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Could a patch of stomach cells in your throat cause swallowing trouble?

NCT ID NCT07510984

Knowledge-focused Sponsor: Knappschaft Kliniken GmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study is investigating whether heterotopic gastric mucosa (HGM), a patch of stomach-like tissue found in the upper esophagus, is associated with swallowing difficulties (dysphagia) and indigestion (dyspepsia). Researchers will compare symptoms and quality of life between adults with and without HGM who are already scheduled for a routine upper endoscopy. The study aims to better understand the role of HGM in these common symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could clarify whether heterotopic gastric mucosa causes swallowing problems, potentially guiding future diagnosis and treatment.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not lead to direct clinical changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 721 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults (≥18 years) undergoing clinically indicated upper gastrointestinal endoscopy (gastroscopy) at a single center will be consecutively screened and invited to participate over a 12-month period. After informed consent, participants complete symptom and health-related quality-of-life questionnaires prior to endoscopy. During routine gastroscopy, the presence or absence of heterotopic gastric mucosa (HGM) in the proximal esophagus is assessed based on endoscopic appearance (and histology from routine care if available). Participants are grouped as HGM present vs no HGM for comparative analyses.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Planned upper gastrointestinal endoscopy (gastroscopy) for clinical reasons (any indication) * Age ≥ 18 years * Written informed consent * Ability to complete the study questionnaires prior to endoscopy Exclusion Criteria: * Previously known heterotopic gastric mucosa (HGM) * Previously diagnosed dysphagia with prior therapeutic intervention (including pre-established diet modification, partial oral/enteral nutrition, steroid therapy, botulinum toxin injection, etc.) * Mechanical ventilation * Presence of a tracheostomy * Inadequate endoscopic assessability of the proximal esophagus, including: * General condition insufficient for careful endoscopic inspection (investigator's judgement) * Increased risk of aspiration * Inadequate visibility during the procedure (e.g., bleeding, food residue) * Complications preventing careful inspection of the proximal esophagus * History of surgery involving the pharynx or esophagus * Relevant severe neurological disorder (e.g., ALS, stroke) * Severe dementia * Severe depressive disorder * Lack of cooperation / inability to comply with study procedures * Planned PEG placement * Emergency endoscopy

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Conditions

The condition(s) this trial relates to.

Deglutition Disorders dyspepsia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dyspepsia Dysphagia Gastric inlet patches Heterotopic gastric mucosa of the proximal esophagus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Knappschaftskrankenhaus Bottrop

    RECRUITING

    Bottrop, North Rhine-Westphalia, 46240, Germany

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