New targeted pill takes on tough lung cancer in major trial

NCT ID NCT06281964

First seen Dec 29, 2025 · Last updated May 14, 2026 · Updated 19 times

Summary

This study tests a new oral drug, PLB1004, against standard chemotherapy (with or without an immunotherapy) in about 327 people with advanced non-small-cell lung cancer that has a specific genetic change called EGFR exon 20 insertion. The goal is to see if PLB1004 can keep the cancer from growing longer than chemo. Participants must have confirmed EGFR Exon20ins and have not had prior treatment for advanced disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangzhou, 510080, China

Conditions

Explore the condition pages connected to this study.