New drug shows promise for Hard-to-Treat cancers

NCT ID NCT03401385

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug, DS-1062a, in people with advanced solid tumors like lung and breast cancer that haven't responded to other treatments. It's the first time this drug is being used in humans, so the main goals are to check safety, find the right dose, and see if it helps shrink tumors. About 890 participants will take the drug, and those who benefit can continue until their disease gets worse or side effects become too severe.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hormone receptor-positive breast cancer non-small cell lung carcinoma triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Aichi Cancer Center

    Nagoya, Aichi-ken, 464-8681, Japan

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02115, United States

  • Johns Hopkins Sibley Memorial Hospital

    Washington D.C., District of Columbia, 20016, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • National Cancer Center Hospital

    Chūōku, 104-0045, Japan

  • National Cancer Center Hospital East

    Kashiwa, 277-8577, Japan

  • Next Oncology

    San Antonio, Texas, 78229, United States

  • START Oncology

    San Antonio, Texas, 78229, United States

  • Sarah Cannon Research Institute

    Nashville, Tennessee, 37205, United States

  • Showa Medical University Hospital

    Shinagawa-Ku, Tokyo, 142-0064, Japan

  • The Cancer Institute Hospital of Japanese Foundation For Cancer Research

    Koto-Ku, Tokyo, 135-8550, Japan

  • Tisch Cancer Institute, Icahn School of Medicine

    New York, New York, 10029, United States

  • University of California, Los Angeles

    Los Angeles, California, 90095, United States

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, 30322, United States