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New hope for ALK-Positive lung cancer: drug combo shows promise

NCT ID NCT05200481

Ongoing Disease control Sponsor: Intergroupe Francophone de Cancerologie Thoracique Source: ClinicalTrials.gov ↗

First seen Nov 17, 2025 · Last updated Apr 29, 2026 · Updated 19 times

Summary

This study tests two treatments for people with advanced ALK-positive non-small cell lung cancer who haven't had treatment yet. One group gets the targeted drug brigatinib alone, the other gets brigatinib plus chemotherapy. The goal is to see if the combination helps keep the cancer from growing longer. About 110 adults will take part across multiple centers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • CHU Besançon - Hôpital J. MINJOZ

    Besançon, 25030, France

  • CHU Côte de Nacre

    Caen, 14000, France

  • CHU Dupuytren

    Limoges, 87042, France

  • CHU Rennes - Hôpital Pontchaillou

    Rennes, 35033, France

  • CHU d'Angers

    Angers, 49033, France

  • Centre Alexis Vautrin

    Vandœuvre-lès-Nancy, 54511, France

  • Centre Georges-François Leclerc

    Dijon, 21079, France

  • Centre Hospitalier

    Mulhouse, 68070, France

  • Centre Hospitalier

    Saint-Quentin, 02100, France

  • Centre Hospitalier Intercommunal de Créteil

    Créteil, 94000, France

  • Centre Hospitalier de Villefranche-sur-Saône

    Villefranche-sur-Saône, 69655, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63011, France

  • Centre Léon Bérard

    Lyon, 69373, France

  • Chu Grenoble

    Grenoble, 38043, France

  • HIA Sainte-Anne

    Toulon, 83800, France

  • Hospices Civils de Lyon - Hôpital Louis Pradel

    Bron, 69677, France

  • Hôpital APHP Ambroise Paré

    Boulogne, 92104, France

  • Hôpital Arnaud de Villeneuve

    Montpellier, 34295, France

  • Hôpital BICHAT

    Paris, 75877, France

  • Hôpital Calmette

    Lille, 59037, France

  • Hôpital Charles Nicolle

    Rouen, 76031, France

  • Hôpital Cochin

    Paris, 75014, France

  • Hôpital Haut-Lévèque

    Pessac, 33604, France

  • Hôpital Larrey (CHU)

    Toulouse, 31059, France

  • Hôpital Nord

    Marseille, 13915, France

  • Hôpital TENON

    Paris, 75970, France

  • Institut Paoli Calmettes

    Marseille, 13273, France

  • Institut de Cancérologie de l'Ouest - René Gauducheau

    Saint-Herblain, 44805, France

  • Nouvel Hôpital Civil - Hôpitaux Universitaires de Strasbourg

    Strasbourg, 67091, France

Conditions

Explore the condition pages connected to this study.

ALK GENE MUTATION NON SMALL CELL LUNG CANCER NON SMALL CELL LUNG CANCER