Can a bean extract soothe your upset stomach?
NCT ID NCT04482478
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a natural extract from the hyacinth bean (EDL) can reduce stomach symptoms like pain, fullness, and burning in people with functional dyspepsia. About 100 adults will take EDL or a placebo daily for 12 weeks. Researchers will measure symptom changes using a standard stomach symptom scale.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2020
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Those over the age of 19 2. Those diagnosed with functional dyspepsia (Rome IV\*) \* One or more of the following symptoms are diagnosed when there is no organic cause in the test including the upper gastrointestinal endoscopy(if symptoms begin 6 months prior to Visit 1, and the symptoms are present in the past 3 months). * Othersome postprandial fullness * Unpleasant early satiation * Unpleasant epigastric pain * Unpleasant epigastric burning 3. A person who has 4 or more of the 10 symptoms in the GIS (Gastrointestinal Symptom) questionnaire and has a total score of 12 or more (5-point Likert scale) 4. When there is no organic disease in the gastroscopy performed at Visit 1 (however, it can be replaced by the test results within 3 months from Visit 1) 5. A person who consented to participate in this clinical trial and signed a Informed consent form before the trail began. Exclusion Criteria: 1. Persons who are currently being treated with severe cardiovascular system, immune system, respiratory system, hepatobiliary system, kidney and urinary system, nervous system, musculoskeletal system, mental, infectious diseases, and malignant tumors (however, considering the condition of the subjects, subjects can participate in the test according to investigator's judgment.) 2. Persons with a history of peptic ulcer and reflux esophagitis within 6 months of Visit 1 3. Those who have gastrointestinal surgery (except appendectomy and hemorrhoidectomy) 4. Persons with a history of malignancy of the digestive system 5. Those who have taken H2 receptor blockers, anticholinergic agents (muscarinic receptor antagonists), gastrin receptor antagonists, prostaglandin preparations, proton pump inhibitors, gastric mucosal protective agents, other drugs intended to treat gastritis, gastric health-related health functional food within 2 weeks of Visit 1 6. Those who need to constantly take medications that can cause gastritis, such as adrenal cortical hormones, nonsteroidal anti-inflammatory drugs, and aspirin during the human application test {However, low-dose aspirin for cardiovascular disease prevention (100 mg/day or less) permit} 7. In the Drinking Habit Questionnaire, those who had an average alcohol intake of 14 units or more for men and or more 7 units for women per week for the past month. 8. Uncontrolled hypertension persons (systolic blood pressure of 160 mmHg or higher, or diastolic blood pressure of 100 mmHg or higher, measurement criteria after 10 minutes of stability in human subjects) 9. Persons with uncontrolled diabetes (fasting blood sugar is over 180 mg/dL) 10. Those whose Creatinine is more than twice the normal upper limit of the study institution 11. Those whose AST(GOT) or ALT(GPT) is more than 3 times the normal upper limit of the study institution 12. Persons who are sensitive or allergic to investigational product for this clinical trial 13. Pregnant, lactating or planning to become pregnant within 3 months 14. Those who participated in other clinical trials within 3 months of Visit 1 or plan to participate in other clinical trials after the start of this clinical trials. 15. A person who determines that the Investigator is inappropriate for clinical trials 16. Employee of Department of Digestive Internal Medicine, Seoul National University Bundang Hospital
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13620, South Korea
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