New pill shows promise against Hard-to-Treat HER2 cancers

NCT ID NCT04886804

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 4 times

Summary

This early-stage trial tests a new daily pill, zongertinib, in adults with advanced cancers that have HER2 gene changes, including non-small cell lung cancer. The first part finds the safest dose; the second checks if it shrinks tumors. Participants stay on the drug as long as it helps and side effects are manageable.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Azienda Ospedaliera Unversitaria di Parma

    Parma, 43100, Italy

  • Beijing Cancer Hospital

    Beijing, 100036, China

  • Brussels - HOSP Jules Bordet

    Anderlecht/Brussels-Capital, 1070, Belgium

  • CTR Leon Berard

    Lyon, 69373, France

  • Chungbuk National University Hospital

    Chungju, 28644, South Korea

  • City of Hope - Seacliff

    Huntington Beach, California, 92648, United States

  • City of Hope-Duarte-56419

    Duarte, California, 91010, United States

  • City of Hope-Irvine-69674

    Irvine, California, 92618, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • First Affiliated Hospital of Xiamen University

    Xiamen, 361003, China

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109, United States

  • Fujian Cancer Hospital

    Fuzhou, 350014, China

  • Georgetown University

    Washington D.C., District of Columbia, 20007, United States

  • Guangdong Provincial People's Hospital

    Guangzhou, 510080, China

  • HOP Pontchaillou

    Rennes, 35000, France

  • HOP Timone

    Marseille, 13385, France

  • Hamamatsu University Hospital

    Shizuoka, Hamamatsu, 431-3192, Japan

  • Hammersmith Hospital

    London, W12 0HS, United Kingdom

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • Hawaii Cancer Care - Honolulu

    Honolulu, Hawaii, 96813, United States

  • Henan Cancer Hospital

    Zhengzhou, 450008, China

  • Hiroshima University Hospital

    Hiroshima, Hiroshima, 734-8551, Japan

  • Holy Cross Hospital-Fort Lauderdale-57892

    Fort Lauderdale, Florida, 33308, United States

  • Hospital CUF Porto

    Porto, 4100-180, Portugal

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Duran i Reynals

    L'Hospitalet de Llobregat, 08907, Spain

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28007, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hôpital Louis Pradel

    Bron, 69677, France

  • INS Curie

    Paris, 75005, France

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Istituto Di Candiolo

    Candiolo (TO), 10060, Italy

  • Istituto Nazionale IRCCS Tumori Fondazione Pascale

    Naples, 80131, Italy

  • Jilin Province Cancer Hospital

    Changchun, 130012, China

  • Justus-Liebig Universität Gießen

    Giessen, 35392, Germany

  • Karolinska Universitetssjukhuset Solna

    Stockholm, 171 76, Sweden

  • Kindai University Hospital

    Osaka, Sakai, 590-0197, Japan

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Leids Universitair Medisch Centrum (LUMC)

    Leiden, 2333 ZA, Netherlands

  • Macquarie University

    Macquarie Park, New South Wales, 2109, Australia

  • Mary Crowley Cancer Research Center

    Dallas, Texas, 75230, United States

  • Meir Medical Center

    Kfar Saba, 44281, Israel

  • National Cancer Center Hospital

    Tokyo, Chuo-ku, 104-0045, Japan

  • National Cancer Center Hospital East

    Chiba, Kashiwa, 277-8577, Japan

  • National Cancer Centre Singapore

    Singapore, 169610, Singapore

  • National University Hospital-Singapore-22806

    Singapore, 119228, Singapore

  • Nederlands Kanker Instituut

    Amsterdam, 1066 CX, Netherlands

  • Ordensklinikum Linz GmbH

    Linz, 4020, Austria

  • Osaka International Cancer Institute

    Osaka, Osaka, 541-8567, Japan

  • Pius-Hospital, Oldenburg

    Oldenburg, 26121, Germany

  • Precision NextGen Oncology

    Beverly Hills, California, 90212, United States

  • Prince of Wales Hospital-Hong Kong-20715

    Hong Kong, 999077, Hong Kong

  • Queen Mary Hospital

    Hong Kong, Hong Kong

  • Rambam Medical Center

    Haifa, 3109601, Israel

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • Sarah Cannon Research Institute-Nashville-48456

    Nashville, Tennessee, 37203, United States

  • Seoul National University Bundang Hospital

    Seongnam, 13620, South Korea

  • Severance Hospital

    Seoul, 03722, South Korea

  • Shanghai Chest Hospital

    Shanghai, 200030, China

  • Shikoku Cancer Center

    Ehime, Matsuyama, 791-0280, Japan

  • Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Technische Universität Dresden

    Dresden, 01307, Germany

  • The Affiliated Cancer Hospital, Guangxi Medical University

    Nanning, 530021, China

  • The Chaim Sheba Medical Center Tel HaShomer

    Tel Litwinsky, 52621, Israel

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, 450052, China

  • The First Affiliated Hospital, Zhejiang University

    Hangzhou, 310003, China

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • The Royal Marsden Hospital, Chelsea

    London, SW3 6JJ, United Kingdom

  • The Royal Marsden Hospital, Sutton

    Sutton, SM2 5PT, United Kingdom

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T

    Wuhan, 430030, China

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233, United States

  • University of California Davis

    Sacramento, California, 95817, United States

  • University of California Irvine

    Orange, California, 92868, United States

  • Universitätsklinikum Augsburg

    Augsburg, 86156, Germany

  • Universitätsklinikum Köln (AöR)

    Cologne, 50937, Germany

  • Valkyrie Clinical Trials

    Los Angeles, California, 90067, United States

  • Virginia Cancer Specialists, PC

    Fairfax, Virginia, 22031, United States

  • Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Wuhan Union Hospital

    Wuhan, 430022, China

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

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Other studies related to the condition(s) this trial covers.