New hope for tough lung cancers: drug combo targets resistant tumors

NCT ID NCT05020457

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 26 times

Summary

This study tests a new drug called SI-B001 combined with chemotherapy in 69 people with advanced non-small cell lung cancer that no longer responds to standard treatments. The goal is to see if the combination can shrink tumors or slow the disease. Participants must have a specific type of lung cancer (EGFR and ALK negative) and have already tried immunotherapy with or without chemo.

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Contacts and locations

Locations

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing Municipality, China

  • Shandong Cancer Hospital

    Jinan, Shandong, China

  • Sun Yat-sen University Cancer Center (SYSUCC)

    Guangzhou, Guangdong, 510075, China

  • TaiZhou Hospital of Zhejiang Province

    Taizhou, Zhejiang, China

  • The Second Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong, China

  • The Second Affiliated Hospital of Guilin Medical University

    Guilin, Guangxi, China

Conditions

Explore the condition pages connected to this study.