Female reproductive system disorder

This study tests whether a temporary uterus transplant from a living donor can allow women with uterine factor infertility—who lack a functioning uterus—to become pregnant and deliver a healthy baby. Recipients receive immunosuppressive drugs to prevent rejection, and the uterus …

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This early-phase trial is testing an experimental drug called BI-1808, alone or with the immunotherapy pembrolizumab (Keytruda), in people with advanced cancers like ovarian cancer, T-cell lymphoma, and melanoma. The main goals are to check safety, find the best dose, and see how…

This study looks at how hormone replacement therapy (HRT) affects adolescents aged 11-19 with premature ovarian insufficiency (POI), a condition where ovaries stop working before age 40. Participants receive estrogen patches and progesterone pills over 2 years, with regular check…

This phase 3 trial tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can better shrink tumors in people with HER2-positive endometrial cancer. The study plans to enroll 360 participants with various stages of the disease. However, the trial…

This study tests whether adding palbociclib to neratinib works better than neratinib alone for people with HER2-positive solid tumors (excluding breast cancer). Both drugs block signals that help cancer cells grow. The trial enrolls 70 adults with advanced or recurrent gynecologi…

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This Phase 3 trial tests whether a targeted therapy called sacituzumab tirumotecan (Sac-TMT), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer without their cancer growing. About 900 participants who have finished initial chemotherapy will…

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has sprea…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

This Phase 3 trial tests whether the drug BNT323 (trastuzumab pamirtecan) works better than standard chemotherapy for people with recurrent endometrial cancer that expresses HER2. About 480 participants will be split into two groups based on their HER2 levels. The study measures …

This phase 2 trial tests a drug called lorigerlimab (MGD019) in 47 people with advanced cervical cancer that has spread or come back. The goal is to see if the drug can help control the cancer and improve survival. Participants receive the drug through an IV. The study is current…

This early-phase trial is testing a new radioactive drug that seeks out a protein called Nectin-4 found on many cancer cells. The drug delivers a dose of radiation directly to the tumor, aiming to destroy it while sparing healthy tissue. About 150 adults with advanced bladder, br…

This early-stage study tests a new treatment for people with ovarian cancer that has come back. The therapy uses a patient's own immune cells, which are modified in a lab to recognize and attack a protein (FSHR) found on cancer cells. The main goal is to check the safety of these…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer getting worse. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive eith…

This study tests a new drug called WJB001 combined with various chemotherapy drugs in people with advanced solid tumors that have not responded to standard treatments. The trial has three stages to find the safest dose, check how the body processes the drug, and see if it shrinks…

This phase II trial is testing whether combining two immunotherapy drugs, nivolumab and ipilimumab, works better than nivolumab alone for women with recurrent endometrial cancer that has a specific DNA repair defect (dMMR). About 81 participants will receive either the combinatio…

This phase 2 trial is testing whether a targeted antibody-drug conjugate called sacituzumab tirumotecan, given alone or together with the immunotherapy pembrolizumab, can shrink tumors in people with ovarian clear cell carcinoma that has returned after prior immunotherapy. The st…

Researchers are testing a shorter, adapted form of radiation therapy for people with high-risk endometrial cancer after surgery. The trial enrolls 20 patients and uses daily imaging to adjust the radiation plan to each person's anatomy. Participants receive moderately hypofractio…

Researchers are testing a new oral drug called DC05F01 in adults with recurrent ovarian cancer and other advanced solid tumors that have worsened after standard treatment. The trial aims to see how well the drug shrinks tumors, how long it keeps cancer from growing, and what side…

This study is testing an experimental oral drug called ATX-295 in people with advanced solid tumors, including ovarian cancer, that have not responded to standard treatments. The main goal is to find a safe and tolerable dose and to see if the drug can shrink tumors. About 90 par…

This early-phase study tests a new drug called BG-C9074, designed to target and kill cancer cells in people with advanced solid tumors that have not responded to standard treatments. The study will first find the safest dose, then test it alone or with other cancer drugs. About 3…

This study tests an experimental oral drug, GSK5460025, alone or with other cancer drugs, in adults whose solid tumors have specific genetic changes (dMMR or MSI-H). The goal is to see if the drug can shrink tumors and to check its safety. About 47 people with advanced cancers th…

Researchers are testing whether adding inhaled manganese chloride to standard chemotherapy and an anti-PD-1 immunotherapy can help people with advanced ovarian cancer that has worsened after at least two prior treatments. The trial enrolls about 120 participants and randomly assi…

Researchers are testing whether adding an experimental immunotherapy drug called GLS-010 to standard platinum-based chemotherapy, with or without bevacizumab, helps women with persistent, recurrent, or metastatic cervical cancer live longer. The trial enrolls about 424 women aged…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This early-stage trial is testing a new treatment called GB-5267 for people with ovarian cancer that no longer responds to platinum-based chemotherapy. GB-5267 is a type of immune cell therapy (CAR T cell) that has been engineered to better target cancer cells and includes an ext…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This phase 3 trial tests whether adding a gene therapy called IMNN-001 (given into the abdomen) to standard chemotherapy helps people with advanced ovarian, fallopian tube, or peritoneal cancer live longer. About 500 newly diagnosed patients will be randomly assigned to receive e…

This study tests whether a probiotic called EXE-346 can help treat anal high-grade squamous intraepithelial lesions (HSIL) and reduce persistent high-risk HPV infection in people living with HIV. The trial will enroll 90 participants who will take the probiotic or a placebo daily…

This study tests whether a daily pill called isoquercetin, made from a plant compound, can reduce blood markers linked to clot risk in people with ovarian cancer. About 90 participants receiving chemotherapy will take either isoquercetin or a placebo for up to 6 weeks. The goal i…

This study tests a new drug called INCB123667 in 160 people with a type of ovarian cancer that no longer responds to platinum chemotherapy and has high levels of a protein called cyclin E1. The goal is to see if the drug can shrink tumors or slow the cancer's growth. Participants…

This Phase 3 trial tests a new oral drug, INCB123667, against standard chemotherapy in 466 people with platinum-resistant ovarian cancer that overexpresses cyclin E1. The goal is to see if the new drug can delay cancer growth or improve survival. Participants will be randomly ass…

This phase II study is testing whether women with certain types of early-stage endometrial cancer can safely receive less aggressive treatment after surgery. The approach is guided by the tumor's molecular profile—either POLE-mutated or p53 wildtype/NSMP. Around 393 participants …

This study is testing whether the immunotherapy drug dostarlimab (TSR-042), followed by standard chemoradiation and surgery, can effectively treat advanced mismatch repair deficient (dMMR) solid tumors. About 212 adults with locally advanced dMMR cancers will receive the drug int…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study tests whether adding the experimental drug IMNN-001 to standard chemotherapy and bevacizumab can better eliminate remaining cancer in people with newly diagnosed advanced ovarian, fallopian tube, or primary peritoneal cancer. About 30 participants will be randomly assi…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This phase 2 trial is testing an experimental drug called ubamatamab, alone or combined with other cancer drugs, in 220 people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has stopped responding to platinum-based chemotherapy. The study aims to see how…

This study compares two surgical approaches for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have received chemotherapy before surgery. One group will have minimally invasive surgery (small incisions), and the other will have standard open surger…

This study is testing a new experimental drug called GI-101, given alone or with pembrolizumab or lenvatinib, in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults w…

This study tests a combination of two drugs, nilotinib (a pill) and paclitaxel (given by IV), for people with rare advanced cancers that have not responded to standard treatments. The goal is to see if the drugs can shrink or stop tumor growth. About 82 adults with specific rare …

This study tests a new drug called TUB-040 for people with ovarian cancer that no longer responds to platinum chemotherapy, or with a type of lung cancer that has come back. TUB-040 is an antibody-drug conjugate, meaning it delivers a powerful chemotherapy directly to cancer cell…

This study tests a new drug called SHR-A1811 combined with standard chemotherapy (carboplatin and bevacizumab) in 150 women whose ovarian cancer has returned but still responds to platinum-based drugs. The goal is to find the safest dose and see if the combination shrinks tumors …

This study tests a new drug called raludotatug deruxtecan (R-DXd) in people whose high-grade serous ovarian, peritoneal, or fallopian tube cancer has returned after platinum chemotherapy. R-DXd is an antibody-drug conjugate that seeks out cancer cells and delivers a toxic payload…

This study tests a new drug called AZD8205, alone or with another drug (rilvegostomig), in people with advanced solid tumors like breast, ovarian, and lung cancers. The trial has two phases: first to find the safest dose, then to see if it shrinks tumors. About 460 adults whose c…

This phase 2 trial is testing an experimental drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers. The study aims to see if the drug can shrink tumors and how safe it is. About 257 partic…

This study is testing a new drug called ubamatamab, given alone or with another drug called cemiplimab, in people with ovarian cancer or other cancers that have come back after treatment. The main goals are to check safety, find the right dose, and see if the drugs can shrink tum…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This early-phase study tests a new drug called BGB-43395 in people with advanced HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. Researchers want to find the safest and most effective dose, either alone or combined wi…

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This early-phase trial is testing whether combining two targeted drugs—abemaciclib and olaparib—can help women with ovarian cancer that has stopped responding to platinum-based chemotherapy. The study will enroll 42 participants to find the safest dose and check for side effects.…

This study tests whether transplanting vaginal fluid from healthy donors can restore a healthy bacterial balance in women with recurrent bacterial vaginosis (BV). Participants receive either the transplant or a placebo after antibiotic treatment. The goal is to see if the transpl…

This early-phase study tests a new drug called DT2216 combined with the chemotherapy paclitaxel in people whose ovarian cancer has returned and is resistant to platinum-based treatments. The main goal is to find the highest safe dose of DT2216 when given with paclitaxel. About 30…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This early-phase study tests a new drug called FORX-428 in about 40 adults with advanced solid tumors that have certain gene changes (like BRCA1/2 mutations). The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors or slow their growth. …

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced cervical cancer that has stopped responding to initial treatment. The trial enrolls 35 adults whose cancer has spread or cannot be removed by surgery. The goal is…

This early-phase trial is testing a new treatment called B7-H3 CAR T cells for adults with ovarian cancer that has come back and no longer responds to platinum chemotherapy. The treatment involves taking a patient's own immune cells, modifying them in a lab to better recognize an…

Researchers are testing a combination of a gonadotropin-releasing hormone agonist injection and the drug letrozole in obese women with early-stage endometrial cancer that has not responded to progestin. The goal is to see if this hormone-blocking approach can shrink tumors and al…

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

Researchers test whether a combination of GnRHa and letrozole can shrink early endometrial cancer or atypical hyperplasia in non-obese patients who have not responded to progestin therapy. The trial compares this regimen with Diane-35 plus metformin. About 80 participants receive…

This clinical trial is testing whether a combination of two drugs—dostarlimab (an immunotherapy) and niraparib (a PARP inhibitor)—works better than standard chemotherapy for women with a rare and aggressive type of uterine or ovarian cancer called carcinosarcoma. The study will e…

This trial tests a personalized mRNA vaccine called NeoOVIV in people with stage II or III ovarian cancer who have had surgery. The vaccine is designed to teach the immune system to recognize and attack cancer cells. Participants receive the vaccine alongside standard chemotherap…

This Phase 3 trial tests whether adding the experimental drug Rina-S to standard care (bevacizumab or monitoring) can help keep platinum-sensitive ovarian cancer from returning after chemotherapy. About 528 participants will receive either Rina-S alone, Rina-S plus bevacizumab, b…

This early-stage trial tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. M7437 is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells that have a specific marker (Ly6E). The study ai…

This study tests whether giving the targeted drug mirvetuximab soravtansine together with standard chemotherapy (carboplatin) before surgery can shrink advanced ovarian, fallopian tube, or peritoneal cancers that have a specific protein (FRα). About 140 adults with stage III or I…

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after platinum-based chemo and immunotherapy. About 660 participants will be randomly assigned to receive either Rina-…

This early-phase study tests a new radioactive drug, 225Ac-ETN029, in 116 adults with advanced DLL3-positive cancers like small cell lung cancer or neuroendocrine tumors. The main goal is to check safety and find the right dose, while also seeing if the drug can shrink tumors. Pa…

This phase 3 trial compares a new drug called Rina-S to standard chemotherapy in 82 people with platinum-resistant ovarian cancer. Participants are randomly assigned to receive either Rina-S or one of four approved chemotherapies. The goal is to see if Rina-S can delay cancer gro…

This early-phase trial is testing whether a personalized mRNA vaccine called NeoOVSV, given alongside standard chemotherapy and an immunotherapy drug, can safely help prevent ovarian cancer from returning after surgery. The vaccine is designed to train the immune system to recogn…

This early-stage study tests a new drug called NPX372 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to help the body's immune cells recognize and attack cancer cells. The main goals are to check the drug's safety and fin…

This early-phase trial tests a combination of two drugs—DS-8201a and olaparib—in people with advanced HER2-expressing cancers that have spread or cannot be removed. DS-8201a delivers chemotherapy directly to HER2-positive tumor cells, while olaparib blocks DNA repair in cancer ce…

This early-stage trial tests a new drug called ONC-783 in 20 people with advanced solid tumors, including colorectal, ovarian, pancreatic, or breast cancer. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goal is to find a safe d…

This large Phase 3 study tests a new medicine called Sofetabart Mipitecan for people with ovarian, fallopian tube, or peritoneal cancer. It includes two groups: those whose cancer stopped responding to platinum chemotherapy within six months (platinum-resistant), and those whose …

This phase III trial tests whether giving an extra round of chemotherapy and immunotherapy (pembrolizumab) before the usual chemoradiation can help people with high-risk, locally advanced cervical cancer live longer without the cancer growing. About 336 participants will be rando…

This study tests a new drug called AZD4956, alone or with other cancer drugs, in people with advanced or spreading solid tumors that have a specific DNA repair defect (HRR deficiency). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. …

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This trial tests whether screening women with endometriosis for pain complications before surgery, and offering specialized pain care to those who need it, improves their quality of life a year after the operation. Researchers will compare women who receive this extra pain manage…

This pilot study tests whether adding extra doses of the antibiotic azithromycin to standard care can improve outcomes for pregnant people whose water breaks very early (between 22 and 28 weeks). Thirty participants will be randomly assigned to receive either the standard antibio…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This early-stage study tests an experimental drug called IMGS-001 in about 105 people with advanced solid tumors that have come back or not improved after standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. The study has two parts: first, t…

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This Phase III trial tests whether adding the drug bevacizumab to a standard chemotherapy plus immunotherapy regimen can help people with a specific type of advanced or recurrent endometrial cancer (pMMR, TP53 mutated). About 255 participants will be randomly assigned to one of t…

This early-stage study tests a new treatment called ZI-MA4-1, made from specially engineered immune cells, in people with advanced ovarian, lung, sarcoma, or head and neck cancers that have not responded to other therapies. The treatment aims to help the body's immune system atta…

This early-phase trial is testing the safety and best dose of two drugs, M1774 and ZEN-3694, given together to patients with recurrent ovarian or endometrial cancer. The drugs work by blocking enzymes that cancer cells need to grow. The study aims to find a dose that is safe and …

This study tests a new treatment called FB301, a capsule containing beneficial bacteria, for women with an imbalance of vaginal bacteria who have had a failed frozen embryo transfer (IVF). Thirty women aged 18-40 will receive FB301 or a placebo during a mock IVF cycle, with some …

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This phase 3 trial is testing whether a targeted drug (trastuzumab deruxtecan) combined with immunotherapy (rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific prot…

This early-stage trial is testing an investigational drug called ARR-002 in adults with advanced or metastatic ovarian or endometrial cancer, including cases that have stopped responding to platinum-based chemotherapy. The main goals are to assess the drug's safety, tolerability,…

This early-stage trial is testing a new drug called CTIM-76 in people with advanced ovarian, testicular, or endometrial cancers that have not responded to standard treatments. CTIM-76 is a bispecific antibody designed to attach to a protein called Claudin-6 on cancer cells and he…

This phase 3 trial tests whether a new drug, sacituzumab tirumotecan, given with or without bevacizumab, can help people with platinum-sensitive recurrent ovarian cancer live longer without their cancer worsening. About 770 participants who have already completed two rounds of ch…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study is tracking the safety and effectiveness of durvalumab (with or without olaparib) in about 50 Korean patients with endometrial cancer who are already prescribed these drugs. Researchers will follow participants for up to 12 months to see how well the treatment works in…

This study tests a new drug called BNT326, given alone or with other cancer immunotherapies, in about 980 adults with advanced solid tumors that have spread or come back after prior treatment. The goal is to find the best dose and see if it is safe and effective. It is an early-s…

This study tests whether a probiotic supplement containing Lactobacillus crispatus can reduce the number of times bacterial vaginosis (BV) comes back in women who have had it repeatedly. About 156 women aged 18-45 will take either the probiotic or a placebo daily for 12 weeks aft…

This early-phase study tests a new drug called DSB2455 in adults with advanced cancers (breast, ovarian, prostate, pancreatic, or brain metastases) that have a specific DNA repair problem. The main goals are to check safety and see if the drug shrinks tumors. About 180 participan…

This study tests a new drug called PYX-201 combined with pembrolizumab in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the combination can shrink tumors. About 220 adults with certain cancers like head an…

This trial compares HHK001, an investigational version of leuprorelin acetate, to Enantone, an approved treatment for endometriosis. Both contain the same active ingredient, but HHK001 uses an updated formulation. The study will enroll 30 women aged 18-45 with endometriosis, who …

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This trial is testing whether an experimental drug called TUB-040, when added to standard chemotherapy and a targeted therapy, is safe and tolerable for women with a specific type of advanced ovarian cancer. The study involves about 72 participants whose cancer has returned but s…

This large Phase 3 trial will test a new drug called Rina-S, alone or with bevacizumab, against standard platinum-based chemotherapy for women with ovarian cancer that has returned after initial treatment. About 688 participants will be randomly assigned to receive either the new…

This study tests a radiation treatment called Cesium-131 brachytherapy for women whose cervical or endometrial cancer has returned in the vagina after prior pelvic radiation. Tiny radioactive seeds are placed directly into the tumor to kill cancer cells while sparing healthy orga…

This phase II trial tests an experimental drug called SYS6041, alone or combined with chemotherapy and other agents, in women whose ovarian cancer has returned. The study evaluates safety, the best dose, and how well the treatments shrink tumors. Participants must have a specific…

This trial tests whether obese patients with endometrial cancer or a precancerous condition can safely undergo a hysterectomy and weight loss surgery at the same time. Researchers want to see if a fast-track referral process can get patients to surgery within 8 to 12 weeks of dia…

This large Phase 3 study tests a new drug called mocertatug rezetecan (Mo-Rez) against standard chemotherapy for people with endometrial cancer that has progressed after platinum-based chemo and immunotherapy. About 600 participants will be randomly assigned to receive either Mo-…

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This phase 2 trial tests whether combining disitamab vedotin, AK104, and bevacizumab can shrink tumors in people with recurrent or persistent clear cell ovarian cancer. Clear cell ovarian cancer is a rare and aggressive subtype that often stops responding to standard platinum-bas…

This trial is testing whether a shorter, more intense course of radiation therapy can be a safe and effective option for people with high-risk endometrial cancer after surgery. Instead of the usual weeks of daily radiation, the study uses just five sessions of a higher dose, guid…

This phase III trial compares a shorter course of radiation therapy (hypofractionated) against the standard longer course for people with cervical cancer. Both groups also receive chemotherapy and brachytherapy. The goal is to see if the shorter schedule controls the cancer just …

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This study is testing whether a shorter course of radiation therapy, given after surgery, can be as well-tolerated as the standard longer course for women with endometrial or cervical cancer. Instead of many small doses, the new approach uses five larger, precisely targeted doses…

This early-stage trial tests a new mRNA cancer vaccine called CryptiVax-1001 in 50 women with advanced ovarian cancer. The vaccine is designed to train the immune system to recognize and attack cancer cells, potentially delaying or preventing the cancer from coming back. The main…

This phase 3 study tests whether a new drug called azenosertib works better than standard chemotherapy for people with a specific type of ovarian cancer that no longer responds to platinum-based treatments. The trial enrolls 420 women whose tumors have a high level of a protein c…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This trial asks whether robot-assisted hysterectomy is as effective as traditional open surgery for treating early-stage cervical cancer. About 800 women with stage IB (excluding IB3) or IIA1 cervical cancer will be randomly assigned to one of the two surgical approaches. The mai…

This study tests a traditional Chinese medicine called Yulinzhu in 60 women aged 18-40 with diminished ovarian reserve (low egg supply). Participants take the herbal therapy for 12 weeks, and researchers measure changes in hormone levels and egg count. The goal is to see if the t…

This trial tests whether placing a small closed-suction drain under the skin before closing the incision can reduce wound complications in women with thick subcutaneous tissue (2.5 cm or more) undergoing midline abdominal surgery for gynecologic cancer. Half of the participants w…

This trial compares two surgical approaches for early-stage cervical cancer: robotic-assisted surgery using the da Vinci system versus traditional open surgery. Researchers are asking whether the minimally invasive robotic method can match or improve upon open surgery in terms of…

This study tests whether giving heated chemotherapy directly into the abdomen during surgery is safe for women aged 70 and older with advanced ovarian cancer. The treatment, called NIPEC with carboplatin, is delivered at normal body temperature for 90 minutes right after the surg…

This trial investigates whether salsalate, an anti-inflammatory drug, can reduce the elevated risk of cardiovascular disease seen in women with endometriosis. Researchers will measure blood vessel function and markers of inflammation in 24 women with endometriosis compared to hea…

This study tests whether a program of exercise and nutrition counseling helps women with ovarian or endometrial cancer stick with their chemotherapy plan. About 200 women who are about to start chemotherapy will be randomly assigned to either receive weekly coaching sessions on p…

This study investigates whether a special preparation made from umbilical cord blood, called platelet-rich plasma (hUC-PRP), can help thicken the uterine lining in women with Asherman syndrome or thin endometrium. Participants receive a single injection of hUC-PRP into the uterin…

This phase 2 trial investigates whether adding stereotactic body radiotherapy (SBRT) to the PARP inhibitor niraparib can improve control of ovarian cancer that has spread to a limited number of new spots after prior PARP inhibitor therapy. Participants will receive SBRT alone or …

This study tests whether giving two injections of a long-acting hormone (GnRH-a) before standard hormone therapy can improve pregnancy rates in women with deep infiltrating endometriosis undergoing their first frozen embryo transfer. The hormone pretreatment aims to suppress endo…

This trial investigates whether infusing a woman's own platelet-rich plasma (PRP) into her ovaries can improve egg production and hormone levels in those with poor ovarian response to fertility treatments. The study involves 100 women who have had difficulty producing enough eggs…

This study investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can improve egg production and hormone levels. It includes women aged 40 and older who have a poor response to standard fertility treatments. Participants receive either PRP or a p…

This trial investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can restart menstrual cycles and improve hormone levels. It includes 100 women under 40 with premature ovarian failure (early menopause). Participants receive either PRP or a place…

This study tests whether adding a precise local treatment—like focused radiation or ablation—can help people whose cancer has a few new or growing spots while on standard therapy. Participants continue their usual medication while the resistant tumors are treated directly. The go…

This study tests whether injecting a woman's own platelet-rich plasma (PRP) or platelet-free plasma (PFP) into her ovaries can restart menstrual cycles and improve hormone levels. The trial includes 100 women aged 45-55 who have been in menopause for at least a year. Researchers …

This study investigates whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can restart regular menstrual cycles and improve hormone levels. The trial includes perimenopausal women aged 40 and older who have irregular cycles or elevated FSH. Participants r…

This trial tests a new radiation technique for people with abdominal or pelvic tumors. Standard radiation gives the same dose each session, but this approach adjusts the dose daily based on the exact position of the tumor and nearby organs. The goal is to deliver more radiation t…

This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer can improve live birth rates in women with adenomyosis. About 222 participants will be randomly assigned to either the new regimen or standard care. The …

This trial tests whether placing a surgical mesh during abdominal closure can prevent incisional hernias in women undergoing ovarian cancer surgery. It also examines if a negative pressure wound dressing reduces infection risk. Participants are randomly assigned to one of four gr…

This study follows 261 people with persistent, recurrent, or metastatic cervical cancer who are taking pembrolizumab (Keytruda) with or without bevacizumab (Avastin). Some participants may choose to stop pembrolizumab early if their tumor shrinks or disappears, while others conti…

This Phase III trial in sub-Saharan Africa tests whether giving higher doses of rifampicin plus linezolid, along with aspirin, can reduce deaths from tuberculous meningitis (TBM) in both HIV-positive and HIV-negative people. About 768 adolescents and adults will receive either th…

This trial investigates whether using a lab test (IL-6) from amniotic fluid to guide antibiotic and steroid treatment can safely prolong pregnancy in people whose water breaks too early (preterm premature rupture of membranes, or pPROM). Participants are randomly assigned to eith…

This early-stage trial explores whether injecting the immunotherapy drug nivolumab directly into lymph nodes before standard surgery is feasible and safe for people with cervical cancer. The study involves 12 participants and aims to see if this targeted approach can shrink tumor…

This study tests whether a shorter, 3-week course of radiation works as well as the standard 5-week course for women with locally advanced cervical cancer. About 396 women will be randomly assigned to one of the two schedules, both combined with chemotherapy. If the shorter sched…

This study tests a new gel called OCF001 for treating acute yeast infections in women. About 36 women with a confirmed yeast infection will use the gel or a placebo for 7 days. Researchers will check if the infection clears up and if the gel is safe and well-tolerated.

This phase 2 trial is testing a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy before surgery in 103 women with locally advanced cervical cancer. The goal is to see if this approach can shrink tumors enough to allow less extensive…

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This early-phase trial tests a new drug called AVA6103 in 174 people with advanced solid tumors (like pancreatic, stomach, or lung cancer) that have not responded to standard treatments. The drug is designed to activate only inside tumors, potentially killing cancer cells while r…

This study compares a new barbed suture (SYMMCORA) with a standard one (V-Loc) for closing the vaginal cuff after laparoscopic hysterectomy. The goal is to see if the new suture reduces stitching time without increasing complications. About 132 women having elective laparoscopic …

This study looks at two different surgeries for advanced ovarian cancer that has spread to the bowel. One method removes only the tumor from the bowel, while the other removes a piece of the bowel along with the tumor. The goal is to see which approach helps patients live longer …

This study tests a new treatment using specially designed immune cells (CAR-NK cells) that target two cancer markers at once. It is for people with ovarian, peritoneal, or fallopian tube cancer that has come back or not responded to standard treatments. The therapy is personalize…

This phase 2 trial is testing two immunotherapy drugs, durvalumab and tremelimumab, alone or together, in 60 people with colorectal or endometrial cancer. The goal is to see if these drugs can shrink tumors or slow cancer growth. The study focuses on patients with different genet…

This study is testing Bearing nsPVA particles, used during a procedure called uterine artery embolization, to treat uterine fibroids in 100 women. The goal is to see if these particles safely block blood flow to fibroids, reducing symptoms like pain and heavy bleeding. Participan…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This study is for women with advanced ovarian, fallopian tube, or peritoneal cancer whose tumors did not shrink enough with standard chemotherapy. Researchers are testing a new method called PIPAC, which delivers chemotherapy as a pressurized spray directly into the abdomen, comb…

This early-phase trial is testing a new type of cell therapy called p95HER2.CAR-TECH2Me for people with advanced HER2-positive breast, gastric, or endometrial cancers that have spread. The treatment uses a patient's own immune cells, which are modified in a lab to better recogniz…

This phase 3 trial tests whether a new immunotherapy drug (QL1706) combined with bevacizumab can slow cancer growth better than standard chemotherapy in women with advanced ovarian clear cell carcinoma. About 226 participants will be randomly assigned to receive either the experi…

This early-stage trial tests two vaccines designed to help the immune system fight HPV16, a virus linked to cervical cancer. The study includes 30 women with persistent HPV16 infection and mild cervical cell changes (ASC-US or LSIL). Participants receive a DNA vaccine followed by…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This early-stage trial tests a new treatment called EB-DUALNK for adults with ovarian cancer that has come back or not responded to standard therapies. The treatment uses specially designed natural killer (NK) cells that target two markers on cancer cells. After a short course of…

This pilot study tests a conservative management strategy for placenta accreta, a serious pregnancy complication where the placenta grows too deeply into the uterine wall. Instead of the standard treatment—a hysterectomy (removing the uterus) after a C-section—doctors will leave …

This study compares two common surgeries for uterine prolapse (when the womb drops down). About 426 women will be randomly assigned to have either a Manchester procedure or a vaginal hysterectomy. Researchers will track success rates, symptom relief, and quality of life for up to…

This phase II trial is testing whether the immunotherapy drug dostarlimab, alone or combined with bevacizumab, can control recurrent gynecological clear cell carcinoma better than standard chemotherapy. About 198 women with this rare cancer type will be randomly assigned to one o…

This study is testing a new device called PAGETEX that uses light therapy (photodynamic therapy) to treat a rare skin condition called vulvar Paget's disease. The disease often comes back after surgery, so researchers want to see if this light treatment can control it better. Abo…

This phase 2 trial is testing two drugs, abemaciclib and letrozole, in 100 people with rare estrogen receptor-positive ovarian cancers (low grade serous carcinoma or granulosa cell tumors). The goal is to see if the combination can shrink tumors and control the disease. Participa…

Stanford University is testing the da Vinci Xi robot for various surgeries in children aged 6-21. The study will enroll 250 participants to check if the robot is safe and works well. The goal is to see if robotic surgery can be a good option for kids needing procedures like gallb…

This phase 3 trial compares two ways to prepare the womb lining for a frozen embryo transfer: a modified natural cycle using progesterone only, versus standard hormone replacement therapy. The study will enroll 336 women aged 21-44 with regular cycles to see which method leads to…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study is for women with advanced ovarian cancer who have had complete surgery and chemotherapy. It compares two maintenance treatments: niraparib alone versus niraparib plus bevacizumab. The goal is to see which approach better delays cancer progression. About 390 participan…

This early-phase trial is testing a new approach to CAR-T cell therapy for adults with advanced solid tumors that have not responded to standard treatments. The therapy uses a patient's own immune cells, engineered to recognize two cancer-specific targets chosen based on each per…

This study looks at whether proton therapy can safely treat cancers that return after standard radiation. Proton beams are more targeted than traditional X-rays, so they may deliver stronger doses to the tumor while sparing healthy tissue. Researchers will track side effects and …

This study tests if giving chemotherapy as a pressurized mist directly into the abdomen (PIPAC) alongside standard IV chemo can help more women with advanced ovarian cancer have successful tumor-removal surgery. It includes 160 women aged 18-75 with stage IIIB-IIIC disease. The g…

This early-phase study tests a new drug called azenosertib (ZN-c3) combined with standard chemotherapy or bevacizumab in people with ovarian, peritoneal, or fallopian tube cancer that has stopped responding to platinum-based treatment. About 172 participants will receive differen…

This early-stage trial is testing a new treatment called VET3-TGI, a virus designed to infect and destroy cancer cells. It is being given alone or with the immunotherapy drug atezolizumab to 60 people with advanced solid tumors that have not responded to standard treatments. The …

This study tests whether an immunomodulatory drug (rituximab) can improve or normalize ovarian function in women aged 18-38 with autoimmune premature ovarian insufficiency (POI). Participants receive either rituximab or a placebo, and those who respond may undergo IVF. The goal i…

This study tests whether removing tiny cell fragments from day-4 embryos (a procedure called defragmentation) can help them develop into healthy blastocysts and lead to more pregnancies. About 320 women undergoing IVF will be randomly assigned to have their embryos defragmented o…

This study compares a newer, less invasive laparoscopic hysterectomy (with special tumor-free techniques) to the standard open abdominal surgery for stage IB2 cervical cancer. About 524 women will be randomly assigned to one of the two surgeries. The main goal is to see if the la…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This study tests a new treatment using specially engineered natural killer (NK) cells to fight ovarian cancer that has come back or not responded to standard therapies. The treatment is personalized: each participant's tumor is checked for three markers, and they receive NK cells…

This study compares three surgical treatments for endometriomas (ovarian cysts from endometriosis) in 332 women aged 18-43 who want to become pregnant. Participants are randomly assigned to cystectomy, plasma vaporization, or sclerotherapy. The main goal is to see which approach …

This study compares a new surgical technique called transobturator cystocele repair (TOCR) to the standard anterior repair for fixing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. About 592 women aged 50 and older with at least stage 2 pro…

This study tests a new approach for advanced ovarian cancer. Patients take a targeted drug (olaparib) for a week before surgery, then receive heated chemotherapy directly in the abdomen during the operation. The goal is to see if this combination is safe and effective. The trial …

This study tests whether a single, extremely high dose of radiation, guided by advanced MRI technology, can control liver tumors that have spread from other cancers better than the usual high dose. About 114 adults with up to 3 liver metastases will be randomly assigned to receiv…

This study looks at whether giving the 9vHPV (Gardasil-9) vaccine to women who already have HPV16 or 18 can reduce the virus's ability to infect others. Researchers will measure viral activity in cervical, anal, and oral samples before and after vaccination. The goal is to see if…

Researchers at Semmelweis University are building and testing artificial intelligence algorithms that read standardized transvaginal ultrasound images. The study includes women aged 18 to 45 who have suspected endometriosis or adenomyosis, a confirmed uterine mass scheduled for s…

Researchers at University Health Network in Toronto are testing a device called Vagina-View to see if it can clearly show vaginal tumor tissue and help position a brachytherapy applicator during treatment for vaginal cancer. Ten participants with gynecological cancer who are sche…

High-grade serous ovarian cancer is often found too late, and no screening test exists. Researchers are studying whether DNA taken from routine cervical smears can show signs of this cancer early. They use a method called shallow-coverage whole genome sequencing to look for genom…

This study tests whether a smartphone-based AI ultrasound, operated by health workers with minimal training, can accurately estimate gestational age, detect placenta position, and identify fetal presentation in pregnant women in rural Democratic Republic of the Congo. The goal is…

This phase 2 study tests whether a radioactive tracer called [68Ga]BED003 can improve PET/CT scans for detecting cancer in the peritoneum (the lining of the abdomen). The trial includes adults with colorectal, ovarian, gastric, pancreatic, or a type of breast cancer. Researchers …

The ORACLE study watches people who have finished treatment for early-stage solid tumors, such as lung, breast, colon, and pancreatic cancers. Researchers want to see if a blood test called Guardant Reveal can find tiny traces of tumor DNA that might signal the cancer is coming b…

This study explores whether a uterine lavage—a procedure that rinses the fallopian tubes with saline to collect cells—can help detect early genetic changes linked to ovarian cancer in women with BRCA mutations. Participants are high-risk women planning risk-reduction surgery. Res…

Researchers are comparing two ways to assess ovarian cancer risk in people who are cancer-free but may be at higher risk because of family history or genetics. One approach follows standard national guidelines, using family history and sometimes genetic testing. The other uses th…

Preeclampsia is a serious high blood pressure condition that can develop during pregnancy and is a leading cause of death for mothers and babies in Africa. Doctors struggle to predict which women with high blood pressure will become severely ill because current tests are not accu…

This study tests whether taking multiple MRI scans before, during, and after standard radiation therapy can help doctors see how tumors change. Researchers will enroll people with advanced esophageal cancer, glioblastoma, prostate cancer, vulvar cancer, or pediatric glioma. The g…

This trial tests whether a simple blood test can help detect and monitor cervical cancer. Researchers will analyze tiny DNA fragments and particles in the blood, called cell-free DNA and extracellular vesicles, to see if they act as early warning signs. The study involves 100 wom…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This study compares two methods for detecting bacteria in amniotic fluid: standard laboratory cultures and nanopore DNA sequencing. Researchers will collect fluid from pregnant women with a short cervix or preterm rupture of membranes, as well as from healthy pregnant women. The …

This study is collecting vaginal fluid samples from 4,200 people to develop a new test for endometrial cancer. Participants include those with abnormal uterine bleeding or a recent endometrial cancer diagnosis. The goal is to find biomarkers that could lead to a simple, non-invas…

This trial is testing whether a new radioactive tracer, called 68Ga-SorB, can help doctors see certain solid tumors on PET/CT scans. The tracer targets sortilin, a protein that is often found on cancer cells. About 50 adults with melanoma, liver, lung, breast, pancreatic, or ovar…

This study tests a low-cost HPV test that can be done in one visit, so women get results and treatment on the same day. It aims to reduce the number of women lost to follow-up in cervical cancer screening programs. The study will enroll 1,000 women in remote areas of El Salvador.

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This trial tests whether applying vaginal estrogen before a colposcopy helps doctors see the cervix more clearly in women aged 50 and older. As women age, the area where precancerous changes occur can become harder to view, which may lead to missed diagnoses or repeat procedures.…

This study will test a new diagnostic device called the Nanopath assay, which aims to quickly detect bacteria or yeast causing vaginitis. Up to 1000 women with symptoms like itching or discharge will provide vaginal swab samples, either collected by a clinician or themselves. The…

This study evaluates whether an HPV DNA test can more accurately detect pre-cancerous cervical changes than standard Pap smears in 1,500 women in South Africa, including those with and without HIV. Participants undergo HPV testing, followed by colposcopy and biopsy if needed. The…

This trial investigates whether advanced MRI scans can better detect placenta adhesion abnormalities (PAA) in pregnant women between 30 and 38 weeks. PAA occurs when the placenta grows too deeply into the uterine wall, raising risks of severe bleeding and emergency hysterectomy d…

This study looks at whether vaginal fluid can help detect gynaecological cancers early. Researchers will collect samples from 250 women, including those with and without cancer, to compare specific markers. The goal is to develop a non-invasive test that could improve detection a…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findin…

This study follows 20,000 women who take a new saliva test (Endotest) to diagnose endometriosis. Researchers want to see how the test result—positive or negative—affects their quality of life, emotions, and care decisions. Participants fill out questionnaires and share medical da…

This study aims to improve how doctors tell the difference between borderline ovarian tumors and early-stage invasive ovarian cancer before surgery. Researchers will test a panel of nine blood-based biomarkers in 400 women with suspicious ovarian cysts. If successful, this could …

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study is testing whether a simple urine sample can be used instead of a cervical swab to screen for HPV, the virus that causes most cervical cancers. The researchers will collect first-void urine from 350 women aged 30–65 using a special device and compare the results to the…

This study explores whether DNA from routine Pap smears can detect early signs of ovarian cancer in women with high-risk gene mutations. Researchers will compare genetic changes in Pap test samples with tissue removed during preventive surgery. If the method works, it could becom…

This study tests whether ultrasound images of healthy ovaries can predict if a woman carries a harmful BRCA gene mutation, which raises the risk of breast and ovarian cancers. Researchers will develop a computer model using thousands of images from women with known BRCA status. I…

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at changes after surgery. If successful, this could …

This study aims to find a gentler way to detect uterine cancer early in people with abnormal bleeding. Instead of relying only on a biopsy, researchers will use a health questionnaire and a self-collected vaginal swab to look for cancer-related genetic changes and microbiome patt…

This study compares a dye called ICG alone against the standard two-method approach (ICG plus a radioactive tracer) to find cancer in lymph nodes of women with early vulvar cancer. About 58 women will take part. If ICG alone works just as well, it could simplify surgery and reduc…

The SENTRY study is testing whether changes in platelet RNA (a type of genetic material in blood cells) can help diagnose ovarian cancer early. Researchers will collect blood samples from 245 women—those with ovarian masses and healthy volunteers—to see if their new test can accu…

This study is testing whether a self-administered Pap smear is as accurate as the traditional one done by a healthcare provider. Researchers will recruit 250 women in rural Alabama who need routine cervical cancer screening. Each woman will do a self-collected sample right before…

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study is testing whether giving women a simple self-sampling kit to use at home can increase the number of women who get screened for cervical cancer. The trial will enroll 15,000 women in Czech Republic, especially those who haven't had a Pap smear in over 3 years. Particip…

This study is looking at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers will measure L-PGDS levels in vaginal swabs, blood, and urine from 60 women with…

This study tests a new device called the Calla introducer for cervical cancer screening. Researchers want to see if women prefer it over the standard speculum used during Pap smears. About 305 healthy women aged 21-65 will participate. The goal is to improve comfort and screening…

Researchers are testing whether giving the antibiotic zinacef during labor lowers infections for women with meconium-stained amniotic fluid at term and for their newborns. The trial enrolls 182 women with a single full-term pregnancy and meconium in the fluid. Half receive zinace…

Women treated for vulvar high-grade squamous intraepithelial lesion (vHSIL), a precancerous condition linked to HPV, often see it return. This trial tests whether giving the Gardasil 9 HPV vaccine alongside standard treatment (surgery, laser, or imiquimod) can lower that recurren…

Researchers at Florida A&M University are testing whether a virtual educational session led by a lay health advisor, called a promotora, helps Hispanic women who are behind on cervical cancer screening get tested. The trial enrolls about 160 Hispanic women ages 21 to 65 who have …

This trial tests whether placing a special gel inside the uterus after fibroid removal surgery can prevent the formation of scar tissue (adhesions) that may harm fertility. Women aged 18 to 45 who are scheduled for laparoscopic or abdominal myomectomy and have no pre-existing ute…

This study tests whether adding a polygenic risk score (PRS) — a measure based on 313 genetic markers — to the standard CanRisk model can improve breast cancer risk prediction and prevention. About 100 women at increased risk will receive genetic counseling, a blood draw, and the…

This study tests two self-care methods—virtual ear acupressure and Baduanjin qigong—to prevent or reduce period pain in 145 women aged 16–35 with primary dysmenorrhea. Participants will be randomly assigned to one of three groups and practice their assigned technique for 12 weeks…

This study tests whether taking green tea extract (EGCG) and vitamin D3 daily can prevent uterine fibroids from growing back after surgical removal. About 240 women who have had fibroid surgery will receive either the supplements or a placebo. The goal is to see if this simple co…

This study tests whether at-home HPV self-sampling (using urine or a vaginal swab) can help more people get screened for cervical cancer compared to the traditional in-clinic Pap smear. About 735 Latinx individuals aged 30-65 who haven't had a Pap test in at least three years wil…

This study tests whether a general practitioner's encouragement can increase the number of women who get screened for cervical cancer. Over 11,000 women aged 25-65 in France who are behind on screening will be involved. The goal is to see if a simple conversation with their famil…

This study checks how well the HPV vaccine prevents cervical HPV infection in women in Sikkim, India, about 7 years after the vaccine was introduced. Researchers will collect cervical samples from 5,500 married women aged 18-22 and compare infection rates to those before vaccinat…

This study offers free genetic testing to 5,000 women, trans men, and non-binary people with female reproductive organs, regardless of family history. The goal is to find hidden gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smart…

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

When a woman's waters break at term but labour has not started, doctors often use oxytocin to get contractions going. This trial tests whether adding a single intravenous dose of papaverine, a drug that relaxes smooth muscle, helps oxytocin work faster. Two hundred women with ter…

Researchers are testing whether a thin, drug-free patch called the Jovi Patch can reduce menstrual pain and related symptoms. The patch contains conductive micro-metal particles and no medication, wires, or batteries. About 50 pre-menopausal women with moderate to severe menstrua…

This study is testing a precise type of radiation (proton beam) given to the pelvis after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surger…

This study tests if a newer, shorter course of radiation therapy (MH-ART) is as good as the standard longer course (CF-IMRT) for women who have had surgery for cervical or endometrial cancer. The goal is to see if the new approach causes fewer side effects and improves quality of…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

Cancer treatment often leaves patients with a deep, lasting tiredness that few treatments can fix. Researchers are testing whether guarana, a caffeine-rich Amazonian plant, can reduce that fatigue and improve daily life. The study gives 60 people with breast, lung, colorectal, ce…

Researchers are testing whether a quadratus lumborum nerve block reduces pain after laparoscopic myomectomy, a surgery to remove uterine fibroids while keeping the uterus. The block is a temporary anesthetic injection into a lower back muscle. In this double-blind, randomized tri…

This study tests whether ultrasound-guided alcohol sclerotherapy can reduce pelvic pain and improve quality of life in women aged 18-45 with ovarian endometriomas. Participants are randomly assigned to receive the procedure or no treatment (expectant management) and are followed …

Researchers in Taiwan are testing LillyBot, an AI chatbot that provides personalized sexual health education and consultation for women who have had gynecologic cancer. The trial will enroll 90 survivors and compare two versions of the system, one with proactive nurse contact and…

This study tests a new drug called vipoglanstat to see if it can reduce pelvic pain in people with endometriosis. About 190 women aged 18 to 44 with moderate to severe pain will take either the drug or a placebo for four months. The goal is to find a better treatment option for t…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This study will test whether Emotional Freedom Technique (a type of tapping) and music therapy can reduce stress, anxiety, and depression in women with a high-risk pregnancy due to early rupture of membranes. About 177 women will be randomly assigned to receive these therapies or…

Researchers at Mount Sinai are testing whether a reinforcement learning system can deliver personalized daily exercise recommendations to people with chronic pelvic pain. The study enrolls 45 adults who receive alternating standard and AI-generated exercise advice over four two-w…

This trial tests whether preparing the cervix with medication before office hysteroscopy helps postmenopausal women have a more successful and less painful procedure. Participants are randomly assigned to receive either oral misoprostol, vaginal estrogen for 7 or 14 days, or no p…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce fear of cancer returning in 20 women with early-stage breast or ovarian cancer who are currently in remission. Participants receive a moderately high d…

This study looks at possible eye-related side effects in people with cervical cancer that has returned or spread, who are being treated with the drug TIVDAK. About 100 participants will receive TIVDAK every 3 weeks and undergo regular eye exams before, during, and after treatment…

This study tests whether taking a short chain fatty acid supplement can reduce gut-related side effects in people receiving radiation therapy for cancers in the abdomen or pelvis. About 122 adults will be randomly assigned to receive either the supplement or a placebo. The goal i…

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can help women who have trouble urinating after surgery for cervical cancer. About 208 participants will receive either real or fake electroacupuncture alongside standard care. The ma…

This trial tests a program that screens cancer survivors for fear of recurrence and refers those who need help to psychological services. The program is being rolled out in cancer clinics in Hong Kong, with nurses trained to identify at-risk patients. Researchers will measure how…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests whether the drug misoprostol, given before a cervical exam, can help doctors see the cervix more clearly. 420 women with a hard-to-examine cervix (called Type 3 transformation zone) will receive either misoprostol or a placebo. The goal is to see if the drug make…

This trial tests whether an acupressure band with vaccaria seeds, worn on the lower leg, can reduce menstrual pain in college students with primary dysmenorrhea. Thirty participants will be randomly assigned to either the active band or a control band without seeds, and they will…

This trial tests a stepped-care program to help cancer survivors manage fear of their cancer returning. The program starts with an online intervention called eConquerFear, which teaches strategies to control worry and accept uncertainty. If needed, participants receive additional…

This trial tests whether a three-day low-residue diet and deeper muscle relaxation, alone or together, can improve the surgical view during vNOTES hysterectomy (a scarless procedure through the vagina). The study involves 160 women having hysterectomy for non-cancer conditions. R…

This trial investigates whether a minimally invasive procedure called endovascular embolization can relieve chronic pelvic pain in women with pelvic congestion syndrome. The study will enroll 30 women who have had pelvic pain for more than six months and have imaging evidence of …

This trial tests whether a custom-formulated, high-CBD hemp product can reduce pain in women with endometriosis, adenomyosis, or chronic pelvic inflammatory disease. Over 7 days, participants receive either the CBD product or a placebo. Researchers will measure how the body proce…

This trial tests whether a 10-session group program called Social Management Training can improve mental health, executive function, and social skills in adults aged 16 to 69 who have sex chromosome aneuploidies (extra or missing sex chromosomes). Participants complete questionna…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests whether a specialized kit helps women with endometriosis manage pain during sex. The kit includes a guidebook, a tracking app, a TENS device, lubricants, and supplements. One hundred women aged 18 to 45 with confirmed endometriosis and sexual pain will either use…

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study looks at whether low-intensity shock wave therapy can help women with vulvodynia, a chronic pain condition of the vulva. Researchers will review medical records from 50 women who already received four sessions of this non-invasive treatment in routine care. They want t…

This study tests whether taking omega-3 fish oil capsules and doing simple resistance exercises with elastic bands can help cancer patients maintain muscle mass and strength. It involves 288 adults with various cancers who are at risk of muscle wasting. The goal is to improve phy…

This study tests a new program called EASE, which uses a simple writing exercise to help adults with advanced cancer manage their fear of the future and related trauma symptoms. The study will include 250 people with advanced solid tumors, glioblastoma, or certain ovarian or lung…

This study tests whether infusing platelet-rich plasma (PRP) into the uterus can thicken the uterine lining and improve pregnancy success in women with infertility who have had failed IVF cycles due to a thin lining. About 62 women will receive either PRP or a placebo during a fr…

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study is testing whether a shorter course of pelvic radiation after surgery works as well as the standard longer schedule for people with cervical or endometrial cancer. The shorter schedule means fewer hospital visits and less time in treatment. About 120 participants will …

This study tests a new surgical technique called intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) for treating bowel endometriosis. Researchers will compare it to standard laparoscopic surgery in 192 women aged 18-55. The goal is to see if the new method leads to bette…

This study looks at whether whole-body vibration exercises combined with relaxation techniques can help adolescent female athletes who have Female Athlete Triad Syndrome—a condition involving low bone density, irregular periods, and low energy. About 50 participants will follow a…

This study is testing whether a low-FODMAP diet can reduce pain and improve quality of life in women with endometriosis who also have gut symptoms like bloating and nausea. Researchers will compare the diet to standard care in 150 women aged 18-45. The goal is to see if changing …

This study tests whether Reiki therapy can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers. 70 participants will either receive Reiki or standard care during their treatment. Researchers will measure changes in anxiety, pain, and mood using quest…

This study tests whether physiotherapy and a special light therapy (photobiomodulation) can reduce pain in women with provoked vestibulodynia, a condition that causes pain during intercourse or tampon use. About 240 Canadian women will receive one of four treatments: light therap…

This study tests if a special type of acupuncture (on the tongue area) can reduce taste problems caused by chemotherapy in people with gynecologic cancers. 75 participants will be randomly assigned to real acupuncture, fake acupuncture, or standard dietary advice. The goal is to …

This study tests a coaching program called POSTCARE-O for women with ovarian cancer who have finished their initial treatment. The program provides support during the transition to survivorship, focusing on quality of life and emotional well-being. 120 women will be randomly assi…

This study tests a 4-week online cognitive-behavioral therapy (CBT) program for women with BRCA1/2 mutations who have finished cancer treatment and still worry a lot about cancer coming back. Researchers will compare those who get therapy right away to those on a waitlist, measur…

This study looks at whether a smartphone app with daily mindfulness exercises can help reduce anxiety and improve quality of life for women undergoing IVF. About 150 women will either use the app for 15 minutes a day or receive standard care. Researchers will measure anxiety, dep…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study tests whether a program of exercise, nutrition advice, and mental support before surgery helps gynecological cancer patients recover faster and feel better. About 64 women with ovarian or endometrial cancer will be randomly assigned to either standard care or the preha…

This study tests whether taking Gushen Antai pills, a blend of 10 herbs, can increase the chance of an ongoing pregnancy (past 12 weeks) in women with normal ovarian reserve who are undergoing IVF. 800 women will be randomly assigned to receive either the herbal pill or a placebo…

This study tests a new way of giving radiation for cervical cancer. Instead of using the same plan for weeks, an AI adjusts the radiation daily based on the tumor's position, and weekly MRI scans help guide it. The goal is to reduce side effects like bladder and bowel problems. A…

Researchers at the University of New Mexico collect ascites fluid, the liquid that builds up in the abdomen, from women undergoing surgery for ovarian cancer. They study this fluid and tumor tissue in the lab to learn how the tumor environment helps cancer spread within the perit…

This large screening trial enrolls up to 2,900 people with advanced solid tumors that have spread or not responded to standard treatment. Researchers use genetic tests on tumor samples to find specific mutations, then assign patients to treatment trials testing drug combinations …

This study collects and stores ovarian tissue from females aged 4 to 35 who choose to freeze a sample before cancer treatment that could harm their fertility. Researchers will also gather medical data and annual surveys for up to 30 years. The goal is to build a national database…

This study follows people with a rare genetic condition called DICER1 syndrome, which raises the risk of certain childhood cancers like pleuropulmonary blastoma. Researchers will collect medical histories, genetic samples, and tissue from up to 1,500 participants and their relati…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

Researchers at the University of California, San Francisco, are comparing two ways to prepare sperm before intrauterine insemination (IUI). One method uses a microfluidic device called Zymot Multi to sort sperm, while the other uses density gradient centrifugation, a standard lab…

This study is creating a European registry for people with idiopathic granulomatous mastitis (IGM), a rare inflammatory breast condition that causes pain, redness, and abscesses. Researchers will collect information from 1,000 participants to better understand symptoms, treatment…

This study tracks 125 cancer patients receiving standard chemotherapy and radiation to understand why they feel tired. Researchers will collect blood, stool, and survey data before, during, and after treatment. The goal is to find patterns that could help predict and manage fatig…

This study looks at whether removing only a few key lymph nodes (sentinel node biopsy) is better than removing no nodes at all in women with early-stage endometrial cancer. The goal is to see if this approach helps women return to normal activities faster and does not increase th…

This study looks at how well different labs agree when testing for a protein called FRa in stored tumor samples from women with ovarian cancer. About 1,000 women's archived tissue will be tested, but no new treatments or visits are needed. The goal is to improve consistency of FR…

This study is creating a registry of 750 people with a rare and aggressive form of cervical cancer called neuroendocrine carcinoma. Researchers will collect information from medical records to learn more about the disease, how it is treated, and what happens to patients over time…

This study looks at whether preserving the left colic artery during colon or rectal cancer surgery helps keep the remaining colon well-supplied with blood. Surgeons will temporarily clamp the main artery and use a green dye to measure blood flow. The goal is to see if this techni…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

Researchers are studying atypical endometriosis, a form of the condition whose cells look unusual under the microscope and may sometimes precede ovarian cancer. The study enrolls about 200 adults scheduled for endometriosis surgery or surgery for suspected ovarian or endometrial …

This study is testing whether a blood test that looks for tiny bits of tumor DNA (called ctDNA) can help doctors decide who needs extra treatment after ovarian cancer surgery. Researchers will analyze stored blood samples from 50 patients taken before and after surgery. The goal …

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study looks at whether a blue dye injected into the ovary can help doctors find the first lymph node where cancer might spread, instead of removing many lymph nodes. The goal is to see if this less invasive method works as well as standard surgery for early-stage ovarian can…

This study is observing how well robotic-assisted surgery works for women with gynecological conditions. It will follow 1,250 participants in Germany for up to 12 months after surgery to track complications, recovery, and patient-reported outcomes. The goal is to gather real-worl…

This study looks at how non-food-related stressors (like work or emotional stress) affect menstrual health in pre-menopausal women. Researchers will measure stress hormones and sex hormones in 600 women over 6 months. The goal is to understand if stress directly causes menstrual …

Researchers at Lille University are following 350 people, including cancer patients recently diagnosed with breast, gynecological, testicular or digestive cancer, their caregivers, and healthcare professionals. Over one year, participants answer questionnaires about post-traumati…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This observational study in Vietnam looks at archived tumor samples from patients with several solid cancers, including liver, colorectal, gastric, breast, lung, endometrial, melanoma, and pancreatic cancer. Researchers will measure the presence of two proteins, ENPP1/cGAS and FA…

This study looks at the genetic makeup of advanced endometrial cancer in 500 women in Russia. Researchers will test tumor samples for specific gene changes to see how common they are and what treatments patients receive. The goal is to gather information, not to test a new treatm…

This observational study will follow 45 women with primary ovarian insufficiency (POI)—a condition that causes early menopause—who are starting estrogen replacement therapy. Researchers will measure heart health markers before and after 6 months of treatment and compare them to h…

This study uses ultrasound to measure muscle, fat, and fluid changes in 121 critically ill pregnant or gynecological patients in the ICU. The goal is to see if these body composition changes are linked to serious outcomes like death, need for a breathing machine, or longer hospit…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

This study will test tumor samples from 350 adults with gynecological cancers (endometrial, ovarian, cervical, vulvar, and vaginal) to see how often they have high levels of the HER2 protein. Researchers will use two standard lab tests to measure HER2. The goal is to learn how co…

This study explores whether people with Lynch syndrome can use a self-collected vaginal swab at home to detect early signs of uterine cancer. Researchers will enroll 30 participants who will collect samples and answer surveys. The main goal is to see if this approach is practical…

This study collects discarded ovarian tissue from girls aged 0 to 18 who are having surgery on their ovary for conditions like cysts or torsion. Researchers will examine the tissue to count follicles at different stages and compare them across ages and conditions. The goal is to …

Researchers in Ethiopia are studying whether tuberculosis infection changes how the placenta develops and works. They will enroll 500 pregnant women at delivery clinics and use a blood test to identify those with TB infection. The team will compare placental tissue and infant out…

This observational study will look at how ovarian cancer is currently treated in Brazil, including surgeries, chemotherapy, and genetic testing. Researchers will collect data from 250 patients to find what is working well and what needs improvement. The goal is to use these insig…

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study aims to collect blood, urine, tumor samples, and health data from up to 1,000 people with malignant mesothelioma or other cancers that express a protein called mesothelin. Participants will be followed over time to track the course of their disease. The goal is to buil…

This study collects blood or cheek swab samples from 1,100 cancer patients at the National Cancer Institute to analyze genetic differences that may influence how their bodies process cancer treatments. The goal is to understand why some patients experience more side effects or le…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This study looks at women who had surgery for deep endometriosis affecting the ureters, the tubes that carry urine from the kidneys to the bladder. The goal is to see how their kidney function and blood pressure fare years after the operation, and whether the type of surgery matt…

This study looks at whether vitamin D levels in the blood and cervical fluid before treatment can predict how well chemoradiotherapy works for locally advanced cervical cancer. Researchers will measure vitamin D in 100 women undergoing standard treatment and track their response …

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study follows 1,500 women with mullerian anomalies — differences in the shape or structure of the uterus, cervix, or vagina. Researchers aim to learn how these variations affect fertility, pregnancy, and the success of surgical treatments. The goal is to improve diagnosis an…

This study aims to understand the challenges women with endometriosis face when trying to access pelvic health physiotherapy in Quebec. Researchers will interview patients, survey physiotherapists, and hold group discussions with patients and healthcare providers. The goal is to …

This study examines whether concentrating ovarian cancer surgery in specialized centers and changes in treatment during the COVID-19 pandemic affect how long patients live without their cancer returning. Researchers will follow about 200 women diagnosed with epithelial ovarian ca…

This study looks at how deeply argon beam coagulation (a tool that uses ionized gas to seal tissue) penetrates the ovary during laparoscopic surgery for ovarian endometriomas. Researchers will apply the technique to the cyst surface before removing it, then examine the tissue und…

This study looks at how surgery for severe deep endometriosis impacts a woman's egg supply, measured by a hormone called AMH. Researchers will follow 100 women aged 18 to 39 for 12 months after surgery. The goal is to see if the procedure lowers AMH levels, which could help guide…

This study looks at whether it is safe for women with endometrial cancer to fast overnight before their surgery. Many women with this cancer have high blood sugar and inflammation, which may help the cancer grow. The study will check if fasting is doable and liked by patients, an…

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete …

This study looks at how common menstrual cycle symptoms—like pain, mood changes, and bleeding patterns—relate to physical and mental health in Spanish women aged 18 to 45 who have natural periods. Researchers will use questionnaires and urine ovulation tests to track symptoms and…

This study investigates why some advanced or recurrent endometrial cancers respond to immunotherapy while others do not. Researchers will collect tumor samples from 510 patients before they start immunotherapy and use lab-grown tumor models to study molecular and genetic features…

This study looks at the bacteria living in the mouth, stool, and tumors of Colombian adults with advanced cancers of the stomach, colon, breast, cervix, or head and neck who are starting immunotherapy as standard care. Researchers will compare these microbial profiles to those of…

This study follows thousands of very low birth-weight and premature infants to track their development over time. Researchers collect data on pregnancy, birth, and early childhood outcomes to identify factors that influence brain and body development. No treatments are tested—thi…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study explores whether a blood test that detects circulating tumor DNA (ctDNA) can help doctors personalize treatment for people with five types of advanced cancer: non-small cell lung cancer, gastrointestinal stromal tumors, colorectal cancer, biliary tract cancer, and ovar…

This study is looking at 135 women with and without endometriosis to understand how hormones, environmental chemicals, and vaginal bacteria differ between the groups. Researchers hope to find patterns that could lead to faster diagnosis and better treatments. Participants give bl…

This observational registry is gathering data from 500 adults whose gynecologic cancer has returned after prior radiation therapy. Doctors are using reirradiation or other ablative strategies as part of standard care, and the registry will track how well these treatments control …

This study looks at whether tracking FSH levels during ovarian stimulation can help predict how many eggs a woman will produce. Researchers will monitor 150 women undergoing IVF to find the ideal FSH range for better outcomes. The goal is to tailor hormone doses to each patient, …

This study is looking at 180 women with advanced cervical cancer who were treated with radiation and chemotherapy. Researchers want to see if high levels of certain proteins (called IAPs) in the original tumor biopsy can predict whether the cancer will come back within two years.…

This study is observing 300 women with female sexual organs who are receiving radiotherapy for certain cancers. Researchers want to understand why some patients have more sexual side effects than others. They will track sexual quality of life and look at radiation doses to find p…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study follows women aged 18 to 44 who are trying to conceive at a fertility clinic. Researchers want to learn how lifestyle habits like sleep, nutrition, and physical activity before pregnancy affect the chances of having a baby. Participants will be followed for up to 25 ye…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study aims to better understand pre-eclampsia and intrauterine growth restriction (IUGR), serious pregnancy complications affecting about 9% of pregnancies. Researchers will collect placenta, blood, and urine samples from 500 pregnant women—both with and without these condit…

This study tests an online training program designed to help primary health care workers in Brazil give better advice on physical activity and reducing sedentary time. Over 3,300 health professionals will take the self-paced course and have their counseling skills measured before…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study follows 1080 women diagnosed with premature ovarian insufficiency (POI) before age 40. Researchers will track their health over time, including bone density, hormone levels, and mental well-being. The goal is to identify risk factors and understand how POI affects over…

This study looks at whether a family history screening program can help more women in rural public health clinics get tested for genetic risks linked to breast and ovarian cancer. About 3,200 women over age 25 will take part. The goal is to see if the program increases the number…

This pilot study is testing whether a 7-day integrative oncology retreat called 'Via Shalva' is practical and helpful for women who have finished primary treatment for breast or gynecologic cancer. Thirty participants will either attend the retreat or receive usual follow-up care…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study listens to 150 people with endometriosis across Europe to understand how they manage their condition every day. Researchers want to learn what makes people feel empowered or abandoned by their support systems. Participants will share their stories through diaries, inte…

This study aims to validate a gene test that identifies oxygen-starved (hypoxic) tumours in bladder and prostate cancer patients. About 30 participants will provide tumour samples and blood, and some will have MRI scans. The goal is to see if this test can help doctors choose mor…

This pilot study tests whether an AI-based system can help doctors better manage fluids and blood pressure during complex ovarian cancer surgery. The system uses special software to guide fluid infusions and predict drops in blood pressure. The goal is to reduce complications lik…

This study is for people with advanced cancers who are taking long-term targeted treatments. Researchers want to learn about their experiences through interviews. The goal is to find better ways to support these patients. The study is currently recruiting 75 participants.

This study looks at how brain chemicals called neuroactive steroids change across the menstrual cycle in women with Premenstrual Dysphoric Disorder (PMDD) compared to healthy women. It also tests whether a low-dose antidepressant (sertraline) affects these chemical levels. The go…

This study compares two types of uterine incisions (high vs low) during a first cesarean section to see which leads to fewer scar defects. 168 pregnant women having their first C-section will be randomly assigned to one of four groups, combining incision type with a stitching tec…

This trial is testing whether using a uterine manipulator during minimally invasive hysterectomy for endometrial cancer affects the chance of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surgery with or without the de…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study is collecting information from 30 patients with an extremely rare ovarian cancer called primary ovarian leiomyosarcoma. Researchers will look at past and new cases to find patterns in how the cancer is diagnosed and treated. The goal is to create better guidelines for …

This study takes tumor samples from people with triple-negative breast cancer, colorectal cancer, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to provide person…

This study looks at how common and severe menopause-like symptoms (like vaginal dryness and pain) are in breast cancer survivors compared to healthy women. Researchers will ask 264 women to fill out questionnaires about their symptoms, quality of life, and mental health. The goal…

This study looks at how exercising without eating beforehand (fasted) might change menstrual hormones and cycle length in women who regularly run or cycle. Over about 3 months, 64 participants will track their cycles, complete three 90-minute exercise sessions either fed or faste…

This study looks at how well different fluids (albumin and Ringer's solution) increase blood volume during laparoscopic surgery. About 60 adults having abdominal surgery will receive one of three fluid types. The goal is to see which fluid keeps the heart and blood vessels workin…

This study aims to gather and analyze detailed medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients stay free of the disease and how long they live overa…

This study is testing whether regular patient surveys and a special blood test (circulating tumor DNA) can spot vulva cancer returning earlier than standard check-ups. About 295 women with vulva cancer will fill out symptom surveys every four months and give blood samples for two…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study follows 200 women with gynecologic cancer and their partners to see how sexual function changes over time. Researchers use questionnaires at diagnosis, 6 months, and 12 months after treatment. The goal is to understand when sexual counseling might be most helpful, with…

This study is looking at how the immune system responds to breast and ovarian cancers. Researchers will analyze tumor and blood samples from 160 women before surgery to understand immune cell activity and find markers that might predict survival. The goal is to learn more about h…

This study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find cl…

This study tests whether an artificial intelligence program called STIMAI® can help choose the best day to give the final 'trigger' shot in IVF, compared to doctors making the decision alone. About 644 women undergoing ovarian stimulation for IVF will be randomly assigned to eith…

This study looks at whether an interactive video program, combined with help from a community health worker, can increase cervical cancer screening among African American women who are overdue for a test. About 288 women will take part, completing two phone surveys and having the…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…

This study looks at 50 patients with ovarian cancer that has come back quickly (within 6 months). Researchers will track their health and survival to learn more about who responds best to treatment. The goal is to improve how doctors classify and care for these patients.

This study uses a special contrast dye (SonoVue) during ultrasound to look at blood flow in the placenta of pregnant women with fetal growth restriction. The goal is to better understand how the placenta works when the baby is not growing well. Thirty women who have already decid…

This study looks at 371 people with advanced ovarian, peritoneal, or fallopian tube cancer to find out what factors—like age, tumor type, and genetics—are linked to how long they live. Researchers will collect medical data and blood samples over two years. The goal is to build a …

This study tests whether artificial intelligence can help more women in Occitanie, France, complete cervical cancer screening. About 3,000 women aged 30-65 who haven't been screened recently will be invited to use a self-sampling kit. The goal is to see if AI-assisted decision-ma…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study aims to better understand cervical mucus and find biological markers that could help diagnose or predict reproductive problems like infertility. Researchers will use infrared spectroscopy to analyze mucus samples from 24 women—some healthy and some with unexplained inf…

This study looks at whether testing for HPV DNA from a cervical swab or a blood sample can help find cervical cancer that has come back after radiotherapy. Researchers will follow 120 patients for two years after treatment, collecting samples at regular visits. The goal is to see…

This study collects tumor, fluid, blood, and other samples from 350 ovarian cancer patients to find biological markers that predict how the disease will respond to treatment. Researchers will analyze genetic changes before and after therapy to understand why some cancers become r…

This study follows 200 women aged 20-50 with adenomyosis, a condition causing pelvic pain and heavy bleeding. Researchers will observe which treatments doctors prescribe and how well they work over 12 months. The goal is to understand current medical practices and help develop be…

This study is a large registry that collects information on very low birth weight infants (weighing 401-1000 grams or born before 29 weeks) at multiple hospitals. Researchers track the babies' health, treatments, and outcomes to find patterns and improve future care. No experimen…

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study is looking for better ways to predict who might develop or have a return of certain cancers, including breast, colon, ovarian, melanoma, and lung cancer. Researchers will collect blood samples from 850 participants to study genetic and other biological markers. The goa…

This study looks at whether a special PET scan and a blood test for HPV can detect any remaining cervical cancer cells after standard chemoradiation. About 64 people with cervical cancer will be followed after their usual treatment. The goal is to see if these tests can predict i…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study looks at whether MRI scans can help doctors predict which women with endometriosis will benefit from the drug dienogest. Researchers will follow 48 women aged 19-45 who are starting dienogest for the first time. By comparing MRI images before treatment with changes in …

This study follows 1,000 women newly diagnosed with epithelial ovarian cancer to see how their genetic makeup (BRCA and HRD status) influences their response to standard treatments. Researchers will track surgery outcomes, treatment response, and survival. The goal is to gather r…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions regress on their own or after surgery. Researchers will track HPV and Pap test results to identify factors that predict healing. The goal is to create a model that h…