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Zapping the brain to sharpen mind and stride

NCT ID NCT06608316

Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Researchers are testing whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation can improve dual-task walking, balance, and thinking in older adults with mild cognitive impairment. The study enrolls 72 people aged 65 and older who have mild cognitive symptoms but can walk independently. Participants receive stimulation to one or both sides of the front of the brain, and researchers measure changes in walking speed, reaction time, and brain activity during dual-task conditions. The goal is to see if this approach helps and whether stimulating both sides works better than one.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intermittent theta-burst stimulation, a form of transcranial magnetic stimulation
What this could lead to
If it works, this could offer a non-drug way to help older adults with mild cognitive impairment stay steadier on their feet and sharper mentally. It could also show which part of the brain is the best target for stimulation.
What could go wrong
This is a small, early-stage study of 72 people, so any benefits may not hold up in larger trials or apply to everyone. Brain stimulation can cause scalp discomfort or headaches, and the long-term effects are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

72 people

The number who actually took part.

Started

Nov 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged≥65 years; * Patient-reported subjective cognitive decline and the total score of the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) was between 19 and 25; * Intact daily functioning in ADL scales and being independent in daily living, and ability to walk at least for 1 minute independently without an assistive device; * No serious visual or hearing impairment and can complete relevant assessment and testing; * Signed informed consent of patients and their families for iTBS treatment. Exclusion Criteria: * Identified with contraindications in the rTMS screening questionnaire; * Cognitive dysfunction due to craniocerebral trauma or neurological diseases; * Presence of severe physical illnesses such as speech disorders or unstable cardiac arrhythmias; * Currently in a critical condition such as fever, infection, or organ failure; * Significant damage to the left frontal lobe cortex; * Currently taking antidepressants or psychostimulants; * Unstable vital signs or organ failure; * Neuropsychiatric comorbidity or affective disorder that could affect the test results; * Patients with dementia.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment (MCI)

Contacts and locations

Locations

  • The Hong Kong Polytechnic University

    Hong Kong, Hong Kong, 000000, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.