Prolapse of female genital organ

This study tests whether injecting poly-L-lactic acid (PLLA), a substance already used in cosmetic treatments, into the vaginal wall can safely and effectively treat cystocele (a type of pelvic organ prolapse). Twenty women with stage 2 cystocele will receive either PLLA or a pla…

This trial tests a new surgical mesh implant, called LatGYNious, used in a keyhole procedure to repair pelvic organ prolapse — a condition where pelvic organs drop from their normal position. The study will enroll about 85 women who need surgery for prolapse and will measure whet…

This study looks at women who had surgery to repair a cystocele — a type of pelvic organ prolapse where the bladder bulges into the vagina — using a special mesh coated with collagen. The goal is to see whether the repair holds up well and remains safe more than five years after …

This study compares a new barbed suture (SYMMCORA) with a standard one (V-Loc) for closing the vaginal cuff after laparoscopic hysterectomy. The goal is to see if the new suture reduces stitching time without increasing complications. About 132 women having elective laparoscopic …

This study compares two laparoscopic surgeries for apical prolapse, a common condition in aging women. The standard surgery, sacrocolpopexy, is effective but technically challenging. The newer pectopexy may be safer and faster to learn. Thirty women with advanced prolapse will be…

This study compares two common surgeries for uterine prolapse (when the womb drops down). About 426 women will be randomly assigned to have either a Manchester procedure or a vaginal hysterectomy. Researchers will track success rates, symptom relief, and quality of life for up to…

This study compares a new surgical technique called transobturator cystocele repair (TOCR) to the standard anterior repair for fixing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. About 592 women aged 50 and older with at least stage 2 pro…

This study tests whether a new biological mesh (OviTex) works better than the standard synthetic mesh for women having robotic surgery for pelvic organ prolapse. About 184 participants will be followed to compare complications and symptom relief. The goal is to find a safer and m…

This study tests two surgical techniques to fix vulvovaginal gaping, a condition that can cause discomfort and sexual problems. One hundred women with genital prolapse will be randomly assigned to either a newer muscle-plication surgery or a standard repair. The goal is to see wh…

This study is testing a device called Anchorsure, used during surgery to fix pelvic organ prolapse (when organs like the uterus or bladder slip down). The device is meant to make the surgery faster, with less pain and fewer nerve injuries. Researchers will follow 120 women for 3 …

This study compares two laparoscopic surgeries—lateral suspension and sacrocolpopexy—for women with vaginal cuff prolapse after hysterectomy. Fifty women will be randomly assigned to one surgery, and researchers will track recurrence, complications, recovery, and satisfaction. Th…

This trial tests whether a three-day low-residue diet and deeper muscle relaxation, alone or together, can improve the surgical view during vNOTES hysterectomy (a scarless procedure through the vagina). The study involves 160 women having hysterectomy for non-cancer conditions. R…

This study looks at whether combining two types of pelvic floor exercises—functional movement retraining and hypopressive exercises—can reduce pain, improve bladder and bowel symptoms, and boost quality of life in women with mild uterine prolapse. Thirty-two women aged 30-60 with…

This study tests whether injecting the local anesthetic bupivacaine into the small surgical cuts and the vaginal cuff at the end of a laparoscopic hysterectomy can lower postoperative pain. 120 women having the surgery for non-cancer reasons will be randomly assigned to receive t…

This study compares two surgical methods (through the anus or through the vagina) to treat a condition called rectocele, where the wall between the rectum and vagina weakens, causing constipation and difficulty passing stool. About 62 women who have not improved with other treatm…

This study compares two types of laparoscopic pectopexy surgery for women with pelvic organ prolapse after hysterectomy. One method uses a mesh to support the vagina, while the other does not. The goal is to see which approach leads to fewer relapses and better quality of life, w…

This study looks at how blood clots form and break down in women after surgery for uterine prolapse or urine incontinence. Researchers will measure clot properties and thrombin generation in 60 women aged 18-70 who did not improve with medication. The goal is to better understand…