New chemo combo strategy aims to outsmart pancreatic cancer

NCT ID NCT07163273

Recruiting now Disease control Sponsor: Northwell Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests a new approach for people with metastatic pancreatic cancer: alternating two standard chemotherapy regimens every month instead of using just one. The goal is to see if this switching strategy can keep the cancer from growing for at least 6 months. About 41 participants will receive both NALIRIFOX and gemcitabine/nab-paclitaxel in a monthly rotation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: chemotherapy (NALIRIFOX and gemcitabine/nab-paclitaxel)
What this could lead to: If it works, this could offer a new way to slow tumor growth and extend the time before pancreatic cancer worsens.
What could go wrong: This is a small, early-phase trial with only 41 people, so results may not apply widely. Chemotherapy side effects can be severe.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pancreatic adenosquamous carcinoma pancreatic ductal adenocarcinoma undifferentiated pancreatic carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Locations

Imbert Cancer Center
RECRUITING

Bay Shore, New York, 11706, United States
Long Island Jewish Medical Center
RECRUITING

New Hyde Park, New York, 11040, United States
Manhattan Eye, Ear and Throat Hospital
RECRUITING

New York, New York, 10065, United States
NHPP Medical Oncology at Rego Park
RECRUITING

Rego Park, New York, 11374, United States
Northern Westchester Cancer Center
RECRUITING

Mount Kisco, New York, 10549, United States
Phelps Cancer Center
RECRUITING

Sleepy Hollow, New York, 10591, United States
Zuckerberg Cancer Center
RECRUITING

New Hyde Park, New York, 11042, United States

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