Mammary-digital-nail syndrome

MONDO:0013368

Mammary-digital-nail syndrome is a syndromic limb malformation characterized by congenital onychodystrophy/anonychia, brachydactyly of the fifth finger, digitalization of the thumbs, with absence or hypoplasia of the distal phalanges of the hands and feet in association with juvenile hypertrophy of the breast with gigantomastia in peripubertal females.

Also known as: MDN syndrome, mammary-digital-nail syndrome, onycho-digito-mammary syndrome, MDNS

1 clinical trial for this condition and its sub-types, 0 tagged with Mammary-digital-nail syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary disease (18187) ↑ Female reproductive system disorder (3567) ↑ Dysostosis (85) ↑ Congenital limb malformation (61)

Including sub-types (1) Tagged with Mammary-digital-nail syndrome (0)

Completed 1

Kids test new bionic foot design

Knowledge-focused Completed

This study tested a new prosthetic foot for children with leg amputations or birth defects. Thirteen kids walked with the device and gave feedback on stiffness and performance. The goal was to gather ideas to improve future foot designs.

Sponsor: Össur Iceland ehf • Aim: Knowledge-focused

Last updated Jun 27, 2026 14:00 UTC

Mammary-digital-nail syndrome

Where it sits in the disease tree

Kids test new bionic foot design