Could zapping thigh muscles and sipping protein shakes stop muscle wasting after cancer surgery?
NCT ID NCT06964438
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive a whey protein drink to see if it boosts the effect. The study involves 45 adults undergoing curative surgery, and measures muscle size, strength, and physical function in the days after the operation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Neuromuscular electrical stimulation (NMES) and whey protein supplement drink
- What this could lead to
- If it works, this approach could help people recover faster and maintain muscle strength after major abdominal surgery for gastrointestinal cancer.
- What could go wrong
- This is a small, early-stage trial with only 45 participants, so results may not apply to everyone. The benefits of adding protein to electrical stimulation are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients (age 18 or over at the time of diagnosis made at MDT (multi-disciplinary team meeting) * MDT outcome of colorectal or gastric cancer or non-invasive neoplasia (tissue-proven, or radiologically diagnosed and clinically suspected) with the intention to treat with curative abdominal surgery * Agreed management plan for open or minimally invasive (laparoscopic or robot assisted) segmental abdominal (colonic or gastric) resection at the Royal Derby Hospital * Sufficient mobility and fitness to complete normal ERAS (enhanced recovery after surgery) protocols following surgery * Basic conversational spoken English language * Ability to give informed consent Exclusion Criteria: * Upper GI (gastrointestinal) cancer requiring thoracotomy/thoracoscopy * Pre-existing neuromuscular disease (including Parkinsons disease) * Pacemaker, implantable cardiac defibrillator or other implanted nerve stimulator device * Metal prostheses or other metal-work in either upper legs (hip/knee/femur) * Dementia or other cognitive problem or language barrier causing an inability to follow instructions and operate NMES machine * Inability to give informed consent * Disability preventing completion of ERAS after surgery (requiring Zimmer frame/wheeled frame/wheelchair to mobilise or bed-bound) * Peripheral vascular disease * Epilepsy * Pre-existing diagnosis of chronic kidney disease or estimated glomerular filtration rate \<60 on screening visit * Pre-existing diagnosis of liver disease * Intubation or intensive care admission during study period (between day 0-5 post-op); (surgical high dependency unit patients will be included) * Return to theatre for surgical complication within first 5-days post operation * History of rhabdomyolysis * Pregnancy * Deep vein thrombosis within past 6-months * Allergy to whey protein * Patient refusal of whey protein products on grounds of dietary requirements or intolerance * Participating in another clinical trial concurrently or within the last 6 months * Known infection with blood borne virus
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Royal Derby Hospital
RECRUITINGDerby, Derbyshire, DE22 3NE, United Kingdom
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