New hope for chinese lung cancer patients with rare gene mutation

NCT ID NCT05195632

First seen Jan 07, 2026 · Last updated Apr 29, 2026 · Updated 20 times

Summary

This study tests a combination of two targeted drugs, encorafenib and binimetinib, in Chinese adults with a specific genetic mutation (BRAF V600E) in advanced non-small cell lung cancer that has spread. Participants must not have received prior treatment with similar drugs. The goal is to see if the combo shrinks tumors and is safe, with a small initial group checking for early side effects.

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Contacts and locations

Locations

  • Beijing Cancer Hospital

    Beijing, China

  • Beijing Chest Hospital, Capital Medical University

    Beijing, China

  • Chongqing University Cancer Hospital

    Chongqing, China

  • First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, China

  • Fujian Medical University Union Hospital

    Fuzhou, China

  • Fuzhou Tuberculosis Prevention and Control Hospital of Fujian Province (Fuzhou Pulmonary Hospital of Fujian)

    Fuzhou, China

  • Guangdong Provincial People's Hospital

    Guangzhou, China

  • Guangxi Medical University Affiliated Tumor Hospital

    Nanning, China

  • Hainan General Hospital

    Haikou, China

  • Harbin Medical University Cancer Hospital

    Harbin, China

  • Henan Cancer Hospital

    Zhengzhou, China

  • Liaoning Cancer Hospital & Institute

    Shenyang, China

  • Linyi Cancer Hospital

    Linyi, China

  • Peking University First Hospital

    Beijing, China

  • Peking University Shenzhen Hospital

    Shenzhen, China

  • Shandong Cancer Hospital

    Jinan, China

  • Shanxi Provincial Cancer Hospital

    Taiyuan, China

  • Sichuan Cancer Hospital

    Chengdu, China

  • Sun Yat-sen University Cancer Center

    Guangzhou, China

  • Taipei Veterans General Hospital

    Taipei, Taiwan

  • The First Affiliated Hospital of Jinzhou Medical University

    Jinzhou, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, China

  • The First Hospital of China Medical University

    Shenyang, China

  • The First Hospital of Jilin University

    Changchun, China

  • The Fourth Hospital of Hebei Medical University

    Shijiazhuang, China

  • The Northern Jiangsu People's Hospital

    Yangzhou, China

  • The Second Hospital of Dalian University

    Dalian, China

  • Tianjin Cancer Hospital Airport Hospital

    Tianjin, China

  • Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, China

  • Union Hospital Tongji medical college Huazhong University of Science and Technology

    Wuhan, China

  • Xiangya Hospital Central South University

    Changsha, China

  • Yantai Yuhuangding Hospital

    Yantai, China

  • Zhejiang Cancer Hospital

    Hangzhou, China

  • Zhejiang University School of Medicine, Sir Run Run Shaw Hospital

    Hangzhou, China

Conditions

Explore the condition pages connected to this study.