Lung cancer combo therapy shows promise in High-Risk patients

NCT ID NCT04547504

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 25 times

Summary

This phase 3 trial compares two first-line treatments for advanced non-small-cell lung cancer with high PDL1 levels (50% or more). About 349 participants receive either pembrolizumab alone or pembrolizumab plus chemotherapy. The goal is to see if the combination delays cancer progression better than the single drug, especially for patients at risk of early worsening.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for NON SMALL CELL LUNG CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • APHP - Hôpital Cochin

    Paris, 75014, France

  • CH Intercommunal de Créteil

    Créteil, 94010, France

  • CH La Roche Sur Yon - CHD Les Oudairies

    La Roche-sur-Yon, 85000, France

  • CH La Réunion - Site Félix Guyon

    Saint-Denis, 97400, France

  • CH MEAUX

    Meaux, 77108, France

  • CH d'Annecy-genevois

    Pringy, 74374, France

  • CH de Lorient - Hôpital du Scorff

    Lorient, 56100, France

  • CH du Pays d'Aix

    Aix-en-Provence, 13616, France

  • CHRU de Brest

    Brest, 29609, France

  • CHU AMIENS - Hôpital Sud

    Amiens, 80054, France

  • CHU Bordeaux - Hôpital du Haut Levêque

    Pessac, 33604, France

  • CHU La Réunion - Groupe Hospitalier Sud

    Saint-Pierre, 97410, France

  • CHU MARSEILLE_ Hopital Nord

    Marseille, 13915, France

  • CHU RENNES - Hôpital Pontchailloux

    Rennes, 35033, France

  • CHU ROUEN - Hôpital Charles Nicolle

    Rouen, 76031, France

  • Centre Hospitalier Métropole Savoie

    Chambéry, 73000, France

  • Centre Hospitalier de Cornouaille

    Quimper, 29000, France

  • Centre Léon Berard

    Lyon, 69008, France

  • Centre de lutte contre le cancer - Centre François Baclesse

    Caen, 14000, France

  • Ch Villefranche Sur Saone

    Villefranche-sur-Saône, 69655, France

  • Chu Angers

    Angers, 49033, France

  • Chu Dupuytren

    Limoges, 87042, France

  • Hôpital Européen Marseille

    Marseille, 13003, France

  • Hôpital d'Instruction des Armées Toulon - Saint Anne

    Toulon, 83041, France

  • Institut Gustave Roussy

    Villejuif, 94800, France

  • Institut Paoli-Calmette

    Marseille, 13000, France

  • Institut de Cancérologie Strasbourg Europe

    Strasbourg, 67200, France

  • SAINT-PRIEST EN JAREZ - Institut de Cancérologie de la Loire

    Saint-Priest-en-Jarez, 42271, France

  • Saint Aubin Les Elbeuf

    Saint-Aubin-lès-Elbeuf, 76503, France

Conditions

Explore the condition pages connected to this study.