New combo attack on lung cancer: adding radiation to immunotherapy and chemo

NCT ID NCT03774732

Ongoing Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether adding radiation to the standard combination of pembrolizumab (an immunotherapy) and chemotherapy can improve survival in people with advanced non-small cell lung cancer. About 327 participants with stage IIIB/IV disease will receive either the triple therapy or standard care. The goal is to see if radiation boosts the immune response against tumors outside the radiation field.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pembrolizumab (a drug that helps the immune system fight cancer) combined with chemotherapy (carboplatin, paclitaxel, nab-paclitaxel, cisplatin, or pemetrexed) and radiation therapy
What this could lead to: If successful, this combination could extend survival for people with advanced lung cancer beyond current standard treatments.
What could go wrong: This is a Phase 3 trial, but the added radiation may increase side effects without improving outcomes. Results may not apply to all lung cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL CARCINOMA OF LUNG, TNM STAGE 4 NON-SMALL CELL LUNG CANCER NON-SMALL CELL LUNG CANCER METASTATIC

Contacts and locations

Locations

CHRU de Brest

Brest, France
CHU St Etienne

Saint-Etienne, France
CHU Sud de la Réunion

La Réunion, France
CHU de Nîmes

Nîmes, France
CHU de Toulouse Hôpital Larrey

Toulouse, France
Centre André DUTREIX

Dunkirk, France
Centre Antoine Lacassagne

Nice, France
Centre Azuréen De Cancérologie

Mougins, France
Centre Catalan d'Oncologie

Perpignan, France
Centre François Baclesse

Caen, France
Centre Frédéric JOLIOT

Rouen, France
Centre Georges Francois Leclerc

Dijon, France
Centre Henri Becquerel

Rouen, France
Centre Hospitalier Dr Jean-Eric TECHER

Calais, France
Centre Hospitalier Intercommunal De Creteil

Créteil, France
Centre Hospitalier Princesse Grace

Monaco, Monaco
Centre Hospitalier Universitaire De Caen - Hôpital Cote De Nacre

Caen, France
Centre Hospitalier William Morey

Chalon-sur-Saône, France
Centre Hospitalier de Dunkerque

Dunkirk, France
Centre Hospitalier de Montelimar

Montélimar, France
Centre Hospitalier des Pays de Morlaix

Morlaix, France
Centre Jean Perrin

Clermont-Ferrand, France
Centre Joliot Curie

Saint-Martin-Boulogne, France
Centre Marie Curie

Arras, France
Centre Marie Curie

Valence, France
Centre Oscar Lambret

Lille, France
Centre Paul Strauss

Strasbourg, France
Centre Pierre Curie

Beuvry, France
Centre de cancérologie du grand Montpellier-Clinique Clementville

Montpellier, France
Centre de radiothérapie et de cancérologie de Blois

La Chaussée-Saint-Victor, France
Centre hospitalier de Cannes Simone Veil

Cannes, France
Clinique Ambroise Pare

Beuvry, France
Clinique Chenieux

Limoges, 87039, France
Clinique Saint-Hilaire

Rouen, France
Fondation Hôpital Saint-Joseph

Paris, France
Gustave Roussy

Villejuif, France
Hopital Charles Nicolle

Rouen, France
Hopital Pitie Salpetriere

Paris, France
Hopital Tenon

Paris, France
Hôpital Européen Marseille

Marseille, France
Hôpital Privé Arnault Tzanck

Mougins, France
Hôpital Privé Arras Les Bonnettes

Arras, France
Hôpital Privé Clairval

Marseille, France
Hôpital Privé Drôme Ardèche

Valence, France
Hôpital Simone Veil Blois

Blois, France
Hôpital de Bicêtre

Le Kremlin-Bicêtre, France
Institut Bergonie

Bordeaux, France
Institut Claudius Regaud

Toulouse, France
Institut Curie - Hôpital René Huguenin

Saint-Cloud, France
Institut De Cancerologie De Lorraine

Vandœuvre-lès-Nancy, France
Institut Jean Godinot

Reims, France
Institut Sainte Catherine

Avignon, France
Institut de Cancérologie de Bourgogne

Chalon-sur-Saône, France
Institut de Cancérologie de Bourgogne

Dijon, France
Institut de Cancérologie de l'Ouest - Site Paul Papin

Angers, France
Polyclinique de l'Ormeau

Tarbes, France
Polyclinique du Parc Drevon

Dijon, France
Pôle départemental de Cancérologie Libérale 37

Chambray-lès-Tours, France

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