New pill targets hard-to-treat cancers in early human trial
NCT ID NCT05163028
First seen Nov 01, 2025 · Last updated Jun 13, 2026 · Updated 24 times
Summary
This early-phase study tests an experimental oral drug, HBI-2376, in 42 adults with advanced solid tumors (lung, colon, pancreatic, or other) that have KRAS or EGFR mutations and have stopped responding to standard treatments. The main goals are to find the safest dose and understand how the drug moves through the body. This is not a cure; it aims to control the disease.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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BRCR Medical Center
Plantation, Florida, 33322, United States
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California Cancer Associates for Research and Excellence, Inc. (cCare)
Encinitas, California, 92024, United States
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California Cancer Associates for Research and Excellence, Inc. (cCare)
San Marcos, California, 92069, United States
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City of Hope
Duarte, California, 91010, United States
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Gabrail Cancer Center
Canton, Ohio, 44718, United States
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Orlando Health, Inc.
Orlando, Florida, 32806, United States
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Pan American Center for Oncology Trials (PanOncology Trials)
Rio Piedras, Puerto Rico, 00935, Puerto Rico
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Providence Medical Foundation
Fullerton, California, 92835, United States
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Sarcoma Oncology
Santa Monica, California, 90403, United States
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Texas Oncology - Tyler
Tyler, Texas, 75702, United States
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UCLA Hematology/Oncology
Santa Monica, California, 90404, United States
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
Conditions
Explore the condition pages connected to this study.