PANCREATIC DUCTAL ADENOCARCINOMA

This study is testing a more thorough surgical technique for removing pancreatic head cancer. The goal is to see if removing more surrounding tissue during the main operation reduces the chance of the cancer coming back and helps patients live longer. Researchers will follow 90 p…

This early-stage study is testing a new drug called BI 765049 in adults with advanced colorectal, stomach, or pancreatic cancer that has spread or cannot be removed by surgery. The main goal is to find the highest dose patients can safely tolerate and determine the best way to gi…

This early-stage study is testing a new implant called PTM-101, which is placed near the pancreas to deliver chemotherapy directly to the tumor. The goal is to see if this approach, combined with standard pre-surgery chemo, is safe and can shrink tumors in people with borderline …

This is an early-stage trial testing a new drug called LY3962673 in people with advanced pancreatic, lung, or colorectal cancer that has a specific genetic change called KRAS G12D. The main goals are to find a safe dose and see if the drug, given alone or with other chemotherapie…

This study is testing whether a combination of two immunotherapy drugs can help control pancreatic cancer after initial chemotherapy. The treatment is given as maintenance therapy to patients whose cancer hasn't gotten worse after 4-6 months of standard chemotherapy. Researchers …

This study is testing if a special surgical glue can prevent dangerous fluid leaks after major pancreas cancer surgery. About 194 patients having surgery for pancreatic or related cancers will be randomly assigned to receive the standard surgical connection or the same connection…

This is a very early-stage study to test the safety of a new drug called GV20-0251 in adults with advanced solid tumors that have progressed despite standard treatments. The main goal is to find a safe dose by giving the drug to small groups of patients at different levels. It is…

This early safety study is testing whether transplanting healthy gut bacteria from donor stool can help control pancreatic cancer. It involves 10 patients with pancreatic cancer who are scheduled for surgery. Patients receive the transplant via colonoscopy and then take weekly ca…

This study aims to see if quickly analyzing the genetic makeup of a pancreatic tumor can help doctors choose the most effective treatment. It will enroll 200 adults with pancreatic cancer that has not spread to distant organs. Participants will receive standard chemotherapy and p…

This study is testing whether a wearable device that delivers low-intensity electric fields (called TTFields) is safe and helpful when used alongside standard chemotherapy for advanced pancreatic cancer that has spread. It will involve about 30 adults to see if the combination ca…

This program provides access to an experimental immunotherapy called ELI-002 7P for patients with a specific type of pancreatic cancer (with KRAS or NRAS mutations) who are at high risk of the cancer coming back after surgery. It is for patients who have no other good treatment o…

This study tests whether adding new immune-boosting drugs to standard radiation before surgery can help the body fight advanced pancreatic cancer more effectively. It will enroll 60 patients who have already completed initial chemotherapy and are candidates for surgery. Researche…

This study is testing a new oral drug called ART0380 in people with advanced or metastatic solid tumors that have spread and are hard to treat. The main goals are to find the safest and most effective dose of ART0380 when given alone or combined with standard chemotherapy drugs, …

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific genetic change called KRAS G12D. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack canc…

This early-stage study is testing a new drug called ASP2138 for people with pancreatic cancer that can be removed by surgery and has a specific protein called CLDN18.2. Participants receive one injection of ASP2138 two weeks before their scheduled surgery, with the goal of helpin…

This study is testing new targeted drugs called RAS inhibitors in combination with standard cancer treatments for people with advanced colorectal or pancreatic cancer. The goal is to find safe and effective doses while seeing if these new drug combinations can help control cancer…

This early-stage study is testing a new radioactive drug treatment for people with advanced solid tumors that have stopped responding to standard therapies. Researchers will first use a special imaging scan to see if patients' tumors are likely to respond, then give the radioacti…

This study is testing whether adding a special surgical glue to the connection made during pancreas cancer surgery can prevent dangerous fluid leaks. Researchers are comparing the glue method against standard techniques in 100 patients undergoing this complex operation. The goal …

This is an early-stage study testing a new drug called Spevatamig (PT886) in people with advanced cancers of the stomach, pancreas, and bile ducts. The main goals are to find a safe dose and see how well the body handles the drug. It will be tested alone and in combination with s…

This study is testing if switching between two different chemotherapy combinations each month works better than standard treatment for people with metastatic pancreatic cancer. It aims to see if this alternating approach can keep the cancer from growing for longer and help patien…

This study is testing a new oral drug called IPN01194 in adults with advanced solid tumors that have spread and have specific genetic changes. The main goals are to find a safe and tolerable dose and to see if the drug can help shrink tumors. The study is open to people with cert…

This early-stage study is testing a new oral drug called VS-7375, which is designed to block a specific cancer-driving mutation known as KRAS G12D. Researchers will give the drug alone and in combination with other cancer therapies to adults with advanced solid tumors, including …

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer. The goal is to see if a combination of high-dose chemotherapy drugs, vitamins, and the patient's own stem cells is safe and can overcome the cancer's resistance to treatment.…

This early-stage trial is testing a new experimental drug called AZD5863 for people with advanced stomach, esophageal junction, esophageal, or pancreatic cancers that have spread. The study aims to find the safest dose and see if the treatment can shrink tumors. It's for adults w…

This early-stage study is testing a new drug called AZD4360 in adults with advanced cancers of the stomach, pancreas, and related areas. The main goals are to find a safe dose and see if the drug shows any signs of helping to control the cancer. The drug is designed to target a s…

This study is testing whether adding an experimental drug called BMS-986504 to standard chemotherapy works better than chemotherapy alone for people with advanced pancreatic cancer that has spread and has a specific genetic change (MTAP deletion). The trial will involve about 470…

This study is testing a new drug called tegavivint in children, teens, and young adults whose solid tumors or lymphomas have come back or haven't responded to other treatments. The main goals are to find the safest dose, understand the side effects, and see if the drug can help s…

This early-phase trial is testing a new treatment for advanced pancreatic cancer that has spread and carries a specific genetic change (KRAS G12D mutation). The treatment uses tiny natural packages from cells (called exosomes) to deliver a gene-silencing drug directly to the canc…

This study compares two surgical approaches for removing pancreatic and nearby tumors. Researchers want to know if a minimally invasive laparoscopic surgery is as safe and effective as the traditional open surgery. The trial will enroll 90 adult patients with resectable tumors an…

This early-stage trial is testing the safety and dosing of an experimental drug called PF-08046050 in adults with advanced solid tumors that have returned or stopped responding to standard treatments. The drug is designed to attach to cancer cells and deliver a toxic payload dire…

This study is testing an experimental drug called AZD0901, both by itself and combined with standard chemotherapy, for people with advanced cancers of the stomach, pancreas, and bile ducts. The main goals are to see if the treatment is safe and if it can shrink tumors. It is for …

This early-stage trial is testing a new treatment for advanced pancreatic cancer. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack cancer cells with a specific KRAS G12V mutation, and then infuse them back into the pati…

This is the first time researchers are giving the experimental drug ASP5834 to people. The study aims to find a safe dose and check for side effects in adults with advanced solid tumors that have specific changes in a gene called KRAS. Some participants with colorectal cancer wil…

This study is testing two new drugs, elironrasib and daraxonrasib, for people with advanced lung, colorectal, or pancreatic cancer that has a specific genetic change called KRAS G12C. The main goals are to find safe doses and see if the drugs, given alone or together, can shrink …

This study is testing a three-part treatment for advanced pancreatic cancer that cannot be removed by surgery. Doctors will first use a special ultrasound probe to heat and destroy the main tumor, then give standard chemotherapy along with an immunotherapy drug called pembrolizum…

This is the first study in people for a new radioactive drug called [225Ac]-FPI-2068. It aims to find a safe dose and see how the drug travels in the body of 70 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check safety…

This study is testing a new drug called MK-2870, both by itself and combined with other cancer treatments, for people with advanced colorectal, pancreatic, or biliary tract cancers. The main goals are to see if the treatment is safe and if it helps shrink or eliminate tumors. The…

This is the first human study of an experimental drug called JANX008 for people with advanced solid tumors that have spread and stopped responding to standard treatments. The main goal is to find a safe dose and understand how the body handles the drug. Researchers will also look…

This study is testing a new type of targeted radiation therapy for people with advanced solid tumors that have stopped responding to standard treatments. The therapy uses a radioactive drug designed to seek out and deliver a powerful dose of radiation directly to cancer cells. Th…

This early-stage study is testing a new radioactive drug called [177Lu]Lu-NNS309 in patients with advanced pancreatic, lung, breast, or colorectal cancers that have stopped responding to standard treatments. Researchers will first use a special imaging scan to see if patients' tu…

This is an early-stage study to check the safety and initial activity of an experimental drug called DR-0202. It is for adults with advanced cancers that have spread, returned, or stopped responding to at least two prior treatments. The main goal is to find a safe dose and see ho…

This study aims to develop a better test to catch pancreatic cancer early. Researchers are collecting urine and blood samples from 3,500 people who have symptoms or are at risk for the disease. They will analyze these samples to see if a new combination of markers can accurately …

This study is testing whether a new screening program using artificial intelligence (AI) can help detect pancreatic cancer earlier in people at high risk. Researchers will enroll 100 adults aged 50-85 who have recently developed diabetes and have a high risk score for pancreatic …

This study is testing a new radioactive tracer called [18F]FPyQCP for PET scans to see if it can better detect five specific cancers: colorectal, ovarian, gastric, breast, and pancreatic. Researchers will check if the tracer is safe, measure its radiation dose, and see how accura…

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study aims to confirm if a new blood test can find pancreatic cancer at its earliest, most treatable stages. Researchers will test the method in 2,000 people, including those with and without pancreatic cancer. The test looks for tiny genetic signals in the blood that may in…

This study is testing if a special type of MRI scan can find tiny liver tumors that standard CT scans often miss in people with pancreatic cancer. The goal is to help doctors make better treatment decisions, potentially avoiding surgeries that wouldn't help if the cancer has alre…

This study aims to find pancreatic cancer earlier in people at high risk due to family history or certain genetic conditions. Researchers will enroll 700 participants to compare two screening methods: MRI and endoscopic ultrasound. The goal is to see if regular screening can lead…

This study is testing a new, experimental type of MRI scan that looks at how a pancreatic tumor uses energy. The goal is to see if this scan can tell doctors earlier than current scans whether a patient's standard cancer treatment is working. About 70 adults with advanced pancrea…

This study is testing whether a simple blood test can tell doctors if chemotherapy is working for metastatic pancreatic cancer faster than the current standard of waiting 8 weeks for scans. Researchers will measure tumor DNA in the blood of 50 participants at different time point…

This study aims to create a blood test that can predict which pancreatic cancer patients will respond well to chemotherapy given before surgery. Researchers will analyze archived blood samples from 200 patients who already received standard chemotherapy and surgery. The goal is t…

This study is creating a large registry of people at high risk for pancreatic cancer to help researchers find better ways to detect the disease early. It will collect blood samples, pancreatic fluid, and medical images from 5,000 participants over ten years. The goal is to use th…

This study aims to learn how to detect pancreatic cancer earlier by observing and collecting samples from up to 20,000 people at high risk, such as those with a strong family history or certain genetic changes. Participants will be followed over time, but this is an observational…

This early-stage study aims to understand the safety and imaging properties of an experimental radioactive tracer called RAD301. The research involves 9 participants, including both healthy volunteers and people with specific cancers like pancreatic, lung, or ovarian cancer. Part…

This study aims to learn more about pancreatic cysts, which are fluid-filled sacs in the pancreas often found by accident on scans. Researchers will follow 4,000 adults with these cysts over time to see which ones stay harmless and which might develop into cancer. The goal is to …