New drug shows promise for rare lung cancer subtype
NCT ID NCT04919811
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a drug called taletrectinib in 217 people with advanced or metastatic ROS1-positive non-small cell lung cancer and other solid tumors. The main goal is to see how well the drug shrinks tumors and to check its safety. Participants take the drug by mouth daily, and researchers track tumor response and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- taletrectinib (a targeted cancer drug)
- What this could lead to
- If successful, this could provide a new treatment option for people with ROS1-positive lung cancer that has spread or cannot be removed by surgery.
- What could go wrong
- This is a mid-stage trial with no placebo group, so results may not confirm real-world benefit. Side effects are possible, and the drug may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AOU Cagliari- P.O. Policlinico Universitario Duilio Casula
Monserrato, 09042, Italy
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APHP- Hôpital Europeen Georges Pompidou (HEGP)
Paris, 75015, France
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Aichi Cancer Center Hospital
Nagoya, 464-8681, Japan
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Asan Medical Center
Seoul, 05505, South Korea
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Azienda Ospedaliera Universitaria- Università degli Studi della Campania
Naples, 80131, Italy
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Beijing Cancer Hospital
Beijing, Beijing Municipality, 100142, China
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Beverly Hills Cancer Center
Beverly Hills, California, 90211, United States
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CHU Grenoble Alpes- Hospital Michallon
La Tronche, 38700, France
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CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel
Bron, France
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CHU Rennes - Hospital Pontchaillou
Rennes, 35033, France
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CHU de Poitiers Pole regional
Poitiers, 86000, France
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Cancer Specialists of North Florida
Jacksonville, Florida, 92868, United States
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Center for Cancer Research
Brick, New Jersey, 08724, United States
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Centre Léon Bérard
Lyon 08, 69373, France
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Centre d'Essais Précoces de Cancerologie de Marseille
Marseille, 13005, France
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Chonnam National University Hwasun Hospital
Hwasun, 58128, South Korea
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Clinica Mi Tres Torres
Barcelona, 08017, Spain
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Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168, Italy
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Henan Cancer Hospital
Zhengzhou, China
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Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
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Hospital Quironsalud Barcelona
Barcelona, 08023, Spain
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Hospital Regional Universitario de Malaga
Málaga, 29010, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario 12 de Octubre
Madrid, 28041, Spain
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Hospital Universitario Clinico San Carlos
Madrid, 28040, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Humanitas Istituto Clinico Catanese, Misterbinanoco
Catania, 95045, Italy
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Hunan Cancer Hospital
Changsha, China
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ICO l'Hospitalet - Hospital Duran i Reynals L'Hospitalet de Llobregat
Barcelona, 08908, Spain
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IEO Istituto Europeo di Oncologia
Milan, 20141, Italy
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Institut De Cancérologie De L'ouest
Saint-Herblain, 44805, France
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Institut Gustave Roussy
Saint-Herblain, 44805, France
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Institut Jean Godinot
Reims, 51726, France
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Instituto Valenciano de Oncologia IVO
Valencia, 46009, Spain
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Instytut Centrum Zdrowia Matki Polki
Lodz, Poland
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Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico
Bari, 70124, Italy
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Keck Medicine of University of Southern California
Los Angeles, California, 90089, United States
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Kindai University Hospital
Osaka, 589-8511, Japan
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Korea University Guro Hospital
Seoul, 08308, South Korea
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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MICS Centrum Medyczne Toruńa
Torun, 87-100, Poland
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Mayo Clinic
Rochester, Minnesota, 55902, United States
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McGill University Health Centre Research Institute
Montreal, Quebec, Canada
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Med-Polonia Sp. z o.o.
Poznan, 60-693, Poland
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Memorial Cancer Institute at Memorial Hospital East
Hollywood, Florida, 33021, United States
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Memorial Cancer Institute at Memorial Hospital West
Pembroke Pines, Florida, 33028, United States
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Moores Cancer Center at UC San Diego
La Jolla, California, 92037, United States
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National Cancer Center Hospital
Tokyo, 104-0045, Japan
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National Cancer Center Hospital East
Kashiwa, 104-0045, Japan
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National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
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Northwest Medical Specialties, PLLC
Tacoma, Washington, 98405, United States
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Ospedale San Raffaele
Milan, 20132, Italy
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Princess Margaret Cancer Centre
Toronto, Ontario, Canada
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Pusan National University Hospital
Busan, 49241, South Korea
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Pusan National University Yangsan Hospital
Gyeongsang, 999007, South Korea
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Renovatio Clinical
El Paso, Texas, 19915, United States
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Renovatio Clinical
The Woodlands, Texas, 77380, United States
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SCRI - Florida Cancer Specialists South
Fort Meyers, Florida, 33901, United States
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SCRI - Hematology Oncology Clinic
Baton Rouge, Louisiana, 70809, United States
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SCRI - Tennessee Oncology
Nashville, Tennessee, 37203, United States
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Sendai Kousei Hospital
Miyagi, 980-0873, Japan
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Shandong Cancer Hospital
Jinan, China
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Shanghai Pulmonary Hospital
Shanghai, Shanghai Municipality, 200433, China
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Shizuoka Cancer Center
Shizuoka, 411-8777, Japan
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Texas Oncology, P.A.
Dallas, Texas, 75246, United States
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The Cancer Institute Hospital of JFCR
Tokyo, 135-8550, Japan
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
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The Oncology Institute of Hope and Innovation
Glendale, California, 91204, United States
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UCI Medical Center
Orange, California, 92868, United States
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Ventura County Hematology-Oncology Specialists
Oxnard, California, 93030, United States
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West China Hospital
Chengdu, China
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Wuhan Union Hospital
Wuhan, China
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