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New drug combo before surgery shows promise against genetic lung cancer

NCT ID NCT04351555

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 09, 2026 · Last updated Jun 11, 2026 · Updated 1 time

Summary

This study tests whether giving the targeted drug osimertinib, alone or with chemotherapy, before surgery can shrink tumors more than chemotherapy alone in people with a specific genetic mutation (EGFR) in early-stage lung cancer. About 358 adults with resectable non-small cell lung cancer will be randomly assigned to one of three treatment groups. The main goal is to see how many patients have a major response in their tumor tissue after treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site

    Duarte, California, 91010, United States

  • Research Site

    Irvine, California, 92618, United States

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    San Francisco, California, 94143, United States

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    Santa Monica, California, 90404, United States

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    Santa Rosa, California, 95403, United States

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    Boston, Massachusetts, 02215, United States

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    Lebanon, New Hampshire, 03756, United States

  • Research Site

    Commack, New York, 11725, United States

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    New York, New York, 10032, United States

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    Houston, Texas, 77030, United States

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    Fairfax, Virginia, 22031, United States

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    Seattle, Washington, 98104, United States

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    Graz, 8036, Austria

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    Vienna, 1210, Austria

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    Barretos, 14784-400, Brazil

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    Fortaleza, 60135-040, Brazil

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    Jaú, 17204310, Brazil

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    Porto Alegre, 90035-000, Brazil

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    Porto Alegre, 90610-000, Brazil

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    Recife, 52010-075, Brazil

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    Rio de Janeiro, 22271-110, Brazil

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    Santa Maria, 97015-450, Brazil

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    São José do Rio Preto, 15090-000, Brazil

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    São Paulo, 01327-001, Brazil

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    São Paulo, 04038-034, Brazil

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    São Paulo, 04501-000, Brazil

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    Panagyurishte, 4500, Bulgaria

  • Research Site

    Pleven, 5804, Bulgaria

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    Sofia, 1113, Bulgaria

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    Toronto, Ontario, M5G 2N2, Canada

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    Montreal, Quebec, H4A 3J1, Canada

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    Las Condes, 7560908, Chile

  • Research Site

    Santiago, 7500713, Chile

  • Research Site

    Santiago, 7500921, Chile

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    Beijing, 100142, China

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    Beijing, 100191, China

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    Beijing, CN-100730, China

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    Changsha, 410008, China

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    Changsha, 410013, China

  • Research Site

    Chengdu, 610041, China

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    Chongqing, 400037, China

  • Research Site

    Guangzhou, 510062, China

  • Research Site

    Guangzhou, 510095, China

  • Research Site

    Guangzhou, 510120, China

  • Research Site

    Guangzhou, 510515, China

  • Research Site

    Hangzhou, 310009, China

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    Hangzhou, 310022, China

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    Kunming, 650118, China

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    Nanchang, 330006, China

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    Nantong, 226001, China

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    Shandong, China

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    Shanghai, 200030, China

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    Shanghai, 200032, China

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    Shanghai, 200433, China

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    Suzhou, 215006, China

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    Ürümqi, 830000, China

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    Wanzhou, 404000, China

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    Wenzhou, CN-325000, China

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    Xiamen, 361004, China

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    Yangzhou, 225001, China

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    Avignon, 84902, France

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    Bordeaux, 33000, France

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    Berlin, 12351, Germany

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    Bielefeld, 33611, Germany

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    Cologne, 51109, Germany

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    Esslingen a.N., 73730, Germany

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    Freiburg im Breisgau, 79106, Germany

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    Gauting, 82131, Germany

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    Georgsmarienhütte, 49124, Germany

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    Halle, 06120, Germany

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    Oldenburg, 26121, Germany

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    Würzburg, 97067, Germany

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    Mumbai, 400012, India

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    Namakkal, 637001, India

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    New Delhi, 110029, India

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    Varanasi, 221005, India

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    Haifa, 3109601, Israel

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    Jerusalem, 91120, Israel

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    Kfar Saba, 95847, Israel

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    Petah Tikva, 49100, Israel

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    Ramat Gan, 5265601, Israel

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    Tel Aviv, 62748, Israel

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    Bari, 70124, Italy

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    Florence, 50134, Italy

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    Monza, 20900, Italy

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    Orbassano, 10043, Italy

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    Padova, 35128, Italy

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    Rozzano, 20089, Italy

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    Varese, 21100, Italy

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    Akashi-shi, 673-8558, Japan

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    Bunkyō City, 113-8431, Japan

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    Chiba, 260-8677, Japan

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    Hiroshima, 734-8551, Japan

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    Kashiwa, 227-8577, Japan

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    Kōtoku, 135-8550, Japan

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    Kyoto, 606-8507, Japan

  • Research Site

    Niigata, 951-8566, Japan

  • Research Site

    Osaka, 541-8567, Japan

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    Sakai, 590-0197, Japan

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    Sakaishi, 591-8555, Japan

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    Sendai, 981-0914, Japan

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    Shinjuku-ku, 160-0023, Japan

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    Sunto-gun, 411-8777, Japan

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    Yokohama, 241-8515, Japan

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    Aguascalientes, 20230, Mexico

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    D.F, 14050, Mexico

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    Mexico City, '14080, Mexico

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    La Libertad, 13013, Peru

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    Lima, 0051, Peru

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    Lima, 15036, Peru

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    Lima, L41, Peru

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    Lima, LIMA 34, Peru

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    Olsztyn, 10-357, Poland

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    Kazan', 420029, Russia

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    Krasnoyarsk, 660133, Russia

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    Moscow, 105229, Russia

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    Nizhny Novgorod, 603081, Russia

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    Obninsk, 249036, Russia

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    Perm, 614990, Russia

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    Saint Petersburg, 191036, Russia

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    Saint Petersburg, 197758, Russia

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    Daegu, 41404, South Korea

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    Hwasun-gun, 58128, South Korea

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    Incheon, 21431, South Korea

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    Seoul, 02447, South Korea

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    Seoul, 08308, South Korea

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    Seoul, 42601, South Korea

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    Yangsan, 50612, South Korea

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    Barcelona, 08035, Spain

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    Madrid, 28040, Spain

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    Majadahonda, 28222, Spain

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    Málaga, 29010, Spain

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    Winterthur, 8401, Switzerland

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    Zurich, CH-8091, Switzerland

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    Taichung, 40201, Taiwan

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    Taichung, 40447, Taiwan

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    Tainan, 73657, Taiwan

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    Taipei, 10002, Taiwan

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    Taipei, 110, Taiwan

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    Taipei, 112, Taiwan

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    Taipei, 235, Taiwan

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    Bangkok, 10330, Thailand

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    Bangkok, 10400, Thailand

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    Chiang Mai, 50200, Thailand

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    Khon Kaen, 40002, Thailand

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    Pathum Thani, 12120, Thailand

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    Phisanulok, 65000, Thailand

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    Ankara, 06010, Turkey (Türkiye)

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    Ankara, 06800, Turkey (Türkiye)

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    Ankara, 6500, Turkey (Türkiye)

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    Istanbul, 34010, Turkey (Türkiye)

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    Istanbul, 34214, Turkey (Türkiye)

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    Malatya, 44280, Turkey (Türkiye)

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    Birmingham, B9 5SS, United Kingdom

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    Liverpool, L7 8YA, United Kingdom

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    Hanoi, 100000, Vietnam

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    Ho Chi Minh City, 700000, Vietnam

  • Research Site

    Ho Chi Minh City, 70000, Vietnam

Conditions

Explore the condition pages connected to this study.

NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER

Conditions inferred from the trial description

These were inferred from the trial's summary, not listed by the trial registrant.

RESECTABLE EGFR MUTATION-POSITIVE NON-SMALL CELL LUNG CANCER