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Massive canadian study tracks 1,500 brains to unlock dementia secrets

NCT ID NCT03402919

Knowledge-focused Sponsor: McGill University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better understand dementia and related conditions, not to test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,573 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2016

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

2300 English and/or French-speaking participants recruited from across Canada in the following groups: * 650 Cognitively healthy volunteers * 300 volunteers with Subjective Cognitive Decline * 400 volunteers with Mild Cognitive Impairment * 200 volunteers with Vascular Mild Cognitive Impairment * 150 volunteers with Alzheimer's disease * 200 volunteers with Dementia of Mixed Etiology * 200 volunteers with Parkinson's disease and cognitive impairment * 200 volunteers with Frontotemporal spectrum dementia

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Has subjective or objective cognitive impairment * Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member) * Sufficient proficiency in English or French to undertake self report and neuropsychological testing * Geographic accessibility to the study site * Must have a study partner who can participate as required in the protocol (provide corroborative information) * Up to 12 years of education * Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment Exclusion Criteria: * The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses * Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures * Symptomatic stroke within the previous year * Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia frontotemporal dementia Lewy body dementia Lewy Body Disease Mixed Dementias Parkinson disease subjective cognitive decline

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer disease (AD) Cognitively unimpaired Dementia Frontotemporal dementia (FTD) Lewy body disease(LBD) Mild cognitive impairment (MCI) Mixed dementia Parkinson's disease (PD) Subjective cognitive decline (SCD) Subjective cognitive impairment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baycrest Clinical Unit

    RECRUITING

    Toronto, Ontario, M6A 1W1, Canada

  • Bruyère Research Institute

    ACTIVE_NOT_RECRUITING

    Ottawa, Ontario, K1N 5C8, Canada

  • Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUS

    ACTIVE_NOT_RECRUITING

    Sherbrooke, Quebec, J1J3H5, Canada

  • Clinique de cognition Institut universitaire de gériatrie de Montréal

    RECRUITING

    Montreal, Quebec, H3W 1W5, Canada

  • Djavad Mowafaghian Centre for Brain Health

    RECRUITING

    Vancouver, British Columbia, V6T 1Z3, Canada

  • Gait and Brain Lab

    RECRUITING

    London, Ontario, N6C 5J1, Canada

  • Hamilton General Hospital

    RECRUITING

    Hamilton, Ontario, L8L 2X2, Canada

  • Hôpital Enfant-Jésus

    RECRUITING

    Québec, Quebec, G1J 1Z4, Canada

  • Island Health

    NOT_YET_RECRUITING

    Victoria, British Columbia, V8R 6R3, Canada

  • Jewish General Hospital/McGill Memory Clinic

    RECRUITING

    Montreal, Quebec, H3T 1E2, Canada

  • Kawartha Centre

    ACTIVE_NOT_RECRUITING

    Peterborough, Ontario, K9H 2P4, Canada

  • Research Institute of the McGill University Health Centre

    ACTIVE_NOT_RECRUITING

    Montreal, Quebec, H3G 1A4, Canada

  • St. Joseph's Health Care London

    RECRUITING

    London, Ontario, N6A 4V2, Canada

  • Sunnybrook Health Sciences Centre

    ACTIVE_NOT_RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • University Health Network Memory Clinic

    ACTIVE_NOT_RECRUITING

    Toronto, Ontario, M5T 2S8, Canada

  • University of Alberta Hospital

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Calgary

    RECRUITING

    Calgary, Alberta, T2N 1N4, Canada

  • University of Waterloo

    ACTIVE_NOT_RECRUITING

    Waterloo, Ontario, N2L 3G1, Canada

  • Veteran's Memorial Building

    RECRUITING

    Halifax, Nova Scotia, B3E 2E1, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.