New drug combo targets hard-to-treat chest cancers with genetic flaw

NCT ID NCT06333951

Ongoing Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 13, 2026 · Updated 35 times

Summary

This early-stage study tests a new drug called anvumetostat, alone or with other treatments, in adults with advanced chest cancers (like lung cancer) that have a specific missing gene (MTAP-deletion). The main goals are to find the safest dose and check for side effects. About 49 people will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Adana Sehir Egitim ve Arastirma Hastanesi

Adana, 01370, Turkey (Türkiye)
Aichi Cancer Center

Nagoya, Aichi-ken, 464-8681, Japan
Alexandra Hospital

Athens, 11528, Greece
Ankara Bilkent Sehir Hastanesi

Ankara, 06800, Turkey (Türkiye)
Asan Medical Center

Seoul, 05505, South Korea
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
Beijing Cancer Hospital

Beijing, 100142, China
Beneficencia Portuguesa de Sao Paulo - Bp

São Paulo, São Paulo, 01509-900, Brazil
Cemic

Ciudad Autonoma Buenos Aires, C1431FWO, Argentina
Centre Hospitalier Universitaire de Liege - Sart Tilman

Liège, 4000, Belgium
Centro Ricerche Cliniche Di Verona Societa responsabilita limitata

Verona, 37126, Italy
Centrum Medyczne Hope Clinic Sebastian Szklener

Lublin, 20-701, Poland
Cipo - Centro Integrado de Pesquisa em Oncologia

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
City of Hope National Medical Center

Duarte, California, 91010, United States
City of Hope Orange County Lennar Foundation Cancer Center

Duarte, California, 91010, United States
Comprehensive Blood and Cancer Center

Bakersfield, California, 93309, United States
Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada, 89169, United States
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
European Interbalkan Medical Center

Thessaloniki, 57001, Greece
Fondazione IRCCS Istituto Nazionale dei Tumori

Alessandria, 15100, Italy
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Fund Faculdade Regional Med Sao Jose Rio Preto

São José do Rio Preto, São Paulo, 15090-000, Brazil
Futuremeds spolka z ograniczona odpowiedzialnoscia

Krakow, 31-501, Poland
General Hospital Of Thessaloniki Papageorgiou

Thessaloniki, 56429, Greece
Guangdong Provincial Peoples Hospital

Guangzhou, Guangdong, 510000, China
Gustave Roussy

Villejuif, 94805, France
Hacettepe Universitesi Tip Fakultesi Hastanesi

Ankara, 06230, Turkey (Türkiye)
HealthPartners Institute

Saint Paul, Minnesota, 55102, United States
Hightower Clinical

Oklahoma City, Oklahoma, 73102, United States
Hopital de la Timone

Marseille, 13005, France
Hospital Clinic i Provincial de Barcelona

Barcelona, Catalonia, 08036, Spain
Hospital Universitari Vall d Hebron

Barcelona, Catalonia, 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Austral

Pilar, Buenos Aires, B1629ODT, Argentina
IRCCS Istituto Clinico Humanitas

Rozzano (MI), 20089, Italy
Institut Bergonie

Bordeaux, 33000, France
Institut de Cancerologie de l Ouest Rene Gauducheau

Saint-Herblain, 44805, France
Instituto Argentino de Diagnóstico y Tratamiento

Ciudad Automona de Buenos Aires, Buenos Aires, C1117ABC, Argentina
Instituto Cancer Sao Paulo Icesp

São Paulo, 01246-000, Brazil
Instytut Centrum Zdrowia Matki Polki

Lodz, 93-338, Poland
Jilin Cancer Hospital

Changchun, Jilin, 130012, China
Medizinische Universitaet Graz

Graz, 8036, Austria
Medizinische Universitaet Innsbruck

Innsbruck, 6020, Austria
Mengchao Hepatobiliary Hospital of Fujian Medical University

Fuzhou, Fujian, 350028, China
Narodowy Instytut Onkologii im Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy

Gliwice, 44-102, Poland
National Cancer Center Hospital East

Kashiwa-shi, Chiba, 277-8577, Japan
National Cheng Kung University Hospital

Tainan, 70403, Taiwan
New York University Grossman School of Medicine

New York, New York, 10016, United States
Northwest Medical Specialties, PLLC

Tacoma, Washington, 98405, United States
Oncology Consultants Cancer Center

Houston, Texas, 77030, United States
Oncosite Centro de Pesquisa Clinica Em Oncologia Ltda

Ijuí, Rio Grande do Sul, 98700-000, Brazil
Orange Health Service

Orange, New South Wales, 2800, Australia
Perlmutter Cancer Center at New York University Langone Hospital----Long Island

New York, New York, 10016, United States
Prince of Wales Hospital, Chinese University of Hong Kong

Shatin, New Territories, Hong Kong
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Queen Mary Hospital, The University of Hong Kong

Hong Kong, Hong Kong
Radboud Universitair Medisch Centrum

Nijmegen, 6525 GA, Netherlands
Rocky Mountain Cancer Centers

Denver, Colorado, 80218, United States
Roswell Park Cancer Institute

Buffalo, New York, 32224, United States
Saint Lukes Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Seoul National University Hospital

Seoul, 03080, South Korea
Shizuoka Cancer Center

Sunto-gun, Shizuoka, 411-8777, Japan
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Texas Oncology - Dallas Fort Worth

Dallas, Texas, 75246, United States
Texas Oncology Northeast Texas

Tyler, Texas, 75702, United States
The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450052, China
The Queen Elizabeth Hospital

Woodville South, South Australia, 5011, Australia
Translational Research in Oncology US Inc, Trio Central Pharmacy

Los Angeles, California, 90095, United States
US Oncology Research Investigational Products Center

Dallas, Texas, 75246, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China
United States Oncology Regulatory Affairs Corporate Office

Nashville, Tennessee, 37203, United States
Universitaetsklinikum Essen

Essen, 45147, Germany
Universitaetsklinikum Heidelberg

Heidelberg, 69126, Germany
Universitaetsklinikum Wuerzburg

Würzburg, 97078, Germany
University of California Irvine

Orange, California, 92868-3217, United States
University of California Los Angeles

Santa Monica, California, 90404, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of Tennessee Medical Center Knoxville

Knoxville, Tennessee, 37920, United States
Uniwersyteckie Centrum Kliniczne

Gdansk, 80-214, Poland
Upstate University Hospital

Syracuse, New York, 13210, United States
Virginia Cancer Specialists PC

Fairfax, Virginia, 22031, United States
Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510, Japan
West China Hospital Sichuan University

Chengdu, Sichuan, 610041, China

Conditions

Explore the condition pages connected to this study.

NON SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER THORACIC TUMORS