HIV infectious disease

This study tests whether tuberculosis (TB) treatment can be tailored to each person's risk of a poor outcome. About 900 adults with drug-sensitive TB will be grouped as lower-risk or higher-risk. Lower-risk participants may get a shorter treatment course, while higher-risk partic…

This study tests a two-part HIV vaccine in healthy adults who do not have HIV. The vaccine uses a DNA 'prime' followed by a protein 'boost' to train the immune system against multiple HIV strains. Researchers are checking if the vaccine is safe and whether it triggers a strong im…

This early-stage trial will test two experimental mRNA vaccines designed to teach the immune system to make antibodies that target HIV. About 42 adults with well-controlled HIV will receive the vaccines and then temporarily pause their regular HIV medication under close monitorin…

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

This study tests a drug called foscenvivint in people with liver cirrhosis caused by HIV and hepatitis C co-infection who also have hemophilia. Participants receive the drug once a week for 24 weeks. Researchers will check if the drug improves liver function and is safe to use.

This study tests whether offering rapid HIV testing during a dental visit leads more people to get tested than simply referring them to a lab. About 6,700 adult dental patients at four community health centers will be offered either a quick oral swab test on-site or a referral fo…

This study looks at whether people with HIV who need a liver transplant can safely receive a liver from a donor who also had HIV. Researchers will compare infections and cancer rates between those who get an HIV-positive donor liver and those who get an HIV-negative donor liver. …

This study tests whether a new ultra-long-acting injectable HIV medication works as well as the current long-acting version. About 564 adults and teens with well-controlled HIV will receive either the ultra-long-acting or the standard long-acting shots. The goal is to see if the …

This study will test a doula support program for 15 pregnant women with HIV in South Florida. The doula will provide education, adherence support, and lactation counseling from pregnancy through 12 weeks after birth. The goal is to see if this program is feasible and acceptable, …

This study tests whether a combined approach—offering HIV PrEP (pills or injections) and STI prevention (doxycycline after sex) along with smartphone tools—helps young men at high risk stay protected. About 400 men aged 18-29 who have sex with men will be followed for a year to s…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This trial tests whether adding a lab-made antibody (ePGT121v1-LS) to standard HIV medication can help infants under one year old achieve better viral suppression. About 87 infants in South Africa will receive either the antibody or a placebo injection every 12 weeks for 48 weeks…

This trial tests whether adding two lab-made antibodies (ePGT121v1-LS and VRC07-523-LS) to standard antiretroviral therapy can help infants living with HIV achieve viral suppression. Infants up to one year old in Mozambique and Cameroon receive four injections of the antibodies o…

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This early-stage study tests whether two lab-made antibodies can help people with HIV control the virus after stopping their regular antiretroviral therapy. The 40 participants all started HIV treatment very early after infection. Researchers will monitor safety and see if the an…

This small Phase 2 trial tests whether alendronate, a drug used for bone health, can reduce the hidden HIV reservoir in people already on antiretroviral therapy. About 30 participants will receive either alendronate or a placebo, and researchers will measure changes in HIV DNA an…

This study looks at how long-acting injectable HIV drugs (cabotegravir and rilpivirine) work in the body during pregnancy and after childbirth. About 40 pregnant women with HIV will receive the shots every 4 weeks. The goal is to measure drug levels and see if they stay effective…

This Phase 2 trial tests whether switching to a combination of two injectable drugs, GS-3242 and lenacapavir, works as well as staying on the daily pill Biktarvy for people with HIV who already have the virus under control. About 175 participants will be randomly assigned to eith…

This study will test a Spanish-language program called Healthy Choices for 45 young adults (ages 18-29) living with HIV in the Dominican Republic who also struggle with alcohol use and stigma. The program is designed to help them better manage their health and reduce the impact o…

This study tests a program called NPOWER365 for Black men who have sex with men and are living with HIV. The program uses a smartphone app, online forums, and resource referrals to help with medication adherence, mental health, and access to care. About 350 participants in the At…

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This study will compare two different HIV medication combinations in 60 people who also have active tuberculosis. Participants will receive either a newer drug (Ainuovirine) or a standard one (Efavirenz), along with their TB meds. The goal is to see which regimen better suppresse…

This early-stage trial tests whether combining two drugs—ibalizumab and chidamide—can safely reduce the hidden HIV reservoir in people living with HIV. The study will enroll up to 29 adults on stable antiretroviral therapy. Researchers will monitor side effects and measure change…

This study will test a mobile app called MindBodyU designed to help young people (ages 16-25) living with HIV in South Carolina stay connected to their care and take their HIV medication regularly. The goal is to see if the app is easy to use, liked by users, and helps improve me…

This study will test a two-drug HIV pill (Dolutegravir/Lamivudine) in 210 pregnant women who have never taken HIV medication. The goal is to see if it controls the virus and prevents passing HIV to their babies. Participants will be compared to those on standard three-drug therap…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study tests whether a self-applied cream (5-fluorouracil) after a heat procedure (thermal ablation) can clear HPV better than a placebo cream in 140 women with HIV in Kenya. Participants will use the cream every two weeks for 24 weeks and be followed for 48 weeks total. The …

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This study tests a program called iSYV that combines peer-led group sessions with a gamified text-message game to support mental health and HIV care for 5,000 youth aged 15-24 in Tanzania. The goal is to see if it helps them keep their virus under control and stay in care. The pr…

This phase 2 trial tests whether a mix of intensified antiretrovirals, a latency-reversing drug, an anti-proliferative drug, and a personalized vaccine can shrink the hidden HIV reservoir enough to allow people to stop their daily medication. The study will enroll 70 adults with …

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This phase 3 trial tests whether adding a steroid (hydrocortisone) and a stronger mix of antibiotics to standard care can improve survival in HIV patients with sepsis in sub-Saharan Africa. The study will enroll 344 adults and measure how many are alive after 28 days. It aims to …

This study looks at whether switching to a daily pill containing bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) can help people with HIV who previously did not respond to a long-acting injectable treatment (CAB/RPV LAI). The study includes 30 adults and will …

This study tests whether a shorter, 5-month combination of TB drugs works as well as the standard 6-month treatment for people with both HIV and drug-susceptible tuberculosis. It involves 148 participants with very weak immune systems (CD4 count under 100). The goal is to see if …

This study tests a smartphone app called ESCAPE, designed specifically for Black adults with HIV who smoke. The app teaches ways to handle stress, anxiety, and nicotine cravings, and is paired with nicotine patches or gum. 300 participants across the US will be randomly assigned …

This trial tests whether adding a fluoroquinolone antibiotic to the standard three-drug treatment helps HIV patients with a serious bacterial infection called disseminated MAC. About 124 adults will be randomly assigned to get either the standard therapy or the four-drug combo fo…

This early-stage trial tests a combination therapy to target hidden HIV reservoirs. Twenty HIV-positive adults on stable antiretroviral therapy will receive chidamide (to reactivate dormant virus) followed by infusions of engineered NK cells designed to kill the reactivated cells…

This study tests an experimental drug called JL18008 in people with HIV whose immune systems have not fully recovered despite standard antiretroviral therapy. The goal is to see if adding this drug can safely increase CD4+ T cells, which are crucial for fighting infections. The t…

This study looks at whether people with HIV who are already well-controlled on daily pills can switch to a long-acting injection given every two months. The goal is to see how many stay on the injection without stopping or needing to change treatment over 48 weeks. The study will…

This study tests a program called Coach Mpilo, where trained peers (coaches) provide one-on-one support to men living with HIV. The goal is to help these men stay engaged in HIV care, take their medication regularly, and achieve viral suppression. The trial will enroll 800 men in…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatment. The drug works by 'waking up' exhausted immune cells. Fifty adults with HIV and a hard-to-treat infe…

This early-stage trial tests a topical ointment called ACU-D1 for HPV-related vulvar and perianal lesions in people with HIV. Nine participants will apply the cream twice daily for 4 weeks. The main goal is to find the safest dose and see if the treatment can boost immune markers…

This study tests whether a one-visit, point-of-care test and treat approach helps more people with HIV, hepatitis B, or hepatitis C complete hepatitis C treatment within 24 weeks compared to standard care. About 1,280 participants will be randomly assigned to either the simplifie…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests whether pharmacy technicians can help people with HIV get long-acting injectable medication more easily at community clinics in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to improve access to modern HIV tr…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their usual medication-assisted therapy in a single appointment. The goal is to make it easier for veterans to get tested and treated for infectio…

This study tests whether baricitinib, an FDA-approved drug for other conditions, can keep HIV under control after participants stop their usual antiretroviral therapy (ART). Twenty people with well-controlled HIV will take baricitinib alongside ART for 26 weeks, then continue bar…

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This study compares vaginal estradiol tablets (Vagifem) to a vaginal moisturizer (Replens) for treating menopause-related vaginal and urinary symptoms in women living with HIV. Researchers will also check how these treatments affect the vaginal microbiome. The study includes 62 p…

This study tests whether giving young people (ages 18-35) living with HIV a monthly payment of $500 for 18 months helps them stay in care and keep the virus under control. About 304 participants who have faced financial hardship will be randomly assigned to receive either the cas…

This early-stage study tests a new experimental HIV drug called VH4770359 in 214 healthy adults aged 18-55. The goal is to check its safety, side effects, and how the body processes it. Participants will take either the drug or a placebo, and some will also receive midazolam to s…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

This study looks at whether people with HIV who have stopped their medication for at least 12 weeks can safely restart treatment with a single daily pill (B/F/TAF) on the same day they return to care. About 200 adults will take part to see if this quick restart helps lower the vi…

This study tests a program to help people with HIV who also have high blood pressure stick to their medication. Participants will get educational materials, a home blood pressure monitor, and regular check-ins with a nurse. The goal is to see if this approach is practical and hel…

This study looks at how well a long-acting combination of two HIV drugs (cabotegravir and lenacapavir) works in 50 adults with HIV-1. Participants either already take this treatment or will start it by doctor's order. The main goal is to see if the virus stays suppressed (below 5…

This study tests a 3-session telehealth counseling program called IDEAS for Hope, delivered by nurses, to help adults living with HIV in Tanzania who have had recent thoughts of suicide. The goal is to reduce suicidal thinking and improve engagement in HIV care, including medicat…

This study tests whether two safe dietary supplements—a probiotic and blueberry extract—can reduce signs of accelerated aging in people with HIV who drink alcohol. Researchers will measure changes in immune cells and biological age markers. The trial involves 160 participants age…

This early-stage trial tests an experimental drug called JL18008 in HIV patients whose immune systems have not fully recovered despite standard antiretroviral therapy. The study will enroll 52 adults and give them a single injection of JL18008 or a placebo. Researchers will check…

This study explores whether letting people choose their own HIV support method helps them stay in care. 140 adults starting or restarting HIV treatment in Cape Town will be randomly assigned to standard care, in-person group support, or a choice of in-person, WhatsApp group, or a…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study offers continued access to HIV medications (fostemsavir or dolutegravir/lamivudine) for 183 people who completed earlier ViiV Healthcare studies and are still benefiting. The goal is to provide treatment while collecting more safety information. Participants must have …

This early-stage trial tests whether a combination of three existing drugs (topiramate, lenalidomide, and pyrimethamine) can wake up dormant HIV hiding in the body and then help the immune system eliminate those infected cells. The goal is a 'functional cure' where the virus is c…

This study tests whether daily text reminders, paired with small rewards like school supplies or sports items, can help adolescents (ages 15-19) with HIV take their antiretroviral medicine on time. 327 teens in Ethiopia will be split into three groups: two receiving different typ…

This study tests whether valganciclovir, a drug that stops CMV from multiplying, can safely lower CMV levels in the blood of people with advanced HIV. About 130 adults and adolescents with very weak immune systems will be randomly assigned to take either valganciclovir or a place…

This study tests whether two different chemotherapy drugs, paclitaxel and pegylated liposomal doxorubicin, work equally well for treating Kaposi sarcoma in people living with HIV in sub-Saharan Africa. About 130 participants will receive one of the drugs every three weeks for six…

This study tests whether a once-daily pill containing doravirine, lamivudine, and tenofovir can quickly control HIV in people who have never taken HIV drugs before. One hundred newly diagnosed adults will take the pill for 48 weeks. The main goal is to see how many have undetecta…

This study will test two ways to find TB in pregnant women with HIV: using symptoms or a blood test. It will also compare starting TB prevention medicine right away versus after giving birth. The goal is to reduce harm to mothers and babies. About 1,500 pregnant women in Uganda w…

This study in Nairobi, Kenya, will test whether a drug called cytisine, combined with counseling, can help 300 people with HIV quit smoking and reduce heavy drinking. Participants will receive either cytisine or a placebo, plus either intensive counseling or standard advice. The …

This pilot study tests whether a peer-led program called Yuva Sath can help young people (ages 18-29) who inject drugs stay engaged in substance use treatment and HIV prevention. The program includes six one-on-one sessions with a peer counselor and weekly text check-ins. Researc…

This study tests a peer navigation program for 250 people living with HIV who also use substances. The program assigns a trained peer to help participants stay connected to HIV care and substance use services. Researchers will measure viral suppression and clinic attendance to se…

This study tests an immunotherapy called PDS0101 in 27 adults with both HIV and HPV 16. The goal is to see if it is safe and can strengthen the immune system's response against HPV, which can cause cancers like anal and cervical cancer. All participants will receive three doses o…

This study tests a new robotic bronchoscopy system that uses real-time 3D imaging to help doctors biopsy lung nodules in people with HIV. The goal is to see if this robot-guided approach is more accurate and safer than current navigation methods. One hundred participants will be …

This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…

This study will test a new rapid device called TruPlex that checks for HIV, Hepatitis B, and Syphilis using a single fingerstick blood sample. About 500 adults at risk for these infections will take part. Researchers want to see if the test is accurate and easy for trained staff …

This study will test a new computer tool that helps emergency doctors spot patients at high risk for hepatitis C and HIV. The tool uses a machine learning algorithm to analyze patient data and pops up an alert for the doctor. Researchers will compare this targeted screening with …

This study will test a rapid fingerstick test for HIV and syphilis in pregnant women who come to the emergency department without prior prenatal care. Researchers want to see if offering this test leads to more women being diagnosed and starting treatment right away. The goal is …

This study tests a special microscope that takes very clear, detailed pictures of cervical tissue right where the patient is being seen. The goal is to see if it can give doctors the same quality images as a standard lab test, but much faster. About 400 women in Mozambique and Br…

This study will check if a new device called MagIA H3S can accurately detect HIV, hepatitis B, hepatitis C, and syphilis in pregnant women in the Democratic Republic of the Congo. About 7,500 pregnant women will take part. The goal is to see if this quick test works as well as st…

This study will test a chatbot designed to increase awareness and use of PrEP, a daily pill that prevents HIV, among Black men who have sex with men (MSM) in the Southern United States. About 145 participants will interact with the chatbot over 90 days, answering questions and re…

This study tests a 5-month text-messaging program called #TranscendentHealth, created specifically for transgender boys and gender-diverse youth assigned female at birth, ages 14 to 18. The program aims to improve condom use, birth control use, and HIV/STI testing by addressing t…

This study tests a six-session behavioral program for stimulant-using men at high risk for HIV. The program focuses on positive thinking, mindfulness, and building supportive networks to help participants start taking PrEP (a daily pill that prevents HIV) and reduce stimulant use…

This study tests a simpler way to give TB preventive therapy to household contacts of TB patients and people living with HIV. Instead of monthly clinic visits, some participants get the full course of pills at once in their community. Researchers want to see if this approach help…

This study adapts a program called CARES to help 2,100 adolescent girls and young women (ages 16-24) in South Africa and Zimbabwe consistently use HIV prevention methods like pills, rings, or injections. The program includes counseling, text reminders, and peer support. Researche…

This study tests a mobile app called LOTUS designed to help people who use drugs engage with HIV prevention services like testing and PrEP. The app provides tips, reminders, peer support, and a way to ask healthcare professionals questions. The trial will enroll 40 participants t…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study tests whether letting people choose where they get their follow-up HIV prevention injections (home, community, or clinic) helps them stick with the treatment. 400 HIV-negative adults in Massachusetts will receive the same-day injectable drug lenacapavir and be randomly…

This study tests a virtual platform called LEARN 2 that provides tailored education to help men living with HIV prevent related health problems like heart disease and metabolic issues. Participants will use the platform weekly, attend live health educator sessions, and track thei…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This study will compare two enhanced flu vaccines—one with an adjuvant (MF59) and one with a higher dose—in 350 adults living with HIV. The goal is to see which vaccine triggers a stronger immune response. Participants will receive one shot and have their antibody levels checked …

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study aims to help outpatient clinics provide HIV prevention medication (PrEP) and sterile injection equipment to people who inject drugs. Researchers will work with clinics to develop and test a bundle of strategies, including patient education, provider training, and syste…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This pilot study will test a program called INSPIRE, designed to reduce stigma and increase HIV testing among Chinese immigrant women who work in massage parlors in Queens, NYC. The program involves four one-on-one conversations with a peer advocate over six weeks, plus weekly te…

This study tests a new program where trained village health workers use tablet-based tools to provide HIV prevention services, including PrEP and emergency PEP, to people at high risk in rural Lesotho. About 380 participants will be enrolled to see if this approach increases mont…

This study tests a mobile health program called PrEP Choice to help young people ages 13-24 start and stick with HIV prevention pills or shots. It also looks at whether taking the antibiotic doxycycline after sex (DoxyPEP) can prevent other sexually transmitted infections. About …

This study tests Project LYNX, a program that helps young adults (ages 18-29) who have recently been involved with the criminal legal system find and connect to substance use treatment and HIV-prevention services. The program pairs each participant with a trained peer navigator a…

This study will test two behavioral programs designed to help Black men who have sex with men (MSM) take PrEP regularly to prevent HIV. The C4 program offers personalized support to overcome barriers like stigma and healthcare access. The C4+3MV program adds group sessions to enc…

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…

This study aims to help 400 male commercial minibus drivers in Nigeria use HIV self-testing and long-acting injectable medications for both HIV treatment and prevention. Drivers will be trained as peer educators to promote these tools among their community. The goal is to make it…

This study tests a group-based HIV prevention program designed specifically for Black women aged 50 and older living in subsidized housing. The program aims to improve HIV knowledge, condom use, and testing. Participants will be randomly assigned to start the program right away o…

This study tests whether adding a remote nurse via telehealth to pharmacy-based PrEP/PEP services helps more people start and continue HIV prevention. About 1,580 pharmacy clients in Kenya will either get standard pharmacy care or extra telehealth support with SMS reminders. The …

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

This study will test a mobile app called HealthMPowerment designed to help Black adolescents and young adults in Alabama take PrEP, a daily pill that prevents HIV. Ten teens and their adult supporters will use the app for a few weeks, and researchers will check if it's easy and a…

This study tests whether trained young mentor mothers (YMMs) can help pregnant and breastfeeding teenage girls and young women (ages 15-24) in Zimbabwe use HIV prevention tools like PrEP and contraception. About 600 participants will be assigned to either receive support from YMM…

This study will test a smartphone app designed to help Black teenagers and young adults in Atlanta take their HIV prevention medication (PrEP) consistently. Researchers will work with 10 participants and their adult supporters to see if the app is easy to use and helpful. The goa…

This study looks at how to keep HIV self-test kits available for adolescent girls and young women in sub-Saharan Africa. Researchers will test two subsidy levels (high and low) for shopkeepers, with decreasing support over time. The goal is to find a sustainable way for private d…

This study tests a new way to help young people (ages 13-24) stick with PrEP, a medication that prevents HIV. Participants get PrEP delivered to a community spot (like home or a mobile van) and use a smartphone app for reminders and support. The goal is to see if this combo impro…

This study tests a digital teleconsultation program called E-PrevenT to help transgender sex workers and their clients access HIV and STI prevention services. The program aims to reach people who are often left out of traditional prevention efforts. Researchers will enroll 250 pa…

This study tests a counseling program called Healthy Families PrEP for HIV-negative women in rural Uganda who are planning pregnancy or recently gave birth. The program provides information and support to help women take daily PrEP pills to prevent HIV. Researchers will enroll 66…

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study tests whether having trained peer workers deliver HIV prevention medication (PrEP) in community settings helps more young people in Brazil start and stay on PrEP compared to standard clinic care. About 1,400 youth aged 15-24 who are sexually active and not currently us…

This study tests whether making HIV and STI testing and PrEP navigation a routine, opt-out part of primary care increases their use. About 700 adults aged 18-45 at health centers in Mississippi will take part. Researchers will compare a standard-care period to an integrated-care …

This study tests whether a single daily pill that combines HIV prevention (PrEP) and birth control is easier for women to take consistently than taking two separate pills. About 300 women without HIV will try both approaches in a crossover design, and researchers will measure adh…

This study aims to see if watching video logs and receiving personalized messages can make Black women more willing to use PrEP, a daily pill that prevents HIV. It also looks at whether healthcare providers become more willing to prescribe PrEP. About 78 participants in Texas wil…

This study tests a tablet-based tool called PrEPwise, delivered by community health workers, to help Black women in eastern Virginia learn about and decide whether to start PrEP (a daily pill that prevents HIV). The trial will enroll 108 Black women who are eligible for PrEP and …

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study tests a training package called YACHT in 42 HIV testing clinics across Florida. The training helps staff use motivational interviewing to improve HIV testing and PrEP referrals for young men who have sex with men. Researchers will track whether testing rates and servic…

This study will offer young people aged 15-35 in Cape Town a choice of HIV prevention methods: a new twice-yearly injection (lenacapavir), a two-monthly injection (cabotegravir), or daily pills. Researchers want to see which option people stick with over 18 months and how best to…

This study looks at how to help people who use drugs start and keep taking PrEP, a daily pill that prevents HIV. Researchers will follow 200 participants from the emergency department for one year, tracking who stays on the medication and what helps or hinders them. They will als…

This study tests whether a text-message program can help 18-22 year-olds in Uganda prevent HIV. Participants receive texts with quizzes, badges, and advice to encourage HIV testing and condom use. The goal is to see if these messages make a difference over 12 months compared to n…

This study will test whether offering HIV prevention medication, routine STI testing, and a preventive antibiotic at retail pharmacies helps young women avoid infections. About 720 women aged 15 to 24 who visit pharmacies for birth control will take part. Researchers will check h…

This study looks at whether a one-on-one coaching method called academic detailing can help pediatricians feel more comfortable prescribing PrEP, a daily pill that prevents HIV. Fifty doctors will take part in brief, interactive sessions with a trained educator. The goal is to se…

This study looks at ways to help Black women get PrEP, a daily pill that prevents HIV. Researchers will try special strategies at family planning clinics to see if more women start and stay on PrEP. About 250 women with a recent STI will take part.

This study tests whether nurses, instead of doctors, can safely and effectively give long-acting HIV prevention shots in rural public health clinics. About 250 adults at risk for HIV will take part across several clinics in Missouri. The goal is to see if this nurse-driven approa…

This study tests a new tool to help people in emergency departments and urgent care start and continue taking PrEP, a daily pill that prevents HIV. About 120 people who are eligible for PrEP will use the tool, which is designed to address their medical and social needs. The goal …

This study tests a program called PrEP & Soccer, run through CVS pharmacies, to help men learn about and start PrEP—a daily pill that prevents HIV. About 800 men aged 18-54 who are at risk for HIV will take part. Some pharmacies will offer personalized PrEP navigation and a socce…

This study will train 75 Louisiana pharmacists to prescribe PrEP, a daily pill that prevents HIV. The training includes lessons on health disparities and implicit bias, plus mentoring. Researchers want to see if this increases the number of PrEP prescriptions, especially in commu…

This study looks at ways to improve care for teens and young adults who have experienced sexual assault. The goal is to offer same-day HIV prevention medicine and substance use support during their emergency room visit. Researchers will work with young people to design and test t…

This study will adapt two proven prevention programs (SISTA/SIHLE) to help Black adolescent girls in Paterson, New Jersey avoid HIV/AIDS and substance abuse. Researchers will use focus groups with 10 girls aged 13-18 to understand their needs and then measure changes in drug use,…

This study tests two smartphone tools to help HIV-negative men who have sex with men take their daily HIV prevention pill (PrEP) regularly and reduce methamphetamine use. One hundred men with mild to moderate meth use disorder will use the apps for 6 months. Researchers will chec…

This study tests a 6-session telehealth program called EMPOWER for African American women in the South. The program helps women make informed choices about HIV prevention, including PrEP. Researchers will enroll 80 women to see if the program is feasible and acceptable.

This study adapts Project YES+, a behavioral program, to improve mental health and reduce HIV-related stigma for adolescent and young men who have sex with men living with HIV in Vietnam. Eighty participants aged 16-24 will receive individual and group sessions with peer mentors.…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This study tests an enhanced version of depression treatment (COMBEX) for youth aged 15-24 with HIV. It combines therapy, medication management, and extra support strategies to improve mood and HIV care. Researchers will compare it to standard combination therapy over 72 weeks in…

This study tests whether metformin, a standard diabetes drug, can help treat depression in people living with HIV. Researchers will enroll 600 adults with HIV and depression, giving them metformin, fluoxetine (a standard antidepressant), both, or a placebo for up to 12 weeks. The…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study looks at sleep health in people with HIV who are on different antiretroviral therapies. Some participants switch from a dolutegravir-based regimen to a doravirine-based one, while others stay on dolutegravir. Sleep is measured using questionnaires, wrist-worn activity …

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This pilot study looks at how migration experiences and social bonds influence HIV prevention decisions among first-generation African immigrants aged 18-50 in New York and Massachusetts. Researchers will work with the community to develop a relationship-tailored behavioral inter…

This study investigates whether a simple coronary CT scan can detect early signs of heart disease in people with HIV. Researchers will measure calcium buildup in the heart arteries of 384 Mexican adults with HIV who have undetectable viral loads. The goal is to better understand …

This study tests whether a video app that explains 'Undetectable = Untransmittable' (U=U) can help people with HIV stay on treatment and keep the virus under control. About 880 people from clinics in South Africa will use the app during counseling. The goal is to see if better un…

This study looks at how HIV-1 hides in immune cells in the gut of people on effective antiretroviral therapy. Researchers will collect blood and colon tissue from 30 HIV-positive volunteers and healthy controls during routine colonoscopies. The goal is to understand why these gut…

This study tests a method to help clinics prescribe long-acting injectable PrEP, a shot that prevents HIV. Researchers will work with 20 healthcare providers and staff to improve how they offer this option. The goal is to see if a simple, flexible strategy can increase the number…

This study looks at how women in Blantyre, Malawi choose and use HIV prevention pills or injections. Researchers will follow 384 women to see why some stop taking PrEP and how tracing them can help re-engage them in care. The goal is to improve HIV prevention services for women a…

This study will look at over 12,000 adults in the Basque Country to compare how common multiple health conditions, taking many medications, and getting risky prescriptions are among people with HIV versus the general population. Researchers will use electronic health records to g…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study looks at how HIV might change the way the body handles fats in the liver, leading to fatty liver disease. Researchers will collect one blood sample from 120 adults: people with HIV and fatty liver, people without HIV but with fatty liver, and healthy controls. By analy…

This observational study will use cardiac MRI to examine how stimulant and polysubstance use affects heart scarring and inflammation in 400 people with and without HIV. Participants will have one study visit for a detailed heart scan. The goal is to better understand the combined…

This study looks at how to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore using HPV self-testi…

This study looks at whether hairdressers in the East of England can become sexual health champions for Black African women. The goal is to see if it's possible and acceptable for hairdressers to share information about HIV prevention and local sexual health services with their cl…

This study tests whether training healthcare providers to reduce stigma can increase the use of HIV and STI prevention services, like testing and preventive medications. It will involve 8 clinics in the Mississippi Delta and track changes in how often patients receive these servi…

This study tests better ways to screen and treat cervical cancer in women living with HIV in Kenya, who face a much higher risk. Researchers will use HPV self-testing, care navigators, and a mobile app to help more women get diagnosed and treated. The goal is to find strategies t…

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study looks at better ways to screen for HPV and prevent cervical cancer in women living with HIV. Researchers will test a new method that identifies specific HPV types and viral load. The goal is to see if this approach is practical for a larger future study. About 750 wome…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study looks at whether sharing results from a blood test that shows recent alcohol use can help people with HIV drink less. Researchers will enroll 80 people in Uganda who drink heavily. Half will get standard counseling plus their blood test results, and half will get couns…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to find more people with undiagnosed HIV or subs…

This study aims to reduce medical mistrust and improve HIV prevention among Hispanic/Latino gay and bisexual men in Mecklenburg County, NC. Researchers will train peer navigators to support their social networks for 12 months, then measure changes in mistrust, HIV testing, and Pr…

This study tests whether a pop-up alert in electronic medical records can help primary care doctors order screening for HIV, hepatitis B, and hepatitis C all at once. About 50 primary care providers will participate, and their patient visits will be randomly assigned to either se…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This pilot study will test a series of brief, private text messages sent via WhatsApp or Telegram to help people who use drugs in Kazakhstan feel more comfortable seeking PrEP, an HIV prevention pill. The messages address stigma, confidentiality worries, and misinformation. Forty…

This study tests a quality improvement method called SAIA to help emergency departments in Kenya offer more HIV tests to people who often miss out, like men, teens, and key populations. Researchers will compare hospitals that use SAIA with those that don't, measuring how many pat…

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Participants answer anonymous questions about their comfort, knowledge of HIV, and use of safety protocols. The goal is to identi…

This study will compare 80 adults aged 40 and older—half living with HIV and half healthy—to see if those with HIV experience frailty, muscle loss, and cognitive decline earlier. Researchers will assess physical function, nutrition, and thinking skills. The goal is to understand …

This study will enroll 1,260 pregnant women in Botswana, Kenya, and Zimbabwe to test a package of support that includes problem-solving sessions, infant feeding advice, and play groups. The goal is to see if these interventions improve child development and growth by age 2. Resea…

This study tests a 12-week group program for HIV-negative Latino men who have sex with men and use methamphetamine. The program aims to help them cope with stigma, build resilience, and reduce meth use while also improving their interest in and use of PrEP, a medication that prev…

This study will follow 5,160 pregnant women in France who have HIV, hepatitis B, hepatitis C, or an arbovirus infection (like Zika or dengue), along with their children, for up to 7 years. Researchers want to learn how these viruses and their treatments affect pregnancy, the moth…

This study tests whether a multi-day training program can reduce stigma that doctors in Vietnam show toward people with HIV and men who have sex with men. Researchers will send trained actors ("standardized patients") to clinics to pose as real patients and measure how doctors tr…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will survey 128 adults in Louisville, Kentucky who are already taking or starting a long-acting injectable HIV PrEP shot. Participants will answer questionnaires about their satisfaction and adherence to either lenacapavir or cabotegravir over 12 months. The goal is to…

This study will test whether an artificial intelligence chatbot can encourage men who have sex with men in Kuala Lumpur, Malaysia to get tested for HIV. 80 participants will be randomly assigned to receive either automated chatbot messages with HIV testing information or standard…

This study will compare frailty and other age-related health problems in 600 older adults (60+) in Burkina Faso, Côte d'Ivoire, and Togo — half living with HIV, half without. Researchers will use surveys, medical checks, and interviews to understand how HIV affects aging and what…

This study looks at whether a rapid fingerstick test that gives results in 10-20 minutes can help more people get screened for HIV, hepatitis C, and syphilis during mobile clinic visits. About 200 patients of the WVU Street Medicine team can choose the rapid test, a traditional b…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study explores whether a text-message education program and a mail-in HPV self-sampling kit can help women living with HIV who are overdue for cervical cancer screening get tested. Researchers will enroll 130 women and healthcare providers to see if the approach is practical…

This pilot study will test whether an 8-session telehealth program can help people who inject drugs in the rural South build coping skills and resilience. The goal is to improve access to HIV prevention (PrEP), hepatitis C treatment, and medication for opioid use disorder. The st…

This study will test a new way to screen and treat cervical cancer in women with HIV in Mozambique. About 8,445 women aged 25-49 who are already receiving HIV care will be offered HPV testing and same-day treatment if needed. The goal is to see if this approach can screen more wo…

This study is testing a new program to help men living with HIV in Uganda feel more comfortable telling their sexual partners about their HIV status. The program includes education, counseling, and practice conversations. Researchers want to see if it helps more men share their s…

This study looks at whether making it easier for teens to have private, confidential talks with their doctor can increase HIV testing. Researchers will work with 4 pediatric clinics to see if this approach is practical and well-liked by staff. The goal is to learn how to make HIV…

This study tests a questionnaire called POSITIVE OUTCOMES to help doctors focus on what matters to people living with HIV, like mental health and social concerns. About 17,000 adults from five clinics in the UK and US will try it out. The goal is to see if using this tool improve…

This study tests whether a one-hour online training video can reduce unconscious racial bias among pharmacy interns who prescribe HIV prevention medication (PrEP). Researchers will recruit 70 pharmacy interns in Boston to watch the video and then measure changes in bias using a s…

This study tests a software tool called smART that helps doctors pick the best combination of HIV drugs for each patient. The tool considers drug resistance, other health conditions, and medication safety. Researchers will compare treatment choices made with and without the tool …

This pilot study will enroll 65 people living with HIV to see if two simple body shape calculations (the Body Roundness Index and A Body Shape Index) can accurately estimate how much body fat and visceral fat a person has. Participants will have their waist, height, and weight me…

This study looks at whether inflammation from HIV affects thinking skills in teens aged 13-19 in Eswatini. Researchers will compare 50 HIV-positive teens on antiretroviral therapy with 30 HIV-negative teens. They will test memory, attention, and processing speed, and measure infl…