New drug combo shows promise against tough cancers
NCT ID NCT04198766
First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 22 times
Summary
This study tests an experimental drug called INBRX-106, given alone or with the immunotherapy pembrolizumab (Keytruda), in people with advanced solid tumors (like lung, head and neck, melanoma, stomach, kidney, or bladder cancer) that have stopped responding to standard treatments. The main goals are to find the safest dose and to see if the combination shrinks tumors. About 296 adults will take part in this early-phase trial.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Asan Medical Center
Seoul, South Korea
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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California Research Institute
Los Angeles, California, 90027, United States
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Changhua Christian Hospital (CCH)
Changhua, Taiwan
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City of Hope
Duarte, California, 91010, United States
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Clermont Oncology Center
Clermont, Florida, 34711, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Curie Oncology
Singapore, Singapore
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E-Da Cancer Hospital
Kaohsiung City, Taiwan
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Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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HealthPartners Cancer Research Center
Saint Louis Park, Minnesota, 55426, United States
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HealthPartners Cancer Research Center (Regions Hospital)
Saint Paul, Minnesota, 55101, United States
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Henry Ford Cancer Institute
Detroit, Michigan, 48202, United States
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Icon Cancer Centre Farrer Park
Singapore, Singapore
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Icon Cancer Centre Mount Alvernia
Singapore, Singapore
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Intermountain Health Cancer Centers of Montana
Billings, Montana, 59102, United States
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Kaohsiung Medical University Chung-Ho Memorial Hospital (KMUH)
Kaohsiung City, Taiwan
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Los Angeles Cancer Network
Glendale, California, 91204, United States
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Mid Florida Hematology and Oncology Center
Orange City, Florida, 32763, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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NEXT Oncology
San Antonio, Texas, 78229, United States
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National Cheng Kung University Hospital
Tainan, Taiwan
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Nebraska Cancer Specialists
Omaha, Nebraska, 68130, United States
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Norton Cancer Institute
Louisville, Kentucky, 40202, United States
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Providence Medical Foundation
Santa Rosa, California, 95403, United States
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Providence Portland Medical Center
Portland, Oregon, 97213, United States
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Renovatio Clinical
The Woodlands, Texas, 77380, United States
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Renovatio Clinical - El Paso
El Paso, Texas, 79915, United States
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START Midwest
Grand Rapids, Michigan, 49546, United States
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Sarah Cannon Research Institute at Mary Crowley
Dallas, Texas, 75230, United States
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Severance Hospital, Yonsei University Health System
Seoul, South Korea
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Taipei Veterans General Hospital
Taipei, Taiwan
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The Catholic University of Korea Seoul St. Mary's Hospital,
Seoul, South Korea
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The Catholic University of Korea, St. Vincent's Hospital
Gyeonggi-do, South Korea
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The University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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The University of Texas Health Science Center at Tyler
Tyler, Texas, 75701, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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Valkyrie Clinical Trials
Los Angeles, California, 90069, United States
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Valkyrie Clinical Trials
Murrieta, California, 92562, United States
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Vanderbilt University School of Medicine
Nashville, Tennessee, 37204, United States
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Virginia Cancer Specialists
Fairfax, Virginia, 22031, United States
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Winship Cancer Institute - Emory University
Atlanta, Georgia, 30322, United States
Conditions
Explore the condition pages connected to this study.