Does exercising on an empty tank mess with your period?
NCT ID NCT06471582
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how exercising without eating beforehand (fasted) might change menstrual hormones and cycle length in women who regularly run or cycle. Over about 3 months, 64 participants will track their cycles, complete three 90-minute exercise sessions either fed or fasted, and provide saliva samples. The goal is to understand how energy timing affects reproductive health, not to test a treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 64 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2024
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * participates in structured running or cycling exercise for at least 30 minutes on 3 or more days per week * accustomed to exercising for 90 minutes or more * has regular periods every 21-35 days * have not taken hormonal contraceptives for at least the past 6 months * is not currently or trying to become pregnant or breastfeeding, and has not been pregnant or breastfeeding in the past 12 months * does not currently have a diagnosis of a major menstrual cycle disorder (i.e., amenorrhea, polycystic ovary syndrome \[PCOS\], endometriosis, ovarian cancer, ovarian insufficiency, uterine or endometrial cancer) * does not currently have a metabolic disease (i.e., hypothyroidism, hyperthyroidism, Cushing disease, Addison's disease, diabetes, congenital adrenal hyperplasia) * does not currently have a major cardiovascular or respiratory disease Exclusion Criteria: * miss more than 7 consecutive days of aerobic activity (i.e., running, cycling, cross training) * demonstrate clinical low energy availability as defined as energy availability \<30 kcal/kg fat free mass * report menstrual cycle lengths \<21 or \>35 days in the first 2 months of at-home monitoring * do not demonstrate an anticipated rise in luteinizing hormone and progesterone in the first 2 months of at-home monitoring * begin taking a hormonal contraceptive * become pregnant * are diagnosed with a menstrual cycle disorder (i.e., amenorrhea, polycystic ovary syndrome \[PCOS\], endometriosis, ovarian cancer, ovarian insufficiency, uterine, or endometrial cancer) * are diagnosed with a metabolic disease (i.e., hypothyroidism, hyperthyroidism, Cushing disease, Addison's disease, diabetes) * are diagnosed with a major cardiovascular or respiratory disease * are unable to follow instructions for any of the procedures
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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Contacts and locations
Locations
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William J. Hybl Sports Medicine and Performance Center
RECRUITINGColorado Springs, Colorado, 80918, United States
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