New hope for early lung cancer: pill may keep disease from returning

NCT ID NCT05120349

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether the targeted drug osimertinib (Tagrisso) can prevent lung cancer from returning in patients with early-stage (IA2-IA3) non-small cell lung cancer that has a specific EGFR mutation. About 390 participants who have had complete tumor removal surgery will receive either osimertinib or a placebo daily. The study measures how long they remain cancer-free and overall survival, with treatment continuing until the cancer returns or side effects become unacceptable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Osimertinib (Tagrisso), a targeted cancer pill
What this could lead to: If successful, this could offer a way to reduce the risk of early-stage lung cancer returning after surgery, potentially improving long-term survival.
What could go wrong: This is an early-stage cancer trial, and the benefit over placebo may be small. Side effects like rash, diarrhea, or lung inflammation are possible, and the drug must be taken indefinitely until recurrence or toxicity.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

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Locations

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Anchorage, Alaska, 99508, United States
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Los Angeles, California, 90024, United States
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Orange, California, 92868, United States
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Grand Junction, Colorado, 81501, United States
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Newark, Delaware, 19713, United States
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Atlanta, Georgia, 30322, United States
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Chicago, Illinois, 60612, United States
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Frederick, Maryland, 21702, United States
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Morristown, New Jersey, 07960, United States
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Flushing, New York, 11355, United States
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New York, New York, 10032, United States
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New York, New York, 10065, United States
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White Plains, New York, 10601, United States
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Houston, Texas, 77030, United States
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Fort Belvoir, Virginia, 22060, United States
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Buenos Aires, C1431FWO, Argentina
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CABA, C1012AAR, Argentina
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Cipolletti, 8234, Argentina
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La Plata, 1900, Argentina
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Rosario, 2000, Argentina
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Rosario, S2000CVB, Argentina
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S.C. de Bariloche, 8400, Argentina
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Barretos, 14784-400, Brazil
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Belo Horizonte, 30380-090, Brazil
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Porto Alegre, 90610-000, Brazil
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Recife, 52010-075, Brazil
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Rio de Janeiro, 22271-110, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 04501-000, Brazil
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Vancouver, British Columbia, V5Z 1M9, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Toronto, M5G 2M9, Canada
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Beijing, 100005, China
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Beijing, 100029, China
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Beijing, 100142, China
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Beijing, 100210, China
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Beijing, 100730, China
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Beijing, 102218, China
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Changchun, 130012, China
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Changsha, 410013, China
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Changsha, 430033, China
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Chengdu, 610000, China
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Fuzhou, 350014, China
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Guangzhou, 510060, China
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Guangzhou, 510100, China
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Hangzhou, 310022, China
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Harbin, 150049, China
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Jinan, 250117, China
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Nanjing, 210029, China
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Shanghai, 200030, China
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Shanghai, 200032, China
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Shenzhen, 518116, China
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Suzhou, 215006, China
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Taiyuan, 030000, China
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Xi'an, 710061, China
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Xintai, 54031, China
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Yangzhou, 225001, China
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Zhengzhou, 450008, China
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Berlin, 13125, Germany
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Esslingen am Neckar, 73730, Germany
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Georgsmarienhütte, 49124, Germany
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Lübeck, 23538, Germany
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München, 81377, Germany
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Würzburg, 97067, Germany
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Bari, 70124, Italy
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Catania, 95100, Italy
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Florence, 50134, Italy
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Genova, 16132, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Parma, 43100, Italy
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Roma, 00144, Italy
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Chiba, 260-0877, Japan
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Fukuoka, 812-8582, Japan
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Hiroshima, 734-8551, Japan
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Kashiwa, 227-8577, Japan
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Kōtoku, 135-8550, Japan
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Kyoto, 606-8507, Japan
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Niigata, 951-8566, Japan
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Osaka, 541-8567, Japan
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Sakai, 590-0197, Japan
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Sendai, 981-0914, Japan
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Shinjuku-ku, 160-0023, Japan
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Sunto-gun, 411-8777, Japan
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Wakayama, 641-8510, Japan
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Kuala Lumpur, 59100, Malaysia
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Kuala Selangor, 46050, Malaysia
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Kuching, 93586, Malaysia
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Pulau Pinang, 10450, Malaysia
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Poznan, 60-569, Poland
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Warsaw, 01-138, Poland
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Bucharest, 022328, Romania
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Bucharest, 050098, Romania
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Perm, 614990, Russia
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Saint Petersburg, 191036, Russia
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Singapore, 169610, Singapore
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Singapore, 308433, Singapore
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Daegu, 42415, South Korea
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Jinju, 52727, South Korea
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Seoul, 03082, South Korea
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Seoul, 05505, South Korea
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Seoul, 07061, South Korea
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Suwon, 16247, South Korea
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Suwon, 16499, South Korea
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Barcelona, 08041, Spain
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Málaga, 29010, Spain
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Valencia, 46010, Spain
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Vigo, 36312, Spain
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Zaragoza, 50009, Spain
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Taichung, 40201, Taiwan
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Taichung, 40705, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 100, Taiwan
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Taipei, 11217, Taiwan
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Taipei, 114, Taiwan
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Taipei, 235, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10300, Thailand
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Bangkok, 10330, Thailand
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Bangkok, 10700, Thailand
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Hat Yai, 90110, Thailand
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Khon Kaen, 40002, Thailand
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Muang, 50200, Thailand
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Ankara, 06010, Turkey (Türkiye)
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Bursa, 16059, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Izmir, 35040, Turkey (Türkiye)
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Kadıkoy/Istanbul, 34722, Turkey (Türkiye)
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Birmingham, B9 5SS, United Kingdom
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Blackpool, FY3 8NR, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SW10 9NH, United Kingdom
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London, SW3 6NP, United Kingdom
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Nottingham, NG5 1PB, United Kingdom
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Wythenshawe, M23 9LT, United Kingdom
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Hanoi, 100000, Vietnam
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Ho Chi Minh City, 700000, Vietnam
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Hồ Chí Minh, 700000, Vietnam

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