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Could zapping thigh muscles and sipping protein shakes stop muscle wasting after cancer surgery?

NCT ID NCT06964438

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether using a device that sends mild electrical pulses to the thigh muscles (neuromuscular electrical stimulation, or NMES) can prevent muscle loss and weakness after abdominal surgery for colorectal or gastric cancer. Some participants will also receive a whey protein drink to see if it boosts the effect. The study involves 45 adults undergoing curative surgery, and measures muscle size, strength, and physical function in the days after the operation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Neuromuscular electrical stimulation (NMES) and whey protein supplement drink
What this could lead to
If it works, this approach could help people recover faster and maintain muscle strength after major abdominal surgery for gastrointestinal cancer.
What could go wrong
This is a small, early-stage trial with only 45 participants, so results may not apply to everyone. The benefits of adding protein to electrical stimulation are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (age 18 or over at the time of diagnosis made at MDT (multi-disciplinary team meeting) * MDT outcome of colorectal or gastric cancer or non-invasive neoplasia (tissue-proven, or radiologically diagnosed and clinically suspected) with the intention to treat with curative abdominal surgery * Agreed management plan for open or minimally invasive (laparoscopic or robot assisted) segmental abdominal (colonic or gastric) resection at the Royal Derby Hospital * Sufficient mobility and fitness to complete normal ERAS (enhanced recovery after surgery) protocols following surgery * Basic conversational spoken English language * Ability to give informed consent Exclusion Criteria: * Upper GI (gastrointestinal) cancer requiring thoracotomy/thoracoscopy * Pre-existing neuromuscular disease (including Parkinsons disease) * Pacemaker, implantable cardiac defibrillator or other implanted nerve stimulator device * Metal prostheses or other metal-work in either upper legs (hip/knee/femur) * Dementia or other cognitive problem or language barrier causing an inability to follow instructions and operate NMES machine * Inability to give informed consent * Disability preventing completion of ERAS after surgery (requiring Zimmer frame/wheeled frame/wheelchair to mobilise or bed-bound) * Peripheral vascular disease * Epilepsy * Pre-existing diagnosis of chronic kidney disease or estimated glomerular filtration rate \<60 on screening visit * Pre-existing diagnosis of liver disease * Intubation or intensive care admission during study period (between day 0-5 post-op); (surgical high dependency unit patients will be included) * Return to theatre for surgical complication within first 5-days post operation * History of rhabdomyolysis * Pregnancy * Deep vein thrombosis within past 6-months * Allergy to whey protein * Patient refusal of whey protein products on grounds of dietary requirements or intolerance * Participating in another clinical trial concurrently or within the last 6 months * Known infection with blood borne virus

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal Derby Hospital

    RECRUITING

    Derby, Derbyshire, DE22 3NE, United Kingdom

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