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Could probiotics soothe reflux? new study begins

NCT ID NCT07600008

Symptom relief Sponsor: University Hospital Olomouc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a probiotic supplement can improve gut health and reduce symptoms in people with reflux disease (GERD) who are already taking standard medication. Fifty participants will take either the probiotic or a placebo for six weeks. Researchers will check changes in gut bacteria and track symptom relief through questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
probiotic dietary supplement (blend of Lactobacillaceae, Streptococcus, and Bifidobacterium)
What this could lead to
If it works, this could point toward a simple probiotic supplement to help manage GERD symptoms alongside standard medication.
What could go wrong
This is a very early, small trial (50 people) testing only a 6-week supplement. It may show no benefit over placebo, and results may not apply to everyone with reflux.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed GERD. * Stable health without current complications. * Patients on stable pharmacological PPI therapy (rabeprazole). Exclusion Criteria: * Use of probiotics or prebiotics within the last 4 weeks. * Pregnancy or breastfeeding. * Systemic antimicrobial therapy within the last 4 weeks. * Infectious disease of the respiratory or gastrointestinal tract within the last 2 weeks. * Serious chronic disease that could affect study results, including cancer, diabetes, inflammatory bowel disease, diagnosed SIBO. * Prior surgeries, especially fundoplication and resections of the esophagus or stomach. * Patients with psychiatric or cognitive disorders. * Hypersensitivity to components of the investigational product.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Microbiome Probiotics supplement Reflux disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital Olomouc

    RECRUITING

    Olomouc, 77900, Czechia

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