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New hope for tough lung cancers: triple therapy trial targets progression

NCT ID NCT05781308

Ongoing Disease control Sponsor: Intergroupe Francophone de Cancerologie Thoracique Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding an immunotherapy drug (atezolizumab) to a standard two-drug chemotherapy (paclitaxel and bevacizumab) can help people with advanced non-squamous lung cancer whose disease has worsened after prior immunotherapy and chemotherapy. About 156 participants will be randomly assigned to receive either the two-drug or three-drug combination. The main goal is to see if the three-drug combo can keep the cancer from growing for at least 6 months in more patients.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

  • APHM Hôpital Nord

    Marseille, France

  • CH Annecy Genevois

    Pringy, France

  • CH Avignon

    Avignon, France

  • CH Cholet

    Cholet, France

  • CH Côte Basque

    Bayonne, France

  • CH Le Mans

    Le Mans, France

  • CH Pasteur

    Colmar, France

  • CH Pau

    Pau, France

  • CH Versailles

    Le Chesnay, France

  • CH Villefranche Nord Ouest

    Villefranche-sur-Saône, 69655, France

  • CHD Vendée

    La Roche-sur-Yon, France

  • CHR Orléans

    Orléans, France

  • CHU Amiens

    Amiens, France

  • CHU Besançon - Hôpital J. MINJOZ

    Besançon, 25030, France

  • CHU Bordeaux Haut-Lévèque

    Pessac, France

  • CHU Côte de Nacre

    Caen, 14000, France

  • CHU Dijon

    Dijon, France

  • CHU Gabriel Montpied

    Clermont-Ferrand, France

  • CHU Lille

    Lille, France

  • CHU Limoges

    Limoges, 87042, France

  • CHU Poitiers

    Poitiers, France

  • CHU Rouen

    Rouen, 76031, France

  • CHU Saint Etienne

    Saint-Etienne, France

  • CHU Toulouse

    Toulouse, 31059, France

  • CHU Tours

    Tours, France

  • CHU d'Angers

    Angers, 49033, France

  • Centre Georges-François Leclerc

    Dijon, 21079, France

  • Centre Hospitalier Intercommunal Créteil CHIC

    Créteil, France

  • Centre Léon Bérard

    Lyon, 69373, France

  • Chu Grenoble

    Grenoble, 38043, France

  • Clinique Teissier

    Valenciennes, France

  • GHR Mulhouse et Sud Alsace GHRMSA

    Mulhouse, 68070, France

  • Groupe Hospitalier Paris Saint Joseph GHPSJ

    Paris, France

  • HIA Sainte-Anne

    Toulon, 83800, France

  • Hospices Civils de Lyon - URCOT

    Pierre-Bénite, France

  • Hôpital APHP Ambroise Paré

    Boulogne, 92104, France

  • Hôpital BICHAT

    Paris, 75877, France

  • Hôpital Européen

    Marseille, France

  • Hôpital TENON

    Paris, 75970, France

  • Hôpitaux Privés de Metz Robert Schuman

    Metz, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut de Cancerologie de l'Ouest ICO

    Saint-Herblain, France

  • Nouvel Hôpital Civil - Hôpitaux Universitaires de Strasbourg

    Strasbourg, 67091, France

  • Polyclinique Bordeaux Nord Aquitaine

    Bordeaux, France

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