NON-SMALL CELL LUNG CANCER

This early-phase study tests a new drug called RNDO-564, alone or with another drug (pembrolizumab), in adults with advanced solid tumors (like lung, bladder, or breast cancer) that have stopped responding to standard treatments. The main goals are to check safety, find the best …

This study tests a combination of three drugs (avutometinib, sotorasib, and defactinib) in adults with a specific genetic mutation (KRAS G12C) in non-small cell lung cancer. The goal is to see if the combination can shrink tumors and control the disease, both in patients who have…

This study tests a new drug called ivonescimab, given before surgery for non-small cell lung cancer. It compares this drug to standard treatments to see if it better shrinks tumors and helps understand why it works. About 80 people with early-stage lung cancer will take part.

This study tests whether adding high-dose vitamin C (ascorbate) to the usual combination of chemotherapy and radiation helps control non-small cell lung cancer. About 43 participants receive the standard treatment plus high-dose vitamin C. The goal is to see if the tumor shrinks …

This study tests several targeted therapies for people with advanced or metastatic non-small cell lung cancer. A simple blood test identifies specific genetic changes in the tumor, allowing doctors to match each patient with a drug that may work better for their cancer. The goal …

This study tests a drug called entrectinib in people with advanced solid tumors that have certain gene changes (NTRK, ROS1, or ALK). The drug aims to shrink or control the cancer by blocking these faulty genes. About 534 adults with various cancers, including lung, breast, and br…

This study tests whether giving the drug trilaciclib before chemotherapy can prevent dangerous drops in blood cell counts (bone marrow suppression) in people with advanced non-small cell lung cancer. About 41 participants will receive trilaciclib before their standard platinum-ba…

This early-stage study tests a new drug, HBI-2438, in people with advanced cancers (like lung, colon, or pancreatic) that have a specific genetic change called KRAS G12C. The main goals are to find the safest dose and understand how the drug moves through the body. About 44 adult…

This phase 3 study tests whether a new drug called ensartinib works better than the current standard crizotinib for people with a specific type of advanced lung cancer (ALK-positive NSCLC). Participants had up to one prior chemotherapy but no prior ALK-targeted treatment. The mai…

This early-stage study tested a new drug called amivantamab, alone or with other treatments, in 751 people with advanced non-small cell lung cancer that had spread or couldn't be removed. The goal was to find the safest dose and see if the drug could shrink tumors. While not a cu…

This study looks at whether giving a lower dose of radiation over a few days (instead of a single high dose) can lower the chance of side effects in people with brain tumors from cancers like lung, breast, kidney, or melanoma. All participants are also receiving immunotherapy. Th…

This study looks back at how patients with non-small-cell lung cancer that has spread only to a few spots in the brain were treated. The goal is to see which treatment strategies worked best. About 46 adults from one hospital are included. The study does not test a new treatment …

This study tests whether a team of experts (Molecular Tumor Board) who review each patient's tumor genetics can help choose better treatments than usual care. About 659 people with advanced non-small cell lung cancer will take part. The goal is to see if this approach improves su…

This study compares two types of minimally invasive lung surgery for early-stage lung cancer: robotic-assisted surgery and video-assisted thoracoscopic surgery (VATS). The goal is to see which approach leads to better quality of life and lower costs. About 446 adults with stage I…

This study looks at 120 people with suspected or confirmed non-small cell lung cancer who need a tissue sample for genetic testing. During a routine ultrasound-guided biopsy, participants are randomly assigned to have either 2 or 3 samples taken from each lymph node. They also gi…