New drug combo targets Hard-to-Treat cancers in early trial

NCT ID NCT05789069

First seen Nov 21, 2025 · Last updated May 12, 2026 · Updated 21 times

Summary

This study tests an experimental drug called HFB200603, alone or with another immunotherapy (tislelizumab), in adults with advanced solid tumors like kidney, lung, skin, stomach, or colorectal cancer. The goal is to find a safe dose and see how well the body tolerates it. About 83 participants will receive increasing doses in the first part, then the chosen dose in the second part based on their cancer type.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Centro Ricerche Cliniche di Verona s.r.l.

    Verona, 37134, Italy

  • Clinica Universidad de Navarra - Madrid

    Madrid, 28027, Spain

  • Clinica Universidad de Navarra - Pamplona

    Pamplona, 31008, Spain

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Istituto Nazionale Tumori IRCCS Fondazione G. Pascale

    Naples, 80131, Italy

  • New Experimental Therapeutics of Virginia - NEXT Oncology

    Fairfax, Virginia, 22031, United States

  • South Texas Accelerated Research Therapeutics (START) Madrid - CIOCC

    Madrid, 28050, Spain

  • South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • UOC Fase I - Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore

    Rome, 00168, Italy

  • USC Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

Conditions

Explore the condition pages connected to this study.