Stomach disorder

Researchers are testing a new CAR-T cell therapy called KD-496 in people with advanced solid tumors, including gastric and pancreatic cancer, that have not responded to at least two prior treatments. The therapy uses a patient's own T cells, which are genetically modified to reco…

Researchers are testing a new CAR-T cell therapy called C402-CD19-CAR in adults with large B-cell lymphoma that has come back or stopped responding to treatment. The therapy is made from each participant's own T cells, which are modified to target CD19, a marker on lymphoma cells…

This phase II trial is testing whether the immunotherapy drug dostarlimab can eliminate the need for surgery in people with a specific type of stomach or gastroesophageal junction cancer that has a genetic marker called dMMR/MSI-H. Participants receive dostarlimab infusions, and …

This early-phase study tests a personalized mRNA cancer vaccine (XH001) given alongside standard treatment after surgery for people with high-risk solid tumors (bile duct, gallbladder, pancreatic, liver, or stomach cancer). The main goals are to check safety and see if the vaccin…

This early-stage trial tests an experimental oral drug called SHY-ONC6 in people with advanced or metastatic solid tumors (including breast, colon, lung, pancreatic, and others) that have stopped responding to standard treatments. The study aims to find a safe dose and check for …

This study tests a new drug called AU-007 in people with advanced solid tumors that have spread or cannot be removed by surgery. The drug is designed to help the immune system fight cancer. About 159 participants will receive AU-007 alone or with other medicines to find the safes…

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This early-stage study is testing a new drug called BGB-B2033, alone or with other drugs, in people with advanced liver, stomach, or lung cancers. The goal is to see if it is safe and how well it works. About 392 participants will take part.

This study tests an experimental oral drug called zongertinib, which blocks HER2, a protein that fuels cancer growth. It is given alone or with other cancer drugs to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and not responded to prior treatm…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This clinical trial is testing a new biological therapy called GAIA-102, alone or combined with the immunotherapy pembrolizumab, for people with advanced stomach or pancreatic cancer that has spread and caused fluid buildup in the abdomen (malignant ascites). The study has two pa…

Researchers are comparing a new combination of disitamab vedotin, sintilimab, and S-1 against the standard regimen of trastuzumab plus chemotherapy, with or without sintilimab, for people with advanced HER2-positive gastric or gastroesophageal junction cancer. The trial enrolls a…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This phase 3 trial tests whether adding the targeted drug zolbetuximab to standard immunotherapy (pembrolizumab) and chemotherapy can help people with advanced stomach or gastroesophageal junction (GEJ) cancer live longer. The study enrolls 500 adults whose tumors have specific m…

Researchers are testing whether adding an experimental drug called 2141-V11 to standard immunotherapy is safe for people with advanced esophageal, gastric, or gastroesophageal junction adenocarcinoma. Participants receive injections of 2141-V11 directly into their tumors along wi…

Researchers are testing whether a combination of two drugs, atezolizumab and bevacizumab, can clear tiny amounts of cancer DNA from the blood of people whose gastrointestinal cancer was treated with curative intent. The trial enrolls 20 adults with colon, rectal, gastric, pancrea…

This study tests a new surgery for early gastric cancer that uses two scopes (a laparoscope and an endoscope) to guide the removal of sentinel lymph nodes. The goal is to see if this approach is safe and effective. The study involves 36 people with early-stage stomach cancer.

This phase 3 trial compares a subcutaneous (under-the-skin) injection of tislelizumab to the standard intravenous (IV) infusion, both given with chemotherapy, as a first treatment for advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has sp…

This Phase 3 trial is testing whether a new drug called rilvegostomig, combined with trastuzumab deruxtecan and chemotherapy, works better than the current standard treatment for HER2-positive stomach cancer that has spread. About 840 people whose tumors have a specific protein (…

This early-phase trial tests a new drug called ASP2138, which helps the immune system attack cancer cells that have a specific marker (CLDN18.2). It is for people with advanced stomach, gastroesophageal junction (GEJ), or pancreatic cancer that cannot be removed by surgery or has…

This phase 3 trial tests whether adding the experimental drug ASP2138 to standard chemotherapy and immunotherapy (pembrolizumab) helps people with a specific type of advanced stomach or gastroesophageal junction cancer live longer without their disease worsening. The study enroll…

This clinical trial is testing whether adding the immunotherapy drug nivolumab to standard chemotherapy (paclitaxel and ramucirumab) can help people with advanced stomach or esophageal cancer live longer. The study includes 224 adults whose cancer has a specific marker (PD-L1 CPS…

This early-stage trial tests the safety of a new drug called KK2269, given alone or with chemotherapy (docetaxel), in adults with advanced solid tumors that have no standard treatment options. About 101 participants will take part. The study has two parts: first testing KK2269 al…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This clinical trial is looking at the best timing for local treatments like surgery or radiation in people with esophageal or stomach cancer that has spread to only a few spots. All participants first get 4 months of standard drug therapy. Then, depending on their response, they …

Researchers are testing two investigational radiopharmaceuticals in adults with advanced solid tumors, including colorectal, pancreatic, biliary tract, gastric, esophageal, and head and neck cancers. First, participants receive SKL35502, an imaging agent that highlights tumors ca…

This early-stage trial tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. M7437 is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells that have a specific marker (Ly6E). The study ai…

This study tests a new drug called TAK-505 in adults with advanced solid tumors that cannot be removed by surgery. The main goals are to check safety, find the best dose, and see if the drug can shrink or slow cancer growth. About 151 people with certain cancers, such as stomach,…

This Phase 3 trial is testing whether a new targeted drug called sonesitatug vedotin, combined with chemotherapy (capecitabine) and possibly an immunotherapy (rilvegostomig), can help people with advanced stomach, gastroesophageal junction, or esophageal cancer that has a specifi…

This early-stage trial tests a new drug called IAM1363 in adults with advanced cancers that have HER2 alterations, including breast, lung, and stomach cancers that have spread to the brain. The study aims to find the safest dose and see if the drug can shrink tumors. About 383 pa…

This early-phase trial is testing a new experimental drug, BNT317, in 39 people with advanced solid tumors who have run out of standard treatment options. The main goal is to check the drug's safety, find the right dose, and see how the body handles it. It is too soon to know if …

This phase 2 trial tests whether a series of procedures to remove cancerous tumors, given one after another, can improve outcomes for people with stage IV foregut cancers (like stomach, pancreas, or bile duct cancer) who have no detectable cancer DNA in their blood after initial …

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This trial tests whether neuromodulators, including antidepressants, can ease esophageal symptoms like heartburn and chest pain in people with gut-brain interaction disorders. Many patients do not respond to standard acid-reducing drugs, and this study aims to see if these medica…

This phase 2 trial tests whether apatinib, taken as a daily pill, can control advanced stomach or gastroesophageal junction cancer in people aged 65 and older who cannot or will not undergo chemotherapy. Participants receive apatinib until the disease worsens or side effects beco…

This study compares two drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that hasn't been treated yet. One group gets pumitamig plus chemotherapy, the other gets nivolumab plus chemotherapy. The goal is to see which combo works b…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This early-stage study tests a combination of two drugs—trastuzumab deruxtecan and azenosertib—in people with HER2-positive stomach, gastroesophageal junction, or other solid tumors that have spread or can't be removed by surgery. The goal is to find the safest dose and check for…

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a stand…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This study tests whether a stronger chemotherapy mix (mFOLFIRINOX) works better than the standard mix (FOLFOX) for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. Some participants also receive the immunotherapy dru…

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-s…

This early-phase study tests a new drug, ASP2998, that targets a protein called TROP2 found on many solid tumors. The drug is given alone or with standard treatments like pembrolizumab or carboplatin. The main goals are to check safety and find the right dose. About 428 adults wi…

This study tests a new drug called PYX-201 combined with pembrolizumab in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the combination can shrink tumors. About 220 adults with certain cancers like head an…

This study tests new experimental drugs combined with standard chemotherapy and immunotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery or has spread. About 160 participants will receive the combination to …

This trial tests a new way to treat Helicobacter pylori, a common stomach bacteria linked to ulcers and cancer. Researchers compare a staged regimen that gradually increases the amoxicillin dose against a standard 14-day dual therapy. The study enrolls adults with chronic gastrit…

This Phase 2 trial tests whether adding an extra drug (either SHR2554 or apatinib) to standard immunotherapy plus chemotherapy can help people with advanced gastric cancer who don't get enough benefit from current treatments. About 78 adults with stage III or IV stomach cancer wi…

This trial tests whether adding thread-embedding acupuncture to the standard acid-reducing drug omeprazole improves symptoms in adults with gastroesophageal reflux disease (GERD). Participants receive either omeprazole alone or omeprazole plus acupuncture, with tiny threads place…

This study looks at whether robotic-assisted surgery using a vessel sealer can improve outcomes for people with locally advanced stomach cancer. The vessel sealer is a tool that cuts and seals blood vessels with less heat damage than older devices. Researchers will track 300 pati…

This phase II trial tests whether adding paclitaxel directly into the abdomen, alongside standard systemic chemotherapy, is feasible for people with gastrointestinal cancers that have spread to the peritoneal lining. The study includes patients with gastric, colorectal, appendice…

This study follows 90 adults with upper stomach or gastroesophageal junction cancer who undergo proximal gastrectomy, a surgery that removes the upper part of the stomach. Researchers compare different ways to reconnect the digestive tract, such as double-tract reconstruction or …

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can keep the cancer from growing for at least 6 mo…

This early-phase study is testing an experimental drug called JNJ-89402638 in people with metastatic colorectal or gastric cancer that has progressed after at least two prior treatments. The trial will first find the safest dose and schedule, then test the drug alone or combined …

This early-phase study tests a new drug called BL-B01D1 in people with advanced stomach or other solid tumors that have not responded to standard treatments. The main goals are to find a safe dose and check for any side effects. About 96 adults aged 18 to 75 will take part, and r…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another d…

This early-stage trial is testing a new treatment called DISP-10 for people with advanced gastrointestinal cancers, including colorectal and stomach cancers. The treatment combines a virus (DV-10) with specially engineered immune cells (CAR T cells) to attack cancer. The study ai…

This early-phase trial is testing a new drug called DB-1303/BNT323 in people with advanced HER2-positive solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see if the drug can shrink tumors. About 800 participants will take part ac…

This study tests a new drug called BNT329 in people with advanced solid tumors that have a specific marker (CA19-9). The main goals are to check safety and find the best dose. About 245 participants will take part. The drug works by targeting cancer cells and may help control tum…

This early-stage trial is testing a new type of radiation therapy that seeks out and attacks cancer cells while sparing healthy tissue. It's for people with advanced breast, lung, stomach, or bladder cancer who have run out of standard options. The study will check if the treatme…

This study monitors 377 South Korean patients with advanced stomach or gastroesophageal junction cancer who receive VYLOY (zolbetuximab) as part of their normal treatment. Researchers will track side effects and how long the cancer stays stable. The goal is to confirm the drug's …

This trial is testing whether adding the targeted antibody trastuzumab to standard chemotherapy after surgery can help prevent early-stage (IB-II) HER2-positive gastric cancer from coming back. About 120 adults who have had their tumor removed will be randomly assigned to receive…

This early-phase trial tests a technique called PIPAC, which turns liquid chemotherapy into a fine mist sprayed directly into the abdomen during a minimally invasive surgery. It aims to see if this approach is safe and causes fewer side effects than standard chemotherapy. The stu…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This early-stage trial is testing a new type of immune cell therapy for people with advanced cancers that have a specific protein called KK-LC-1. The cancers being studied include stomach, breast, cervical, and lung cancer. Participants will receive chemotherapy followed by a sin…

This study tests a new therapy where a person's own white blood cells are collected, genetically modified in a lab to recognize and attack cancer cells with a specific mutation (KRAS G12V), and then infused back. Participants also receive chemotherapy and a drug to boost cell act…

This study is testing a drug called tislelizumab combined with chemotherapy as a first treatment for people with advanced stomach or esophageal cancer that cannot be removed by surgery or has spread. It focuses on racial and ethnic minority groups in the US, including Black, Hisp…

This Phase 1 trial tests two experimental mRNA immunotherapies, mRNA-4106 and mRNA-4200, in about 42 people with advanced solid tumors. Unlike personalized cancer vaccines made from a patient's own tumor mutations, these are off-the-shelf therapies designed to target shared antig…

This study tests a new surgical approach for early gastric cancer that uses a fluorescent dye to help surgeons see and remove only the cancerous lymph nodes, sparing healthy tissue. About 312 patients will be randomly assigned to either this new technique or standard surgery. The…

This Phase 2 trial is testing a new drug called denikitug, alone or combined with other cancer drugs, in 120 people with advanced HER2-negative stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. The main goal is to see if the drug …

This early-stage study tests a new drug (177Lu-DOTA-SNA040) that delivers radiation directly to cancer cells with a specific marker (Claudin 18.2). It is for people with advanced stomach, pancreatic, or bile duct cancers that have worsened after standard treatment. The main goals…

This study looks at whether supervised exercise can improve recovery in people who have had surgery for esophageal or gastric cancer. About 171 participants will be assigned to high-intensity interval training, low-intensity continuous training, or usual care for 8 weeks. The goa…

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study tests whether giving the chemotherapy drug paclitaxel directly into the abdominal cavity, along with standard intravenous chemo, can help people with stomach cancer that has spread to the lining of the abdomen. About 148 adults with this condition will be randomly assi…

This trial is testing whether combining an experimental drug called IBI343 with an immunotherapy (sintilimab) and standard chemotherapy can help people with a specific type of advanced stomach or gastroesophageal junction cancer. The study focuses on patients whose tumors have a …

This trial is testing whether adding an immunotherapy drug called adebrelimab to a two-drug combination of apatinib and albumin-bound paclitaxel can help people with advanced stomach or gastroesophageal junction cancer. The study enrolls adults whose cancer has progressed after f…

This observational study is tracking 260 adults in China with HER2-positive gastric or gastroesophageal junction cancer that is locally advanced or has spread. Participants are receiving trastuzumab deruxtecan (T-DXd) as part of their routine care, and researchers are collecting …

This study looks at how well a special mesh called OviTex works for fixing hiatal hernias. About 173 adults having robotic or laparoscopic hernia repair will be followed for 24 months to see if the hernia returns or if there are complications. The goal is to improve long-term out…

This study tests whether taking oral sorbitol, a common sugar alcohol, can enhance the effects of standard chemotherapy and an immunotherapy drug (tirellizumab) in people with locally advanced stomach cancer. Eighty participants will receive either sorbitol or a placebo alongside…

This study tests whether taking oral paclitaxel plus fruquintinib can help people with advanced stomach or gastroesophageal junction cancer after their first treatment stops working. About 150 adults will receive either the new drug combo or standard chemotherapy chosen by their …

This study tests whether adding a second immunotherapy drug (ipilimumab) to the standard combination of sintilimab and chemotherapy helps shrink stomach tumors before surgery and keeps cancer from coming back afterward. About 720 adults with resectable stomach or gastroesophageal…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This trial compares two surgical bypass procedures for people with advanced stomach cancer that blocks the passage of food. The standard approach connects the stomach directly to the small intestine, while the experimental approach adds a partial partition of the stomach to reduc…

This study tests an experimental drug called SG1906 in people with advanced solid tumors that have a specific protein (CLDN18.2) on their surface. The trial has two parts: first, finding the safest dose, and then checking for early signs that the drug can shrink tumors. About 60 …

This trial asks a key question: for people with advanced metastatic stomach cancer whose tumors shrink significantly after initial medical therapy (called conversion therapy), does adding radical surgery improve their chances of living longer without the disease progressing? The …

This trial tests three different ways to reconnect the digestive tract after stomach cancer surgery to see which one best controls blood sugar in people who also have type 2 diabetes. Participants will be randomly assigned to one of three surgical procedures. The main goal is to …

This trial compares two weight-loss surgeries in people with severe obesity (BMI 50-60). One is the standard Roux-en-Y gastric bypass, the other a newer sleeve gastrectomy with duodenojejunal bypass. The goal is to see which procedure leads to healthier hormone responses after me…

This trial is testing an investigational drug called ARV-6723, given as a pill, in people with advanced solid tumors. The drug is designed to help the immune system recognize and attack cancer cells. The study will test ARV-6723 alone and in combination with pembrolizumab, an imm…

This trial tests whether Weifuchun tablets can reverse gastric intestinal metaplasia, a condition where stomach lining cells change and may raise cancer risk. Adults without H. pylori infection will take Weifuchun or folic acid daily for six months, with regular checkups. The stu…

This trial tests whether giving a proton pump inhibitor (PPI) to children with laryngomalacia—a common birth defect of the voice box—can reduce the chance of food or liquid entering the airway (aspiration). Children aged 6 months to 5 years with recurrent choking or aspiration sy…

This early-stage trial is testing an experimental immunotherapy called AB122, given alone or combined with other investigational drugs, in people with advanced solid tumors such as pancreatic, colorectal, lung, and stomach cancers. The goal is to find out which combinations are s…

This trial investigates whether adding the immunotherapy drug serplulimab (HLX10) to standard chemotherapy (S-1 and oxaliplatin) before and after surgery can improve outcomes for people with locally advanced, PD-L1-positive stomach or gastroesophageal junction cancer. Participant…

This study is tracking 245 hernia patients who receive the GORE ENFORM biomaterial mesh during surgery. The mesh is absorbable and used to reinforce the repair. Researchers will monitor hernia recurrence, infections, and other complications for up to two years. The goal is to see…

This study tests a new drug called ATG-022 combined with the immunotherapy pembrolizumab (Keytruda), with or without chemotherapy, in people with advanced stomach or gastroesophageal junction cancer that has a specific marker (CLDN18.2) and is HER2-negative. The trial aims to fin…

This trial is testing an experimental drug called petosemtamab (MCLA-158) in people with advanced solid tumors, including colorectal, head and neck, and lung cancers. The drug is a bispecific antibody designed to block two cancer-related proteins, EGFR and LGR5. Researchers want …

This Phase 2 trial is testing two experimental drugs (SSGJ-705 and SSGJ-612) with or without chemotherapy in 150 adults with advanced HER2-positive solid tumors, including colorectal, bladder, breast, bile duct, and stomach cancers. The goal is to see if the combination can shrin…

This study tests a combination of fruquintinib (a drug that blocks blood vessel growth to tumors) and chemotherapy (albumin-paclitaxel), with or without a PD-1 antibody, for people with advanced stomach or gastroesophageal junction cancer whose first PD-1 treatment stopped workin…

This trial tests whether a procedure called underwater endoscopic mucosal resection (UEMR) can safely and completely remove small type I gastric neuroendocrine tumors (5-9 mm). Instead of traditional surgery, doctors fill the stomach with saline and use a snare to cut out the gro…

This trial tests a new minimally invasive procedure called TRANSOM for people with a leaky mitral valve, a condition where the valve doesn't close properly. Instead of opening the chest, surgeons make a small incision between the ribs and insert a tube directly into the beating h…

This treatment program tests a personalized cell therapy for people with advanced pancreatic or colorectal cancers that have a specific genetic mutation (KRAS G12D). Patients' own immune cells are collected, genetically engineered to recognize and attack the cancer, and then infu…

This trial compares two common laparoscopic surgeries—Nissen fundoplication (full wrap) and Toupet fundoplication (partial wrap)—for treating hiatal hernia with acid reflux. About 200 adults aged 18 to 90 will be randomly assigned to one procedure. Researchers will measure pain, …

This phase 2 trial tests an experimental drug called SAR445877 in adults with advanced gastric or gastroesophageal junction cancer that has worsened after at least one prior treatment. The study includes about 30 participants and looks at whether the drug can shrink tumors. It is…

This pilot trial tests whether feeding directly into the small intestine (transpyloric) is better than feeding into the stomach (gastric) for very preterm infants with bronchopulmonary dysplasia, a chronic lung condition. The study will measure how often babies have low oxygen le…

This study compares two types of laparoscopic surgery (Nissen vs. Hill-Snow fundoplication) for children with severe acid reflux. The goal is to see which technique better preserves normal stomach emptying and reduces post-surgery problems like bloating or trouble swallowing. The…

This study tests a modified version of sleeve gastrectomy, a common weight-loss surgery, to see if it can reduce or prevent acid reflux (GERD) that often occurs after the standard procedure. About 44 adults with obesity and GERD will be randomly assigned to receive either the sta…

This expanded access program offers avexitide to people with post-bariatric hypoglycemia (dangerously low blood sugar) after Roux-en-Y gastric bypass. Eligible patients include those who completed the LUCIDITY trial or other avexitide studies. Participants receive a daily injecti…

This phase II trial tests a modified combination of three chemotherapy drugs—docetaxel, oxaliplatin, and fluorouracil—in people with advanced stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen (peritoneal carcinomatosis) and caused a bowel bl…

This study tests whether a device worn around the neck during sleep can reduce reflux in people who have received a lung transplant. Reflux can damage the new lungs, so researchers are measuring levels of stomach enzymes in lung fluid to see if the device helps. The trial involve…

This phase 3 trial tests whether tegoprazan, a stomach acid blocker, can prevent gastrointestinal complications like bleeding and ulcers in people who have had an ischemic stroke and are taking antiplatelet drugs (blood thinners). About 1,500 adults in South Korea will receive ei…

This trial tests a new approach for people with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery. It combines standard chemotherapy (CAPOX) and radiation with an experimental drug called SHR-1701, which targets two proteins (PD-L1 and TGF-β) …

This phase 3 trial tests whether giving chemotherapy directly into the abdomen (intraperitoneal paclitaxel) along with standard systemic therapy improves survival compared to systemic therapy alone in stomach cancer patients whose cancer has spread to the lining of the abdomen. A…

This study tests a new device (Intrepid TMVR) to replace the mitral valve in people with severe mitral regurgitation (leaky heart valve) who are not candidates for standard surgery or repair. About 400 participants will receive the device and be followed for safety and effectiven…

This trial investigates whether adding a Braun anastomosis—a connection between two loops of the small intestine—during pancreatic cancer surgery can lower the risk of delayed gastric emptying, a frequent complication where the stomach takes too long to empty. About 264 adults sc…

This study looks at a second surgery for people who had gastric bypass but still suffer from severe acid reflux that medication can't control. The procedure wraps part of the stomach to stop reflux. Researchers will follow 17 adults for up to 2 years to see if the surgery works a…

This study investigates the safety and symptom-relieving effects of the drug Tegoprazan (K-CAB) in adults with gastroesophageal reflux disease (GERD). Researchers will track how well the drug reduces heartburn and acid reflux after 4 weeks of use. The study includes over 5,000 pa…

This Phase II trial is testing a combination of three drugs—zanidatamab, pembrolizumab, and chemotherapy—in 80 people with advanced stomach or esophageal cancer that has spread and tests positive for HER2 and PD-L1. The goal is to see if this triple therapy can keep the cancer fr…

This Phase 3 trial tests a new drug called JS107 combined with toripalimab and chemotherapy against a standard treatment for advanced stomach cancer that has a specific marker (CLDN18.2). The study plans to enroll 600 people whose cancer has spread and cannot be removed by surger…

This study tests whether feeding preterm infants with chronic lung disease through a tube placed past the stomach (into the small intestine) helps their breathing more than feeding through a tube in the stomach. About 50 high-risk preterm babies born before 32 weeks will receive …

This study tests a combination of chemotherapy and focused radiation in children newly diagnosed with a rare brain tumor called ETMR. About 70 children will receive standard treatments to see if this approach helps keep the tumor from growing for at least 6 months. The goal is to…

This phase 2 trial is testing whether adding common diabetes drugs (metformin or rosiglitazone) to standard immunotherapy (nivolumab or pembrolizumab) can improve treatment for several advanced solid tumors, including melanoma, lung cancer, and liver cancer. About 72 participants…

This study tests a new way to treat marginal ulcers that can form after gastric bypass surgery. Instead of just taking standard acid-reducing medication, some participants will also receive a low-thermal argon plasma treatment during an endoscopy. The goal is to see if this plasm…

This phase 2 trial tests whether adding an experimental biologic called TRK-950 to the standard combination of ramucirumab and paclitaxel helps people with advanced stomach or gastroesophageal junction cancer. Participants receive either the standard two-drug regimen or the stand…

This study compares three approaches for treating GERD in NICU infants: letting the condition improve naturally, using the drug omeprazole, or using a special added rice formula. Researchers will track 369 babies to see which treatment leads to better feeding and fewer symptoms l…

This Phase 3 trial tests whether a combination of two immunotherapy drugs (botensilimab and balstilimab) can help people with advanced stomach cancer live longer compared to standard treatment. The study includes 132 adults whose tumors have a specific genetic marker (MSI-H/dMMR)…

This trial tests whether a new robotic system that uses only one small incision (single port) can safely perform common abdominal surgeries in children. The study includes children aged 1 to 17 who need procedures like pyeloplasty or reflux treatment. The goal is to see if the si…

This phase 2 trial tests whether delivering FOLFOX chemotherapy directly into the arteries feeding the tumor can help control advanced stomach or gastroesophageal junction cancer. The study includes 31 adults who cannot have surgery due to frailty or other health issues. The main…

This study tests whether a smartphone app called GERDCare can help people with GERD (acid reflux) take their medication and follow lifestyle advice more consistently. About 380 adults with typical reflux symptoms will use the app for four weeks, and researchers will measure how w…

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive…

This early-phase study tests an experimental drug called OKN4395, taken as a pill, alone or together with the immunotherapy pembrolizumab. The goal is to find a safe dose and see if the combination can shrink tumors in people with advanced solid cancers like lung, colorectal, sto…

This phase 3 trial tests whether giving chemotherapy directly into the artery (instead of through a vein) along with immunotherapy can better shrink locally advanced stomach cancer before surgery. About 190 participants will receive either the standard chemo regimen or the arteri…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This early-phase study tests a new drug called CT-95 in people with advanced cancers that have a protein called mesothelin on their cells. The main goals are to find a safe dose and see if the drug can shrink tumors. About 70 adults with ovarian, lung, pancreatic, or other mesoth…

This early-stage trial is testing a new drug called THE-0504 in 30 adults with advanced solid tumors, including lung, colon, stomach, breast, and pancreatic cancers. The main goal is to see if the drug is safe and to find the best dose. Researchers will also watch for any signs t…

This early-stage trial is testing an experimental oral drug called EXS74539 (REC-4539) in about 40 people with various solid tumors, including lung, prostate, ovarian, and breast cancers. The main goal is to check the drug's safety, find the right dose, and see how the body proce…

This study tests a new device called ECLIPSIUM that uses a dissolvable material to hold mesh in place during hernia surgery. The goal is to see if it reduces the chance of the hernia coming back compared to current methods. About 240 adults with small to medium-sized hernias will…

This study tests whether adding the supplement taurine to a standard treatment (immunotherapy drug serplulimab plus chemotherapy) can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. About 96 adults whose tumors have a specific marker…

This study tests a new drug called IAH0968, given alone or with chemotherapy (CAPEOX), in people with advanced HER2-positive stomach cancer or other solid tumors. The goal is to see if the combination is safe and helps slow cancer growth better than standard treatment. About 574 …

This study tests whether adding the drug cadonilimab to standard chemotherapy (FLOT) helps people with a certain type of stomach or gastroesophageal junction cancer that can be removed with surgery. About 37 adults will receive the combination before and after surgery. The goal i…

This early-phase trial tests a new drug called AVA6103 in 174 people with advanced solid tumors (like pancreatic, stomach, or lung cancer) that have not responded to standard treatments. The drug is designed to activate only inside tumors, potentially killing cancer cells while r…

This study tests a new treatment for stomach cancer that has spread to the lining of the belly (peritoneal metastases). About 55 patients will receive chemotherapy directly into the abdomen along with standard intravenous chemotherapy, and possibly immunotherapy or targeted thera…

This study is testing a new way to give radiation therapy (called PULSAR) along with standard chemotherapy and immunotherapy for people with advanced stomach cancer that cannot be removed with surgery. The radiation is given in high doses every few weeks, tailored to each patient…

This early-phase trial tests a new cell therapy called UCLH80-1 in 36 people with advanced solid tumors (colorectal, gastric, pancreatic, and bile duct cancers) that have not responded to standard treatments. The therapy uses specially engineered immune cells to target a protein …

This early-phase trial is testing a new type of cell therapy called p95HER2.CAR-TECH2Me for people with advanced HER2-positive breast, gastric, or endometrial cancers that have spread. The treatment uses a patient's own immune cells, which are modified in a lab to better recogniz…

This study is testing whether giving a protein-enriched intravenous nutrition formula helps patients recover better after surgery for stomach cancer. About 110 adults having stomach cancer surgery will be randomly assigned to receive either the protein-enriched nutrition or stand…

This study looks at the best way to treat a rare and aggressive stomach cancer called signet ring cell adenocarcinoma. It compares two strategies: starting with surgery or starting with chemotherapy before surgery. About 314 patients will take part to see which approach helps peo…

This phase 2 trial is testing whether a combination of immunotherapy drugs (sintilimab, IBI310, and lenvatinib) can help people with non-metastatic dMMR/MSI-H stomach or colon cancers avoid radical surgery. About 34 participants will receive up to 24 weeks of treatment, and those…

This Phase 3 trial tests a new drug, SHR-A1904, in 524 people with advanced stomach or gastroesophageal junction cancer that has a specific protein (CLDN18.2). Participants receive either SHR-A1904 or standard chemotherapy. The main goal is to see if the new drug helps people liv…

This early-phase trial tests a new drug, UCB4594, in people with advanced solid tumors that haven't responded to standard treatments. The drug is a monoclonal antibody that targets a protein called HLA-G on cancer cells, potentially helping the immune system attack them. The stud…

This early-stage study is testing an experimental drug called MK-6204 in about 90 adults with advanced solid tumors (such as colorectal, lung, or stomach cancer) that have not responded to standard therapies. The main goals are to check the drug's safety and find the right dose. …

This phase 2 trial is testing whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab, together called QL1706) plus standard chemotherapy can help people with advanced HER2-negative stomach cancer that has low PD-L1 levels. The study will enroll 77 particip…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study tests whether adding a targeted drug (LM-302) to standard immunotherapy and chemotherapy before surgery can improve outcomes for people with a specific type of stomach cancer that has a protein called claudin 18.2. About 88 adults with advanced but removable stomach ca…

This study tests a new method called PIPAC, which sprays chemotherapy directly into the abdomen as a fine mist. It is for people with stomach, pancreas, or colorectal cancer that has spread to the lining of the abdomen. The goal is to see if this approach can control the cancer a…

This study tests a procedure called TIF (transoral incisionless fundoplication) for people with chronic acid reflux (GERD) who don't get relief from medication. It is done through the mouth, no cuts, and aims to rebuild the valve between the stomach and esophagus. The study will …

This Phase 2 trial tests whether adding an immunotherapy drug (QL1706) to standard chemotherapy before and after surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. About 96 participants will be randomly assigned to receive e…

This study tests a new approach for people with locally advanced stomach or gastroesophageal junction cancer. Before surgery, patients receive low-dose radiation, an immunotherapy drug (tirelizumab), and chemotherapy (SOX). The goal is to see if this combination can completely el…

This study tests whether a newer acid-reducing drug, Vonaprazan, heals acid reflux better than the standard drug Esomeprazole in people who had POEM surgery for achalasia. About 300 adults with moderate to severe esophagitis will take one of the two drugs for 8 weeks. The goal is…

This study compares two types of stomach surgery (partial vs. total removal) for people with advanced upper gastric cancer who have already received chemotherapy combined with an immunotherapy drug. The goal is to see which surgery leads to better long-term outcomes, such as prev…

This study tests a combination of drugs (LM-302, S-1, and intraperitoneal paclitaxel) with or without another drug (cadonilimab) in people with a specific type of advanced stomach cancer (Claudin 18.2-positive) that has spread to the lining of the abdomen. The goal is to see if t…

This Phase 2 trial tests whether adding the immunotherapy drug ivonescimab to standard chemotherapy can improve tumor shrinkage in people with advanced or metastatic stomach or gastroesophageal cancer. About 88 participants will receive treatment every two weeks. The main goal is…

This study tests a new treatment using specially designed immune cells (CAR-NK cells) that target two proteins found on stomach cancer cells. The therapy is given to adults with advanced stomach or gastroesophageal junction cancer that has not responded to standard treatments. Th…

This phase 2 study tests a new approach for people with advanced stomach, esophageal, or gastroesophageal junction cancer that is either PD-L1-negative or has stopped responding to immunotherapy. Participants receive injections of a cancer-killing virus (OBP-301) directly into th…

This study tests whether a 3-day low-leucine diet can make chemotherapy and immunotherapy work better for people with advanced stomach cancer. Researchers believe the diet may activate immune cells in the tumor. The trial involves 73 participants and will measure tumor shrinkage …

This study tests whether a short-term diet low in leucine (an amino acid) can make standard chemo-immunotherapy work better for stomach cancer patients. About 108 people will follow the diet for 3 days during each treatment cycle. Researchers will check if this approach improves …

This study tests a two-step treatment for people with advanced liver cancer (hepatocellular carcinoma) or metastatic stomach cancer that has worsened despite prior immunotherapy. First, doctors deliver a drug called tirapazamine directly into the liver tumor through a procedure c…

This early-phase trial is testing a new approach to CAR-T cell therapy for adults with advanced solid tumors that have not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to recognize two cancer-specific targets chosen based on each per…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This study tests whether inflating a small balloon in the pylorus (the valve between stomach and small intestine) during minimally invasive esophageal cancer surgery can prevent delayed stomach emptying, a common complication. About 116 patients will be randomly assigned to recei…

This study looks at whether people aged 60 or younger who had a stroke caused by a hole in the heart (PFO) can safely stop taking blood thinners one year after the hole is closed. The goal is to see if stopping these drugs reduces the risk of bleeding without increasing the chanc…

This early-stage trial is testing a new type of immune cell therapy called armored dendritic cells in 8 people with solid cancers like pancreatic or colorectal cancer. Participants have already had surgery and at least 4 rounds of chemotherapy. The goal is to see if the treatment…

This study tests two different laser wavelengths (1470 nm and 1940 nm) for a procedure called laser crossectomy to treat varicose veins. The goal is to see which wavelength better prevents vein reflux from returning at the groin junction, while also checking for pain and side eff…

This study tests a new endoscopic procedure called anti-reflux mucosal ablation (ARAT) for people with chronic GERD. The procedure uses argon plasma coagulation to treat the lining of the stomach near the esophagus. 36 participants will be randomly assigned to receive either the …

This study tests whether a continuous glucose monitor (CGM) can better detect low blood sugar episodes in people who had gastric bypass surgery and now have late dumping syndrome. Sixty participants will either use the iCan i3 CGM or standard fingerstick tests for 60 days. The go…

This study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…

This study is testing a drug called zolbetuximab combined with standard chemotherapy in people with a specific type of advanced stomach cancer that has spread. The cancer must have a protein called claudin 18.2 on at least 75% of its cells and be HER2-negative. The goal is to see…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This study tests whether the drug pyrvinium can reverse gastric intestinal metaplasia, a condition that raises the risk of stomach cancer. Thirty-two adults with high-risk features will take pyrvinium or a placebo for 14 days. Researchers will compare biopsies before and after tr…

This study tests whether a new type of radiation machine that uses MRI to guide treatment is safe and practical for people with gastric, breast, or other cancers. About 70 adults will receive radiation guided by real-time MRI, sometimes with chemotherapy. The goal is to see if th…

This study tests whether using Ovitex mesh during robotic surgery can reduce the chance of a large hiatal hernia coming back. About 100 adults with large or paraesophageal hernias will receive the mesh-reinforced repair. Researchers will track hernia recurrence and any mesh-relat…

This study looks at different drug combinations for people with advanced stomach or gastroesophageal junction cancer that has not responded to first-line treatment. Researchers will observe 250 participants receiving albumin-bound paclitaxel-based regimens, including immune check…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This Phase 3 trial tests whether adding fruquintinib to the standard drug trifluridine/tipiracil helps people with advanced stomach or gastro-esophageal cancer live longer. About 324 participants who have already tried at least two prior treatments will receive either the combo o…

This study will follow 600 adults who are already scheduled to receive a standard procedure called POEM, which uses a scope to cut tight muscles in the throat or stomach. The goal is to see how well the procedure works over time for conditions like achalasia, gastroparesis, and Z…

This phase 3 trial is testing whether a personalized program of supplements (vitamin D, mushroom extract, fish oil, probiotics, and whey protein) plus lifestyle coaching can improve recovery and quality of life for people undergoing surgery for lung, stomach, or esophageal cancer…

This early-phase trial is testing an experimental drug called TH9619 in about 43 adults with advanced solid tumors, including colorectal, head and neck, lung, and gastric cancers. The main goal is to check the drug's safety and find the right dose. Participants must have already …

This study is for people with stomach cancer that has spread to a few other places in the body. It tests whether adding surgery and other local treatments to a combination of immunotherapy and chemotherapy helps people live longer without the cancer getting worse. About 84 adults…

This study tests whether combining the targeted drug cabozantinib with immunotherapy drugs (durvalumab, with or without tremelimumab) is safe and effective for people with advanced stomach, esophageal, liver, or colorectal cancer. About 117 adults with stage 3 or 4 disease that c…

This study looks at whether giving heated chemotherapy directly into the abdomen during surgery can help prevent stomach cancer from coming back. About 200 adults with advanced stomach cancer that has spread to the lining of the abdomen will receive the treatment. The goal is to …

This study tests whether a home-based program of exercise, weight loss, and health optimization before ventral hernia surgery can lower the chance of complications. 130 adults with hernias 4-8 cm wide will be randomly assigned to either the prehabilitation program or standard car…

This study tests a combination of three drugs (SHR-1701, rivoceranib, and possibly SHR-2554) in 40 adults with advanced stomach or gastroesophageal junction cancer that worsened after or could not tolerate first-line immunotherapy. The goal is to see if the new combo can shrink t…

This study tests whether adding the targeted drug zolbetuximab to standard chemotherapy (paclitaxel and ramucirumab) can help people with advanced stomach or gastroesophageal cancer live longer. It includes 100 adults whose tumors have a specific protein called CLDN18.2. Particip…

This early-phase trial tests a new combination of the immunotherapy drug tislelizumab plus standard chemotherapy (FLOT) given before surgery for people with stomach, esophageal, or gastroesophageal junction cancer that can be removed. The goal is to see if this longer pre-surgery…

This phase 2 trial is testing whether the immunotherapy drug dostarlimab can work better than standard chemotherapy as a first treatment for people with rare, advanced cancers that have a specific genetic flaw called dMMR/MSI. The study includes 120 adults with cancers like pancr…

This study looks at whether adding an immunotherapy drug (sintilimab) to standard chemotherapy (SOX) can help prevent stomach cancer from coming back after surgery. It involves 460 adults with a specific type of advanced stomach cancer (PD-L1 positive, stage N3). Participants are…

This trial tests capmatinib, a drug already approved for certain lung cancers, in adults with rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if it can shrink tumors or stop them from growing for at least 24 weeks. The goal is …

This study tests whether injecting two drugs directly into the belly can help control fluid buildup (ascites) caused by stomach cancer. The drugs are sintilimab, which helps the immune system fight cancer, and zoledronic acid, which may slow cancer growth. The trial involves 24 a…

This study tests a new treatment called RAK cell therapy, made from human umbilical cord blood, for people with advanced stomach cancer that has spread or come back after standard treatment. The goal is to see if it can help patients live longer and keep the cancer from growing, …

This study tests if a tube-like device called a stent, placed through a scope, can reverse gastric bypass surgery in 20 people who have serious complications like low blood sugar, blockages, or liver problems. The goal is to see if the stent works as well as surgery to fix these …

This study tests whether a combination of three drugs (RC48, sintilimab, and SOX) can shrink advanced stomach cancer enough to allow surgical removal. It includes 30 adults with a specific type of HER2-positive cancer who have not had prior treatment. The goal is to see how many …

This study tests whether adding a stitch (omentopexy) during sleeve gastrectomy reduces new cases of acid reflux. 526 adults with obesity will be randomly assigned to get the standard sleeve or the sleeve plus stitch. Researchers will check reflux symptoms and medication use two …

This phase 2 trial tests whether adding a daily pill containing a specific gut bacterium (EXL01) to standard immunotherapy (nivolumab) and chemotherapy (FOLFOX) can shrink tumors better than the drugs alone in people with advanced gastric cancer. About 120 participants will be ra…

This study compares two types of surgery for advanced stomach cancer: keyhole (laparoscopic) and open total gastrectomy. About 1,018 patients will be randomly assigned to one of the two procedures. The main goal is to see if keyhole surgery offers similar long-term survival with …

This study compares two surgical approaches for stomach cancer: removing the entire omentum (a fatty layer in the abdomen) versus preserving it. The omentum helps fight infections and prevent bowel blockages. Researchers want to see if keeping it leads to fewer complications with…

This study compares two surgical options for people with severe obesity and acid reflux (GERD). Half of the 560 participants will get a newer procedure called Nissen-Sleeve Gastrectomy, which combines stomach reduction with a reflux barrier; the other half will get the standard R…

This study is testing a new type of PET/CT scan called [¹⁸F]FAPI-74 to see if it can better detect when stomach or esophageal cancer has spread to other parts of the body. About 200 adults with these cancers will receive one dose of the scan tracer and be followed for up to 3 mon…

Researchers at Ruijin Hospital are testing two PET imaging tracers, FAPI and Grazytracer, to see if they can predict how well advanced gastric cancer responds to preoperative immunotherapy. The study enrolls 120 adults with resectable or advanced gastric cancer. Participants rece…

This study aims to see if a new office-based test (EsoCheck balloon and EsoGuard lab test) can accurately detect Barrett's esophagus in people who do not have chronic heartburn. Barrett's esophagus is a condition that can lead to esophageal cancer, but it is often missed in peopl…

This phase 2 study tests whether a radioactive tracer called [68Ga]BED003 can improve PET/CT scans for detecting cancer in the peritoneum (the lining of the abdomen). The trial includes adults with colorectal, ovarian, gastric, pancreatic, or a type of breast cancer. Researchers …

Researchers are testing whether measuring aneuploidy (abnormal chromosome numbers) in cell-free DNA from peritoneal lavage fluid can improve the detection of gastric cancer that has spread to the abdominal lining. The study enrolls adults with gastric cancer and non-cancer contro…

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

This study is testing a simple breath test to help detect gastrointestinal cancers—including cancers of the esophagus, stomach, pancreas, liver, and bowel—at an earlier stage. The test measures tiny molecules in exhaled breath that may be linked to these cancers. Participants pro…

This trial tests an experimental imaging agent called [68Ga]Ga-DWJ155 in adults with advanced cancers of the breast, lung, or stomach. The agent is designed to attach to tumor cells and show up on PET scans, helping doctors see where cancer has spread. Researchers will measure ho…

This study tests whether an artificial intelligence (AI) system can help doctors more accurately score a stomach condition called gastric intestinal metaplasia, which can lead to cancer. Eight endoscopists will review videos of stomach exams, some with AI help and some without, t…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

Researchers at Xijing Hospital are testing whether changes in blood methylation levels, a type of genetic marker, can reflect how well stomach cancer treatment is working. The study will enroll 150 adults with gastric or gastroesophageal junction cancer who have not yet had surge…

This study aims to see if testing stool samples for multiple markers can accurately screen for stomach and colorectal cancers. About 5,000 adults scheduled for endoscopy will provide a stool sample before the procedure and be followed for two years. The goal is to develop a non-i…

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This study tests a radioactive compound called IR199 in people with gastric or pancreatic cancer that has a specific marker, Claudin 18.2. The goal is to see how the compound spreads through the body and how much radiation reaches tumors and healthy organs. Ten participants recei…

This study is developing a blood test that looks for tiny genetic molecules called miRNAs, which can signal the presence of several gastrointestinal cancers like liver, pancreatic, and colorectal cancer. Researchers will analyze blood samples from 1,000 adults—half with cancer an…

This study tests whether artificial intelligence (AI) can help doctors better detect H. pylori infection and precancerous stomach changes during routine endoscopy. The goal is to see if AI assistance can reduce deaths from stomach cancer. The trial will enroll 6,000 adults aged 2…

This study is testing a blood test that looks for tiny bits of cancer DNA (ctDNA) in people with esophageal, gastric, or pancreatic cancer. The goal is to see if it can find signs of cancer coming back or getting worse earlier than current methods. About 34 participants will give…

This study tests whether an artificial intelligence (AI) tool can help radiologists more accurately determine the stage of stomach cancer from CT scans. Fifty-four radiologists will review 60 scans each, first without AI help and then with AI assistance, to see if the AI improves…

This study looks at whether a small, wearable continuous glucose monitor (CGM) can accurately diagnose dumping syndrome in people who have had surgery for esophageal cancer. Dumping syndrome happens when food moves too quickly into the small intestine, causing symptoms like dizzi…

This study is testing an artificial intelligence (AI) model designed to help doctors detect early gastric (stomach) cancer during endoscopy. The AI combines images from standard and enhanced endoscopy with patient data to improve accuracy and explain its reasoning. Researchers wi…

This study tests a wearable device called the C-mo System that automatically detects and describes coughs. Researchers want to see if it can accurately count coughs, measure their intensity, and identify wheezing. 300 people aged 2 and older with cough-related conditions will wea…

This study explores whether a magnetic resonance spectroscopy (MRS) scan of the thigh can predict a patient's fitness for major cancer surgery, as an alternative to the standard cardiopulmonary exercise test (CPET). Researchers will compare fat levels in thigh muscles from the MR…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study aims to see if certain chemicals (oncometabolites) in a person's breath and blood can spot early-stage gastro-esophageal cancer. Researchers will compare samples from 1,000 people, including those with cancer, those with Barrett's esophagus (a precancerous condition), …

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study is testing a new blood test that looks for DNA fragments from tumors in people with hereditary cancer syndromes like Lynch syndrome or BRCA mutations. The goal is to see if the test can find cancers earlier than standard screening methods. Researchers will compare canc…

This study looks at whether a small tissue sample taken during an endoscopy (biopsy) can give the same information about gastric cancer as a larger sample taken during surgery. Researchers will compare results from 510 patients to see if the biopsy is just as accurate for key can…

This trial compares a new surgery called partial stomach-partitioning gastrojejunostomy (SPGJ) to the standard surgery for relieving stomach blockage in advanced gastric cancer. The goal is to see which surgery better helps patients eat normally, with fewer complications like del…

This study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study tests a special magnet system to create a new passage between the stomach and small intestine in people with gastric outlet obstruction (a blockage that prevents food from leaving the stomach). The goal is to relieve symptoms without traditional surgery. Ten adults who…

Cancer treatment often leaves patients with a deep, lasting tiredness that few treatments can fix. Researchers are testing whether guarana, a caffeine-rich Amazonian plant, can reduce that fatigue and improve daily life. The study gives 60 people with breast, lung, colorectal, ce…

This phase II trial tests whether a standardized acupuncture protocol can reduce peripheral neuropathy, a common and often lasting side effect of oxaliplatin chemotherapy. Participants are adults with gastrointestinal solid tumors who stopped oxaliplatin-based treatment and still…

This study tests whether an 8-week online mindfulness program can reduce emotional distress and reflux symptoms in 500 adults with gastroesophageal reflux disease (GERD). Participants are randomly assigned to either the mindfulness program or usual care. The goal is to see if lea…

This trial tests whether personalized dietary guidance from a nutritionist can reduce symptoms of gastroesophageal reflux disease (GERD) better than a standard educational leaflet. Adults with chronic reflux symptoms will receive either tailored advice or written guidelines, and …

Many people with acid reflux still feel heartburn or chest discomfort even after taking strong acid-suppressing drugs. Researchers suspect the problem lies in the brain-gut connection, where the esophagus becomes overly sensitive and the mind stays on high alert for symptoms. Thi…

This study compares two types of nerve blocks—coeliac plexus block and splanchnic nerve block—to see which one reduces pain better in adults with upper abdominal cancer. Forty-four participants will receive one of the procedures and be monitored for pain, opioid use, and quality …

This study compares two procedures to treat stomach blockage caused by cancer: a newer method using an endoscope (EUS-GJ) and traditional surgery (S-GJ). The goal is to see which is safer and works better. About 70 adults with advanced cancer will take part.

This study tests whether a special algorithm called PAGODA can reduce unplanned delays during FOLFOX chemotherapy for gastrointestinal cancers like colon, stomach, and esophageal cancer. About 420 participants will be randomly assigned to either standard care or the algorithm-gui…

This study tests whether Afluxin®, a natural gel made from tamarind seed, pea protein, and polyacrylic acid, can reduce heartburn and regurgitation in people with mild-to-moderate GERD. About 208 adults will take the gel or an inactive placebo three times daily for 7 days. The go…

This trial tests whether DA-9701, a drug for stomach discomfort, works better than a placebo or another active drug in people with functional dyspepsia—a condition causing persistent stomach pain and bloating without a clear cause. About 300 adults aged 19 to 75 with moderate to …

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This trial tests whether adding itopride—a drug that helps the stomach empty faster—to the acid-reducing drug vonoprazan provides better symptom relief than vonoprazan alone in people with functional dyspepsia. Functional dyspepsia is a common condition causing upper stomach pain…

This study tests a surgical technique called a jejunal pouch in 26 adults who need their entire stomach removed due to cancer or a high-risk gene mutation. The pouch is created from a section of the small intestine to replace the stomach's reservoir function. The goal is to reduc…

This trial tests whether a wearable TENS device called EmeTerm can reduce nausea in adults who have had nausea for at least 2 months. Participants wear the device on their wrist for 12 weeks and track their symptoms daily. The study compares nausea frequency during device use to …

This study tests whether participating in poetry workshops can reduce anxiety and improve emotional well-being in adults with chronic digestive symptoms like dyspepsia and gastroparesis. Participants either attend facilitated group workshops or receive a poetry manual to write on…

This study tests whether gentle yoga sessions done online can reduce symptoms like nausea, bloating, and abdominal pain in people with diabetic gastroparesis—a condition where the stomach empties too slowly. Participants will join live yoga classes via video call, focusing on bre…

This study will test whether giving dexamethasone, dexmedetomidine, or both right after gallbladder surgery helps the gut start working again sooner. 160 adults having laparoscopic gallbladder removal will be randomly assigned to one of four groups, including a placebo. The main …

This study tests whether combining a nerve-stimulating device (placed on the ear) with behavioral therapy can reduce stomach pain and anxiety in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers will track symptoms and …

This study tests whether traditional Chinese acupuncture can help people whose stomachs stop working properly after partial stomach removal surgery. 176 adults will receive either real or sham acupuncture alongside standard care. The goal is to see if acupuncture shortens the tim…

This study tests a medical device that forms a protective barrier in the esophagus to reduce acid reflux during sleep. Adults with nighttime GERD symptoms take the device or a placebo liquid before bed for 14 days. Researchers measure sleep quality and symptom relief using questi…

This study tests whether riluzole, a drug already used for ALS, can help cancer survivors who struggle with memory, focus, and mental clarity after treatment — a condition called cancer-related cognitive impairment. Researchers will measure changes in a brain protein called BDNF …

This study tests a new medical device that forms a protective barrier in the esophagus to reduce heartburn and other GERD symptoms. Fifty adults with non-erosive GERD will take the device or a placebo four times daily for two weeks, then switch. The goal is to see if it relieves …

This study tests whether a program of physical therapy, nutritional planning, and psychological support before and after surgery can help patients with locally advanced esophageal, gastroesophageal junction, or stomach cancer recover better. Sixty participants will follow the pro…

This study compares a newer, less invasive endoscopic procedure to standard surgery for treating gastric outlet obstruction, a blockage that prevents food from leaving the stomach. The trial will enroll 32 adults with advanced cancers causing this blockage. The main goal is to se…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This study looks at two different ways to reconnect the stomach after surgery for upper stomach cancer. The goal is to see which method causes less acid reflux and helps patients feel better and eat better. About 52 adults with early-stage stomach cancer will take part across six…

This study is testing whether a low dose of olanzapine, a drug usually used for mental health conditions, can prevent or treat the loss of appetite and weight that often happens in cancer patients receiving chemotherapy. About 100 adults with stomach or ovarian cancer will take t…

This study compares intravenous famotidine (a stomach acid reducer) and oral antacids (like Maalox) for treating dyspepsia (stomach pain) in the emergency department. About 80 adults with upper abdominal pain will rate their pain every 15 minutes for an hour. The goal is to see w…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether a probiotic supplement can improve gut health and reduce symptoms in people with reflux disease (GERD) who are already taking standard medication. Fifty participants will take either the probiotic or a placebo for six weeks. Researchers will check changes…

This study compares two common surgical techniques used to reconnect the digestive tract after partial stomach removal for gastric cancer: Billroth II (one connection) and Roux-en-Y (two connections). The goal is to see which method leads to better quality of life one year after …

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study tests if a new single-port robotic surgery system is as safe and effective as traditional laparoscopic surgery for people with early-stage stomach cancer. About 90 adults will be randomly assigned to one of the two surgical methods. The main goal is to see if the new s…

This study tests a personalized rehabilitation program for people recovering from surgery for esophageal or gastric cancer. Participants will receive a structured assessment of their physical, psychological, and social needs, followed by evidence-based support. The goal is to imp…

This study looks at how different FODMAP diets affect gut bacteria, gut barrier function, and symptoms in people with functional gastrointestinal disorders like IBS. About 60 adults will follow either a low FODMAP, gentle FODMAP, or standard dietary advice for two weeks. Research…

This study tests a new infant formula designed to reduce how often babies spit up. About 346 healthy, full-term infants who spit up at least 4 times a day will receive either the new formula or a standard one. Researchers will track changes in spit-up frequency and severity over …

This study looks at why people with indigestion and diabetes have stomach issues, possibly due to increased sensitivity in the small intestine. Researchers are testing ondansetron, a drug used for nausea, to see if it can reduce symptoms like fullness, discomfort, and nausea. The…

This study compares two approaches to supportive cancer care for nearly 3,000 adults with cancer. One group gets information through email or their health record, while the other works one-on-one with a lay health worker over 12 months. The goal is to see which model better impro…

This study tests a software tool called myDIET that helps manage nutrition in people with stomach or esophageal junction cancer who are scheduled for surgery. Patients answer simple questions about eating, weight, and symptoms, and the tool gives tailored advice. The goal is to s…

This study tests whether a natural extract from the hyacinth bean (EDL) can reduce stomach symptoms like pain, fullness, and burning in people with functional dyspepsia. About 100 adults will take EDL or a placebo daily for 12 weeks. Researchers will measure symptom changes using…

This trial tests whether two types of breathing exercises can improve symptoms and quality of life in people with GERD. 42 adults will be randomly assigned to diaphragmatic breathing, incentive spirometry, or standard care for 6 weeks. Researchers will measure acid exposure, esop…

This study looks at whether people with certain cancers prefer getting their immune therapy as a shot under the skin (subcutaneous) or through a needle in a vein (intravenous). About 880 adults who are already eligible for standard treatments like nivolumab or pembrolizumab will …

This study is tracking how well a procedure called G-POEM helps people with gastroparesis, a condition where the stomach empties too slowly. Researchers will follow 75 adults who are already scheduled for the procedure to see if their symptoms like nausea, bloating, and feeling f…

This study tests whether a probiotic called BioAmicus Complete can improve common stomach issues like colic, reflux, constipation, and diarrhea in infants up to 24 months old. About 110 babies will take the probiotic or receive standard care for 42 days. Parents will report sympt…

This study tests whether two common antidepressants, duloxetine and amitriptyline, can reduce coughing in people with refractory chronic cough—a cough that persists despite standard treatments. About 50 adults will receive either a low or high dose of one drug or a placebo for 4 …

This study tests whether ketotifen, a drug that stabilizes certain immune cells, can reduce stomach pain in children aged 8-17 with functional dyspepsia and high levels of eosinophils in the gut. Participants will receive both ketotifen and a placebo at different times to compare…

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study tests a daily supplement containing two types of probiotics and ginger extract in 198 adults with functional dyspepsia, a condition causing stomach pain, fullness, and burning. Participants take one capsule daily for 8 weeks. Researchers will measure changes in symptom…

This study tests whether a newer drug, zastaprazan, can relieve nighttime heartburn better than the standard drug esomeprazole in people with erosive GERD. About 160 Korean adults with nighttime heartburn for over 3 months will take one of the two drugs and report their sleep qua…

This study tests whether attaching a small cap to the endoscope helps doctors find and treat the source of upper gastrointestinal bleeding more quickly. About 72 adults with severe bleeding will be randomly assigned to have an endoscopy with or without the cap. The main goal is t…

This study tests whether a one-time Botox injection into the side abdominal muscles, given 3-7 weeks before surgery, helps surgeons fully close large ventral hernias. About 188 adults will be randomly assigned to receive Botox or a placebo, and neither they nor their doctors will…

This study compares three routine pain control methods used during minimally invasive cancer surgery: a nerve block plus local anesthetic, nerve block alone, or local anesthetic alone. About 48 adults having surgery for various cancers will be randomly assigned to one of the thre…

This study tests a drink made from Chios mastic, a natural resin, to see if it can reduce indigestion symptoms. Sixty adults with dyspepsia will drink either the mastic beverage or a placebo daily for three months. Researchers will measure changes in symptom severity and quality …

Researchers are running an observational registry to study whether vonoprazan, an oral drug for heartburn and acid reflux, is safe to take during pregnancy. The study follows women aged 15 to 50 who took vonoprazan while pregnant and compares their outcomes with women who did not…

This study is for Black adults newly diagnosed with gastrointestinal cancer. It focuses on ensuring patients receive proper biomarker testing and evidence-based care, helping them find and join clinical trials if they choose, and providing easy-to-understand information about the…

Mayo Clinic researchers are studying people with functional dyspepsia, a common condition of stomach discomfort with no approved drug therapy. The study uses three tools: a body-surface sensor that maps the stomach's electrical rhythm, a pressure catheter that measures contractio…

This study looks at whether adding a geriatrician (a doctor who specializes in care for older adults) to cancer treatment can improve outcomes for people aged 70 and older with gastrointestinal cancers like stomach, colon, or pancreatic cancer. Researchers will test if an online …

This study is a registry that collects information from 1,000 people with symptomatic mitral valve disease, including mitral regurgitation and stenosis. The goal is to better understand how correcting these heart valve problems with a less invasive procedure called transcatheter …

Researchers are studying whether stomach cancers that start near the esophagus differ from those in the rest of the stomach. They collect saliva, blood, stool, and tissue samples from 120 adults with stomach cancer and compare them with healthy controls. Using advanced molecular …

This study collects tissue samples from people with solid tumors who are already scheduled for surgery or biopsy at the NIH Clinical Center. Researchers will use the samples to study the biology of cancer and identify new targets for therapy. Up to 1,800 adults and children (age …

This study tests whether giving heated chemotherapy directly into the abdomen (HIPEC) can increase a protein called PD-L1 on stomach cancer cells that have spread to the lining of the belly. Higher PD-L1 levels might make these cancers more responsive to immunotherapy drugs. The …

This observational study in Vietnam looks at archived tumor samples from patients with several solid cancers, including liver, colorectal, gastric, breast, lung, endometrial, melanoma, and pancreatic cancer. Researchers will measure the presence of two proteins, ENPP1/cGAS and FA…

This study tests whether a non-invasive device called Body Surface Gastric Mapping can predict which patients with gastroparesis will benefit from G-POEM surgery. Researchers will monitor 20 patients before and after the procedure using a sticky electrode patch on the stomach are…

Researchers at Qilu Hospital are studying gastric cardia cancer, a type of stomach cancer, by looking at tiny particles called exosomes and individual cells from blood and tissue samples. They will compare samples from 20 cancer patients with samples from healthy controls to find…

This study tests whether bedside ultrasound can measure how quickly the stomach empties in critically ill patients receiving tube feeding, and whether that emptying depends on the dose of blood pressure-supporting drugs called vasopressors. Researchers will scan the stomachs of 6…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study tests whether a digital chatbot can help more adolescents and young adults (AYA) with cancer get genetic counseling and testing compared to standard remote services. About 535 participants aged 18-39 will use either a chatbot or standard telehealth. The goal is to see …

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study looks at children with functional gut disorders, like stomach pain or irritable bowel syndrome, to see how many are also allergic to nickel or certain plant proteins called LTPs. Researchers will test for these allergies and also check in the lab whether a supplement c…

This study aims to collect blood, urine, tumor samples, and health data from up to 1,000 people with malignant mesothelioma or other cancers that express a protein called mesothelin. Participants will be followed over time to track the course of their disease. The goal is to buil…

This study aims to develop and fine-tune a medical artificial intelligence (AI) model to assist with diagnosing and managing gastric, cardiovascular, and cerebrovascular diseases. Researchers will use a large dataset of patient records, medical images, and doctor-patient dialogue…

This study will examine 4,000 adults aged 40 and older in India using high-definition endoscopy to find early stomach cancer and precancerous changes. Participants are people already scheduled for an upper GI endoscopy due to digestive symptoms. The goal is to learn how common th…

This study is testing whether a computer model that analyzes CT scans taken before treatment, combined with basic clinical information, can predict how long people with gastric cancer will live and when their cancer might progress. Researchers will follow 600 adults receiving sta…

This study tests whether tumor organoids grown from biopsies can predict how well patients with gastric or colon cancer and peritoneal carcinomatosis respond to hyperthermic intraperitoneal chemotherapy (HIPEC). Researchers collect tumor samples during standard surgery, grow them…

This study examines tissue samples from adults with gastric cancer who received chemotherapy before surgery. Researchers will analyze gene activity in the tumor and nearby lymph nodes to look for patterns linked to how well the cancer responded to treatment. The goal is to better…

This study aims to create patient-derived tumor models from 500 people with bladder, lung, stomach, or liver cancer, focusing on racial and ethnic minorities in California. By analyzing genetic and treatment response differences, researchers hope to guide more precise therapies f…

This study explores how the brain and stomach communicate in people with functional dyspepsia (a condition causing stomach pain and fullness without a clear cause) and anorexia nervosa. Participants will eat a pineapple pudding snack while undergoing brain scans (fMRI) before and…

This study investigates whether certain Helicobacter bacteria other than H. pylori are present in people with various stomach conditions, including chronic gastritis, precancerous changes, and gastric cancer. Researchers will analyze biopsy samples from about 150 patients to meas…

This study looks at people with gastroparesis (slow stomach emptying) who have a gastric electrical stimulator (GES) implanted. Researchers will turn off the device for up to four hours to see how it changes insulin and other hormone levels. The goal is to understand the device's…

This study looks at whether people with non-celiac wheat sensitivity (NCWS) have a higher chance of having fatty liver or liver scarring. Researchers will compare liver health in people with NCWS to those with irritable bowel syndrome, functional dyspepsia, and celiac disease. Th…

This study follows 130 adults undergoing surgery for stomach or esophageal cancer to see how often they experience postoperative delirium—a state of confusion and disorientation after anesthesia. Researchers will also check whether depression, frailty, poor nutrition, or muscle l…

This study looks at the stomach and esophagus of people living at high altitude in Zaduo County, comparing them with similar patients from lower-altitude Jilin Province. The goal is to see if high-altitude residents have different patterns of conditions like reflux esophagitis an…

This study looks back at the medical records of about 5,000 Chinese patients with gastroesophageal reflux disease (GERD) to build a detailed picture of their symptoms, treatments, and quality of life. The goal is to understand how GERD affects people in China and how well differe…

This study looks back at the medical records of about 5,000 people in China treated for early gastric cancer. It compares different treatment approaches—such as endoscopic removal, laparoscopic surgery, open surgery, or a combination—to see how they affect long-term survival and …

This pilot study is testing whether a real-time continuous glucose monitor (FreeStyle Libre 3) can reveal differences in blood sugar patterns between people with diabetes who have gastroparesis (delayed stomach emptying) and those without it. About 50 adults with type 1 or type 2…

This study looks at whether the presence and distribution of H. pylori bacteria in the stomach, along with tissue features of early gastric cancer, can help predict how the cancer will behave and what the long-term outlook may be. Researchers will analyze data from about 1,500 pe…

This study aims to find out how many adults in rural Bangladesh have functional dyspepsia—a condition causing stomach pain or discomfort without any visible damage in the digestive tract. Researchers will interview 730 adults using a standard questionnaire and perform an upper en…

This study looks at the bacteria living in the mouth, stool, and tumors of Colombian adults with advanced cancers of the stomach, colon, breast, cervix, or head and neck who are starting immunotherapy as standard care. Researchers will compare these microbial profiles to those of…

This study investigates whether a blood test can predict which stomach cancer patients will develop nerve damage (peripheral neuropathy) from the chemotherapy drug paclitaxel. Paclitaxel is a standard second-line treatment for advanced gastric cancer, but nerve damage is a common…

This study is testing a new blood test to find tiny traces of stomach cancer that might be left behind after surgery. The goal is to catch a recurrence earlier than standard scans. Researchers will collect blood samples from 500 people who had their stomach cancer removed and fol…

This study looks at whether giving the chemotherapy drug paclitaxel over a longer period (2-3 hours instead of 1 hour) can help cancer patients with low muscle mass achieve safer drug levels. Researchers will compare drug concentrations in 22 women with breast, stomach, or esopha…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This Phase 1 trial is testing a new drug called linaprazan glurate in 121 healthy adults to see how the body absorbs and processes it, and whether it affects heart rhythm. The study is double-blind and placebo-controlled, meaning some participants get a dummy pill. It is an early…

This study collects small tissue samples from the stomach and upper intestine of people with severe gastroparesis (delayed stomach emptying). Researchers look for specific cell abnormalities that might predict whether a patient will benefit from a gastric electrical stimulation d…

This study is creating a registry of up to 5,000 patients with various gut movement disorders, such as GERD, gastroparesis, and IBS. Doctors will use standard criteria to make accurate diagnoses and collect patient-reported outcomes. The goal is to improve understanding of these …

This study tests a non-invasive device called Gastric Alimetry that records stomach electrical activity in people with functional dyspepsia or gastroparesis. Researchers will compare recordings taken before and during medication to see if the device can predict which treatment wo…

This study looks at how the body absorbs esomeprazole (a stomach acid reducer) when taken as a tablet or dissolved in water, in people who had gastric bypass surgery a year ago. Fifty participants will have a small device placed in their stomach pouch to measure acid levels, and …

This study looks at whether weak esophageal contractions (ineffective motility) improve after partial fundoplication surgery for gastroesophageal reflux. Researchers will perform high-resolution manometry 18-24 months after surgery in 100 patients who had weak contractions before…

Cancer patients face a higher risk of blood clots during chemotherapy, but it's hard to know who is most at risk. This study will measure clotting-related biomarkers in the blood of 380 patients with ovarian, lung, stomach, or pancreatic cancer at four points during their treatme…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This study aims to develop a model that uses genetic information from tumor tissue to predict how well gastric cancer patients will respond to chemotherapy. Researchers will analyze RNA splicing patterns and apply machine learning to identify patients who are less likely to benef…

This study is building a large database of 15,000 patients with esophageal or gastric cancers in France. Researchers will look back at medical records to see how patients fared after surgery, focusing on how long they stayed cancer-free. The goal is to learn more about survival, …

This study tests a program to help doctors and patients safely reduce or stop taking acid-reducing pills (proton pump inhibitors) when they are no longer needed. About 400 adults in Swiss primary care who take these pills daily will be enrolled. The goal is to see if the program …

This study aims to collect normal measurements from the esophagus and stomach in 40 healthy adults aged 18-85. Participants will undergo two quick, FDA-approved tests during a standard upper endoscopy to measure muscle function and tissue health. The data will help doctors better…

This study is testing whether a quick, non-invasive test that measures heart rate and breathing patterns before thoracic surgery can help predict which patients are more likely to have complications after the operation. Researchers will enroll 130 adults undergoing major chest su…

This study collects blood, urine, and bone marrow samples from 620 people with solid cancers like lung, colorectal, and pancreatic cancer. Researchers will look for tumor cells and DNA in these samples to understand how cancer spreads and why it sometimes comes back after surgery…

This study is investigating whether exposure to microplastics is linked to the development of stomach cancer and its early stages. Researchers will ask 450 people with different stomach conditions to fill out a detailed questionnaire about their possible exposure to microplastics…

This study looks at how different amounts of clear liquids (like water or juice) affect stomach contents in teens aged 13-17 before an upper GI endoscopy. Participants are randomly assigned to drink 3, 5, 7, or 10 ml of clear fluid per kilogram of body weight two hours before the…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study is testing whether a personalized blood test that looks for tumor DNA can detect stomach cancer recurrence earlier than standard imaging. About 110 patients who had chemotherapy and surgery for stage II-III stomach cancer will give blood samples over time. The goal is …

This study compares different ways to reconnect the digestive tract after removing the upper part of the stomach due to cancer. The goal is to find which method causes the fewest complications and gives patients the best quality of life. Researchers will follow 400 people in Russ…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…

This study is not testing a new treatment. Instead, it follows up with 610 people who previously received cadonilimab for advanced gastric cancer in earlier trials. Researchers will collect long-term survival data to see if the drug's benefits last. No additional medication is gi…

This study is building a large database of 3000 people with gastroparesis, a condition that causes nausea, vomiting, and stomach pain. Researchers will follow patients over time to see how different treatments—like nerve stimulation, immunotherapy, or pyloric therapies—affect the…

This observational study is investigating whether heterotopic gastric mucosa (HGM), a patch of stomach-like tissue found in the upper esophagus, is associated with swallowing difficulties (dysphagia) and indigestion (dyspepsia). Researchers will compare symptoms and quality of li…

This study looks at whether using a dye called indocyanine green (ICG) during surgery for advanced stomach cancer helps surgeons see cancer more clearly and change their approach. About 360 adults with stomach cancer will take part. The goal is to see if the dye improves how surg…

This registry will follow 510 adults undergoing therapeutic endoscopic ultrasound (EUS) for conditions like stomach or bile duct blockages, pancreatic fluid collections, or gallbladder inflammation. The goal is to see how well these procedures work over the long term and what fac…

This study aims to understand why many cancer patients lose muscle and fat (cachexia), a condition that worsens their health. Researchers will use advanced techniques to analyze samples from 1000 adults with certain cancers. The goal is to find early warning signs and new targets…

This study is creating a registry of 250 people with symptoms of gastroparesis or functional dyspepsia, such as nausea, vomiting, and abdominal pain. Participants will fill out questionnaires, take a nutrient drink test, and have a gastric emptying scan. The goal is to collect da…

This study aims to find out if people with gastroparesis (stomach paralysis) have abnormalities in the pyloric sphincter, the valve between the stomach and small intestine. Researchers will use special imaging tools to measure how flexible and open this valve is. The study will e…

This study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…

This study is creating a national registry of 216 children, teens, and young adults (ages 8-25) with gastroparesis or similar symptoms. Researchers will track how symptoms like nausea and stomach pain change over 48 weeks using questionnaires and stomach-emptying tests. The goal …

This study translates and validates a Korean quality-of-life questionnaire (KOQUSS-40) for Spanish-speaking patients who had stomach cancer surgery. Researchers will enroll 505 adults who are at least one month past surgery and cancer-free. The goal is to create a reliable tool t…

This study looks at how common Helicobacter pylori infection is in people newly diagnosed with stomach cancer in Martinique. Researchers will collect tumor samples, healthy tissue, and blood to build a biobank. The goal is to understand why stomach cancer is more common in the We…

This study looks at whether eosinophilic gastritis, a rare stomach condition, causes problems with how the stomach moves food. Researchers will use a special scan after an oatmeal meal to check stomach emptying in 30 people. The goal is to better understand if these motility issu…

This study looks at how long people with type 2 diabetes need to stop taking GLP-1 medications (like semaglutide) before surgery to make sure their stomach is empty. These drugs slow down digestion, which can increase the risk of food or liquid entering the lungs during anesthesi…

This observational study will follow 1,000 adults in Algeria who have been diagnosed with gastric cancer. Researchers will collect information on patient demographics, risk factors, symptoms, how the cancer is diagnosed, and what treatments are used. The goal is to better underst…

This study compares two surgical procedures for patients with a specific type of cancer where the stomach meets the esophagus. Half of the 120 participants will have only the upper part of the stomach removed (proximal gastrectomy), while the other half will have the entire stoma…

This study aims to find out how many children in the Czech Republic, aged 8-9 and 12-13, have symptomatic gastroesophageal reflux disease (GERD). Researchers will recruit 1,000 children through schools and ask them to complete an online questionnaire about reflux symptoms. Those …

This study looks at tissue samples from 30 adults with stomach or esophageal cancer that spread to the brain. Researchers compare the genetic markers of the original tumor and the brain tumor to see if they differ. The goal is to better understand how these cancers change when th…

This study looks at whether taking one extra tissue sample from a specific part of the stomach (the incisura) helps doctors better identify people with high-risk chronic gastritis. About 400 adults having a routine upper endoscopy will be enrolled. The goal is to see if this simp…

This study looks at how common Helicobacter pylori (a stomach germ linked to cancer) is in adults without stomach symptoms who are already getting a screening colonoscopy. About 1,000 participants will also have a stomach exam (gastroscopy) during the same visit, with small tissu…

This study uses a 20-25 minute survey to find out which features of diagnostic tests for gastro-esophageal cancer matter most to patients and the general public. Researchers aim to understand preferences and regional differences to improve screening decisions. About 2,200 adults …

This study is testing whether a monthly blood test can predict dangerous blood clots in people with certain cancers (lung, pancreatic, stomach, or brain). Cancer patients are at high risk for clots, which can be deadly. Researchers will follow 200 participants for 12 months, taki…

This early-stage trial compares two versions of a drug called AD-115A and AD-1151, designed to treat gastric ulcers. 46 healthy adults will receive a single dose of each version to see how the drug moves through the body and to check for side effects. The goal is to find out whic…

This study follows 600 adults with autoimmune atrophic gastritis, a condition where the immune system attacks the stomach lining, leading to nutrient deficiencies and increased cancer risk. Researchers aim to track how the disease progresses over time and identify factors that le…

This study looks at people with a specific genetic change in the CTNNA1 gene, which may increase the risk of stomach and breast cancers. Researchers will collect family health histories from 100 participants to better understand these risks. The goal is to improve cancer screenin…

This study is looking for markers in the blood that might show early signs of stomach cancer or conditions that can lead to it. Researchers will follow about 192 adults who are already getting stomach function tests. The goal is to see if changes in these markers over time can he…

This study is a large registry that will collect information from about 1,900 people with advanced cancer of the esophagus or stomach who are receiving palliative treatment in Germany. The goal is to understand what treatments are actually used in everyday practice and how patien…

This study looks at 250 people with pancreatic cancer whose stomach is blocked by the tumor. It compares three procedures—surgery, a metal stent placed by endoscopy, and a newer ultrasound-guided stent—to see which helps patients eat better, maintain weight, and tolerate chemothe…

This study is observing 50 adults with advanced cancers (lung, breast, colorectal, gastric, or liver) who are starting immunotherapy. Researchers want to see if changes in ctDNA (bits of tumor DNA in the blood) can predict early whether the treatment is working. They will also ch…

This study is following 2000 adults with functional digestive disorders like irritable bowel syndrome, dyspepsia, and constipation. Researchers will collect medical data and biological samples (biopsies, blood, urine, stool) during routine care. The goal is to find markers that c…

This study looks at using endoscopic vacuum therapy to treat leaks that can happen after stomach cancer surgery. Researchers will track 100 patients to see if this approach lowers death rates, reduces complications, and improves patient satisfaction. The goal is to find a better …

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study follows 320 people who had omega gastric bypass surgery 10 years ago to compare long-term side effects between two surgical techniques (150 cm vs 200 cm loop). Researchers will check for serious complications, nutritional problems, and weight loss. The goal is to deter…

This study looks at why some babies born with esophageal atresia develop dumping syndrome, a condition causing dangerous blood sugar drops after feeding. Researchers will monitor 15 infants with continuous glucose and heart monitors and a stomach-emptying scan at 3 months old. Th…

This study follows 600 people at higher risk for stomach cancer to track precancerous changes in the stomach lining. Researchers collect tissue, blood, and saliva samples during routine endoscopies. The goal is to understand why some people's stomach changes progress to cancer wh…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study tests a new method to help choose cancer drugs for people with hard-to-treat solid tumors. Doctors take a small piece of the tumor, grow it in the lab, and test many drugs on it to see which works best. Then they give that drug to the patient. The goal is to see if thi…

This study looks at how well certain markers in tumors can predict whether a type of targeted cancer treatment called antibody-drug conjugates (ADCs) will work. About 400 adults with advanced breast, stomach, bladder, or lung cancer will provide tumor samples before and after tre…

This study tests whether taking N-acetylcysteine and simethicone before an upper GI endoscopy (a camera exam of the stomach) improves how clearly doctors can see the stomach lining. About 132 adults, both healthy and those with stomach issues, will receive either the medication o…

This study looks at 100 adults in Guadeloupe who have just been diagnosed with stomach cancer. Researchers want to find out how many of them also have an H. pylori infection, a bacteria linked to stomach cancer. By testing tissue and blood samples, they hope to learn more about t…

This study aims to find the best range for removing No.4sb lymph nodes during surgery for advanced stomach cancer. Researchers will track 400 patients to see how often cancer spreads to different parts of these lymph nodes. The goal is to help surgeons remove only the necessary n…

This study is looking at people with eosinophilic gastrointestinal disorders, which cause inflammation in the gut. Researchers want to see if simple questionnaires can tell how well a patient is doing, compared to looking at tissue samples from endoscopies. The goal is to find be…

This study looks at how a hormone called GLP-1 helps control blood sugar and weight loss after gastric bypass surgery. Researchers will give a drug that blocks GLP-1 to 80 people, including those who had surgery and healthy controls, to measure its effects. The goal is to underst…

This study looks at where tumor deposits form after gastric cancer surgery. Researchers will examine tissue from 100 patients who had a specific type of stomach removal. The goal is to learn more about how cancer spreads in the abdomen, which may guide future treatments.

This study is testing whether measuring ctDNA (bits of tumor DNA) in blood or stool can help doctors manage patients with cancers of the digestive tract, including pancreas, colon, and bile duct cancers. Researchers will track survival and see how these markers relate to outcomes…

This study is observing 150 people with stomach cancer who are having surgery to remove the stomach and nearby lymph nodes. The goal is to see how often cancer spreads to a specific group of lymph nodes near the stomach. The findings could help doctors decide exactly which lymph …

This study observes 200 people with stomach cancer who are having a specific type of surgery called distal gastrectomy with D2 lymphadenectomy plus complete mesogastric excision. The goal is to check how often cancer has spread to lymph nodes and tumor deposits in the back stomac…