HIV cure hope: three old drugs aim to flush out and destroy hidden virus
NCT ID NCT07384624
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tests whether a combination of three existing drugs (topiramate, lenalidomide, and pyrimethamine) can wake up dormant HIV hiding in the body and then help the immune system eliminate those infected cells. The goal is a 'functional cure' where the virus is controlled without lifelong medication, but participants will remain on antiretroviral therapy during the study. 30 adults with well-controlled HIV will participate across four medical centers in the Netherlands.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Amsterdam University Medical Center
Amsterdam, Netherlands
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Erasmus MC
Rotterdam, Netherlands
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Radboud University Medical Center
Nijmegen, Netherlands
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University Medical Center Utrecht
Utrecht, Netherlands
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