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Thigh MRI may replace grueling exercise tests for surgery patients

NCT ID NCT06544187

Diagnosis Sponsor: University Hospitals of North Midlands NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study explores whether a magnetic resonance spectroscopy (MRS) scan of the thigh can predict a patient's fitness for major cancer surgery, as an alternative to the standard cardiopulmonary exercise test (CPET). Researchers will compare fat levels in thigh muscles from the MRS scan with CPET results in 56 patients with gastric, esophageal, or pancreatic cancer. If the scan proves reliable, it could offer a less demanding option for patients who cannot tolerate exercise testing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnetic Resonance Spectroscopy (MRS) scan
What this could lead to
If successful, this could provide a less physically demanding way to assess surgical fitness for patients who cannot tolerate exercise tests.
What could go wrong
This is a small, early-phase study with only 56 participants. The MRS method may not correlate well enough with exercise test results to replace them.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Cohort 1: Participants with oesophageal, gastric or pancreatic cancer who are potential candidates for surgical resection (oesophagectomy/gastrectomy/pancreaticoduodenectomy). Cohort 2: Healthy volunteers who are UHNM staff members ≥ 18 years old, with no known contraindication to MRI. Volunteers will be age and gender matched to the participants in cohort 1.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion criteria for patients (cohort 1) * Patients diagnosed oesophageal/gastric or pancreatic cancer. * Patients who have or a under consideration for a CPET investigation. * Aged ≥ 18. * Existing UHNM Patient. * Willing and able to give fully informed consent. * Willing and able to comply with the study procedures. Inclusion criteria for staff volunteers (cohort 2) * Aged ≥ 18 years. * Willing and able to give fully informed consent. * Willing and able to comply with the study procedures. * UHNM member of staff. Exclusion Criteria: Exclusion criteria for patients (cohort 1) * Patients with contraindications to MRI due to safety at 3T. * Patients with metalwork within the imaging field of view (e.g., knee replacement). * Claustrophobic patients. * Patients outside of stated age range to ensure informed consent. * Patients not referred for CPET investigations. * Patients that are pregnant. * Patients that are unable to communicate in English. * Patients lacking the capacity and capability to give fully informed consent. * Patients participating in any other interventional studies with a contraindication to their participation. * Patients for whom the addition of an MRS scan would delay any part of their standard treatment pathway. * History of diabetes. Exclusion criteria for staff volunteers (cohort 2) * Volunteers with contraindications to MRI due to safety at 3T. * Volunteers with metalwork within the imaging field of view (e.g., knee replacement). * Claustrophobic volunteers. * Volunteers outside of stated age range to ensure informed consent. * Volunteers that are pregnant. * Volunteers that are unable to communicate in English. * Volunteers lacking the capacity and capability to give fully informed consent. * Volunteers participating in any other interventional studies with a contraindication to their participation. * Known or suspected medical conditions pertinent to the area being scanned. * History of diabetes.

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Conditions

The condition(s) this trial relates to.

esophageal cancer exocrine pancreatic carcinoma gastric cancer malignant pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Imaging Surgical fitness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospitals of North Midlands NHS Trust

    RECRUITING

    Stoke-on-Trent, United Kingdom

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