PANCREATIC DUCTAL ADENOCARCINOMA

This early-phase study tests an experimental drug called RMC-6291 in adults with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to find a safe dose and see how the body processes the drug. About 222 people with lung, colorectal, or pancreatic cancer th…

This study tests whether combining an experimental drug (ZN-c3) with standard chemotherapy (gemcitabine) can help people with advanced pancreatic cancer that has stopped responding to initial treatment. The trial enrolled 12 participants and measures how many are alive without th…

This study looks at how safe and effective the diabetes drug glipizide is for lowering blood sugar in people with pancreatic cancer. About 29 adults with active pancreatic cancer and high blood sugar will take glipizide, and their glucose levels will be measured before and after …

This early-phase trial tests whether adding the targeted drug ivosidenib to standard chemotherapy can help shrink pancreatic tumors before surgery. About 16 people with resectable pancreatic cancer will take part. The main goal is to find the safest dose and see how well the comb…

This study tests whether adding three cholesterol-lowering drugs (atorvastatin, ezetimibe, and evolocumab) to standard chemotherapy can slow or stop advanced pancreatic cancer. It involves 3 newly diagnosed adults with inoperable or metastatic pancreatic cancer. The goal is to se…

This study tests a new immunotherapy for adults with advanced pancreatic cancer. The treatment uses a special protein and virus to help the immune system kill cancer cells, combined with another drug called ezabenlimab. The goal is to find a safe dose and see if the combination c…

This study tests a new combination of two drugs (AGEN1423 and Botensilimab) with or without chemotherapy for people with advanced pancreatic cancer that has worsened after at least one prior treatment. The goal is to see if the combination can shrink tumors or slow the disease. A…

This early-phase study tests a new drug called LY4066434 in people with advanced solid tumors that have certain KRAS mutations. The main goal is to see if the drug is safe and tolerable when given alone or with other treatments. About 750 participants with pancreatic, lung, or co…

This early-phase study tests an experimental drug called ABBV-400 in about 302 adults with advanced solid tumors, including liver, pancreatic, breast, and ovarian cancers. The main goals are to check safety, side effects, and whether the drug shrinks tumors. Participants receive …

This study compares a three-drug chemotherapy combination (nab-paclitaxel, gemcitabine, plus cisplatin) against the standard two-drug combination (nab-paclitaxel plus gemcitabine) for people with metastatic pancreatic cancer that has spread to other parts of the body. Participant…

This study tests a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) for people with inoperable pancreatic cancer. The goal is to see if using a heat probe to destroy tumor tissue can help patients live longer compared to standard care alone. About 1…

This early-phase study tested a vaccine therapy given directly into the tumor along with a growth factor to boost the immune system in 18 people with advanced pancreatic cancer that could not be removed by surgery. The main goal was to find the safest dose and check for side effe…

This study tests whether giving a single dose of chemotherapy directly to the liver, before standard treatment, is safe and possible for people with localized pancreatic cancer. About 20 adults who are eligible for surgery and standard chemo will take part. The goal is to see if …

This early-stage study tests a new drug (RO7496353) combined with an immunotherapy drug, with or without chemotherapy, in people with advanced lung, stomach, pancreatic, or bladder cancers. The main goal is to check safety and how well the body tolerates the treatment. About 102 …

This study tests an experimental immunotherapy called ELI-002 7P in people with pancreatic or other solid tumors that have specific KRAS or NRAS gene mutations. The treatment aims to help the immune system recognize and attack cancer cells after standard therapies like surgery an…

This early-phase trial tests a combination of two targeted drugs (vismodegib and erlotinib) with or without a standard chemotherapy drug (gemcitabine) in people with advanced pancreatic cancer or other solid tumors that cannot be surgically removed. The main goal is to find the s…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced or inoperable solid tumors, including certain breast, lung, and pancreatic cancers. The goal is to see if the combo can shrink tumors or slow their growth by blocking enzymes that cancer …

This study tests a new drug called chiauranib combined with two standard chemotherapies as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The drug works by blocking several key processes that help tumors grow and spread. The trial …

This study is developing a test using urine and blood samples to detect pancreatic cancer earlier. Researchers are collecting samples from 3,500 people with and without pancreatic disease to see how accurate the test is. The goal is to create a simple, non-invasive way to diagnos…

This study aimed to test a new two-step PET imaging method to locate cancer cells that make a protein called CA19-9. It was designed for people with pancreatic, bladder, or gastrointestinal cancers. However, the study was withdrawn before enrolling any participants, so no results…

This study tests whether a practical diet and exercise program can help people with pancreatic cysts (IPMNs) lower their risk of developing pancreatic cancer. Twenty-four adults with large cysts and obesity will follow a 6-month lifestyle plan. The main goal is to see if the prog…

This study tests whether an 8-week program of personalized nutrition, exercise, and mental health support can help people with pancreatic or esophageal cancer get stronger before surgery. Nine participants will follow the program alongside their standard chemotherapy. The goal is…

This early-phase study tests whether ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen, is safe and can help stabilize or increase weight in people with advanced pancreatic cancer who are experiencing cachexia (unintended weight loss). About 28 partici…

This study creates a database of 600 people with BRCA or PALB2 gene mutations who have pancreatic cancer, along with their close relatives. Researchers collect medical information and biological samples to better understand why some gene mutation carriers develop this cancer. The…

This study collects blood samples from 102 people with non-small cell lung cancer, colorectal cancer, or pancreatic cancer to track genetic changes in their tumors over time. Participants receive standard treatments, and researchers analyze DNA from the blood to see how it relate…

This study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. The goal is to track their health over time to find better ways to detect and prevent the disease early. About 317 participa…

This study tests whether a special PET scan tracer called 18F-FAC can show how much of a standard chemotherapy drug gets into pancreatic tumors. About 30 adults with pancreatic cancer will get a PET scan before starting treatment. The goal is to learn more about drug uptake, not …