HEAD AND NECK SQUAMOUS CELL CARCINOMA

This study is testing whether combining two drugs, ACR-368 and a low dose of gemcitabine, can help control advanced head and neck cancer that has returned or spread. It will involve 43 patients who have already tried standard immunotherapy. Participants will receive the drug comb…

This is a first-in-human study testing a new oral drug called NX-1607 in adults with advanced cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body handles the drug, both alone and combined with a common chemot…

This early-phase study is testing a new type of cell therapy for people with advanced solid tumors, including melanoma, that have spread and are not responding to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack c…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This study is testing whether adding two new drugs (SI-B001 and SI-B003) to standard chemotherapy works better for people with advanced head and neck cancer that has returned or spread. The trial will enroll 60 adults to see if this combination helps shrink tumors and is safe. Re…

This study is testing a three-part treatment for people with advanced head and neck cancer linked to HPV that has come back or spread. The treatment combines a DNA vaccine designed to target the virus, an immune-boosting drug (GX-I7), and an established immunotherapy (nivolumab).…

This early-stage study aims to find a safe and effective dose of a new drug called AZD6750, which is designed to boost the immune system to fight cancer. It will test the drug alone and combined with other cancer treatments in about 60 adults with advanced or spreading solid tumo…

This study is testing whether a new combination of two drugs, SYS6010 and enlonstobart, can help control advanced head and neck cancer that has returned or spread. It will involve about 70 adults whose cancer is not suitable for surgery or standard radiation/chemotherapy. The mai…

This early-stage trial is testing a new combination of two experimental drugs, tislelizumab and pamiparib, given together with a standard course of chemotherapy and radiation. The goal is to find a safe and effective dose for people whose head and neck cancer has come back after …

This study is testing whether a combination of three treatments—a modified immune cell infusion, an immune-stimulating protein, and an approved targeted antibody—is safe and effective for people with advanced head and neck cancer that has returned or spread. It is for patients wh…

This study is testing whether adding a special heat treatment to standard palliative radiotherapy helps control advanced cancers that cannot be cured by surgery. It will involve about 60 patients with certain advanced head, neck, skin, or breast cancers. The goal is to see if the…

This study is testing a new drug called volrustomig, both by itself and combined with chemotherapy, for people with advanced solid tumors that have spread. It is enrolling about 257 adults with specific advanced cancers, including cervical, head and neck, esophageal, and a type o…

This study is testing whether a lower dose of radiation after surgery can safely reduce long-term side effects for people with HPV-positive throat cancer. It will enroll about 304 patients who have had surgery and need follow-up radiation. The main goal is to see if the cancer is…

This early-stage study is testing whether adding a new experimental drug (BI 770371) to standard immunotherapy treatments helps shrink tumors in people with advanced head and neck cancer that has spread or returned. The trial will enroll 90 adults and randomly assign them to one …

This study is testing if adding a new immune-boosting drug (CDX-1140) to an existing immunotherapy (cemiplimab) works better before surgery for advanced head and neck cancer. The goal is to shrink the tumor more effectively, which could lead to less extensive surgery. About 44 pa…

This study is testing whether using virtual reality (VR) to create a 3D map of a patient's tumor before surgery helps surgeons operate more precisely. The goal is to remove all the cancer while sparing healthy tissue, which could lead to fewer repeat procedures and better long-te…

This study is testing two new drugs, BL-B01D1 and SI-B003, given alone and together for people with advanced head and neck cancer that has returned or spread. The main goals are to see if the treatments shrink tumors and are safe for patients. It will include about 186 adults who…

This study is testing whether a patient navigation program called ENDURE helps people with head and neck cancer start their necessary radiation therapy sooner after surgery. It will compare the new program to the usual way patients are scheduled for treatment. The goal is to see …

This is a first-in-human study to test the safety and find the right dose of a new oral drug, OKN4395, for people with advanced solid tumors. The trial will give the drug alone and combined with an existing immunotherapy (pembrolizumab) to about 166 participants with cancers like…

This early-stage study is testing FT836, a new type of 'off-the-shelf' CAR T-cell therapy, in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see how well the body tolerates FT836, which is given al…

This study is testing a new oral medication called NEO212 for adults with specific aggressive brain tumors (like glioblastoma) or brain metastases from other cancers. The main goals are to find a safe and effective dose, see how the body processes the drug, and check if it can he…

This study is testing a new drug called NT219 in combination with two existing cancer drugs (pembrolizumab or cetuximab) for people with advanced head and neck cancer that has returned or spread. The main goal is to see if these combinations can shrink tumors and control the dise…

This early-stage study is testing a new oral drug called VMD-928, both by itself and combined with an existing immunotherapy (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have progressed despite available treatments. The main goals are to find safe…

This is the first study in people to test a new drug called CHS-114, which is designed to help the immune system fight cancer. It will be given alone and in combination with another immunotherapy drug to adults with advanced solid tumors, including head and neck cancer, that have…

This study is testing a new oral drug called IPN01194 in adults with advanced solid tumors that have spread and have specific genetic changes. The main goals are to find a safe and tolerable dose and to see if the drug can help shrink tumors. The study is open to people with cert…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study is testing whether adding a new drug called petosemtamab to standard pembrolizumab treatment works better for advanced head and neck cancer. It will involve about 500 adults whose cancer has returned or spread and who haven't had prior treatment for metastatic disease.…

This is a first-in-human study testing a new personalized cell therapy called NT-175. It is for adults with advanced solid cancers (like lung, colorectal, or breast cancer) that have spread and have a specific genetic mutation (TP53 R175H). The main goals are to find a safe dose …

This study is testing a new, experimental drug called GI-101 in people with advanced cancers that have spread. The main goals are to find a safe dose and see if the drug, given alone or with other approved cancer medicines, can help shrink tumors. The trial will enroll about 317 …

This is the first human study of an experimental cancer drug called CTX-8371. It aims to find safe doses and see how the body handles the drug in 73 patients with advanced cancers that have stopped responding to standard treatments. The study will test different dose levels to de…

This is the first-ever study in people for a new drug called EPI-326. It aims to find a safe dose and see how the body handles the drug in patients with advanced lung cancer (with a specific genetic change called EGFR mutation) or advanced head and neck cancer. The main goal is t…

This is an early-stage study to test a new oral medication called VLS-1488 in adults with advanced solid tumors. The main goals are to find a safe dose and see if the drug shows any early signs of helping to control the cancer. The study is for people with specific advanced cance…

This study is testing whether giving two drugs, cetuximab and cemiplimab, before surgery can help people with head and neck cancer. The goal is to see if this combination can shrink or even eliminate the tumor, which might lead to better long-term results. The trial will enroll 2…

This is an early-stage study to find a safe dose of an experimental therapy called MQ710 for people with advanced solid tumors that have returned, spread, or stopped responding to standard treatments. The therapy is a modified virus designed to be injected directly into tumors. R…

This is a first-in-human study to find a safe and effective dose of a new drug called ONM-501. The drug is injected directly into tumors and is being tested alone and in combination with an approved immunotherapy drug (cemiplimab) in adults with advanced cancers that have stopped…

This is the first study in people to test the safety and behavior of a new drug called azirkitug. It will be given alone and in combination with two other cancer drugs to adults with advanced solid tumors, including lung and head and neck cancers, who have already tried standard …

This early-stage study is testing if adding two immunotherapy drugs (cemiplimab and cetuximab) to standard chemotherapy before surgery is safe for people with advanced head and neck cancer. The main goal is to see if this stronger pre-surgery treatment can work well enough that p…

This study is testing a new approach for people with HPV-linked throat cancer who have surgery. Researchers want to see if a simple blood test can identify patients who are very unlikely to need follow-up radiation. If the blood test after surgery shows no signs of cancer, patien…

This study is testing a new combination treatment for people with advanced head and neck cancer that has come back or spread. Doctors will place tiny, temporary radioactive seeds directly into the tumor to deliver a high dose of radiation, while patients also receive a standard i…

This study aims to see if it's safe and practical to give the drug methylnaltrexone to patients with oral cavity cancer for two weeks before their scheduled surgery. Researchers will enroll about 25 adults to see if they can complete the two-week drug course without major side ef…

This is the first study in people to test a new drug called BL-B01D1. It aims to find a safe dose and see if it can help control advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 470 adults with various solid tumors, including lung, br…

This study is testing a new approach for treating advanced head and neck cancer that has returned or spread. Researchers want to see if using a simple blood test to measure tumor DNA can help decide when to add short bursts of chemotherapy to standard immunotherapy. The goal is t…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This study is testing whether a new drug called SIBP-03, when given with an existing cancer drug (cetuximab), can help control advanced head and neck cancer that has returned or spread. It will involve about 81 adults whose cancer has worsened after previous immunotherapy and che…

This study is testing whether using a lower dose of radiation, combined with chemotherapy and planned surgery, can effectively control certain head and neck cancers. The goal is to see if this approach works while potentially reducing treatment side effects. It is for adults with…

This early-stage study is testing a new radioactive drug called Lutetium-177 BL-ARC001 in people with advanced lung, breast, head/neck, and other solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose, see how the body process…

This is the first study in people for a new radioactive drug called [225Ac]-FPI-2068. It aims to find a safe dose and see how the drug travels in the body of 70 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check safety…

This is the first study in people to test a new cancer drug called SIM0610. It aims to find a safe dose and see if it can shrink tumors in adults with advanced solid cancers that have stopped responding to standard treatments. The study will enroll 260 people with cancers like lu…

This study is testing an experimental drug called petosemtamab for people with advanced head and neck cancer that has spread or returned after standard treatments. It will compare petosemtamab against other single-drug treatments chosen by doctors to see which works better. The m…

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This is the first study in people to test a new cancer drug called KIVU-107. The main goal is to find a safe dose and see how well the body handles it. It is for adults with advanced solid tumors that have spread or cannot be removed by surgery and have stopped responding to avai…

This study is testing a new experimental drug called ALE.P02 for adults with advanced squamous cell cancers that have spread or can't be removed by surgery. The drug is designed to target cancer cells that have a specific marker called Claudin-1. Researchers will first find the s…

This study is testing whether giving two immunotherapy drugs (pembrolizumab and IO102-103) before surgery is safe and effective for people with head and neck cancer that can be removed by surgery. Researchers will give the drugs to 30 participants and closely monitor side effects…

This study is for people who have had surgery for stage III-IVA head and neck cancer. It tests whether adding the chemotherapy drug cisplatin to standard radiation treatment is better at preventing the cancer from coming back than radiation alone. The study also uses a genetic te…

This study is testing a new drug called TER-2013 in people with advanced solid tumors that have specific genetic changes. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for patients who have run out of standard treatment options.

This is an early-stage study testing a new drug called BL-M24D1 in patients with advanced head and neck cancer or other solid tumors. The main goals are to find a safe dose, see how the drug moves through the body, and check for any early signs that it might help shrink tumors. R…

This study is testing if adding a low dose of radiation to a combination of targeted and immunotherapy drugs works better than the drugs alone when given before surgery for operable head and neck cancer. The goal is to shrink the tumor more effectively to improve surgical outcome…

This study is testing if a drug called cetuximab can help control head and neck cancer that has returned or spread after standard immunotherapy has stopped working. It will involve about 38 adults who have already tried a PD-1 inhibitor drug. The main goal is to see if the cancer…

This is an early-stage study to check the safety and initial activity of an experimental drug called DR-0202. It is for adults with advanced cancers that have spread, returned, or stopped responding to at least two prior treatments. The main goal is to find a safe dose and see ho…

This is a small, early-stage study to see if a new type of imaging scan can more accurately find and measure head and neck cancer tumors before surgery. Researchers will compare a new scan using a special tracer to the standard scan patients already receive. The goal is to improv…

This study is testing a new imaging agent to see if it can better detect when head and neck cancer has spread to other parts of the body. Researchers will give 60 participants an infusion of the experimental agent and then perform a special PET/CT scan. They will compare the resu…

This early-stage study is testing a new radioactive imaging drug to see if it can safely and accurately find the first lymph nodes where head and neck cancer has spread. The test involves injecting the drug before surgery and using a special scan to create a map for surgeons. The…

This early-stage study is testing the safety of two new imaging dyes designed to help surgeons see head and neck cancer cells more clearly. The dyes are injected before surgery and make cancer cells glow or show up on special scans, potentially helping surgeons remove more of the…

This small pilot study is testing whether moving a flap of a patient's own fat to the neck area is a safe and practical way to reduce problems that occur after cancer treatment. These problems can include pain, stiffness, swelling, and trouble swallowing. Researchers will also ch…

This study is testing if a supervised heavy weight lifting program is practical and helpful for people who have survived head and neck cancer. It will compare 60 survivors doing 12 weeks of heavy lifting against a group receiving usual care. The main goal is to see if the program…

This study is testing whether adding the medication olanzapine to standard care helps head and neck cancer patients maintain their weight and appetite during intense chemoradiation treatment. About 66 patients will be randomly assigned to receive either standard care alone or sta…

This study is testing if adding an investigational drug called BMX-001 to standard symptom care can better prevent severe mouth sores in people receiving combined chemotherapy and radiation for head and neck cancer. About 98 participants will be randomly assigned to receive eithe…

This study is testing if a shorter, more intense course of radiation can better relieve pain and control tumors in patients with advanced head and neck cancer who cannot be cured. It will compare this new approach to standard, longer radiation schedules. The main goal is to see w…

This large, late-stage trial is testing if a high dose of the drug gabapentin, started early, can prevent the need for strong opioid painkillers in patients receiving chemotherapy and radiation for head and neck cancer. The goal is to manage the severe mouth sores and pain that a…

This study aims to see if drug tests performed on tiny 3D tumor models grown in a lab from a patient's own cancer cells can accurately predict how well standard cancer treatments will work for that patient. Researchers will enroll 100 people with recurrent or metastatic head and …

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …

This study aims to discover biological markers in the blood and tissue of 500 people with advanced head and neck cancer. Researchers will collect samples during patients' standard treatments to understand what makes the disease progress or respond to therapy. The goal is to gathe…

This study is testing whether a new type of PET/CT scan can better detect damage to neck blood vessels caused by radiation therapy for head and neck cancers. Researchers will compare the new scan to the standard scan in about 20 patients before and after their radiation treatment…

This study aims to use repeated MRI scans to better understand how head and neck cancer tumors respond to radiation therapy. Researchers will scan patients during their treatment to see if changes in the tumor can predict outcomes. The goal is to gather information that could hel…