New hope for early lung cancer: targeted combo aims to stop return after surgery

NCT ID NCT06564844

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding two new drugs (datopotamab deruxtecan and rilvegostomig) after surgery can help prevent early-stage lung cancer from coming back. It is for people with stage I adenocarcinoma non-small cell lung cancer who have signs of cancer DNA in their blood or other high-risk features. Participants will receive either the drug combination, rilvegostomig alone, or standard care, and researchers will compare how long they stay cancer-free.

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Conditions

The condition(s) this trial relates to.

adenocarcinoma lung adenocarcinoma non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

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Tucson, Arizona, 85724, United States
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Duarte, California, 91010, United States
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Glendale, California, 91204, United States
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Los Angeles, California, 90089, United States
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Lone Tree, Colorado, 80124, United States
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Washington D.C., District of Columbia, 20007, United States
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Jacksonville, Florida, 32224, United States
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St. Petersburg, Florida, 33709, United States
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Chicago, Illinois, 60637, United States
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Evanston, Illinois, 60201, United States
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Zion, Illinois, 60099, United States
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Kansas City, Kansas, 66160, United States
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Lexington, Kentucky, 40503, United States
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Baltimore, Maryland, 21237, United States
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Farmington Hills, Michigan, 48334, United States
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Grand Rapids, Michigan, 49503, United States
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Minneapolis, Minnesota, 55407, United States
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Billings, Montana, 59102, United States
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Omaha, Nebraska, 68130, United States
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East Syracuse, New York, 13057, United States
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Mineola, New York, 11501, United States
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New York, New York, 10016, United States
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New York, New York, 10065, United States
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Portland, Oregon, 97239, United States
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Bethlehem, Pennsylvania, 18015, United States
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Philadelphia, Pennsylvania, 19107, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Knoxville, Tennessee, 37920, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37203, United States
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Austin, Texas, 78745, United States
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Dallas, Texas, 75231, United States
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Houston, Texas, 77030, United States
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San Antonio, Texas, 78217, United States
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Fairfax, Virginia, 22031, United States
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Seattle, Washington, 98104, United States
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Madison, Wisconsin, 53792, United States
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Barretos, 14784-057, Brazil
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Brasília, 70200-730, Brazil
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Florianópolis, 88034-000, Brazil
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São Paulo, 01323-903, Brazil
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Teresina, 64049-200, Brazil
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Halifax, Nova Scotia, B3H 2Y9, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Montreal, Quebec, H2X 3J4, Canada
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Hong Kong, 999077, Hong Kong
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Bunkyō City, 113-8603, Japan
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Chiba, 260-0877, Japan
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Chūōku, 104-0045, Japan
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Fukuoka, 812-8582, Japan
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Hidaka-shi, 350-1298, Japan
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Hiroshima, 730-8518, Japan
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Hiroshima, 734-8551, Japan
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Iwakuni-shi, 740-8510, Japan
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Kashiwa, 277-8577, Japan
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Kitaadachi-gun, 362-0806, Japan
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Kobe, 650-0017, Japan
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Kōtoku, 135-8550, Japan
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Kumamoto, 860-8556, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8566, Japan
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Osakasayama-shi, 589-8511, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-0873, Japan
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Sendai, 980-8574, Japan
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Wakayama, 641-8510, Japan
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Yokohama, 241-8515, Japan
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuching, 93586, Malaysia
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Kaohsiung City, 80756, Taiwan
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Taipei, 10002, Taiwan
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Taipei, 112, Taiwan
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Taipei, 114, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10400, Thailand
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Bangkoknoi, 10700, Thailand
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Banphaeo, 74120, Thailand
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Dusit, 10300, Thailand
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Hat Yai, 90110, Thailand
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Muang, 40002, Thailand
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Muang, 50200, Thailand
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Ratchathewi, 10400, Thailand
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Ankara, 06010, Turkey (Türkiye)
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Ankara, 06280, Turkey (Türkiye)
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Mersin, 33240, Turkey (Türkiye)
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Hanoi, 100000, Vietnam
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Hà Nội, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Vinh, 460000, Vietnam

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