocognitive Adaptation (dNA) Scale, a questionnaire that measures how much older adults engage in physical, mental, creative, and social activities. Researchers will recruit 265 people aged 65 and older, including t…

This study looks at whether feeling lonely makes it more likely for older adults with mild cognitive impairment (MCI) to develop dementia. Researchers will follow 300 people aged 70 and older for one year to see who progresses to dementia. The goal is to understand loneliness as …