Brain disorder

This study tests two new mRNA vaccines (GBP560) against Japanese encephalitis, a virus that can cause brain swelling. About 402 healthy adults will receive different doses of the vaccine or a comparison vaccine. Researchers will monitor safety and measure immune responses to find…

Researchers compare two versions of a mesh stent used to treat unruptured brain aneurysms. One version has a special coating and is paired with a single blood-thinning drug; the other is the standard device paired with two blood-thinning drugs. The trial measures tiny brain lesio…

Researchers test whether fecal microbiota transplantation delivered by oral capsules can help cirrhosis patients whose hepatic encephalopathy no longer responds to standard lactulose and rifaximin. The trial enrolls 33 adults with cirrhosis and persistent or recurrent hepatic enc…

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This trial is testing whether regular, short periods of sunlight exposure can increase vitamin D levels in children aged 1-5 with cerebral palsy. Half the children will get 10 minutes of sun three times a week for 8 weeks, while the other half continues their usual routine. The s…

This study compares video-based nurse consultations to standard in-person visits for people who recently had a stroke. About 196 participants will be randomly assigned to either telecare or face-to-face follow-up. The goal is to see if remote care can maintain or improve disabili…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This phase 3 trial is testing the safety and tolerability of fenfluramine (Fintepla) in 25 infants aged 1 to 2 years with Dravet syndrome, a severe form of epilepsy. The drug is given as an oral solution twice daily alongside other seizure medications. Researchers will monitor he…

This study tests a combination of laser heat therapy (LITT) and the immunotherapy drug pembrolizumab in 32 adults with recurrent glioblastoma, an aggressive brain cancer. The laser heats and destroys hard-to-reach tumors, while pembrolizumab helps the immune system fight cancer c…

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

Researchers compare two ways of managing blood flow during carotid endarterectomy, a surgery that clears plaque from the neck artery to prevent stroke. One group receives a shunt routinely, while the other gets a shunt only when a pressure measurement suggests it is needed. The t…

Researchers are testing whether adding AGuIX, a gadolinium-based nanoparticle, to whole brain radiation therapy improves how well brain metastases shrink in adults whose cancer has spread to the brain. Participants receive standard whole brain radiation, and some also receive thr…

This study tests different ways to bring mental health treatment into methadone clinics in Ukraine. 1,350 patients from 12 clinics are taking part. Some clinics get extra training and financial rewards to help screen and treat depression. The goal is to see if these strategies im…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

Researchers are testing whether adding brain radiotherapy to PD-1/PD-L1 inhibitors and chemotherapy helps people with untreated stage IV non-small cell lung cancer that has spread to the brain. The trial enrolls about 40 adults whose tumors lack common driver mutations and whose …

Acromegaly is a rare condition where the pituitary gland makes too much growth hormone, causing bones and tissues to enlarge. Researchers are testing a long-acting octreotide injection called SYHX2008 in 78 adults with active acromegaly. Participants receive either the new inject…

Researchers are studying a once-weekly tablet form of brexpiprazole, an antipsychotic drug, in adults with schizophrenia. The trial follows about 247 participants for 52 weeks to see how well they tolerate the medicine and whether it remains safe over the long term. Everyone in t…

This study tested whether giving the cholesterol-lowering drug evolocumab within 24 hours after clot-busting treatment (thrombolysis) can prevent early neurological decline in people with acute ischemic stroke. 132 participants were randomly assigned to receive evolocumab plus st…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This study tested a noninvasive brain stimulation technique (transcranial random noise stimulation) to see if it could reduce cravings in 225 adults with substance use disorder plus another psychiatric condition like ADHD, bipolar disorder, or schizophrenia. The approach targeted…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

This study tested a special program to help people with both bipolar disorder and substance use problems stick to their treatment after leaving the hospital. 178 adults were split into two groups: one received extra counseling and support, while the other got enhanced safety moni…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This study follows adults in the United States who were prescribed zuranolone for postpartum depression (PPD) after giving birth. Researchers will track symptom changes using a standard questionnaire called the Edinburgh Postnatal Depression Scale (EPDS) at several time points, i…

This trial tests whether combining an online form of Acceptance and Commitment Therapy with a noninvasive brain stimulation technique can improve sleep quality in adolescents with depression and sleep problems. About 160 teens aged 11 to 19 are randomly assigned to receive the co…

This phase 3 trial tests whether soticlestat, an experimental oral drug, can reduce convulsive seizures in children and young adults with Dravet syndrome, a severe form of epilepsy. Participants continue their standard antiseizure therapy and also receive either soticlestat or a …

This trial tests whether adding minocycline or celecoxib to a standard antidepressant helps people with treatment-resistant depression. Treatment-resistant depression means symptoms have not improved enough with previous antidepressant treatment. About 78 adults aged 18 to 65 wil…

This trial tests whether a brain-computer interface (BCI) can help people with Parkinson's disease improve their motor skills. Participants wear an EEG cap that reads brain activity while they imagine moving their legs. The system then provides feedback through electrical stimula…

This phase 1 trial tests a genetically engineered virus called C134, made from a herpes simplex virus, in people with recurrent malignant glioma, a type of brain cancer. The virus is injected directly into the tumor, where it aims to infect and kill cancer cells while also trigge…

This study tested a drug called RTA 408 (omaveloxolone) in 172 people with Friedreich's ataxia, a rare genetic disease that affects movement and coordination. The goal was to see if the drug is safe and can improve exercise ability and daily function. Participants took the drug o…

This trial tests whether a home-based virtual reality rehabilitation program called Muvity can improve arm function, balance, and quality of life in people who had a stroke more than six months ago. Participants will be split into two groups: one doing the Muvity program at home …

This study tests whether changing the way deep brain stimulation is delivered can improve tremor control in people with essential tremor who don't get enough relief from their current settings. Researchers will use computer models and brain scans to see how the new stimulation pa…

This trial tests a virtual reality system called RGS that guides stroke survivors through reaching, grasping, and placing virtual objects to aid motor and cognitive recovery. The study enrolls adults who have had a first stroke with mild to moderate arm weakness. Participants use…

This study tested whether the drug rimegepant can help prevent migraines in Chinese adults. 787 participants took either rimegepant or a placebo every other day for 12 weeks. The main goal was to see if rimegepant reduced the number of migraine days per month compared to placebo.…

This phase 2 trial tests whether a single dose of insulin given through the nose can change how the brain produces energy and improve thinking in people with psychotic disorders like schizophrenia, schizoaffective disorder, or bipolar disorder with psychosis. Researchers will com…

This study tested a set of simple, affordable robots called Rehab CARES to help older adults who had a stroke improve arm and hand function. Twenty-seven participants used the robots for one-hour sessions, three times a week for four weeks, while also receiving standard therapy. …

This trial tests two rehabilitation approaches in children aged 6 to 12 with spastic diplegic cerebral palsy. One group does circuit training with stations for balance and strength, while the other does task-oriented training focused on daily activities. Researchers measure chang…

This trial compares two types of technology-assisted balance training for people who had a stroke at least six months ago. One group trains balance using ankle movements, the other uses hip movements, and both also receive a standard rehabilitation program. The goal is to see whi…

This trial tests whether repeat infusions of stem cells from healthy donors can slow the progression of Parkinson's disease. About 45 people with Parkinson's will receive either one of two doses of these stem cells or a placebo. Researchers will measure changes in motor symptoms …

This trial tests whether children with autism improve balance and coordination more when they exercise in a group or on their own. Researchers will randomly assign 16 children aged 3 to 12 to either individual or group exercise sessions, held three times a week for six weeks. The…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This trial tests whether delivering electrical stimulation underwater can help people recovering from a stroke regain hand grip strength and arm movement. Participants who had a stroke within the past six months will receive either real underwater faradic stimulation or a sham ve…

This trial tests whether continuous smartphone monitoring can detect early warning signs of depression or mania in people with bipolar disorder. Participants use an app that tracks activity and location, and some receive personalized alerts from their doctor when the app detects …

This trial compares three painkillers, hydromorphone, fentanyl, and butorphanol, given intravenously to ICU patients who are not on mechanical ventilation. The goal is to find the best dose of hydromorphone that achieves effective pain control while monitoring side effects like l…

This study looked at whether it is safe for people with multiple sclerosis to receive their natalizumab (Tysabri) infusions at home instead of at a hospital. Researchers compared serious side effects, quality of life, and costs over one year in 295 patients. The goal was to see i…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This phase 2 trial tests whether taking colchicine, an anti-inflammatory drug, once daily can prevent major cardiovascular events like heart attacks and strokes in people who have just had a brain bleed (intracerebral hemorrhage). The study includes about 100 adults who have had …

This early-phase trial tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that didn't respond to other treatments. Sixteen participants received chemotherapy to l…

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This phase 2 trial tests a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard chemotherapy in people with classical Hodgkin lymphoma that has come back or stopped responding to treatment. About 200 participants will be randomly assigned to rece…

This trial tests whether pairing vagus nerve stimulation (VNS) with rehabilitation can improve arm function in people who have had an ischemic stroke. Participants receive an implanted VNS device and undergo weeks of therapy, with some receiving active stimulation and others a sh…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This trial tests an experimental oral drug, TAK-861, in people with narcolepsy type 1, a condition that causes severe daytime sleepiness and sudden muscle weakness (cataplexy). Researchers will compare TAK-861 against a placebo to see if it improves alertness and reduces cataplex…

This trial tests whether having a nurse specialist coordinate care for people with Parkinson's or related conditions improves their quality of life over 12 months. Participants are randomly assigned to either standard care with their neurologist or additional support from a nurse…

This trial tests a web-based program called ePACE, which gives teens with mild to moderate substance use and mental health issues personalized choices about content and engagement. It compares ePACE to a fixed, non-tailored program (eFACE) and to a waitlist group. Researchers wil…

This trial tests whether a rehabilitation technique called error-augmented walking can improve gait and brain activity in people who have had a stroke. Participants walk on a split-belt treadmill, which makes the two belts move at different speeds to create a deliberate mismatch,…

This phase 2 trial tests whether levosimendan, a heart medication that widens blood vessels, can reduce dangerous artery spasms and delayed brain injury after a type of bleeding stroke called aneurysmal subarachnoid hemorrhage. Thirty adults in intensive care will receive either …

This trial tests whether combining cognitive behavioral therapy with social skills training helps young people with early-onset psychosis improve their symptoms and daily functioning. Participants receive either this combined therapy or a control program of psychoeducation and he…

This trial tests whether a four-week course of electroacupuncture changes tongue appearance in people recovering from an ischemic stroke. Researchers will use an automated tongue imaging system to capture and analyze tongue color, shape, and coating before and after treatment. Th…

This trial tests whether psilocybin, the active ingredient in magic mushrooms, given alongside psychological therapy, can help adults with treatment-resistant depression. Participants receive either psilocybin or a placebo in a single dosing session, combined with therapy. The st…

This trial tests whether a peer-led support program, where trained patients guide group sessions, can reduce depressive symptoms in adults with major depression. Researchers in Mallorca will compare this approach to an online mental health app. About 70 participants from primary …

This trial tests whether adding a synbiotic supplement to a Mediterranean diet can improve quality of life and reduce disability in people with relapsing-remitting multiple sclerosis. Participants follow the diet for 12 weeks and take either a synbiotic or a placebo pill daily. R…

This trial tests two online programs designed to improve thinking skills in people with schizophrenia. One program focuses on cognitive remediation, helping participants build learning strategies and confidence. The other, metacognitive training, targets how people interpret info…

This trial tests whether a specific acupuncture technique, called Xingnao Kaiqiao (or 'Brain Awakening'), can improve arm movement in people recovering from a stroke. It compares this method to standard electroacupuncture. The study involves 66 adults aged 40-80 who had a stroke …

This trial tests whether adding respiratory muscle training to a standard post-stroke wellness program improves breathing strength, physical activity, and quality of life more than the wellness program alone. Stroke survivors who are at least six months post-stroke will participa…

Researchers are testing a new face mask, the Smart Mask V1 System, that uses built-in light sensors to measure blood oxygen (SpO2) and pulse rate. The study enrolls healthy adults aged 18 to 65 who wear the mask while breathing air with gradually lower oxygen levels in a special …

This study is testing whether a mobile app can help detect postpartum depression early in pregnant women. Researchers will follow 120 women for 6 months, using daily mood questions and monthly surveys through the app. The goal is to understand how symptoms change over time and to…

Researchers are testing whether a bedside ultrasound of the eye can help emergency doctors tell ischemic stroke (caused by a clot) from hemorrhagic stroke (caused by bleeding). The team measures the optic nerve sheath diameter, a marker linked to pressure inside the skull, in adu…

Researchers are checking whether a short 3-question depression survey can identify moderate-to-severe depressive symptoms in older adults having surgery as accurately as the standard 9-question version. The study analyzes existing records from more than 10,000 patients aged 65 an…

Researchers are testing whether tissue samples taken during a routine colon exam can help tell apart Parkinson's disease from two similar conditions: multiple system atrophy and progressive supranuclear palsy. The study includes 34 people aged 50 to 80, some with these conditions…

This study aims to develop computer models that can help diagnose and monitor Parkinson's disease by analyzing eye movements and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is to make diagn…

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, str…

Visual problems after a mild traumatic brain injury often go unnoticed. Researchers at Bispebjerg Hospital are developing and testing a 42-item questionnaire and eye-tracking based screening tools to detect these issues. The study compares 100 adults with persistent symptoms afte…

Researchers are testing whether a special type of MRI, called diffusion tensor imaging, can detect subtle damage to the brain's white matter after a sports concussion. Standard brain scans often look normal after a concussion, even when athletes have lingering symptoms. This stud…

This study tested whether videonystagmography (VNG) with caloric testing, a standard balance exam, can distinguish people with vestibular migraine from those with other migraines and healthy individuals. Researchers compared eye movement patterns in 173 participants across three …

This study tests a new MRI technique called ENRAGED FLAIR that aims to capture two types of brain images (T2-FLAIR and T1-weighted) in a single sequence, instead of the usual two separate scans. Researchers will compare the image quality and time savings against standard MRI in 1…

This study tests whether a handheld, noninvasive device called the Infrascanner Model 2500 can help doctors detect brain hemorrhages faster in people with suspected traumatic brain injury from combat. The device uses near-infrared light to spot bleeding inside the skull. Research…

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

Researchers at Lund University Hospital are testing a new MRI technique called DIVIDE to see if it can measure how sensitive brain metastases are to radiation. Today, doctors only see whether radiation worked by watching tumor size change on scans weeks or months later. This tria…

This study involves 60 young people at high risk for psychosis. They receive a stepped series of psychological treatments, starting with the least intensive options like group support, and moving to more intensive therapy if needed. The goal is to prevent the development of psych…

Researchers at Yale University are testing whether adding cognitive behavioral therapy (CBT) after esketamine treatment helps prevent relapse in people with major depression and suicidal thoughts. All participants receive esketamine, then half are randomly assigned to also get co…

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 d…

This trial tests whether a group prenatal care model that includes social services can improve maternal mental health and reduce preterm birth compared to standard individual care with added services. Pregnant women eligible for Medi-Cal in central California are randomly assigne…

Heavy drinkers who need a breathing machine in intensive care often become agitated, which can lead to pulling out tubes, falling, or harming themselves or staff. This Phase 3 trial tests whether baclofen, a drug that calms the nervous system, can prevent these dangerous events b…

Researchers are testing a school-based program that screens adolescents for anxiety, depression, and other mental health concerns, then offers stepped support. Students at eight schools in Spain complete regular mental health questionnaires. Based on their results, they receive d…

Patients on a breathing machine need the cuff around their endotracheal tube kept at about 25 cmH2O to seal the airway. Nurses usually check and adjust this pressure by hand every few hours, which can let the pressure drop too low between checks. This trial tests whether a mechan…

Researchers are testing whether 24 weeks of Tai Chi training can prevent episodic migraines in Chinese women as effectively as standard preventive medication. The trial enrolls 220 women aged 18 to 65 who have two to six migraines a month. Participants in the Tai Chi group attend…

Researchers are testing whether stopping proton pump inhibitors (PPIs) after a transjugular intrahepatic portosystemic shunt (TIPS) procedure can lower the risk of hepatic encephalopathy, a brain condition linked to liver disease. Adults already taking PPIs and scheduled for TIPS…

This study tests a 12-session program called Forging Hopeful Futures, designed to reduce violence among teens ages 13-19. The program uses group discussions and activities to help youth understand how racism, gender inequality, and economic injustice can lead to violence, and tea…

Researchers are testing whether lavender aromatherapy or calming music can improve sleep and brain oxygen levels in children with epilepsy. The trial enrolls 90 children who have generalized tonic-clonic seizures and take at least one anti-seizure drug. Children are assigned to r…

Researchers are testing whether a combined exercise program can improve muscle thickness, balance, and fall risk in people with multiple sclerosis who also have sarcopenia, a condition involving loss of muscle mass and strength. Participants in the exercise group attend 60-minute…

Researchers at the University of Tulsa are testing a five-session psychological treatment called Exposure, Relaxation, and Rescripting Therapy for adults who have bipolar disorder and chronic trauma nightmares. The therapy asks participants to revisit and rewrite their nightmares…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

This study tests a dual-task training program for children aged 6-8 with unilateral cerebral palsy. About 70 participants will be split into two groups: one doing balance exercises while also performing fine motor tasks, and the other doing single-task exercises. The goal is to s…

Researchers at Karolinska Institutet are testing a program called YourSkills for children aged 10 to 16 who have elevated anger or disruptive behaviors. The program combines cognitive behavioral therapy with virtual reality role-plays to practice social skills. Children attend te…

This study tested an oral soft capsule of nalbuphine, a painkiller, for people recovering from hemorrhoid surgery. 106 adults took either the drug or a placebo for up to 2 days. Researchers measured pain levels and how much extra pain relief was needed. The goal was to see if the…

Researchers compare two six-week stress-management programs for female hospital nurses and midwives: heart rate variability biofeedback and eurythmy therapy. Participants are assigned at random to one program. Before and after, questionnaires and heart rate measurements track cha…

Researchers at Karolinska Institutet are testing a parent training program for parents of children aged 8 to 16 who show angry, defiant, or aggressive behavior. The program teaches cognitive behavioral therapy skills and adds virtual reality role-plays so parents can practice res…

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers test whether an 8-session dance workshop improves balance in adults with hemiparesis, a weakness on one side of the body. Participants are randomly assigned to either the dance program or an upper-limb rehabilitation program. The study measures changes in walking and …

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

Researchers are testing whether giving children a popit toy or a stress ball during inhaled medication can reduce anxiety, fear, and distress. The trial includes children aged 4 to 6 who come to a pediatric emergency unit with a respiratory condition needing nebulizer or inhaler …

Researchers are comparing two diets to see whether either one reduces fatigue in people with relapsing-remitting multiple sclerosis. Participants follow their usual diet for 12 weeks, then are randomly assigned to the Swank low-saturated-fat diet or the Wahls Elimination modified…

This study tests an experimental drug called GM-2505 in people with major depressive disorder. Participants receive two doses of the drug two weeks apart. The study has three parts: one for people not on antidepressants, one for those partially responding to current treatment, an…

Researchers at the University of Tulsa are studying Exposure, Relaxation, and Rescripting Therapy (ERRT), a brief treatment for frequent trauma-related nightmares. The trial enrolls about 90 adults who have experienced trauma and have roughly one nightmare per week. Participants …

Researchers are testing a stepped mental health program for adolescents in Pakistani public schools. The program starts with teacher-led support for emotional distress. Students who do not improve move to a CBT-based guided self-help app. The study checks whether this approach is…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

People with Parkinson's disease often struggle with walking, and their brains have trouble learning new movement skills. Researchers want to know if adding aerobic exercise or resistance exercise after gait training helps them learn and remember walking tasks better than gait tra…

Researchers are testing whether a horticultural therapy program can reduce anxiety and improve quality of life in older adults. The trial enrolls 56 volunteers who take part in gardening activities. Participants complete standard questionnaires about anxiety and well-being before…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on standard Parkinson's medication will use the light at home. The goal is to see if adding this light ther…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

Researchers are testing an accelerated form of brain stimulation called iTBS for depression. A single participant with major depressive disorder receives 50 iTBS sessions over 5 days while researchers monitor blood flow in the brain using fNIRS. The study measures changes in oxyg…

Researchers are testing a home-based program called action observation and motor imagery (AOMI) training for adults with spinal cord injury. Participants watch exercise videos and imagine themselves doing the movements without actually moving. The trial aims to see if this traini…

This study looked at whether mandala art therapy (a structured coloring activity) can lower anxiety and increase comfort in people who received a kidney transplant. Eighty adult first-time kidney transplant recipients took part. The goal was to see if this simple, non-drug approa…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

Researchers are testing whether certain ingredients in toothpaste can trigger migraines. Adults with migraine who do not take preventive medicines join one of two groups: one swaps toothpaste for saline solution when brushing, the other keeps using toothpaste. Both groups follow …

Tonsillectomy causes significant pain in children. Researchers are testing whether injecting ropivacaine, a local anesthetic, around the tonsils during surgery reduces postoperative pain. The trial enrolls 60 children aged 3 to 6 who are having their tonsils removed. Doctors comp…

Researchers are testing a 12-week home-based programme that combines aerobic exercise, strength training, stretching, and self-management education for people who had a stroke more than six months earlier. The trial enrolls 30 community-dwelling survivors aged 20 to 59 who can wa…

Electromyography (EMG) and nerve conduction studies (NCS) check how nerves and muscles work, and many patients find them painful or stressful. Researchers are testing whether letting adults choose and listen to their own music during these tests lowers anxiety and pain compared w…

Researchers are testing whether a dual-task exercise program helps stroke survivors walk while doing a mental task. The study compares dual-task training, which combines walking with cognitive activities, to single-task training, where walking and thinking are practiced separatel…

Researchers are testing a four-week acceptance and commitment therapy program for parents of children with complex medical conditions. The trial enrolls 24 parents who attend two-hour weekly sessions covering stress, values, mindfulness, and goal-setting. The study measures chang…

Researchers at Oregon State University are testing whether a brief, Spanish-language group program can reduce anxiety in Latino/a adults. The program teaches neuroscience-informed cognitive behavioral therapy over three weekly 90-minute sessions and asks participants to track the…

Researchers are testing whether giving mothers with ADHD a stimulant medication along with behavioral parent training works better than parent training alone for reducing ADHD-related problems in their young children. The study enrolls mothers aged 21 and older who meet criteria …

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

This study tests whether playing specially designed, AI-powered games can improve thinking skills and arm/hand function in people who have had a stroke. Forty adults aged 45-60 with mild memory or thinking problems after a stroke will use a smartphone app and motion-sensing games…

This study tested whether a 12-week physical activity program could improve memory and attention in children who had radiation for brain tumors. Thirty-six kids aged 8–17 who finished radiation at least a year ago took part. Half started the program right away, while the other ha…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

Many people who move to a new country face depression, anxiety, stress, and trouble adjusting. This pilot study tests whether EMDR, a psychotherapy that uses guided eye movements to process distressing memories, can help when adapted for migration-related experiences. First-gener…

Researchers are testing whether a home-based program led by community health workers can reduce depression in older adults living in a low-resource district of Lima, Peru. The program, called VIDACTIVA, combines problem-solving exercises and physical activation over eight home se…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

Researchers are studying whether adding a Chinese herbal capsule called Shuganjieyu to the antidepressant fluoxetine helps ease depression symptoms more than fluoxetine alone. The trial enrolls 160 adults with depression, ages 18 to 65, who score at least 18 on a standard depress…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

Intravitreal injections deliver medicine directly into the eye and are usually quick, but many patients feel anxious before and during the procedure. Researchers are testing whether playing classical music during the injection lowers anxiety and pain compared with no music. The t…

This study tests whether a type of brain stimulation called cTBS can improve thinking and memory in people with schizophrenia. Forty participants will receive targeted stimulation to a brain network linked to daydreaming and self-focus. The goal is to see if this changes brain ac…

Ataxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…

Researchers are comparing two ways of delivering exercise therapy to people with multiple sclerosis: supervised sessions with a physiotherapist and a program followed over the internet. The study enrolls 34 adults with moderate to severe disability, measured by an EDSS score of 5…

This study will test whether watching a liquid-gel or sand hourglass during blood collection can reduce pain, fear, and anxiety in children aged 5 to 10. About 120 children will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-d…

Researchers are testing whether propionic acid, a short-chain fatty acid, can slow nerve damage and ease fatigue in people with multiple sclerosis. The trial enrolls 101 adults aged 18 to 60 who have stable MS and signs of immune activity in their spinal fluid. Participants recei…

Researchers are testing whether balance training on a moving platform can change reflex activity and improve reactive balance and walking in children with spastic cerebral palsy. The study includes 24 children aged 5 to 17 with spastic cerebral palsy, plus typically developing ch…

Researchers are studying whether TENS, a device that sends mild electrical pulses through the skin, can lower pain and reduce the need for painkillers after total hip replacement. The trial enrolls 60 adults who have had hip replacement surgery and do not have a pacemaker, heart …

This study tests whether using a virtual reality headset showing nature scenes with relaxing music can reduce pain and anxiety during dressing changes for pressure sores. Sixty-two adults with pressure sores will be randomly assigned to either receive VR during dressing or standa…

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study tested two non-drug methods—reflexology (foot massage) and sleep hygiene education—to improve sleep and comfort in 60 adults on hemodialysis. Both approaches helped, but reflexology was more effective. The results suggest a simple, drug-free option for better rest in d…

This study looked at whether structured play activities could reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in play sessions during chemo. Anxiety levels were measured before and after play. The goal is to s…

This study tests whether adding a gentle, non-invasive nerve stimulation on the ear (taVNS) to standard physical therapy can reduce muscle stiffness, improve movement, and boost quality of life in children with spastic cerebral palsy. Eighteen children aged 8-18 will be split int…

Researchers in Chile are testing whether pediatricians trained to detect and respond to social withdrawal can help late and moderately late preterm infants engage more with their parents. The study enrolls 110 preterm infants born between 32 and 36 weeks and their Spanish-speakin…

This study tests whether an 8-week forest therapy program—combining walking, resistance band exercises, and sensory activities like aromatherapy—can improve muscle strength and well-being in older women with sarcopenia. Thirty-six women aged 55 and older will participate in 16 se…

Researchers are testing whether the experimental drug LY2140023 (pomaglumetad methionil) reduces schizophrenia symptoms better than a placebo. The trial enrolls adults diagnosed with schizophrenia who stay in a hospital or clinic during the four-week study. Participants take the …

Researchers are testing whether an experimental drug, LY2140023, eases schizophrenia symptoms better than placebo in people who are acutely ill. The trial also compares it to risperidone, an approved antipsychotic. About 1,100 patients with schizophrenia join this phase 2 study. …

Researchers in Pakistan are comparing two psychological treatments, Eye Movement Desensitization and Reprocessing (EMDR) and Cognitive Behavioral Therapy (CBT), for people with post-traumatic stress disorder (PTSD) and major depression. The trial enrolls 100 adults aged 18 to 60 …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

Researchers test whether an 8-session mindfulness-based stress reduction program can lower anxiety and work-related burnout and improve job satisfaction among midwives. Midwives at a Turkish hospital join either the program or a control group. The program runs online twice a week…

Researchers are testing whether Iberogast, a herbal blend used for digestive complaints, can relieve constipation in people with Parkinson's disease. The trial enrolls 45 adults aged 30 to 80 who have Parkinson's disease and functional constipation. Participants take Iberogast fo…

This study tests whether dry needling (inserting thin needles into tight muscles) can reduce spasticity—stiffness that makes movement hard—in people who have had a stroke. About 28 adults who can walk independently will receive either real or sham (fake) needling once a week for …

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are testing an experimental drug called TAK-935 in adults with developmental and/or epileptic encephalopathies, severe brain conditions that cause frequent seizures and developmental problems. The trial enrolls a small number of participants who continue their regular…

Researchers are testing whether virtual reality glasses that show nature scenes with nature sounds can reduce pain and anxiety in women after a cesarean section. The trial enrolls 80 women who had spinal anesthesia and a healthy pregnancy, assigning half to use the VR glasses for…

Researchers at Atlas University are comparing three daily breathing practices, mindfulness breathing, box breathing, and Nadi Shodhana pranayama, in 48 healthy adults aged 18 to 40. Participants practice one technique at home for six weeks after learning it in person. The trial m…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This phase 2 trial tests whether fasudil, a drug already used in Japan for blood vessel spasms, is safe and can help symptoms in people with early Parkinson's disease. 75 participants will take either fasudil or a placebo for 3 weeks. The study focuses on safety and tolerability,…

Many people on long-term hemodialysis struggle with persistent pain at night and poor sleep, which lowers their quality of life. Researchers are testing a nurse-led Benson's relaxation program to see whether it reduces night pain intensity and improves sleep quality. The study en…

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

Researchers are testing MDMA-assisted therapy in military veterans who have both alcohol use disorder and post-traumatic stress disorder. The treatment combines two monthly therapy sessions with the drug MDMA, along with preparation and follow-up counseling. The study measures ch…

Researchers are comparing two 9-week group classes for veterans who have a history of mild traumatic brain injury and post-traumatic stress disorder. One class teaches mindfulness, meditation, and yoga; the other teaches how the brain works and recovers after injury. The study me…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve blood sugar control in older Chinese adults with type 2 diabetes and insomnia. The trial compares CBT-I to usual care in 214 participants aged 60 and older. They will measure changes in …

York University researchers are testing two ways to train teachers to help children with dyslexia who have not improved with standard classroom reading instruction. One program adds morphology, which teaches shared word meanings like sign, design, and signal. The other adds set-f…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study will test whether watching a short educational video or having a standard talk with a doctor is better at reducing anxiety and stress in women scheduled for a planned cesarean delivery. 140 women will be randomly assigned to one of the two groups. Their anxiety levels …

Researchers are testing a rehabilitation platform called PRoBio that pairs a robotic arm with virtual reality and wearable sensors. The study enrolls 10 adults with mild Parkinson's disease and mild cognitive impairment. Participants take part in a four-week program with three we…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can help returning veterans who drink heavily. The trial enrolls veterans deployed after September 11, 2001, who have insomnia and at least one heavy drinking episode in the past month. Participants…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

Researchers at the University of Guadalajara are testing whether a short acceptance and commitment therapy (ACT) program can reduce anxiety in medical students. The program runs four in-person group sessions that teach students to accept difficult thoughts and feelings, step back…

Researchers are testing an experimental drug called soticlestat in people with two rare genetic conditions: Dup15q syndrome and CDKL5 deficiency disorder. Both conditions cause frequent motor seizures that are hard to control. The trial enrolls about 20 participants who take one …

Whole-brain radiotherapy is a common treatment for cancer that has spread to the brain, but it often harms memory and thinking. This phase III trial tests whether adding the drug memantine and using a radiation technique that avoids the hippocampus, a brain area key to memory, ca…

This study tests an experimental drug called KDT-3594 in 150 people with advanced Parkinson's disease who already take levodopa. The goal is to see if the drug can improve movement and daily living skills during their 'on' times (when medication is working). Participants take esc…

This study tests whether 80 sessions of a gentle brain stimulation technique called tDCS, given over 12 months, can improve attention, social skills, and language in 180 children aged 6 to 11 who have autism along with rare diseases, genetic problems, or PANDAS. The treatment is …

This trial tests a support package called CaknaStrok for people caring for a family member who just had a stroke. The package includes a mobile app with videos and tools, plus a guidebook, all tailored for Malaysian caregivers. Researchers compare caregivers who get the package w…

Researchers at the University of Sfax are testing whether the timing of exercise changes its benefits for sleep and well-being. They enroll 102 sedentary university students aged 18 to 25 and assign them to three weekly 50-minute sessions, two weekend 75-minute sessions, or a con…

Fatigue is one of the most common problems in multiple sclerosis, and it can make walking, balance, and thinking harder. Researchers want to measure how fatigue changes these functions during a long walking test using wearable sensors. They are also testing whether a high-intensi…

Researchers are testing whether a 10-session mechanical massage program can improve sleep quality, lower stress hormones, and affect immune function in people who report high stress and poor sleep. The study enrolls 32 adults who score high on stress and insomnia questionnaires a…

Researchers are testing a smartphone app called Pai.ACT that uses acceptance and commitment therapy to help parents of children with special needs manage stress and improve well-being. The study enrolls 60 Cantonese-speaking parents in Hong Kong who care for children aged 2 to 8 …

This trial tests whether acupressure, a traditional therapy that presses on specific body points, can reduce pain and anxiety in women who have just had a cesarean delivery. Sixty postpartum women will receive either acupressure or a sham version, along with standard medical care…

This study tests whether special knee strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 participants who had a stroke 3 months to 1 year ago will do either isokinetic knee exercises or standard rehab. The goal is …

Researchers are testing whether soticlestat, an experimental drug, can reduce major drop seizures when added to standard antiseizure therapy in children, teenagers, and adults with Lennox-Gastaut syndrome. About 270 participants will take either soticlestat or a placebo for 16 we…

Researchers are testing a full-spectrum medicinal cannabis extract with very low THC to see if it can reduce the severity of autism spectrum disorder in young people aged 8 to 17. The study compares the extract to a control and then allows some participants to receive it openly. …

Researchers at Saveetha University studied a structured play-based program called the B.A.S.I.C.S. framework for children with autism spectrum disorder. The program combines balance, social, thinking, and self-reliance activities into 45-minute sessions three times a week for six…

Researchers at Ataturk University are testing whether watching nature videos through virtual reality glasses can improve sleep quality and mental well-being in people with multiple sclerosis. The trial enrolls 42 adults aged 18 to 80 who have MS and are not in an attack. One grou…

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

Researchers are studying whether adding myofascial release, a hands-on technique that stretches tight tissue, to standard physiotherapy helps children with cerebral palsy recover better after Achilles tendon surgery. The trial enrolls 40 children aged 2 to 5 in the Gaza Strip who…

Researchers test whether adding cognitive training to a 10-week exercise program helps children with developmental coordination disorder improve balance, motor skills, and fitness more than exercise alone. Twenty children aged 7 to 11 join the study and are randomly assigned to e…

This study tested whether a special type of heated yoga (hyperthermic yoga) could help adults with mild to moderate depression. 80 people were randomly assigned to either take yoga classes twice a week or join a waitlist. The main goals were to see if people would stick with the …

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

This study tests a group cognitive-behavioral therapy (CBT) program designed to help young adults who struggle with uncertainty. The program includes techniques like cognitive restructuring and exposure to uncertain situations, and it considers how a person's social environment a…

Researchers are testing transcranial direct current stimulation (tDCS), a non-invasive technique that applies a weak electrical current to the scalp, in adults with severe obsessive-compulsive disorder that has not improved with at least two antidepressants. The study compares ac…

Researchers at the University of Utah are testing a new non-invasive brain stimulation method for people with moderate-to-severe depression. The study uses a device called the Diadem prototype to deliver personalized low-intensity focused ultrasound to specific brain areas. Parti…

Researchers are testing whether an electromyography-controlled functional electrical stimulator (FitFES) helps stroke survivors regain arm and hand function. The device reads muscle signals and delivers electrical stimulation during task-oriented exercises. Fifty adults who had a…

This study tests whether adding motor imagery—mentally practicing movements without actually moving—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. Forty-two participants will be randomly assigned to receive either …

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

This trial tests whether an 8-week Clinical Pilates program can improve balance and physical function in adults with multiple sclerosis. Participants are randomly assigned to Clinical Pilates, standard physiotherapy, or a control group with no structured exercise. Researchers mea…

Researchers at MIT are testing whether a smartwatch that vibrates in time with your heartbeat can improve interoceptive awareness, the ability to sense what is happening inside your body. The study enrolls 29 people with high alexithymia scores, a trait linked to difficulty ident…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

Researchers are testing a full-spectrum medicinal cannabis extract called NTI164 in girls and young women with Rett syndrome, a rare genetic disorder that affects movement, speech, and behavior. The study includes 14 participants aged 5 to 20 who take the extract daily for 16 wee…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests whether balance training guided by artificial intelligence can improve pelvic alignment and reduce fall risk in people who have had a stroke. Thirty-eight stroke survivors will wear sensors and perform static and dynamic balance exercises. The AI adjusts the exer…

Researchers are testing an AI-integrated proactive thought control program for young adults with social anxiety disorder. The program uses two computer tasks: one where participants type the first word that comes to mind after seeing a social threat word, and another where they c…

Researchers are testing an experimental oral drug called XY03-EA in adults who have just had an acute ischemic stroke. The trial compares several doses of the drug with a placebo to see whether it improves recovery and reduces disability. About 360 participants receive treatment …

Researchers are testing whether transcranial direct current stimulation (tDCS) can reduce symptoms in people with severe obsessive-compulsive disorder that has not improved with standard medications. The study enrolls 20 adults aged 18 to 70 who have chronic OCD and have tried at…

This study tests a smartphone app called CT-155 designed to help people with schizophrenia manage negative symptoms like low motivation and reduced pleasure. About 262 adults with schizophrenia will use the app for 16 weeks, with an optional extension. Researchers will track symp…

Stroke often damages trunk control, balance and walking ability. Researchers are testing whether combining transcranial direct current stimulation, a mild electrical current applied to the scalp, with pelvic proprioceptive neuromuscular facilitation, a hands-on stretching and mov…

This study tests a nasal spray containing (R)-Ketamine, a fast-acting drug, in 98 adults with major depression who are currently having suicidal thoughts. Participants receive either the spray or a placebo twice a week for 4 weeks. The goal is to see if the spray can quickly redu…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

Researchers are testing whether propranolol, a common blood pressure drug, can help people with fibromyalgia who also have post-traumatic stress disorder. Participants take propranolol and then read their own traumatic story about 75 minutes later, once a week for six weeks. The …

Researchers are testing whether a non-invasive brain stimulation technique called temporal interference stimulation can improve motor symptoms in people with early-to-mid-stage Parkinson's disease. The study compares stimulation while participants are on and off their usual Parki…

This trial tests a telephone-based coaching program called MOTIVATE for older veterans who live with chronic musculoskeletal pain and depression. Participants receive eight individual phone sessions with a health coach over up to five months, focusing on managing pain and mood. R…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This trial tests whether a daily oral oil made from a full-spectrum cannabis plant extract with very low THC (FEN164) can safely help children with autism. The study will include 18 children aged 8 to 17 with moderate to severe autism (Level 2 or 3). Over 20 weeks, researchers wi…

This study tests a rehabilitation method called modified constraint-induced movement therapy (mCIMT) for people recovering from a stroke. Participants wear a mitten on their unaffected arm for several hours a day while practicing tasks with the affected arm. The goal is to see if…

This trial tests whether teaching mothers how to perform aspiration care for their children in the intensive care unit can lower their anxiety and hopelessness. Researchers will compare two teaching methods: a video and a picture booklet. The study includes mothers whose children…

Researchers at the University of Reading are testing an online guided-writing program for people who care for a loved one with Parkinson's disease. The program asks caregivers to complete four writing exercises that encourage them to respond to their own struggles with the same k…

This study tests a phone-based sleep therapy for people who have insomnia and drink alcohol in ways that could harm their health. The therapy adapts standard insomnia treatment to also address alcohol-related thoughts and behaviors. Researchers will first refine the approach with…

This trial tests whether a quilling exercise, a paper craft activity, can reduce fear and anxiety in children aged 9-12 who are about to undergo cardiac catheterization and angiography. Half an hour before the procedure, children in the intervention group will spend 15-20 minutes…

This trial tests whether ozone autohemotherapy, a procedure where a person's blood is mixed with ozone and put back into their body, can improve sleep in people who have insomnia after an ischemic stroke. Researchers will measure sleep quality and look at blood markers of inflamm…

This trial tests whether listening to music for 20 minutes can improve sleep quality and reduce risk perception in pregnant women hospitalized due to the threat of premature birth. Researchers will measure sleep using the Richard Campbell Sleep Quality Scale and risk perception w…

This trial tests whether letting children play video games or paint a mask during nebulizer treatment reduces their anxiety and improves how well they cooperate. The study includes children aged 7 to 12 who are receiving their first nebulizer treatment in the hospital. Researcher…

This study tests whether a non-electric, hand-held temple massager—used daily for 4 weeks with a special lotion and optional lavender aromatherapy—can lower stress, improve emotional wellbeing, sleep quality, and overall quality of life in women aged 35 to 65. Participants use th…

This study tested whether a split-belt treadmill (where each leg moves at a different speed) can reduce freezing of gait during turning in people with Parkinson's disease. 26 participants completed a 4-week training program that included practicing everyday turning scenarios. The…

This trial tests whether zolpidem, a common sleep medication, can improve sleep quality and reduce painkiller use in adults recovering from total knee replacement. Half of the participants take zolpidem 10 mg each night for two weeks after leaving the hospital, while the other ha…

This trial tests whether two types of talking therapy can help people with chronic migraine. One is standard cognitive behavioral therapy, and the other is a traditional Islamic psychotherapy that blends psychological methods with Islamic principles. Adults aged 18 to 40 with a n…

This study looks at whether mindfulness meditation can help first-generation college students feel less anxious or depressed and stay in school. About 53 students will be randomly assigned to either mindfulness meditation or a general mental health education group. Researchers wi…

Researchers are testing whether chewing mint-flavored sugar-free gum during childbirth can reduce pain and anxiety in first-time mothers. The trial includes 106 pregnant women at term with no complications, who will chew the gum for at least 20 minutes at different stages of labo…

Researchers are testing whether psilocybin, the active compound in magic mushrooms, can safely help people with Parkinson's disease who also struggle with depression or anxiety. In this pilot study, 12 participants receive two oral doses of psilocybin with psychological support. …

This study is testing whether two devices used together can help new mothers with both depression and urinary incontinence. One device uses magnetic pulses to stimulate brain areas linked to mood, while the other strengthens pelvic floor muscles with electromagnetic energy. Sixty…

This study tests whether a text-message based chatbot support program can reduce symptoms of postpartum depression in people of color who recently gave birth. About 156 participants will either get the chatbot or usual care. The goal is to see if the chatbot lowers depression sco…

This study tested a new cognitive behavioral skills program (CBI) delivered in the metaverse for people with depression and anxiety. 306 participants were split into three groups: one using virtual reality, one using a flat-screen device, and a waitlist group. The program taught …

This study looked at whether prayer can help people with migraines feel less pain and improve anxiety and depression. About 100 adults, half with migraines and half without, took part. They compared the effects of prayer versus reading a neutral text on pain sensitivity and emoti…

This study tests whether high doses of branched chain amino acids (BCAAs), a type of supplement, can help people aged 11 to 23 recover from a concussion more quickly. Participants receive either a BCAA drink or a placebo for 28 days. The main goal is to see if more people in the …

This study tested a device that sends mild electrical pulses to a nerve in the ear (trigeminal nerve) to see if it helps people with migraine. 102 adults with episodic migraine received either real or sham stimulation three times a week for 12 weeks. Researchers measured headache…

This trial tests whether a digital cognitive behavioral therapy (CBT) app called Daylight can reduce anxiety and improve health behaviors in adults who have had a heart event, such as a heart attack or stroke, and also experience significant anxiety. Participants will either use …

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

Researchers are testing whether a series of multisensory stimulation sessions can reduce depressive symptoms in adults with moderate-to-severe depression. Fifteen participants receive nine 20-minute sessions combining auditory, thermal, and pressure stimuli, calibrated to about 6…

This trial tests two ultrasound-guided nerve blocks for pain relief after thoracotomy, a surgery that opens the chest. One block targets the paravertebral space, while the other targets a point between the transverse process and the pleura. Researchers will compare how much morph…

This study tests whether giving a small amount of the sedative midazolam during anesthesia can lower the risk of delirium (sudden confusion) and anxiety in older adults after surgery. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to r…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tested a wearable morning light device (Re-Timer) for women with postpartum depression. 95 women wore either bright or dim light glasses for 60 minutes each morning for 5 weeks. Researchers measured changes in depression symptoms, sleep, and body clock timing. The goal…

Many children with autism are picky eaters, often refusing fruits, vegetables, and proteins, which can lead to poor nutrition and obesity. This trial tests whether nutritional counseling focused on the Mediterranean diet can help these children become less selective and adopt hea…

This study looks at whether fremanezumab, a migraine prevention drug, can reduce the emotional burden on caregivers of people with migraine and depressive symptoms. Researchers will measure caregiver stress and the quality of the couple's relationship before and after six months …

Researchers at Brigham and Women's Hospital are testing whether automated motivational messages or coach support can improve engagement with SilverCloud, a digital mental health intervention for depression and anxiety. The trial enrolls adults with clinically significant symptoms…

This study tests whether using a virtual reality headset during labor can help reduce pain and anxiety and make the childbirth experience more satisfying. About 92 women in Taiwan will be randomly assigned to either use VR with calming nature scenes and music or receive standard …

This study looked at whether teaching patients about pain before a planned hysterectomy (removal of the uterus) could help lower their anxiety, stress, and pain after surgery. 62 adults took part and received either standard care or extra education about pain. The goal was to see…

This study tested two sleep medications (suvorexant and zolpidem) against a placebo in 40 adults with Progressive Supranuclear Palsy (PSP). The goal was to see if targeting the brain's wake-promoting system could improve sleep quality and daytime well-being. Each person tried all…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This small study tests whether empagliflozin (Jardiance), a diabetes medication, can reduce symptoms of major depression. The drug helps the body produce ketones, which may provide an alternative energy source for the brain. Sixteen adults with moderate to severe depression will …

This pilot study tests whether a mindfulness program delivered through a web app can help hospitalized neurological patients and their caregivers cope with stress and anxiety. Participants learn mindfulness techniques in an initial face-to-face session, then practice via weekly o…

This trial tests whether aromatherapy with rose oil or a massage using that oil can reduce pain, anxiety, and discomfort in women after a cesarean delivery. About 90 first-time mothers will be randomly assigned to receive one of these treatments or a placebo. The goal is to see i…

This study tests whether a 6-week group class on nonviolent communication (NVC) can improve mental well-being in parents of primary-school children. About 172 parents with mild to severe anxiety or depression symptoms will be randomly assigned to take the class right away or wait…

This study tested whether a type of compassion meditation could help Veterans with chronic pain who also have depression or PTSD. 142 Veterans were randomly assigned to either compassion meditation training or a health education group. The goal was to see if meditation could redu…

This study tested a new drug called ropanicant in 41 adults with moderate to severe major depressive disorder. The main goal was to check safety and side effects, while also measuring how well it improved depression symptoms using a standard rating scale. The trial was open-label…

This study tests whether wearable sensors and goal-setting sessions with a physiotherapist can help stroke survivors stay active after leaving inpatient rehabilitation. Participants wear sensors to track activity, sleep, and sedentary behavior, and some receive feedback and set g…

This trial tests whether watching short family videos or virtual reality nature scenes can reduce anxiety, agitation, and pain in adults staying in intensive care. Researchers will randomly assign 72 participants to one of three groups: family videos, family videos plus VR nature…

Researchers at UCLA are testing whether a savoring intervention, which teaches people to focus on and amplify positive experiences, can improve mood and reduce inflammation in young adults with low positive affect. The study involves 20 participants aged 18 to 25 who will complet…

This trial tests whether coaching older adults in healthy habits or sleep habits can improve their recovery after hip or knee replacement surgery. Participants receive four hour-long sessions with a therapist, focusing either on general healthy habits like physical activity and n…

This trial investigates whether a structured educational program led by nurses can reduce anxiety and improve outcomes for adults undergoing their first heart surgery. Participants are randomly assigned to receive either the nurse-led program or usual care. The program covers pre…

This study tests whether a common probiotic (Lactobacillus rhamnosus GG) can reduce stomach issues like constipation and diarrhea in children with autism spectrum disorder. About 50 children aged 4 to 12 with both autism and ongoing stomach problems will receive the probiotic or …

This study tested a new therapy called Processing of Positive Memories Technique (PPMT) for people with PTSD. Unlike standard treatments that focus on trauma, PPMT helps patients recall and describe positive memories. 70 adults with PTSD were randomly assigned to either PPMT or s…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This trial tests a year-long caregiver training program called MISC-CBO. The program uses video feedback to help community-based organization caseworkers improve their interactions with orphaned and vulnerable children. Researchers will compare children whose caseworkers receive …

This trial tests a web-based parent training program, called Parenting Wisely for Residential Treatment, for parents of adolescents aged 11 to 17 in psychiatric residential treatment. The program includes online modules and facilitated parent groups to prepare families for the te…

This trial tests whether virtual reality-based breathing yoga can reduce pain and anxiety in adults before chest tube removal after cardiac surgery. Participants are randomly assigned to either watch breathing yoga videos through VR glasses for 15-20 minutes before the procedure,…

This trial tests whether a six-week program of mandala coloring—two 20-30 minute sessions per week—can improve psychological resilience among midwives working in hospital delivery rooms. These professionals face high stress from heavy workloads, shift work, and traumatic events, …

Researchers are testing whether a virtual-reality program called RC2S+ can be used remotely to help people with schizophrenia improve social cognition, such as recognizing emotions and understanding others' thoughts. The study enrolls 15 adults with schizophrenia or related psych…

Researchers are testing whether daily sessions with a bright light lamp can ease depressive episodes in people with bipolar II disorder. The trial compares a bright 10,000 lux lamp against a dim placebo lamp, with each session lasting 30 minutes. Participants are adults whose dep…

This trial tests whether acupressure applied to the Yintang point—a spot on the forehead—can reduce pain, anxiety, and improve satisfaction during childbirth. About 104 first-time mothers in active labor will receive either Yintang acupressure or a light touch at a non-therapeuti…

This study explores whether interactive music and guided imagery, delivered via telehealth, can help ease migraines. Researchers will check if the approach is practical and acceptable for Veterans, and whether it leads to meaningful changes in headache frequency and related outco…

This trial tests whether a structured, adapted physical activity program can improve emotion regulation in adults with depressive disorders who have recently been discharged from psychiatric hospitalization. Participants are randomly assigned to either a standard exercise program…

This trial explores whether an internet-based cognitive behavioral therapy (CBT) program, combined with COPD education, can improve mental health, disease knowledge, and quality of life in adults with chronic obstructive pulmonary disease (COPD). Participants complete the 8-10 we…

This completed study looked at 31 people with early-onset Parkinson's disease (starting before age 50) and their family members to find genetic causes. Researchers collected blood and skin samples to study DNA and create cell lines. The goal was to better understand which gene mu…

This study used brain imaging to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to six visits over nine years, including MRI scans and symptom checks. The…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study looked at 85 people with tremor conditions like Parkinson's disease, essential tremor, and dystonia, plus healthy volunteers. Researchers used tests like brain scans, electrical recordings, and movement tasks to learn how the brain controls movement and what goes wrong…

This study uses advanced brain imaging and non-invasive stimulation to understand how the brain changes in the early stages of Parkinson's disease. Researchers will compare people with early Parkinson's (not yet on medication) to healthy volunteers of similar age and sex. The goa…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

This study looks at how common sleep breathing problems are in children with cerebral palsy across the UK, and how often they use breathing support like CPAP machines. Researchers will track new cases over a year and explore what helps or hinders access to care. The goal is to im…

This early-phase study tested whether ferumoxytol, an iron-based contrast agent, can help MRI scans better detect inflammation in the brains of people with multiple sclerosis (MS). Fourteen participants (some with MS, some healthy) received a single IV dose of ferumoxytol and had…

Researchers are studying whether daily step counts and other smartwatch measurements can predict which cancer patients will be readmitted to the hospital after discharge. Adults who have just left an oncology ward wear a Huawei smartwatch for 30 days to track steps, heart rate, a…

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study looks at whether a parent coaching and family navigation program (Project AFECT) can help families right after a child is diagnosed with autism. About 200 parents of children aged 1 to 5, who are Hispanic/Latino, Black/African-American, or have Medi-Cal insurance, will…

This study explores whether artificial intelligence can simplify the language used in informed consent forms for clinical trials. Researchers will test AI tools like ChatGPT and NotebookLM to rewrite these forms and see if people understand them better. The study involves 230 par…

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This study tests whether wearable sensors and caregiver questionnaires can capture the behavioral signs of apathy in people with dementia during daily life. Patients with Alzheimer's or frontotemporal dementia and their caregivers wear a sensor bracelet for 28 days, while caregiv…

Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by th…

Researchers at Hacettepe University are studying people who had surgery for a massive rotator cuff tear. They want to see how the brain's signals to shoulder muscles, shoulder function, and psychological resilience relate to each other. Participants complete shoulder and mood que…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at how forced and voluntary exercise change brain signals and thinking skills in 25 people with Parkinson's disease who have a brain pacemaker (DBS). Participants did one session of each exercise type while off their usual medications and DBS. The goal was to fi…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This study looked at whether people with alcohol dependence or a history of early life stress have more trouble learning to feel calm after a scary event. Researchers used brain scans, mild electric shocks, and genetic tests to understand these differences. The goal was to learn …

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study tested whether two light-based technologies, fNIRS and DCS, can safely measure brain activity in children with rare neurocognitive disorders like Niemann-Pick disease and Smith-Lemli-Opitz syndrome. 73 participants, including healthy volunteers, wore a cap with lights …

This study explores the connection between anxiety and frailty in people aged 65 and older who are about to have hip replacement surgery. Researchers will measure anxiety and frailty using standard questionnaires before the operation. The goal is to understand how these factors r…

This completed study looked at how the brains of people with schizophrenia work when they are not taking antipsychotic medication. The goal was to tell apart the effects of the illness itself from the effects of the drugs. 648 participants stayed in a hospital and underwent brain…

This early-stage trial in 18 healthy adults compares a new octreotide tablet (T25) with an existing capsule (MYCAPSSA) to see how much drug gets into the blood. It also checks whether a high-fat meal changes absorption of the tablet. Participants take single doses under fasting o…

This study tests a training program called DECIDE for MOM, designed to help healthcare providers better support pregnant and postpartum individuals with mental health concerns. The training teaches skills like shared decision-making and understanding patients' perspectives. Resea…

This clinical trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The trial's status is currently withheld, meaning key details about its progress and results are not publicly available. The purpose appears to be gathering information about th…

This study gathered information from 326 adults with rare central nervous system tumors, such as medulloblastoma and ependymoma. Participants completed surveys about their symptoms, treatments, and lifestyle, and provided a saliva sample for genetic analysis. The goal was to lear…

This completed study from the National Institute of Mental Health looked at nearly 5,000 people with schizophrenia or related disorders, along with their siblings. The goal was to find genes linked to the illness and see how they affect brain function. This research helps scienti…

This study aims to translate and validate a French version of the Sleep Regularity Questionnaire (SRQ), a tool that measures how consistent a person's sleep schedule is. Researchers will enroll 50 adults with chronic insomnia or circadian rhythm disorders, who will fill out the q…

Researchers are testing whether a single oral dose of the experimental drug TAK-935 reaches and blocks a specific enzyme in the brain called cholesterol 24S-hydroxylase (CH24H). The study enrolls healthy adults aged 19 to 55. Using PET imaging with a tracer called [18F]MNI-792, t…

This study tests two leg devices—the geko® nerve stimulator and an intermittent pneumatic compression (IPC) sleeve—to see if they increase blood flow to the brain in people who recently had an ischemic stroke. Eighty adults within 36 hours of stroke onset will use one of the devi…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

Researchers are testing an experimental oral drug called TAK-935 in healthy adults to see how safe and tolerable it is. The trial gives participants multiple increasing doses or a placebo and tracks side effects, vital signs, heart rhythms, and blood levels of the drug. The goal …

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

This completed study looked at how brain lesions from strokes impact cognitive control—the ability to focus, switch tasks, and make decisions. Researchers tested 184 healthy adults and stroke patients using behavioral tasks, brain scans (MRI), and EEG. The goal was to understand …

Researchers at the University of Pavia are studying whether long-term exposure to urban air pollution and work-related stress affects biological aging. The study compares 151 adult workers in Pavia, Italy: outdoor workers such as police officers, taxi drivers and dustmen, and ind…

This study looked at how stimulating a nerve in the ear (tVNS) affects pupil size in stroke survivors and healthy adults. Researchers compared stimulation on one side versus both sides to see which causes a bigger pupil response. The goal is to use pupil changes as a guide for pe…

Researchers at the University of California, San Francisco are studying how the brain processes rewards in people with early-onset schizophrenia, major depressive disorder, post-traumatic stress disorder, or gambling disorder, compared with healthy volunteers. Participants comple…

Children with unilateral cerebral palsy often rely on their stronger arm, leaving the weaker arm underused. Constraint-induced therapy forces them to use the weaker arm for hours a day over several weeks, and clinical tests show it improves movement. This study uses wearable sens…

Researchers are studying whether immune and inflammatory markers in the blood relate to mood, fatigue, and thinking symptoms in people with major depression. The trial follows 30 adults starting SSRI antidepressants and compares them with 20 healthy volunteers. Participants give …

This study tests whether a training program for parents of children who have had a febrile convulsion (a seizure caused by fever) can lower parental anxiety and increase their knowledge about the condition. About 66 parents of children aged 6 months to 5 years will be randomly as…

This study used a non-invasive brain stimulation technique called TMS to measure how the motor cortex responds in people who have had a stroke. Researchers compared brain excitability between 24 stroke survivors and healthy individuals. The goal was to better understand how strok…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

This study is a small survey of 10 adults exploring how nutrition, mental health, and faith-based practices relate to recovery from trauma or PTSD. Researchers want to understand what helps people overcome life challenges after stressful events. The results will be used to design…

Researchers at Jacobs University Bremen are running a three-phase study to understand how environmentally friendly behaviors relate to eco-anxiety, well-being, and loneliness. About 1,684 adults complete surveys about their food choices, consumption habits, and feelings of social…

Idiopathic hypersomnia causes severe daytime sleepiness that differs from narcolepsy, yet researchers do not know what drives it. This study uses 64-electrode EEG to look for local slow waves, a sign of sleep-like activity in parts of an otherwise awake brain, while participants …

This study surveys Indonesian sports science undergraduates to understand how self-esteem, anxiety, sleep habits, and social media use relate to feelings of being a fraud (impostor phenomenon). Researchers aim to identify which psychological, behavioral, and structural factors mo…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

Researchers are studying how the drug dexmedetomidine relieves pain by scanning the brains of 28 epilepsy patients during radiofrequency ablation surgery. Half receive dexmedetomidine and half receive a saltwater placebo. Using intraoperative fMRI, the team compares brain activit…

This study looked at 128 physiotherapy students to see if taking an academic literacy class helped with their reading, writing, and thinking skills. Researchers compared students who took the class to those who did not using surveys. The goal was to understand if such education b…

This study tested whether a 6-session psychoeducation program could improve autism knowledge, sibling relationships, well-being, and resilience in 88 adult siblings of people with autism. Participants were all neurotypical adults living in Greece. The program was designed to prov…

This study looks at whether certain immune system markers (IL-33, sST2, and CRP) are different in people with panic disorder compared to healthy individuals. Researchers will measure these markers in blood samples from 80 participants who have never taken medication for panic dis…

This study will measure levels of two proteins, LRFN5 and OLFM4, in the blood of 120 people—some with schizoaffective disorder and some healthy. Researchers want to see if these proteins are linked to symptoms, overall function, and inflammation. The goal is to better understand …

This study looks at two ways to give oxygen to people with acute brain injury after their breathing tube is removed. One method uses a high-flow nasal cannula, which delivers warm, moist oxygen through the nose. The other is conventional oxygen therapy, like a face mask or nasal …

Researchers are testing whether data from a commercial smartwatch and a mobile app can help personalize treatment for Parkinson's disease. The study enrolls 54 adults with Parkinson's who take levodopa and experience daily motor fluctuations. Participants wear a Garmin Vivosmart …

This study investigates whether balance problems explain why fatigue leads to a greater fear of falling in people with multiple sclerosis (MS). Researchers will assess fatigue, balance, and fear of falling in 40 adults with MS who can walk independently or with a device. The goal…

This study measures two blood proteins, LRFN5 and OLFM4, in people with methamphetamine use disorder, those with methamphetamine-induced psychosis, and healthy volunteers. Researchers want to see if these markers are linked to inflammation and symptom severity. The study involves…

This study looks at 100 people having a mechanical thrombectomy (clot removal) for a major stroke. Researchers will monitor their blood sugar continuously during the procedure and check recovery 3 months later. The goal is to see if lower blood sugar at the time of reperfusion (w…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

This study aims to help people from underserved communities talk about their wishes for end-of-life care and complete advance directives. Researchers will use trusted community networks to host events where two conversation tools are tested. About 1500 adults will participate to …

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tools lik…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

People with multiple sclerosis often do not report side effects from their oral disease-modifying drugs, which leaves safety monitoring incomplete. This trial compares two ways of encouraging reports: a nurse who trains the patient and follows up by phone over six months, versus …

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study looks at 406 patients with acute brain injury who need a breathing machine. Doctors often struggle to know when it's safe to remove the tube, and many patients fail. The goal is to find clues that predict successful weaning, so patients can avoid unnecessary procedures…

This study tested two advanced rehabilitation devices—a treadmill and an overground walking trainer—to help 80 stroke patients regain their ability to walk. Participants used either the C-Mill treadmill or the Andago overground device alongside standard therapy. The goal was to s…

This study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …

This trial tests whether two mental training methods, computer-based multiple object tracking and mental imagery, can improve tennis performance, thinking skills, anxiety, and body responses in university students taking a tennis course. Participants either practiced tracking mov…

Researchers want to know whether people with depression spend more time looking at their own reflection after recalling a personal failure. The study uses an eye tracker to measure where participants look on a reflective black screen before and after a directed autobiographical r…

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

Researchers are observing older adults, aged 65 and up, who arrive at the hospital with a brain injury. They will record blood levels of sodium, potassium, calcium, and other electrolytes over five days, along with measures like the Glasgow Coma Scale. The study compares patients…

Researchers at the University of Ioannina are studying stroke patients who have both movement and vision problems. They will evaluate each patient twice, once shortly after the stroke and again weeks later, to measure how these deficits change. The goal is to see whether improvem…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This trial tests whether a single session of transcranial magnetic stimulation (TMS) can alter brain activity related to reward processing in people with major depressive disorder. Researchers will compare active TMS to a sham (inactive) version, measuring brain signals during a …

This observational study examines how the brain processes rewards in people with major depressive disorder compared to those without. Using MRI and EEG, researchers measure brain responses during reward anticipation and feedback. The goal is to identify distinct neural patterns, …

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

This study follows people with idiopathic normal pressure hydrocephalus (iNPH) who are already scheduled for shunt surgery. Researchers measure changes in thinking skills and frailty one year after the procedure to identify which patients are most likely to improve. The goal is t…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

This study tests whether a computer algorithm can predict neurological decline in people who arrive at the hospital within 6 hours of a traumatic brain injury. Researchers will collect vital sign data and use machine learning to see if it can forecast worsening brain function, su…

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some str…

This completed study at Massachusetts General Hospital tested whether a gentle brain stimulation technique called tDCS could help 86 adults with obsessive-compulsive disorder (OCD) unlearn fear responses. Participants received either real or fake (sham) stimulation while undergoi…

Researchers are studying blood samples from people who have had a stroke to understand how blood clotting and inflammation affect recovery. They will take samples at several time points during the first week and measure markers of coagulation and inflammation. The goal is to see …

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study looked at whether asking children with developmental language disorder to repeatedly recall new words helps them learn better than just hearing the words. Twenty-seven 4- and 5-year-olds learned made-up words during storybook reading. The goal was to see if retrieval p…

This study looks at how autistic people who also have anorexia nervosa differ in brain structure and behavior from autistic people without anorexia. Researchers want to understand if 'masking' (acting non-autistic to fit in) is linked to eating disorder symptoms and brain changes…

This study investigates whether people with multiple sclerosis experience kinesiophobia, a fear of movement, and how it relates to fatigue. Researchers will assess 352 adults with MS using scales for disability, spasticity, walking speed, pain, sleep, anxiety, and depression. The…

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study compares two ways of teaching nurses about Parkinson's disease: a PechaKucha presentation with 20 slides that auto-advance every 20 seconds, versus a traditional PowerPoint with flexible pacing. Seventy-two nurses are split into two groups, each receiving the same educ…

This study uses advanced PET brain scans to measure dopamine, acetylcholine, and tau protein levels in people with GBA gene mutations, both with and without Parkinson's disease. Researchers also analyze typing patterns on a computer or touchscreen to detect subtle motor changes. …

This study tests whether a structured communication protocol called StOP? helps surgical teams talk more clearly during operations. Researchers will compare death rates and other outcomes in 400 patients whose surgeons use the tool versus those who don't. The goal is to see if be…

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

Researchers are testing whether a non-invasive brain stimulation technique called high-definition transcranial alternating current stimulation (HD-tACS) can change brain wave activity in people with schizophrenia who hear voices. The study compares patients with auditory hallucin…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study tests whether a simple team debriefing tool, called an After-Action Review, can help child welfare teams better connect children and families to mental health services. Researchers will work with 320 participants, including caseworkers and family members, to see if the…

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This study looks at whether the amount of radiation reaching a small brainstem region, the dorsal vagal complex, is linked to nausea in people receiving radiation for benign brain tumors. Researchers will track nausea scores and radiation doses in 100 adults. The goal is to find …

This study tests whether a practice resource called PReDAS helps occupational therapists who work with stroke patients feel more confident and make better decisions about driving. Eight occupational therapists on acute stroke units will receive the resource and a one-hour trainin…

This pilot study tested whether a nurse-led community-based rehabilitation program is feasible and acceptable for people with psychosis in Blantyre, Malawi. Sixty adults with psychosis were randomly assigned to either usual care or the home-based program. The study focused on rec…

Researchers at the University of Aberdeen are investigating whether gut bacteria differ in people with Parkinson's disease, especially those with constipation. They will collect stool samples from 30 participants: newly diagnosed Parkinson's patients who have not yet started medi…

This completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …

This study follows 400 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery, a treatment that uses implanted electrodes to ease motor symptoms. After the operation, some patients experience postoperative delirium, a state of confusion that can s…

This study tests whether brain scans and decision-making tasks can predict how well people with anxiety and depression respond to different types of talk therapy. Participants will be randomly assigned to one of three therapies: behavioral activation, exposure-based therapy, or s…

Researchers are asking whether people with multiple sclerosis who have trouble reading emotions also face more difficulties in family life, friendships, and social integration. The study compares three groups: MS patients with emotional processing problems, MS patients without su…

This study looks at women who have had bariatric (weight-loss) surgery and later given birth. It aims to understand if these women face higher rates of depression or anxiety after childbirth, and how their weight and nutrition change during this time. By tracking these factors, r…

This trial is testing whether an artificial intelligence (AI) tool can accurately predict how patients with acute ischemic stroke will recover. The AI analyzes patient data in real time to forecast outcomes, such as functional disability, which is then compared with the actual ou…

This study follows children with specific reading disorders (like dyslexia) who previously took part in a training program using the Poppins Clinical app, which combines musical, cognitive, and written language exercises. The goal is to see if the benefits of that training on rea…