Can a 'Mini Tumor' in a dish predict your best cancer drug?

NCT ID NCT06686342

Recruiting now Knowledge-focused Sponsor: Huashan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study enrolls 100 people with recurrent or metastatic head and neck squamous cell carcinoma. Researchers will take a small tumor sample, grow it in the lab as a 3D organoid, and test various drugs on it. They then compare the lab results to how the patient's actual tumor responds to their prescribed treatment. The goal is to see if the organoid test accurately predicts drug effectiveness. No treatment decisions are changed based on the test.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that patient-derived organoids reliably predict which drugs will work, paving the way for personalized treatment in head and neck cancer.
What could go wrong: This is an observational study—no treatment decisions are based on the organoid test. It only checks consistency, not whether using organoids improves outcomes. Results may not change current practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG SENSITIVE TEST IN VITRO HEAD AND NECK SQUAMOUS CELL CARCINOMA PATIENT DERIVED ORGANOID

Contacts and locations

Locations

Huashan Hospital, Fudan University
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200040, China
Huashan Hospital, Fudan University
RECRUITING

Shanghai, Shanghai Municipality, 200040, China

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