Exercise your brain: simple workouts may ward off Alzheimer's

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * inactive men and women aged 50-80 years (inclusive) with subjective cognitive symptoms but no dementia who have one or more vascular risk factors (see below) for ADRD; * Inactivity will be assessed with a physical activity questionnaire and defined as engagement in \<3 sessions/week of 20 min or more of vigorous exercise; * Subjective cognitive symptoms will be self-reported using the MAC-Q Memory Complaint Questionnaire, recently validated as a measure of subjective memory complaints in healthy elderly subjects, in patients with mild cognitive impairment, and in relation to AD biomarkers; participants with a score of ≥25 will be considered eligible. * Vascular risk factors for ADRD including the following: * history of hypertension; * diabetes mellitus; * obesity (body mass index (BMI) \<40 kg/m2) * elevated cholesterol; * currently smoking; * past history of coronary artery disease without recent (\<5 years) symptoms. Participants must provide a completed PAR-Q+ form (www.csep.ca), the standard method of obtaining physician approval for participation in an exercise program. For participants without a family doctor to provide this form, we will provide information on how to find a family doctor. Exclusion Criteria: * diagnosis of a developmental handicap; * history of dementia (DSM-V criteria)\*\*; * terminal illness (life expectancy \< 1 year) * not fluent in verbal and written English; * history of stroke; * currently participating in another trial; * comorbid medical or neurological illnesses (e.g., multiple sclerosis) that would confound cognitive assessments or make trial completion unlikely (in the site investigator's opinion); * contraindication for the intervention; * contraindication for an MRI exam. * \*\*Existing or suspected dementia will be identified by medical history, cognitive impairment on the Telephone Interview for Cognitive Status (TICS-modified; score≤ 20), or impaired Instrumental Activities of Daily Living (IADL) - a response of needs assistance or dependent due to cognitive impairments on any item on the Lawton scale.